The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109 8,279 92,700 SH   SOLE   0 0 92,700
89BIO INC COM 282559103 79,809 4,004,442 SH   SOLE   4,004,442 0 0
9 METERS BIOPHARMA INC COM 654405109 14,591 25,716,755 SH   SOLE   25,716,755 0 0
ABBVIE INC COM 00287Y109 45,556 464,000 SH   DFND 1 65,100 0 398,900
ABBVIE INC COM 00287Y109 9,818 100,000 SH Call DFND 1 31,500 0 68,500
ACADIA HEALTHCARE COMPANY IN COM 00404A109 34,670 1,380,160 SH   DFND 1 164,500 0 1,215,660
ACCELERON PHARMA INC COM 00434H108 12,147 127,500 SH   DFND 1 4,000 0 123,500
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 68,711 3,290,744 SH   DFND 1 357,697 0 2,933,047
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 37,144 4,015,524 SH   SOLE   4,015,524 0 0
AERPIO PHARMACEUTICALS INC COM 00810B105 6,492 5,193,946 SH   SOLE   5,193,946 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 92,436 1,728,421 SH   DFND 1 207,500 0 1,520,921
AGIOS PHARMACEUTICALS INC COM 00847X104 5,348 100,000 SH Call DFND 1 32,000 0 68,000
AKOUOS INC COM 00973J101 7,088 315,000 SH   SOLE   0 0 315,000
ALCON AG ORD SHS H01301128 20,168 351,380 SH   DFND 1 125,800 0 225,580
ALECTOR INC COM 014442107 146,037 5,975,322 SH   SOLE   5,975,322 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 241,989 2,156,000 SH   DFND 1 311,300 0 1,844,700
ALEXION PHARMACEUTICALS INC COM 015351109 11,224 100,000 SH Call DFND 1 32,000 0 68,000
ALPINE IMMUNE SCIENCES INC COM 02083G100 35,645 3,670,955 SH   SOLE   3,670,955 0 0
AMGEN INC COM 031162100 21,581 91,500 SH   SOLE   0 0 91,500
ANAPTYSBIO INC COM 032724106 8,395 375,800 SH   DFND 1 35,200 0 340,600
APPLIED THERAPEUTICS INC COM 03828A101 44,019 1,217,678 SH   DFND 1 58,532 0 1,159,146
APTOSE BIOSCIENCES INC COM NEW 03835T200 6,000 950,841 SH   DFND 1 169,700 0 781,141
ARCTURUS THERAPEUTICS HLDG I COM 03969T109 11,180 239,186 SH   DFND 1 48,026 0 191,160
ARCUS BIOSCIENCES INC COM 03969F109 5,451 220,350 SH   DFND 1 26,900 0 193,450
ARCUTIS BIOTHERAPEUTICS INC COM 03969K108 141,337 4,673,850 SH   DFND 1 4,067,564 0 606,286
ARENA PHARMACEUTICALS INC COM NEW 040047607 4,199 66,700 SH   SOLE   0 0 66,700
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 2,941 68,100 SH   SOLE   0 0 68,100
ARVINAS INC COM 04335A105 986 29,400 SH   SOLE   0 0 29,400
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 231,166 1,562,986 SH   DFND 1 1,287,486 0 275,500
ATHENEX INC COM 04685N103 55,169 4,009,346 SH   DFND 1 229,000 0 3,780,346
ATRICURE INC COM 04963C209 55,207 1,228,189 SH   DFND 1 187,000 0 1,041,189
AURINIA PHARMACEUTICALS INC COM 05156V102 19,441 1,196,347 SH   SOLE   0 0 1,196,347
AVIDITY BIOSCIENCES INC COM 05370A108 5,652 200,000 SH   SOLE   0 0 200,000
AVROBIO INC COM 05455M100 13,850 793,712 SH   DFND 1 129,000 0 664,712
BELLUS HEALTH INC NEW COM NEW 07987C204 53,001 5,137,216 SH   DFND 1 3,954,800 0 1,182,416
BENEFYTT TECHNOLOGIES INC COM CL A 08182C106 19,701 962,900 SH   DFND 1 160,400 0 802,500
BIOGEN INC COM 09062X103 191,539 715,900 SH   DFND 1 79,200 0 636,700
BIOLINERX LTD SPONSORED ADS 09071M205 118 69,240 SH   SOLE   69,240 0 0
BIOMX INC COM 09090D103 12,770 2,313,489 SH   SOLE   2,313,489 0 0
BOSTON SCIENTIFIC CORP COM 101137107 170,189 4,847,300 SH   DFND 1 939,400 0 3,907,900
BRISTOL-MYERS SQUIBB CO COM 110122108 169,473 2,882,200 SH   DFND 1 450,300 0 2,431,900
BRISTOL-MYERS SQUIBB CO RIGHT 99/99/9999 110122157 1,253 350,000 SH   DFND 1 120,140 0 229,860
BURNING ROCK BIOTECH LTD SPONSORED ADS 12233L107 128,191 4,746,071 SH   DFND 1 523,598 0 4,222,473
CALLIDITAS THERAPEUTICS AB SPONSERED ADS 13124Q106 5,220 225,000 SH   SOLE   0 0 225,000
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 8,125 625,000 SH   DFND 1 84,800 0 540,200
CENTENE CORP DEL COM 15135B101 84,884 1,335,700 SH   DFND 1 179,300 0 1,156,400
CIGNA CORP NEW COM 125523100 82,510 439,700 SH   DFND 1 84,900 0 354,800
CORBUS PHARMACEUTICALS HLDGS COM 21833P103 2,937 350,000 SH Put DFND 1 126,500 0 223,500
CORVUS PHARMACEUTICALS INC COM 221015100 18,408 6,767,584 SH   SOLE   6,767,584 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 48,242 2,753,567 SH   SOLE   2,753,567 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 51,261 697,524 SH   DFND 1 56,200 0 641,324
CTI BIOPHARMA CORP COM 12648L601 11,044 9,520,600 SH   SOLE   9,520,600 0 0
CURIS INC COM NEW 231269200 1,502 1,241,494 SH   SOLE   0 0 1,241,494
DECIPHERA PHARMACEUTICALS IN COM 24344T101 67,227 1,125,700 SH   DFND 1 190,100 0 935,600
DEXCOM INC COM 252131107 91,783 226,400 SH   DFND 1 33,500 0 192,900
EDWARDS LIFESCIENCES CORP COM 28176E108 36,656 530,400 SH   DFND 1 83,400 0 447,000
EHEALTH INC COM 28238P109 62,732 638,558 SH   DFND 1 86,021 0 552,537
ESSA PHARMA INC COM NEW 29668H708 9,125 1,471,853 SH   SOLE   1,471,853 0 0
EXELIXIS INC COM 30161Q104 57,073 2,404,100 SH   DFND 1 288,800 0 2,115,300
FLEXION THERAPEUTICS INC COM 33938J106 22,145 1,684,000 SH   DFND 1 84,100 0 1,599,900
FLUIDIGM CORP DEL COM 34385P108 11,657 2,907,100 SH   DFND 1 341,700 0 2,565,400
FORTE BIOSCIENCES INC COM 34962G109 13,856 950,316 SH   DFND 1 375,301 0 575,015
FUSION PHARMACEUTICALS INC COM 36118A100 56,337 3,224,770 SH   DFND 1 2,930,670 0 294,100
GENMARK DIAGNOSTICS INC COM 372309104 10,768 732,000 SH   DFND 1 62,200 0 669,800
GILEAD SCIENCES INC COM 375558103 14,788 192,200 SH   SOLE   0 0 192,200
GLAUKOS CORP COM 377322102 46,527 1,211,000 SH   SOLE   1,211,000 0 0
HARPOON THERAPEUTICS INC COM 41358P106 30,473 1,835,704 SH   DFND 1 1,020,704 0 815,000
HEALTH CATALYST INC COM 42225T107 5,239 179,598 SH   SOLE   179,598 0 0
HERON THERAPEUTICS INC COM 427746102 9,715 660,420 SH   SOLE   0 0 660,420
HORIZON THERAPEUTICS PUB LTD SHS G46188101 159,398 2,867,910 SH   DFND 1 357,500 0 2,510,410
HUMANA INC COM 444859102 108,686 280,300 SH   DFND 1 42,300 0 238,000
IGM BIOSCIENCES INC COM 449585108 5,895 80,760 SH   DFND 1 7,460 0 73,300
IMARA INC COM 45249V107 75,151 2,719,902 SH   DFND 1 2,532,402 0 187,500
IMMUNOMEDICS INC COM 452907108 26,860 757,900 SH   SOLE   0 0 757,900
IMMUNOVANT INC COM 45258J102 8,634 354,575 SH   DFND 1 84,400 0 270,175
INFLARX NV COM N44821101 3,114 678,525 SH   DFND 1 122,500 0 556,025
INSPIRE MED SYS INC COM 457730109 30,196 347,000 SH   SOLE   347,000 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 2,882 137,100 SH   SOLE   137,100 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 64,277 112,800 SH   DFND 1 18,500 0 94,300
IOVANCE BIOTHERAPEUTICS INC COM 462260100 182,408 6,645,100 SH   DFND 1 1,337,800 0 5,307,300
IQVIA HLDGS INC COM 46266C105 24,829 175,000 SH   SOLE   0 0 175,000
IVERIC BIO INC COM 46583P102 16,575 3,250,000 SH   DFND 1 609,756 0 2,640,244
KALA PHARMACEUTICALS INC COM 483119103 56,783 5,402,730 SH   DFND 1 4,651,895 0 750,835
KEROS THERAPEUTICS INC COM 492327101 62,995 1,679,417 SH   DFND 1 1,268,734 0 410,683
KITOV PHARMA LTD SPONSORED ADS 49803V107 3,843 3,461,983 SH   SOLE   3,461,983 0 0
LARIMAR THERAPEUTICS INC COM 517125100 12,001 933,960 SH   DFND 1 201,637 0 732,323
LOGICBIO THERAPEUTICS INC COM 54142F102 54,709 6,466,783 SH   SOLE   6,466,783 0 0
MEIRAGTX HLDGS PLC COM G59665102 46,497 3,713,820 SH   DFND 1 133,500 0 3,580,320
MENLO THERAPEUTICS INC COM 586858102 1,027 593,883 SH   SOLE   0 0 593,883
MERCK & CO. INC COM 58933Y105 200,215 2,589,100 SH   DFND 1 382,100 0 2,207,000
MERSANA THERAPEUTICS INC COM 59045L106 44,694 1,910,008 SH   DFND 1 75,500 0 1,834,508
MIRATI THERAPEUTICS INC COM 60468T105 151,172 1,324,100 SH   DFND 1 195,500 0 1,128,600
NABRIVA THERAPEUTICS PLC SHS G63637105 3,133 4,644,600 SH   SOLE   4,644,600 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109 34,997 1,192,400 SH   DFND 1 156,400 0 1,036,000
NATERA INC COM 632307104 161,572 3,240,514 SH   DFND 1 882,714 0 2,357,800
NEUROCRINE BIOSCIENCES INC COM 64125C109 144,682 1,185,915 SH   DFND 1 137,470 0 1,048,445
NEXTCURE INC COM 65343E108 58,124 2,711,013 SH   SOLE   2,711,013 0 0
NOVO-NORDISK A S ADR 670100205 21,608 330,000 SH   SOLE   0 0 330,000
NOVUS THERAPEUTICS INC COM 67011N105 1,459 3,183,314 SH   SOLE   3,183,314 0 0
OBSEVA SA COM H5861P103 15,347 2,605,531 SH   SOLE   2,605,531 0 0
ORIC PHARMACEUTICALS INC COM 68622P109 98,558 2,921,967 SH   DFND 1 2,765,717 0 156,250
PASSAGE BIO INC COM 702712100 190,296 6,962,899 SH   DFND 1 5,947,323 0 1,015,576
PREVAIL THERAPEUTICS INC COM 74140Y101 205,955 13,822,463 SH   SOLE   13,822,463 0 0
PROGYNY INC COM 74340E103 8,801 341,004 SH   DFND 1 39,000 0 302,004
PROTHENA CORP PLC SHS G72800108 37,075 3,544,475 SH   DFND 1 613,800 0 2,930,675
REGENERON PHARMACEUTICALS COM 75886F107 19,271 30,900 SH   SOLE   0 0 30,900
REPARE THERAPEUTICS INC COM 760273102 106,285 3,426,325 SH   DFND 1 3,276,325 0 150,000
RESTORBIO INC COM 76133L103 10,385 4,830,387 SH   SOLE   4,830,387 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 8,004 382,400 SH   DFND 1 65,600 0 316,800
SAREPTA THERAPEUTICS INC COM 803607100 89,734 559,649 SH   DFND 1 68,000 0 491,649
SCPHARMACEUTICALS INC COM 810648105 35,307 4,797,148 SH   SOLE   4,797,148 0 0
SELECTA BIOSCIENCES INC COM 816212104 5,947 2,093,869 SH   SOLE   2,093,869 0 0
SELECTQUOTE INC COM 816307300 31,789 1,255,000 SH   DFND 1 167,900 0 1,087,100
SI BONE INC COM 825704109 22,018 1,381,300 SH   DFND 1 76,000 0 1,305,300
SIERRA ONCOLOGY INC COM NEW 82640U404 17,876 1,477,320 SH   DFND 1 1,306,860 0 170,460
SINOVAC BIOTECH LTD SHS P8696W104 25,500 2,839,500 SH   SOLE   0 0 2,839,500
SPRINGWORKS THERAPEUTICS INC COM 85205L107 311,065 7,406,307 SH   SOLE   7,406,307 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 16,215 1,094,100 SH   DFND 1 78,600 0 1,015,500
SYNLOGIC INC COM 87166L100 4,121 2,029,996 SH   SOLE   2,029,996 0 0
TELA BIO INC COM 872381108 39,237 3,027,542 SH   SOLE   3,027,542 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 23,861 1,935,200 SH   DFND 1 269,500 0 1,665,700
THERAVANCE BIOPHARMA INC COM G8807B106 53,618 2,554,470 SH   DFND 1 244,054 0 2,310,416
THERMO FISHER SCIENTIFIC INC COM 883556102 39,966 110,300 SH   DFND 1 16,800 0 93,500
TRICIDA INC COM 89610F101 264,200 9,614,280 SH   SOLE   9,614,280 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 9,797 1,211,000 SH   DFND 1 391,800 0 819,200
TURNING POINT THERAPEUTICS I COM 90041T108 177,321 2,745,327 SH   DFND 1 2,027,550 0 717,777
UNIQURE NV SHS N90064101 43,667 969,079 SH   DFND 1 138,100 0 830,979
VAXCYTE INC COM 92243G108 26,869 850,000 SH   SOLE   0 0 850,000
VERONA PHARMA PLC SPONSORED ADS 925050106 5,852 1,250,396 SH   SOLE   1,250,396 0 0
VERRICA PHARMACEUTICALS INC COM 92511W108 16,292 1,479,733 SH   SOLE   1,479,733 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 193,375 666,100 SH   DFND 1 113,100 0 553,000
X4 PHARMACEUTICALS INC COM 98420X103 10,126 1,086,493 SH   SOLE   1,086,493 0 0
XENON PHARMACEUTICALS INC COM 98420N105 31,324 2,497,917 SH   DFND 1 786,612 0 1,711,305
XTANT MED HLDGS INC COM NEW 98420P308 8,324 9,248,678 SH   SOLE   9,248,678 0 0
ZYMEWORKS INC COM 98985W102 21,004 582,302 SH   DFND 1 15,300 0 567,002