The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
4D MOLECULAR THERAPEUTICS IN COM 35104E100 5,181 125,000 SH   SOLE   0 0 125,000
89BIO INC COM 282559103 90,887 3,729,442 SH   SOLE   3,729,442 0 0
9 METERS BIOPHARMA INC COM 654405109 22,091 25,716,755 SH   SOLE   25,716,755 0 0
908 DEVICES INC COM 65443P102 2,278 40,000 SH   SOLE   40,000 0 0
ABBVIE INC COM 00287Y109 92,395 862,300 SH   DFND 1 125,000 0 737,300
ABCELLERA BIOLOGICS INC COM 00288U106 338,047 8,400,768 SH   DFND 1 8,200,768 0 200,000
ACADIA HEALTHCARE COMPANY IN COM 00404A109 52,027 1,035,160 SH   DFND 1 123,500 0 911,660
ACADIA PHARMACEUTICALS INC COM 004225108 14,208 265,772 SH   SOLE   0 0 265,772
ACUTUS MED INC COM 005111109 157,820 5,477,958 SH   SOLE   5,477,958 0 0
ADICET BIO INC COM 007002108 94,255 6,708,507 SH   SOLE   6,708,507 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 59,632 5,501,144 SH   DFND 1 655,897 0 4,845,247
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 31,602 4,015,524 SH   SOLE   4,015,524 0 0
AERPIO PHARMACEUTICALS INC COM 00810B105 5,090 5,193,946 SH   SOLE   5,193,946 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 95,643 2,207,321 SH   DFND 1 258,200 0 1,949,121
AKOUOS INC COM 00973J101 6,246 315,000 SH   SOLE   0 0 315,000
ALCON AG ORD SHS H01301128 23,357 351,380 SH   DFND 1 125,800 0 225,580
ALECTOR INC COM 014442107 33,602 2,225,313 SH   SOLE   2,225,313 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 26,405 169,000 SH   SOLE   0 0 169,000
ALPINE IMMUNE SCIENCES INC COM 02083G100 38,694 3,070,955 SH   SOLE   3,070,955 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105 12,930 150,000 SH   SOLE   0 0 150,000
AMGEN INC COM 031162100 21,038 91,500 SH   SOLE   0 0 91,500
ANTHEM INC COM 036752103 99,698 310,500 SH   DFND 1 39,800 0 270,700
APPLIED THERAPEUTICS INC COM 03828A101 38,998 1,771,831 SH   DFND 1 105,006 0 1,666,825
APTOSE BIOSCIENCES INC COM NEW 03835T200 35,171 8,030,000 SH   SOLE   0 0 8,030,000
ARCTURUS THERAPEUTICS HLDGS COM 03969T109 55,530 1,280,086 SH   DFND 1 159,626 0 1,120,460
ARCUTIS BIOTHERAPEUTICS INC COM 03969K108 170,857 6,073,850 SH   DFND 1 4,267,564 0 1,806,286
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 56,121 336,500 SH   DFND 1 61,000 0 275,500
ATHENEX INC COM 04685N103 40,856 3,694,061 SH   DFND 1 211,800 0 3,482,261
ATRICURE INC COM 04963C209 68,373 1,228,189 SH   DFND 1 187,000 0 1,041,189
AURINIA PHARMACEUTICALS INC COM 05156V102 65,748 4,754,000 SH   DFND 1 590,000 0 4,164,000
AVROBIO INC COM 05455M100 11,064 793,712 SH   DFND 1 129,000 0 664,712
BELLUS HEALTH INC NEW COM NEW 07987C204 12,573 4,189,593 SH   DFND 1 3,954,800 0 234,793
BIOGEN INC COM 09062X103 129,629 529,400 SH   DFND 1 59,400 0 470,000
BIOMX INC COM 09090D103 14,760 2,313,489 SH   SOLE   2,313,489 0 0
BOSTON SCIENTIFIC CORP COM 101137107 234,502 6,523,000 SH   DFND 1 939,400 0 5,583,600
BRISTOL-MYERS SQUIBB CO COM 110122108 220,151 3,549,100 SH   DFND 1 545,300 0 3,003,800
BRISTOL-MYERS SQUIBB CO RIGHT 99/99/9999 110122157 276 400,000 SH   DFND 1 135,907 0 264,093
BURNING ROCK BIOTECH LTD SPONSORED ADS 12233L107 96,135 4,161,675 SH   DFND 1 404,099 0 3,757,576
CALITHERA BIOSCIENCES INC COM 13089P101 1,229 250,300 SH Put DFND 1 91,000 0 159,300
CENTENE CORP DEL COM 15135B101 119,682 1,993,700 SH   DFND 1 277,100 0 1,716,600
CHANGE HEALTHCARE INC COM 15912K100 57,698 3,093,700 SH   DFND 1 398,000 0 2,695,700
CHINOOK THERAPEUTICS INC COM 16961L106 19,825 1,250,001 SH   DFND 1 250,000 0 1,000,001
COGENT BIOSCIENCES INC COM 19240Q201 7,356 655,000 SH   DFND 1 187,350 0 467,650
COMPASS PATHWAYS PLC SPONSORED ADS 20451W101 16,674 350,000 SH   DFND 1 106,300 0 243,700
CORVUS PHARMACEUTICALS INC COM 221015100 24,093 6,767,584 SH   SOLE   6,767,584 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 38,853 2,753,567 SH   SOLE   2,753,567 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 69,175 451,800 SH   DFND 1 42,300 0 409,500
CTI BIOPHARMA CORP COM 12648L601 30,656 9,520,600 SH   SOLE   9,520,600 0 0
CURIS INC COM NEW 231269200 35,762 4,366,494 SH   DFND 1 195,900 0 4,170,594
DECIPHERA PHARMACEUTICALS IN COM 24344T101 64,244 1,125,700 SH   DFND 1 190,100 0 935,600
DEXCOM INC COM 252131107 103,189 279,100 SH   DFND 1 37,000 0 242,100
DYNE THERAPEUTICS INC COM 26818M108 7,350 350,000 SH   SOLE   0 0 350,000
EDWARDS LIFESCIENCES CORP COM 28176E108 93,584 1,025,800 SH   DFND 1 151,600 0 874,200
EHEALTH INC COM 28238P109 59,598 844,046 SH   DFND 1 113,200 0 730,846
ESSA PHARMA INC COM NEW 29668H708 5,494 460,500 SH   SOLE   460,500 0 0
FLEXION THERAPEUTICS INC COM 33938J106 26,635 2,308,083 SH   DFND 1 84,100 0 2,223,983
FLUIDIGM CORP DEL COM 34385P108 23,354 3,892,346 SH   DFND 1 393,100 0 3,499,246
FORTE BIOSCIENCES INC COM 34962G109 3,357 92,200 SH   DFND 1 19,439 0 72,761
FUSION PHARMACEUTICALS INC COM 36118A100 37,891 3,224,770 SH   DFND 1 2,930,670 0 294,100
GALECTO INC COM 36322Q107 51,178 4,090,937 SH   DFND 1 3,803,255 0 287,682
GILEAD SCIENCES INC COM 375558103 11,198 192,200 SH   SOLE   0 0 192,200
GRAYBUG VISION INC COM SHS 38942Q103 129,889 4,475,847 SH   DFND 1 4,163,347 0 312,500
GUARDANT HEALTH INC COM 40131M109 69,363 538,200 SH   DFND 1 58,100 0 480,100
HARPOON THERAPEUTICS INC COM 41358P106 30,491 1,835,704 SH   DFND 1 1,020,704 0 815,000
HEALTH CATALYST INC COM 42225T107 7,818 179,598 SH   SOLE   179,598 0 0
HEALTH SCIENCES ACQ CORP 2 ORD SHS G4411D109 6,405 500,000 SH   DFND 1 100,000 0 400,000
HERON THERAPEUTICS INC COM 427746102 25,225 1,191,846 SH   SOLE   0 0 1,191,846
HORIZON THERAPEUTICS PUB L SHS G46188101 220,090 3,008,755 SH   DFND 1 357,500 0 2,651,255
HUMANA INC COM 444859102 117,378 286,100 SH   DFND 1 48,100 0 238,000
I MAB SPONSORED ADS 44975P103 28,576 606,070 SH   DFND 1 136,360 0 469,710
IMARA INC COM 45249V107 59,974 2,719,902 SH   DFND 1 2,532,402 0 187,500
IMMUNOGEN INC COM 45253H101 16,473 2,553,900 SH   DFND 1 322,900 0 2,231,000
INFLARX NV COM N44821101 2,797 556,025 SH   SOLE   0 0 556,025
INOZYME PHARMA INC COM 45790W108 8,264 400,400 SH   SOLE   0 0 400,400
INTUITIVE SURGICAL INC COM NEW 46120E602 92,282 112,800 SH   DFND 1 18,500 0 94,300
IOVANCE BIOTHERAPEUTICS INC COM 462260100 308,333 6,645,100 SH   DFND 1 1,337,800 0 5,307,300
KALA PHARMACEUTICALS INC COM 483119103 37,053 5,465,030 SH   DFND 1 4,714,195 0 750,835
KEROS THERAPEUTICS INC COM 492327101 118,466 1,679,417 SH   DFND 1 1,268,734 0 410,683
KINNATE BIOPHARMA INC COM 49705R105 153,071 3,847,929 SH   DFND 1 3,397,929 0 450,000
LARIMAR THERAPEUTICS INC COM 517125100 18,981 886,560 SH   DFND 1 154,237 0 732,323
LOGICBIO THERAPEUTICS INC COM 54142F102 64,602 8,466,783 SH   DFND 1 7,948,265 0 518,518
MEIRAGTX HLDGS PLC COM G59665102 62,118 4,102,925 SH   DFND 1 133,500 0 3,969,425
MERCK & CO. INC COM 58933Y105 217,531 2,659,300 SH   DFND 1 382,100 0 2,277,200
MEREO BIOPHARMA GROUP PLC ADS 589492107 49,463 13,816,488 PRN   DFND 1 9,210,992 0 4,605,496
MERSANA THERAPEUTICS INC COM 59045L106 20,579 773,348 SH   DFND 1 41,550 0 731,798
MILESTONE PHARMACEUTICALS IN COM 59935V107 16,704 2,493,109 SH   SOLE   0 0 2,493,109
MIRATI THERAPEUTICS INC COM 60468T105 251,554 1,145,300 SH   DFND 1 170,900 0 974,400
MOLINA HEALTHCARE INC COM 60855R100 34,539 162,400 SH   DFND 1 20,600 0 141,800
NANOBIOTIX SA SPONSORED ADS 63009J107 8,250 500,000 SH   SOLE   0 0 500,000
NANOSTRING TECHNOLOGIES INC COM 63009R109 108,807 1,626,900 SH   DFND 1 180,700 0 1,446,200
NATERA INC COM 632307104 210,057 2,110,700 SH   DFND 1 273,300 0 1,837,400
NEUROCRINE BIOSCIENCES INC COM 64125C109 124,769 1,301,715 SH   DFND 1 137,470 0 1,164,245
NEXTCURE INC COM 65343E108 29,550 2,711,013 SH   SOLE   2,711,013 0 0
NOVUS THERAPEUTICS INC COM 67011N204 1,105 73,650 SH   SOLE   73,650 0 0
NURIX THERAPEUTICS INC COM 67080M103 9,864 300,000 SH   SOLE   0 0 300,000
OAK STR HEALTH INC COM 67181A107 27,406 448,100 SH   DFND 1 54,000 0 394,100
OLEMA PHARMACEUTICALS INC COM 68062P106 31,300 650,992 SH   DFND 1 225,992 0 425,000
ORIC PHARMACEUTICALS INC COM 68622P109 98,909 2,921,967 SH   DFND 1 2,765,717 0 156,250
OTONOMY INC COM 68906L105 21,028 3,250,000 SH   DFND 1 769,200 0 2,480,800
OUTSET MED INC COM 690145107 7,105 125,000 SH   DFND 1 16,000 0 109,000
PANDION THERAPEUTICS INC COM 698340106 21,992 1,480,940 SH   DFND 1 1,040,825 0 440,115
PASSAGE BIO INC COM 702712100 178,041 6,962,899 SH   DFND 1 5,947,323 0 1,015,576
PFIZER INC COM 717081103 133,127 3,616,600 SH   DFND 1 501,700 0 3,114,900
PMV PHARMACEUTICALS INC COM 69353Y103 450,894 7,330,423 SH   DFND 1 6,589,330 0 741,093
PRAXIS PRECISION MEDICINES I COM 74006W108 14,063 255,600 SH   SOLE   0 0 255,600
PRELUDE THERAPEUTICS INC COM 74065P101 1,115,813 15,594,877 SH   DFND 1 14,805,377 0 789,500
PREVAIL THERAPEUTICS INC COM 74140Y101 318,884 13,822,463 SH   SOLE   13,822,463 0 0
PROGYNY INC COM 74340E103 71,024 1,675,500 SH   DFND 1 189,700 0 1,485,800
PROTARA THERAPEUTICS INC COM STK 74365U107 10,895 450,000 SH   DFND 1 60,000 0 390,000
PROTHENA CORP PLC SHS G72800108 21,587 1,797,458 SH   DFND 1 312,000 0 1,485,458
PULMONX CORP COM 745848101 8,628 125,000 SH   SOLE   0 0 125,000
PURPLE BIOTECH LTD SPONSORED ADS 74638P109 1,319 346,197 SH   SOLE   346,197 0 0
RELAY THERAPEUTICS INC COM 75943R102 14,546 350,000 SH   SOLE   0 0 350,000
REPARE THERAPEUTICS INC COM 760273102 117,523 3,426,325 SH   DFND 1 3,276,325 0 150,000
SAREPTA THERAPEUTICS INC COM 803607100 91,902 539,049 SH   DFND 1 68,000 0 471,049
SAREPTA THERAPEUTICS INC COM 803607100 8,525 50,000 SH Call DFND 1 15,000 0 35,000
SCPHARMACEUTICALS INC COM 810648105 25,377 4,797,148 SH   SOLE   4,797,148 0 0
SELECTA BIOSCIENCES INC COM 816212104 1,634 539,169 SH   SOLE   539,169 0 0
SI BONE INC COM 825704109 40,918 1,368,500 SH   DFND 1 63,200 0 1,305,300
SIERRA ONCOLOGY INC COM NEW 82640U404 23,681 1,477,320 SH   DFND 1 1,306,860 0 170,460
SILVERBACK THERAPEUTICS INC COM 82835W108 405,053 8,740,887 SH   DFND 1 7,788,510 0 952,377
SINOVAC BIOTECH LTD SHS P8696W104 72,000 2,839,500 SH   SOLE   0 0 2,839,500
SPRINGWORKS THERAPEUTICS INC COM 85205L107 537,105 7,406,307 SH   SOLE   7,406,307 0 0
STRONGBRIDGE BIOPHARMA PLC SHS USD G85347105 8,479 3,489,369 SH   DFND 1 502,500 0 2,986,869
STRYKER CORPORATION COM 863667101 57,584 235,000 SH   DFND 1 42,200 0 192,800
SUTRO BIOPHARMA INC COM 869367102 7,599 350,000 SH   SOLE   0 0 350,000
SYNDAX PHARMACEUTICALS INC COM 87164F105 26,041 1,170,900 SH   DFND 1 85,800 0 1,085,100
SYNLOGIC INC COM 87166L100 4,385 2,029,996 SH   SOLE   2,029,996 0 0
SYROS PHARMACEUTICALS INC COM 87184Q107 16,953 1,562,500 SH   SOLE   0 0 1,562,500
TCR2 THERAPEUTICS INC COM 87808K106 7,710 249,279 SH   SOLE   0 0 249,279
TELA BIO INC COM 872381108 45,534 3,027,542 SH   SOLE   3,027,542 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 18,675 1,935,200 SH   DFND 1 269,500 0 1,665,700
THERAVANCE BIOPHARMA INC COM G8807B106 110,514 6,219,110 SH   DFND 1 674,898 0 5,544,212
THERMO FISHER SCIENTIFIC INC COM 883556102 51,376 110,300 SH   DFND 1 16,800 0 93,500
TRICIDA INC COM 89610F101 67,781 9,614,280 SH   SOLE   9,614,280 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 43,545 2,960,200 SH   DFND 1 206,900 0 2,753,300
TURNING POINT THERAPEUTICS I COM 90041T108 334,518 2,745,327 SH   DFND 1 2,027,550 0 717,777
UNIQURE NV SHS N90064101 35,013 969,079 SH   DFND 1 138,100 0 830,979
UNITEDHEALTH GROUP INC COM 91324P102 136,870 390,300 SH   DFND 1 56,500 0 333,800
VAXCYTE INC COM 92243G108 16,746 630,260 SH   SOLE   0 0 630,260
VERONA PHARMA PLC SPONSORED ADS 925050106 39,864 5,694,841 SH   DFND 1 5,028,174 0 666,667
VERRICA PHARMACEUTICALS INC COM 92511W108 17,032 1,479,733 SH   SOLE   1,479,733 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 197,131 834,100 SH   DFND 1 134,300 0 699,800
VIATRIS INC COM 92556V106 10,029 535,149 SH   DFND 1 69,607 0 465,542
VISTAGEN THERAPEUTICS INC COM NEW 92840H202 14,550 7,500,000 SH   DFND 1 1,875,000 0 5,625,000
X4 PHARMACEUTICALS INC COM 98420X103 6,986 1,086,493 SH   SOLE   1,086,493 0 0
XENON PHARMACEUTICALS INC COM 98420N105 38,418 2,497,917 SH   DFND 1 786,612 0 1,711,305
XTANT MED HLDGS INC COM NEW 98420P308 87,080 72,803,072 SH   SOLE   72,803,072 0 0
ZYMEWORKS INC COM 98985W102 14,982 317,002 SH   SOLE   0 0 317,002