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ORBIMED ADVISORS LLC
> AMGN
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | AMGEN INC | AMGN | 127,300 | 50,600 | 28,263,146,000 | 9,720,921,000 | $222,020.00 |
| 03/31/2023 | AMGEN INC | AMGN | 76,700 | 76,700 | 18,542,225,000 | 18,542,225,000 | $241,750.00 |
| 09/30/2022 | AMGEN INC | AMGN | 0 | -57,100 | 0 | -13,892,000 | |
| 06/30/2022 | AMGEN INC | AMGN | 57,100 | 0 | 13,892,000 | 84,000 | $243.29 |
| 03/31/2022 | AMGEN INC | AMGN | 57,100 | 0 | 13,808,000 | 962,000 | $241.82 |
| 12/31/2021 | AMGEN INC | AMGN | 57,100 | 0 | 12,846,000 | -1,072,000 | $224.97 |
| 06/30/2021 | AMGEN INC | AMGN | 57,100 | -34,400 | 13,918,000 | -8,848,000 | $243.75 |
| 03/31/2021 | AMGEN INC | AMGN | 91,500 | 0 | 22,766,000 | 1,728,000 | $248.81 |
| 12/31/2020 | AMGEN INC | AMGN | 91,500 | 0 | 21,038,000 | -2,218,000 | $229.92 |
| 09/30/2020 | AMGEN INC | AMGN | 91,500 | 0 | 23,256,000 | 1,675,000 | $254.16 |
| 06/30/2020 | AMGEN INC | AMGN | 91,500 | -13,700 | 21,581,000 | 254,000 | $235.86 |
| 03/31/2020 | AMGEN INC | AMGN | 105,200 | -16,900 | 21,327,000 | -8,108,000 | $202.73 |
| 12/31/2019 | AMGEN INC | AMGN | 122,100 | 0 | 29,435,000 | 5,807,000 | $241.07 |
| 09/30/2019 | AMGEN INC | AMGN | 122,100 | 0 | 23,628,000 | 1,127,000 | $193.51 |
| 06/30/2019 | AMGEN INC | AMGN | 122,100 | 0 | 22,501,000 | -696,000 | $184.28 |
| 03/31/2019 | AMGEN INC | AMGN | 122,100 | 0 | 23,197,000 | -572,000 | $189.98 |
| 12/31/2018 | AMGEN INC | AMGN | 122,100 | -29,500 | 23,769,000 | -7,656,000 | $194.67 |
| 09/30/2018 | AMGEN INC | AMGN | 151,600 | 27,500 | 31,425,000 | 8,517,000 | $207.29 |
| 06/30/2018 | AMGEN INC | AMGN | 124,100 | -321,210 | 22,908,000 | -53,008,000 | $184.59 |
| 03/31/2018 | AMGEN INC | AMGN | 445,310 | -851,790 | 75,916,000 | -149,650,000 | $170.48 |
| 12/31/2017 | AMGEN INC | AMGN | 1,297,100 | 44,000 | 225,566,000 | -8,074,000 | $173.90 |
| 09/30/2017 | AMGEN INC | AMGN | 1,253,100 | -49,600 | 233,640,000 | 9,276,000 | $186.45 |
| 06/30/2017 | AMGEN INC | AMGN | 1,302,700 | -135,600 | 224,364,000 | -11,618,000 | $172.23 |
| 03/31/2017 | AMGEN INC | AMGN | 1,438,300 | -893,500 | 235,982,000 | -104,950,000 | $164.07 |
| 12/31/2016 | AMGEN INC | AMGN | 2,331,800 | -104,900 | 340,932,000 | -65,534,000 | $146.21 |
| 09/30/2016 | AMGEN INC | AMGN | 2,436,700 | -596,800 | 406,466,000 | -55,081,000 | $166.81 |
| 06/30/2016 | AMGEN INC | AMGN | 3,033,500 | 3,033,500 | 461,547,000 | 461,547,000 | $152.15 |
| 03/31/2016 | AMGEN INC | AMGN | 2,876,000 | -45,000 | 431,199,000 | -42,967,000 | $149.93 |
| 12/31/2015 | AMGEN INC | AMGN | 2,921,000 | 2,088,400 | 474,166,000 | 402,396,000 | $162.33 |
| 09/30/2015 | AMGEN INC | AMGN | 3,013,000 | 2,180,400 | 416,758,000 | 344,988,000 | $138.32 |
| 06/30/2015 | AMGEN INC | AMGN | 0 | -832,600 | 0 | -71,770,000 | |
| 03/31/2015 | AMGEN INC | AMGN | 3,049,000 | 2,216,400 | 487,383,000 | 415,613,000 | $159.85 |
| 12/31/2014 | AMGEN INC | AMGN | 2,708,000 | 1,875,400 | 431,357,000 | 359,587,000 | $159.29 |
| 09/30/2014 | AMGEN INC | AMGN | 2,603,000 | 1,770,400 | 365,617,000 | 293,847,000 | $140.46 |
| 06/30/2014 | AMGEN INC | AMGN | 2,245,000 | 1,412,400 | 265,741,000 | 193,971,000 | $118.37 |
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