The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABS COM 002824100 9,914 237,000 SH   DFND 1 79,000 0 158,000
ABBVIE INC COM 00287Y109 422,442 7,395,700 SH   DFND 1 3,400,500 0 3,995,200
ACADIA PHARMACEUTICALS INC COM 004225108 39,189 1,401,600 SH   DFND 1 598,400 0 803,200
ACHILLION PHARMACEUTICALS IN COM 00448Q201 88,932 11,519,700 SH   DFND 1 4,978,600 0 6,541,100
ACHILLION PHARMACEUTICALS IN COM 00448Q201 1,544 200,000 SH Call DFND 1 78,500 0 121,500
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 3,567 438,784 SH   SOLE   438,784 0 0
ADVAXIS INC COM NEW 007624208 5,748 636,600 SH   DFND 1 0 0 636,600
AETNA INC NEW COM 00817Y108 8,539 76,000 SH   DFND 1 27,000 0 49,000
AFFIMED N V COM N01045108 14,705 3,931,800 SH   SOLE   3,931,800 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 139,276 3,495,000 SH   DFND 1 1,510,800 0 1,984,200
ALEXION PHARMACEUTICALS INC COM 015351109 260,425 1,870,600 SH   DFND 1 709,400 0 1,161,200
ALIMERA SCIENCES INC COM 016259103 2,625 1,500,000 SH   DFND 1 670,000 0 830,000
ALLERGAN PLC SHS G0177J108 421,535 1,572,715 SH   DFND 1 783,025 0 789,690
ALLERGAN PLC SHS G0177J108 26,803 100,000 SH Call DFND 1 39,500 0 60,500
ALLERGAN PLC PFD CONV SER A G0177J116 95,774 104,200 SH   DFND 1 30,300 0 73,900
AMARIN CORP PLC SPONS ADR NEW 023111206 536 350,000 SH   DFND 1 350,000 0 0
AMGEN INC COM 031162100 431,199 2,876,000 SH   DFND 1 1,092,400 0 1,783,600
ANACOR PHARMACEUTICALS INC COM 032420101 2,849 53,300 SH   DFND 1 0 0 53,300
ARRAY BIOPHARMA INC COM 04269X105 31,533 10,689,000 SH   DFND 1 4,249,700 0 6,439,300
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 4,122 222,223 SH   SOLE   222,223 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 7,013 1,397,100 SH   DFND 1 647,100 0 750,000
BAXALTA INC COM 07177M103 13,170 326,000 SH   DFND 1 121,000 0 205,000
BIOGEN INC COM 09062X103 397,326 1,526,300 SH   DFND 1 569,400 0 956,900
BIOLINERX LTD SPONSORED ADR 09071M106 1,059 1,038,600 SH   DFND 1 1,038,600 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 84,394 1,023,200 SH   DFND 1 479,500 0 543,700
BIOMARIN PHARMACEUTICAL INC NOTE 0.750%10/1 09061GAE1 579 500,000 PRN   DFND 1 215,000 0 285,000
BIOMARIN PHARMACEUTICAL INC NOTE 1.500%10/1 09061GAF8 594 500,000 PRN   DFND 1 215,000 0 285,000
BIOTIE THERAPIES OYJ SPONSORED ADR 09074D103 7,090 268,672 SH   SOLE   268,672 0 0
BLUEBIRD BIO INC COM 09609G100 40,184 945,500 SH   DFND 1 429,200 0 516,300
BOSTON SCIENTIFIC CORP COM 101137107 422,843 22,479,700 SH   DFND 1 10,472,900 0 12,006,800
BRISTOL MYERS SQUIBB CO COM 110122108 487,079 7,624,900 SH   DFND 1 3,398,700 0 4,226,200
CARDINAL HEALTH INC COM 14149Y108 13,604 166,000 SH   DFND 1 60,000 0 106,000
CELGENE CORP COM 151020104 377,747 3,774,077 SH   DFND 1 1,376,000 0 2,398,077
CELLECTIS S A SPONSORED ADS 15117K103 9,625 350,000 SH   DFND 1 162,100 0 187,900
CERUS CORP COM 157085101 3,429 578,300 SH   DFND 1 238,600 0 339,700
CIGNA CORPORATION COM 125509109 46,044 335,500 SH   DFND 1 141,100 0 194,400
CLOVIS ONCOLOGY INC COM 189464100 12,689 660,900 SH   DFND 1 262,500 0 398,400
COGENTIX MED INC COM 19243A104 1,090 990,745 SH   DFND 1 436,407 0 554,338
COMMUNITY HEALTH SYS INC NEW COM 203668108 40,193 2,171,400 SH   DFND 1 866,500 0 1,304,900
CONNECTURE INC COM 20786J106 4,454 1,740,000 SH   DFND 1 795,000 0 945,000
COOPER COS INC COM NEW 216648402 122,545 795,900 SH   DFND 1 407,000 0 388,900
CORVUS PHARMACEUTICALS INC COM 221015100 76,248 5,258,450 SH   SOLE   5,258,450 0 0
CYNAPSUS THERAPEUTICS INC COM PAR NO PAR 23257Y859 13,221 1,140,325 SH   SOLE   1,140,325 0 0
DIMENSION THERAPEUTICS INC COM 25433V105 42,264 5,397,698 SH   SOLE   5,397,698 0 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 37,993 1,974,700 SH   DFND 1 650,800 0 1,323,900
EDWARDS LIFESCIENCES CORP COM 28176E108 10,144 115,000 SH   DFND 1 45,000 0 70,000
EHEALTH INC COM 28238P109 12,207 1,300,000 SH   DFND 1 600,000 0 700,000
ENANTA PHARMACEUTICALS INC COM 29251M106 7,325 249,400 SH   DFND 1 107,800 0 141,600
ENSIGN GROUP INC COM 29358P101 11,641 514,200 SH   DFND 1 222,200 0 292,000
EXACT SCIENCES CORP COM 30063P105 12,741 1,890,400 SH   DFND 1 0 0 1,890,400
EXPRESS SCRIPTS HLDG CO COM 30219G108 166,298 2,421,000 SH   DFND 1 1,181,000 0 1,240,000
FATE THERAPEUTICS INC COM 31189P102 1,247 692,900 SH   DFND 1 296,100 0 396,800
FLUIDIGM CORP DEL COM 34385P108 14,091 1,746,100 SH   DFND 1 215,500 0 1,530,600
FLUIDIGM CORP DEL NOTE 2.750% 2/0 34385PAA6 5,553 10,000,000 PRN   DFND 1 4,466,000 0 5,534,000
FORWARD PHARMA A/S SPONSORED ADR 34986J105 13,566 798,000 SH   DFND 1 226,500 0 571,500
GALAPAGOS NV SPON ADR 36315X101 9,619 230,000 SH   DFND 1 0 0 230,000
GILEAD SCIENCES INC COM 375558103 277,344 3,019,200 SH   DFND 1 1,118,600 0 1,900,600
GLAUKOS CORP COM 377322102 48,859 2,897,938 SH   DFND 1 2,897,938 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 13,752 190,600 SH   DFND 1 0 0 190,600
HCA HOLDINGS INC COM 40412C101 447,781 5,737,100 SH   DFND 1 2,686,000 0 3,051,100
HORIZON PHARMA INVT LTD NOTE 2.500% 3/1 44052TAB7 11,128 13,000,000 PRN   DFND 1 6,000,000 0 7,000,000
HUMANA INC COM 444859102 62,148 339,700 SH   DFND 1 144,600 0 195,100
ILLUMINA INC COM 452327109 145,899 900,000 SH   DFND 1 371,000 0 529,000
IMMUNOGEN INC COM 45253H101 51,935 6,095,647 SH   DFND 1 1,919,480 0 4,176,167
IMMUNOMEDICS INC COM 452907108 9,505 3,802,000 SH   DFND 1 2,050,550 0 1,751,450
IMMUNOMEDICS INC NOTE 4.750% 2/1 452907AK4 20,384 30,000,000 PRN   DFND 1 16,014,000 0 13,986,000
IMPAX LABORATORIES INC COM 45256B101 216,971 6,776,100 SH   DFND 1 2,765,500 0 4,010,600
INCYTE CORP COM 45337C102 199,661 2,755,078 SH   DFND 1 1,046,900 0 1,708,178
INCYTE CORP NOTE 0.375%11/1 45337CAM4 6,574 4,250,000 PRN   DFND 1 1,816,000 0 2,434,000
INCYTE CORP NOTE 1.250%11/1 45337CAN2 6,727 4,250,000 PRN   DFND 1 1,816,000 0 2,434,000
INFINITY PHARMACEUTICALS INC COM 45665G303 19,623 3,723,528 SH   DFND 1 1,064,000 0 2,659,528
INOTEK PHARMACEUTICALS CORP COM 45780V102 10,293 1,391,000 SH   DFND 1 637,000 0 754,000
INSMED INC COM PAR $.01 457669307 43,964 3,469,900 SH   DFND 1 1,375,200 0 2,094,700
INSYS THERAPEUTICS INC NEW COM NEW 45824V209 72,878 4,557,740 SH   DFND 1 1,754,200 0 2,803,540
INTERCEPT PHARMACEUTICALS IN COM 45845P108 143,886 1,120,000 SH   SOLE   1,120,000 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 8,173 294,000 SH   DFND 1 133,000 0 161,000
INTUITIVE SURGICAL INC COM NEW 46120E602 166,371 276,800 SH   DFND 1 150,600 0 126,200
INVITAE CORP COM 46185L103 4,672 456,666 SH   SOLE   456,666 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 126,361 11,550,400 SH   DFND 1 4,833,500 0 6,716,900
ISHARES TR NASDQ BIOTEC ETF 464287556 29,132 111,700 SH   DFND 1 50,200 0 61,500
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 11,750 90,000 SH   DFND 1 0 0 90,000
JOHNSON & JOHNSON COM 478160104 57,541 531,800 SH   DFND 1 209,400 0 322,400
LILLY ELI & CO COM 532457108 182,999 2,541,300 SH   DFND 1 1,280,400 0 1,260,900
LION BIOTECHNOLOGIES INC COM 53619R102 5,192 1,022,100 SH   DFND 1 272,000 0 750,100
LOXO ONCOLOGY INC COM 548862101 59,488 2,175,857 SH   SOLE   2,175,857 0 0
MACROGENICS INC COM 556099109 5,944 317,000 SH   DFND 1 146,800 0 170,200
MAGELLAN HEALTH INC COM NEW 559079207 129,678 1,909,000 SH   DFND 1 827,300 0 1,081,700
MALLINCKRODT PUB LTD CO SHS G5785G107 80,216 1,309,000 SH   DFND 1 558,000 0 751,000
MARINUS PHARMACEUTICALS INC COM 56854Q101 5,192 965,000 SH   SOLE   965,000 0 0
MCKESSON CORP COM 58155Q103 12,140 77,200 SH   DFND 1 30,400 0 46,800
MEDIGUS LTD SPONSORED ADR 58471G102 1,608 600,000 SH   SOLE   600,000 0 0
MEDIVATION INC COM 58501N101 23,036 501,000 SH   DFND 1 223,800 0 277,200
MEDTRONIC PLC SHS G5960L103 49,972 666,299 SH   DFND 1 234,199 0 432,100
MERCK & CO INC NEW COM 58933Y105 11,132 210,400 SH   DFND 1 100,200 0 110,200
MIRATI THERAPEUTICS INC COM 60468T105 4,234 197,859 SH   SOLE   197,859 0 0
MYLAN N V SHS EURO N59465109 3,235 69,800 SH   SOLE   69,800 0 0
NABRIVA THERAPEUTICS AG SPONSORED ADR 62957M104 11,782 1,315,000 SH   SOLE   1,315,000 0 0
NATERA INC COM 632307104 12,149 1,276,190 SH   SOLE   1,276,190 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 104,961 2,653,874 SH   DFND 1 1,074,270 0 1,579,604
NEWLINK GENETICS CORP COM 651511107 14,870 817,006 SH   DFND 1 260,300 0 556,706
NUVASIVE INC COM 670704105 72,343 1,487,000 SH   DFND 1 806,000 0 681,000
OPHTHOTECH CORP COM 683745103 88,535 2,094,500 SH   DFND 1 1,001,280 0 1,093,220
OREXIGEN THERAPEUTICS INC NOTE 2.750%12/0 686164AB0 2,149 5,210,000 PRN   DFND 1 2,210,000 0 3,000,000
OTONOMY INC COM 68906L105 27,603 1,850,094 SH   SOLE   1,850,094 0 0
PERNIX THERAPEUTICS HLDGS IN COM 71426V108 1,127 1,073,000 SH   DFND 1 485,000 0 588,000
PFIZER INC COM 717081103 122,176 4,122,000 SH   DFND 1 1,621,000 0 2,501,000
PIERIS PHARMACEUTICALS INC COM 720795103 13,793 7,259,620 SH   SOLE   7,259,620 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 17,097 838,100 SH   DFND 1 467,200 0 370,900
PORTOLA PHARMACEUTICALS INC COM 737010108 2,040 100,000 SH Put DFND 1 44,500 0 55,500
PRONAI THERAPEUTICS INC COM 74346L101 10,940 1,623,149 SH   SOLE   1,623,149 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 11,251 2,305,446 SH   DFND 1 973,446 0 1,332,000
PUMA BIOTECHNOLOGY INC COM 74587V107 80,868 2,753,425 SH   DFND 1 1,162,400 0 1,591,025
QIAGEN NV REG SHS N72482107 5,737 256,800 SH   DFND 1 0 0 256,800
QLT INC COM 746927102 995 500,000 SH   DFND 1 200,600 0 299,400
REDHILL BIOPHARMA LTD SPONSORED ADS 757468103 6,920 564,900 SH   SOLE   564,900 0 0
REGENERON PHARMACEUTICALS COM 75886F107 192,115 533,000 SH   DFND 1 233,200 0 299,800
RELYPSA INC COM 759531106 100,270 7,400,000 SH   SOLE   7,400,000 0 0
ROKA BIOSCIENCE INC COM 775431109 2,222 3,220,429 SH   SOLE   3,220,429 0 0
SERES THERAPEUTICS INC COM 81750R102 4,426 166,645 SH   SOLE   166,645 0 0
SHIRE PLC SPONSORED ADR 82481R106 51,634 300,371 SH   DFND 1 140,428 0 159,943
SIENTRA INC COM 82621J105 9,285 1,357,500 SH   SOLE   1,357,500 0 0
SINOVAC BIOTECH LTD SHS P8696W104 17,045 2,667,500 SH   DFND 1 1,219,500 0 1,448,000
SPDR SERIES TRUST S&P BIOTECH 78464A870 50,689 981,200 SH   DFND 1 432,200 0 549,000
STRYKER CORP COM 863667101 22,745 212,000 SH   DFND 1 77,000 0 135,000
SYNDAX PHARMACEUTICALS INC COM 87164F105 10,088 757,365 SH   SOLE   757,365 0 0
SYNERGY PHARMACEUTICALS DEL COM NEW 871639308 6,284 2,276,648 SH   DFND 1 1,114,300 0 1,162,348
TESARO INC COM 881569107 84,185 1,912,000 SH   DFND 1 856,600 0 1,055,400
TEVA PHARMACEUTICAL INDS LTD ADR 881624209 144,263 2,696,000 SH   DFND 1 1,343,000 0 1,353,000
THERMO FISHER SCIENTIFIC INC COM 883556102 203,182 1,435,000 SH   DFND 1 634,000 0 801,000
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 8,123 128,300 SH   DFND 1 58,300 0 70,000
UNIQURE NV SHS N90064101 2,195 184,800 SH   DFND 1 0 0 184,800
UNITEDHEALTH GROUP INC COM 91324P102 104,667 812,000 SH   DFND 1 336,000 0 476,000
VALEANT PHARMACEUTICALS INTL COM 91911K102 5,126 194,900 SH   DFND 1 76,800 0 118,100
VERTEX PHARMACEUTICALS INC COM 92532F100 148,599 1,869,400 SH   DFND 1 792,200 0 1,077,200
VIEWRAY INC COM 92672L107 34,357 7,989,916 SH   SOLE   7,989,916 0 0
WELLCARE HEALTH PLANS INC COM 94946T106 176,531 1,903,300 SH   DFND 1 897,400 0 1,005,900
WRIGHT MED GROUP N V ORD SHS 0.03 PAR N96617118 138,529 8,345,110 SH   DFND 1 3,820,497 0 4,524,613
XENCOR INC COM 98401F105 14,856 1,107,022 SH   DFND 1 0 0 1,107,022
XENOPORT INC COM 98411C100 27,062 6,000,400 SH   DFND 1 2,553,000 0 3,447,400
XTANT MED HLDGS INC COM 98420P100 1,288 475,439 SH   SOLE   475,439 0 0
ZIMMER BIOMET HLDGS INC COM 98956P102 10,983 103,000 SH   DFND 1 37,000 0 66,000