The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABS COM 002824100 9,316 237,000 SH   DFND 1 79,000 0 158,000
ABBVIE INC COM 00287Y109 406,941 6,573,100 SH   DFND 1 3,114,600 0 3,458,500
ACHILLION PHARMACEUTICALS IN COM 00448Q201 91,116 11,681,600 SH   DFND 1 5,140,500 0 6,541,100
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 5,902 724,184 SH   SOLE   724,184 0 0
ADVAXIS INC COM NEW 007624208 3,603 445,400 SH   DFND 1 0 0 445,400
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 6,611 1,360,224 SH   SOLE   1,360,224 0 0
AETNA INC NEW COM 00817Y108 14,240 116,600 SH   DFND 1 46,200 0 70,400
AFFIMED N V COM N01045108 9,362 3,775,000 SH   SOLE   3,775,000 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 158,152 3,565,200 SH   DFND 1 1,581,000 0 1,984,200
ALEXION PHARMACEUTICALS INC COM 015351109 348,110 2,981,411 SH   DFND 1 1,244,900 0 1,736,511
ALIMERA SCIENCES INC COM 016259103 308 250,000 SH   DFND 1 98,300 0 151,700
ALKERMES PLC SHS G01767105 7,434 172,000 SH   DFND 1 0 0 172,000
ALLERGAN PLC SHS G0177J108 310,727 1,344,615 SH   DFND 1 687,825 0 656,790
ALLERGAN PLC SHS G0177J108 34,664 150,000 SH Call DFND 1 61,500 0 88,500
ALLERGAN PLC PFD CONV SER A G0177J116 86,859 104,200 PRN   DFND 1 30,300 0 73,900
AMARIN CORP PLC SPONS ADR NEW 023111206 756 350,000 SH   SOLE   350,000 0 0
AMEDISYS INC COM 023436108 1,010 20,000 SH   DFND 1 8,800 0 11,200
AMGEN INC COM 031162100 461,547 3,033,500 SH   DFND 1 1,202,500 0 1,831,000
ARALEZ PHARMACEUTICALS INC COM 03852X100 225 68,143 SH   DFND 1 27,339 0 40,804
ARRAY BIOPHARMA INC COM 04269X105 39,067 10,973,900 SH   DFND 1 4,534,600 0 6,439,300
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 29,075 2,191,000 SH   SOLE   2,191,000 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 7,754 1,397,100 SH   DFND 1 647,100 0 750,000
BARD C R INC COM 067383109 5,409 23,000 SH   DFND 1 9,600 0 13,400
BEIGENE LTD SPONSORED ADR 07725L102 385 12,925 SH   DFND 1 0 0 12,925
BIOGEN INC COM 09062X103 362,827 1,500,400 SH   DFND 1 570,100 0 930,300
BIOLINERX LTD SPONSORED ADR 09071M106 831 1,038,600 SH   SOLE   1,038,600 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 118,139 1,518,500 SH   DFND 1 698,300 0 820,200
BIOMARIN PHARMACEUTICAL INC NOTE 0.750%10/1 09061GAE1 555 500,000 PRN   DFND 1 215,000 0 285,000
BIOMARIN PHARMACEUTICAL INC NOTE 1.500%10/1 09061GAF8 579 500,000 PRN   DFND 1 215,000 0 285,000
BLUEBIRD BIO INC COM 09609G100 51,333 1,185,800 SH   DFND 1 475,600 0 710,200
BOSTON SCIENTIFIC CORP COM 101137107 540,529 23,129,200 SH   DFND 1 10,956,100 0 12,173,100
BRISTOL MYERS SQUIBB CO COM 110122108 371,839 5,055,600 SH   DFND 1 2,331,700 0 2,723,900
CARDINAL HEALTH INC COM 14149Y108 12,950 166,000 SH   DFND 1 60,000 0 106,000
CELGENE CORP COM 151020104 237,173 2,404,677 SH   DFND 1 906,100 0 1,498,577
CELLECTIS S A SPONSORED ADS 15117K103 9,307 350,000 SH   DFND 1 162,100 0 187,900
CIGNA CORPORATION COM 125509109 42,186 329,600 SH   DFND 1 138,500 0 191,100
COGENTIX MED INC COM 19243A104 953 990,745 SH   DFND 1 436,407 0 554,338
COOPER COS INC COM NEW 216648402 116,033 676,300 SH   DFND 1 359,200 0 317,100
CORVUS PHARMACEUTICALS INC COM 221015100 76,710 5,379,349 SH   SOLE   5,379,349 0 0
CYNAPSUS THERAPEUTICS INC COM PAR NO PAR 23257Y859 17,470 1,140,325 SH   SOLE   1,140,325 0 0
DIMENSION THERAPEUTICS INC COM 25433V105 32,386 5,397,698 SH   SOLE   5,397,698 0 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 35,040 2,403,300 SH   DFND 1 650,800 0 1,752,500
EAGLE PHARMACEUTICALS INC COM 269796108 40,190 1,036,100 SH   DFND 1 457,200 0 578,900
EDWARDS LIFESCIENCES CORP COM 28176E108 51,002 511,400 SH   DFND 1 252,000 0 259,400
EHEALTH INC COM 28238P109 18,226 1,300,000 SH   DFND 1 600,000 0 700,000
EXACT SCIENCES CORP COM 30063P105 26,107 2,131,200 SH   SOLE   2,131,200 0 0
EXPRESS SCRIPTS HLDG CO COM 30219G108 128,754 1,698,600 SH   DFND 1 861,000 0 837,600
FLUIDIGM CORP DEL COM 34385P108 15,767 1,746,100 SH   DFND 1 215,500 0 1,530,600
FLUIDIGM CORP DEL NOTE 2.750% 2/0 34385PAA6 6,098 10,000,000 PRN   DFND 1 4,466,000 0 5,534,000
FORWARD PHARMA A/S SPONSORED ADR 34986J105 14,500 798,000 SH   DFND 1 226,500 0 571,500
GALAPAGOS NV SPON ADR 36315X101 19,564 352,700 SH   SOLE   352,700 0 0
GILEAD SCIENCES INC COM 375558103 256,341 3,072,900 SH   DFND 1 1,172,300 0 1,900,600
GLAUKOS CORP COM 377322102 84,504 2,897,938 SH   SOLE   2,897,938 0 0
HCA HOLDINGS INC COM 40412C101 315,610 4,098,300 SH   DFND 1 1,925,400 0 2,172,900
HUMANA INC COM 444859102 61,105 339,700 SH   DFND 1 144,600 0 195,100
ILLUMINA INC COM 452327109 118,790 846,200 SH   DFND 1 345,700 0 500,500
IMMUNOGEN INC COM 45253H101 18,775 6,095,647 SH   DFND 1 1,919,480 0 4,176,167
IMMUNOMEDICS INC COM 452907108 8,821 3,802,000 SH   DFND 1 2,050,550 0 1,751,450
IMMUNOMEDICS INC NOTE 4.750% 2/1 452907AK4 20,827 30,000,000 PRN   DFND 1 16,014,000 0 13,986,000
IMPAX LABORATORIES INC COM 45256B101 169,655 5,886,700 SH   DFND 1 1,992,000 0 3,894,700
INCYTE CORP COM 45337C102 185,928 2,324,678 SH   DFND 1 883,900 0 1,440,778
INCYTE CORP NOTE 0.375%11/1 45337CAM4 7,055 4,250,000 PRN   DFND 1 1,816,000 0 2,434,000
INCYTE CORP NOTE 1.250%11/1 45337CAN2 7,169 4,250,000 PRN   DFND 1 1,816,000 0 2,434,000
INFINITY PHARMACEUTICALS INC COM 45665G303 4,323 3,250,300 SH   DFND 1 1,064,000 0 2,186,300
INOTEK PHARMACEUTICALS CORP COM 45780V102 10,349 1,391,000 SH   DFND 1 637,000 0 754,000
INSMED INC COM PAR $.01 457669307 41,004 4,158,600 SH   DFND 1 1,764,960 0 2,393,640
INSMED INC COM PAR $.01 457669307 1,972 200,000 SH Call DFND 1 89,500 0 110,500
INSYS THERAPEUTICS INC NEW COM NEW 45824V209 60,666 4,688,240 SH   DFND 1 1,813,500 0 2,874,740
INTELLIA THERAPEUTICS INC COM 45826J105 56,838 2,662,180 SH   SOLE   2,662,180 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 159,802 1,120,000 SH   SOLE   1,120,000 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 34,371 885,400 SH   DFND 1 405,000 0 480,400
INTUITIVE SURGICAL INC COM NEW 46120E602 196,968 297,800 SH   DFND 1 150,600 0 147,200
INVITAE CORP COM 46185L103 3,375 456,666 SH   SOLE   456,666 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 130,083 9,949,000 SH   DFND 1 3,595,700 0 6,353,300
ISHARES TR NASDQ BIOTEC ETF 464287556 13,716 53,300 SH   DFND 1 24,000 0 29,300
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 12,718 90,000 SH   SOLE   90,000 0 0
JOHNSON & JOHNSON COM 478160104 94,323 777,600 SH   DFND 1 325,500 0 452,100
LILLY ELI & CO COM 532457108 116,298 1,476,800 SH   DFND 1 835,500 0 641,300
LION BIOTECHNOLOGIES INC COM 53619R102 27,401 3,382,900 SH   DFND 1 1,446,500 0 1,936,400
LOXO ONCOLOGY INC COM 548862101 50,436 2,175,857 SH   SOLE   2,175,857 0 0
MACROGENICS INC COM 556099109 4,032 149,400 SH   DFND 1 69,200 0 80,200
MAGELLAN HEALTH INC COM NEW 559079207 71,729 1,090,600 SH   DFND 1 472,300 0 618,300
MALLINCKRODT PUB LTD CO SHS G5785G107 79,561 1,309,000 SH   DFND 1 558,000 0 751,000
MARINUS PHARMACEUTICALS INC COM 56854Q101 1,102 867,600 SH   SOLE   867,600 0 0
MCKESSON CORP COM 58155Q103 8,101 43,400 SH   DFND 1 17,100 0 26,300
MEDIGUS LTD SPONSORED ADR 58471G102 1,092 600,000 SH   SOLE   600,000 0 0
MEDIVATION INC COM 58501N101 120,684 2,001,400 SH   DFND 1 855,300 0 1,146,100
MEDTRONIC PLC SHS G5960L103 57,815 666,299 SH   DFND 1 234,199 0 432,100
MERCK & CO INC COM 58933Y105 110,352 1,915,500 SH   DFND 1 910,500 0 1,005,000
MINERVA NEUROSCIENCES INC COM 603380106 3,283 321,500 SH   SOLE   321,500 0 0
MOLINA HEALTHCARE INC COM 60855R100 91,716 1,838,000 SH   DFND 1 867,600 0 970,400
MOLINA HEALTHCARE INC COM 60855R100 17,465 350,000 SH Call DFND 1 157,000 0 193,000
NABRIVA THERAPEUTICS AG SPONSORED ADR 62957M104 9,863 1,315,000 SH   SOLE   1,315,000 0 0
NATERA INC COM 632307104 15,397 1,276,190 SH   SOLE   1,276,190 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 82,513 1,815,474 SH   DFND 1 743,370 0 1,072,104
NEWLINK GENETICS CORP COM 651511107 17,808 1,581,506 SH   DFND 1 591,500 0 990,006
NUVASIVE INC COM 670704105 14,757 247,100 SH   SOLE   247,100 0 0
OPHTHOTECH CORP COM 683745103 109,618 2,148,100 SH   DFND 1 954,880 0 1,193,220
OREXIGEN THERAPEUTICS INC NOTE 2.750%12/0 686164AB0 2,200 5,210,000 PRN   DFND 1 2,210,000 0 3,000,000
OTONOMY INC COM 68906L105 29,379 1,850,094 SH   SOLE   1,850,094 0 0
PERNIX THERAPEUTICS HLDGS IN COM 71426V108 481 1,073,000 SH   DFND 1 485,000 0 588,000
PERNIX THERAPEUTICS HLDGS IN DBCV 4.250% 4/0 71426VAK4 2,549 12,000,000 PRN   DFND 1 6,500,000 0 5,500,000
PFIZER INC COM 717081103 149,421 4,243,700 SH   DFND 1 1,792,800 0 2,450,900
PIERIS PHARMACEUTICALS INC COM 720795103 11,688 7,259,620 SH   SOLE   7,259,620 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 8,753 370,900 SH   SOLE   370,900 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 11,158 2,305,446 SH   DFND 1 973,446 0 1,332,000
PUMA BIOTECHNOLOGY INC COM 74587V107 88,298 2,964,025 SH   DFND 1 1,263,800 0 1,700,225
QLT INC COM 746927102 710 500,000 SH   DFND 1 200,600 0 299,400
REDHILL BIOPHARMA LTD SPONSORED ADS 757468103 6,138 564,900 SH   SOLE   564,900 0 0
REGENERON PHARMACEUTICALS COM 75886F107 178,072 509,900 SH   DFND 1 209,400 0 300,500
RELYPSA INC COM 759531106 136,900 7,400,000 SH   SOLE   7,400,000 0 0
ROKA BIOSCIENCE INC COM 775431109 1,842 3,220,429 SH   SOLE   3,220,429 0 0
SELECTA BIOSCIENCES INC COM 816212104 25,781 1,842,797 SH   SOLE   1,842,797 0 0
SERES THERAPEUTICS INC COM 81750R102 2,498 86,000 SH   SOLE   86,000 0 0
SHIRE PLC SPONSORED ADR 82481R106 72,529 394,009 SH   DFND 1 164,276 0 229,733
SIENTRA INC COM 82621J105 8,932 1,357,500 SH   SOLE   1,357,500 0 0
SINOVAC BIOTECH LTD SHS P8696W104 15,818 2,667,500 SH   DFND 1 1,219,500 0 1,448,000
SPDR S&P 500 ETF TR TR UNIT 78462F103 41,894 200,000 SH Put DFND 1 91,000 0 109,000
SPDR SERIES TRUST S&P BIOTECH 78464A870 40,306 745,300 SH   DFND 1 401,100 0 344,200
STRYKER CORP COM 863667101 25,404 212,000 SH   DFND 1 77,000 0 135,000
SYNDAX PHARMACEUTICALS INC COM 87164F105 7,460 757,365 SH   SOLE   757,365 0 0
SYNERGY PHARMACEUTICALS DEL COM NEW 871639308 22,711 5,976,648 SH   DFND 1 3,262,300 0 2,714,348
TENET HEALTHCARE CORP COM NEW 88033G407 25,299 915,300 SH   DFND 1 394,100 0 521,200
TEVA PHARMACEUTICAL INDS LTD ADR 881624209 138,625 2,759,800 SH   DFND 1 1,406,800 0 1,353,000
THERMO FISHER SCIENTIFIC INC COM 883556102 203,495 1,377,200 SH   DFND 1 621,700 0 755,500
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 8,280 169,300 SH   DFND 1 58,300 0 111,000
UNIQURE NV SHS N90064101 1,440 195,400 SH   SOLE   195,400 0 0
UNITEDHEALTH GROUP INC COM 91324P102 170,598 1,208,200 SH   DFND 1 551,400 0 656,800
VALEANT PHARMACEUTICALS INTL COM 91911K102 3,925 194,900 SH   DFND 1 76,800 0 118,100
VERTEX PHARMACEUTICALS INC COM 92532F100 188,324 2,189,300 SH   DFND 1 942,600 0 1,246,700
VIEWRAY INC COM 92672L107 32,679 7,989,916 SH   SOLE   7,989,916 0 0
WELLCARE HEALTH PLANS INC COM 94946T106 205,817 1,918,500 SH   DFND 1 912,600 0 1,005,900
WRIGHT MED GROUP N V ORD SHS 0.03 PAR N96617118 113,689 6,545,163 SH   DFND 1 1,964,850 0 4,580,313
WRIGHT MED GROUP N V ORD SHS 0.03 PAR N96617118 6,948 400,000 SH Call DFND 1 178,500 0 221,500
XENCOR INC COM 98401F105 16,537 870,822 SH   SOLE   870,822 0 0
XTANT MED HLDGS INC COM 98420P100 908 475,439 SH   SOLE   475,439 0 0
ZIMMER BIOMET HLDGS INC COM 98956P102 103,828 862,500 SH   DFND 1 378,200 0 484,300