The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103 69,741 3,729,442 SH   SOLE   3,729,442 0 0
9 METERS BIOPHARMA INC COM 654405109 9,423 8,565,974 SH   SOLE   8,565,974 0 0
ABBVIE INC COM 00287Y109 131,507 1,167,500 SH   DFND   228,100 0 939,400
ABCELLERA BIOLOGICS INC COM 00288U106 136,906 6,223,019 SH   SOLE   6,223,019 0 0
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 15,516 1,584,845 SH   DFND   178,735 0 1,406,110
ACLARIS THERAPEUTICS INC COM 00461U105 6,357 362,000 SH   SOLE   0 0 362,000
ACUTUS MED INC COM 005111109 93,016 5,477,958 SH   SOLE   5,477,958 0 0
ADAGENE INC ADS 005329107 3,729 275,000 SH   SOLE   275,000 0 0
ADICET BIO INC COM 007002108 74,426 7,232,856 SH   SOLE   7,232,856 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 27,948 4,015,524 SH   SOLE   4,015,524 0 0
AEROVATE THERAPEUTICS INC COM 008064107 12,230 535,714 SH   DFND   107,114 0 428,600
AERPIO PHARMACEUTICALS INC COM 00810B105 8,778 5,193,946 SH   SOLE   5,193,946 0 0
ALECTOR INC COM 014442107 12,737 611,478 SH   SOLE   611,478 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 27,722 150,900 SH   SOLE   0 0 150,900
ALPINE IMMUNE SCIENCES INC COM 02083G100 27,639 3,070,955 SH   SOLE   3,070,955 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105 8,202 150,000 SH   SOLE   0 0 150,000
AMGEN INC COM 031162100 13,918 57,100 SH   SOLE   0 0 57,100
ANTHEM INC COM 036752103 128,170 335,700 SH   DFND   42,900 0 292,800
APPLIED THERAPEUTICS INC COM 03828A101 46,909 2,257,387 SH   DFND   156,706 0 2,100,681
APTOSE BIOSCIENCES INC COM NEW 03835T200 26,660 8,030,000 SH   SOLE   0 0 8,030,000
ARCTURUS THERAPEUTICS HLDGS COM 03969T109 28,713 848,503 SH   DFND   132,403 0 716,100
ARCUTIS BIOTHERAPEUTICS INC COM 03969K108 165,755 6,073,850 SH   DFND   4,267,564 0 1,806,286
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 58,916 447,859 SH   DFND   61,000 0 386,859
ASLAN PHARMACEUTICALS LTD ADS 04522R101 8,316 2,520,000 SH   SOLE   0 0 2,520,000
AURINIA PHARMACEUTICALS INC COM 05156V102 78,655 6,069,032 SH   DFND   585,300 0 5,483,732
BELLUS HEALTH INC NEW COM NEW 07987C204 12,272 3,954,800 SH   SOLE   3,954,800 0 0
BIOGEN INC COM 09062X103 23,339 67,400 SH   SOLE   0 0 67,400
BIOMX INC COM 09090D103 12,632 2,313,489 SH   SOLE   2,313,489 0 0
BOSTON SCIENTIFIC CORP COM 101137107 295,925 6,920,600 SH   DFND   939,400 0 5,981,200
BOSTON SCIENTIFIC CORP COM 101137107 10,690 250,000 SH Call DFND   77,500 0 172,500
BRISTOL-MYERS SQUIBB CO COM 110122108 301,719 4,515,400 SH   DFND   569,100 0 3,946,300
BURNING ROCK BIOTECH LTD SPONSORED ADS 12233L107 54,684 1,856,201 SH   DFND   197,799 0 1,658,402
CATALYST BIOSCIENCES INC COM NEW 14888D208 9,174 2,118,600 SH   SOLE   0 0 2,118,600
CENTURY THERAPEUTICS INC COM 15673T100 11,943 407,047 SH   DFND   115,414 0 291,633
CHEMOMAB THERAPEUTICS LTD SPONSORED ADS 16385C104 49,037 2,578,174 SH   SOLE   2,578,174 0 0
CHINOOK THERAPEUTICS INC COM 16961L106 18,833 1,333,801 SH   DFND   333,800 0 1,000,001
CONVEY HLDG PARENT INC COM 21258C108 11,380 1,000,000 SH   DFND   107,000 0 893,000
CORVUS PHARMACEUTICALS INC COM 221015100 21,502 8,053,298 SH   SOLE   8,053,298 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 56,491 2,996,876 SH   SOLE   2,996,876 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 84,021 519,000 SH   DFND   47,500 0 471,500
CTI BIOPHARMA CORP COM 12648L601 18,802 7,520,600 SH   SOLE   7,520,600 0 0
CULLINAN ONCOLOGY INC COM 230031106 29,513 1,146,145 SH   DFND   959,245 0 186,900
CUREVAC N V COM N2451R105 2,204 30,000 SH Call DFND   11,000 0 19,000
CUREVAC N V COM N2451R105 10,287 140,000 SH Put DFND   52,000 0 88,000
CURIS INC COM NEW 231269200 28,418 3,521,400 SH   DFND   371,600 0 3,149,800
CVRX INC COM 126638105 11,200 400,000 SH   DFND   122,200 0 277,800
CYTOMX THERAPEUTICS INC COM 23284F105 9,578 1,513,168 SH   DFND   729,668 0 783,500
DECIBEL THERAPEUTICS INC COM 24343R106 42,529 4,945,192 SH   DFND   4,061,774 0 883,418
DECIPHERA PHARMACEUTICALS IN COM 24344T101 120,714 3,297,301 SH   DFND   429,600 0 2,867,701
DEXCOM INC COM 252131107 126,990 297,400 SH   DFND   37,000 0 260,400
DYNE THERAPEUTICS INC COM 26818M108 7,364 350,000 SH   SOLE   0 0 350,000
EDGEWISE THERAPEUTICS INC COM 28036F105 297,440 13,944,680 SH   DFND   13,679,055 0 265,625
EDWARDS LIFESCIENCES CORP COM 28176E108 116,661 1,126,400 SH   DFND   151,600 0 974,800
FLEXION THERAPEUTICS INC COM 33938J106 22,792 2,769,383 SH   DFND   301,600 0 2,467,783
FLUIDIGM CORP DEL COM 34385P108 28,717 4,661,871 SH   DFND   508,500 0 4,153,371
FUSION PHARMACEUTICALS INC COM 36118A100 26,056 3,224,770 SH   DFND   2,930,670 0 294,100
GALAPAGOS NV SPON ADR 36315X101 15,907 230,905 SH   DFND   25,700 0 205,205
GALECTO INC COM 36322Q107 20,700 4,090,937 SH   DFND   3,803,255 0 287,682
GEMINI THERAPEUTICS INC COM 36870G105 37,696 5,826,224 SH   SOLE   5,826,224 0 0
GH RESEARCH PLC ORDINARY SHARES G3855L106 31,045 1,428,666 SH   DFND   125,000 0 1,303,666
GILEAD SCIENCES INC COM 375558103 19,804 287,600 SH   SOLE   0 0 287,600
GRACELL BIOTECHNOLOGIES INC SPONSORED ADS 38406L103 102,503 7,884,870 SH   DFND   5,970,672 0 1,914,198
GRAPHITE BIO INC COM 38870X104 33,997 1,106,307 SH   DFND   331,892 0 774,415
GRAYBUG VISION INC COM SHS 38942Q103 22,607 4,163,347 SH   SOLE   4,163,347 0 0
GUARDANT HEALTH INC COM 40131M109 152,431 1,227,400 SH   DFND   108,700 0 1,118,700
HARPOON THERAPEUTICS INC COM 41358P106 36,219 2,611,308 SH   DFND   943,408 0 1,667,900
HEALTH SCIENCES ACQ CORP 2 ORD SHS G4411D109 5,100 500,000 SH   DFND   100,000 0 400,000
HORIZON THERAPEUTICS PUB L SHS G46188101 273,631 2,922,155 SH   DFND   357,500 0 2,564,655
HUMANA INC COM 444859102 148,311 335,000 SH   DFND   55,000 0 280,000
I MAB SPONSORED ADS 44975P103 9,329 111,120 SH   DFND   25,000 0 86,120
IKENA ONCOLOGY INC COM 45175G108 41,193 2,933,941 SH   DFND   1,936,886 0 997,055
IKENA ONCOLOGY INC NONVOTING 000000000 87,265 6,215,466 SH   DFND   5,586,311 0 629,155
IMARA INC COM 45249V107 21,487 2,719,902 SH   DFND   2,532,402 0 187,500
IMMUNOGEN INC COM 45253H101 85,252 12,936,622 SH   DFND   1,646,200 0 11,290,422
INFLARX NV COM N44821101 3,160 1,064,118 SH   SOLE   0 0 1,064,118
INOZYME PHARMA INC COM 45790W108 3,216 188,704 SH   SOLE   188,704 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 128,382 139,600 SH   DFND   20,800 0 118,800
IOVANCE BIOTHERAPEUTICS INC COM 462260100 172,906 6,645,100 SH   DFND   1,337,800 0 5,307,300
JANUX THERAPEUTICS INC COM 47103J105 86,486 3,466,386 SH   DFND   3,042,764 0 423,622
JOUNCE THERAPEUTICS INC COM 481116101 14,602 2,147,400 SH   DFND   659,700 0 1,487,700
KALA PHARMACEUTICALS INC COM 483119103 28,965 5,465,030 SH   DFND   4,714,195 0 750,835
KEROS THERAPEUTICS INC COM 492327101 71,325 1,679,417 SH   DFND   1,268,734 0 410,683
KEZAR LIFE SCIENCES INC COM 49372L100 3,026 557,191 SH   SOLE   557,191 0 0
KINNATE BIOPHARMA INC COM 49705R105 89,580 3,847,929 SH   DFND   3,397,929 0 450,000
LANDOS BIOPHARMA INC COM 515069102 7,866 681,000 SH   SOLE   0 0 681,000
LOGICBIO THERAPEUTICS INC COM 54142F102 37,593 8,466,783 SH   DFND   7,948,265 0 518,518
LONGBOARD PHARMACEUTICALS IN COM 54300N103 1,035 113,500 SH   SOLE   0 0 113,500
MAGENTA THERAPEUTICS INC COM 55910K108 19,890 2,033,759 SH   SOLE   0 0 2,033,759
MEIRAGTX HLDGS PLC COM G59665102 63,595 4,102,925 SH   DFND   133,500 0 3,969,425
MERCK & CO INC COM 58933Y105 290,269 3,732,400 SH   DFND   465,000 0 3,267,400
MEREO BIOPHARMA GROUP PLC ADS 589492107 54,730 17,264,764 PRN   DFND   9,210,992 0 8,053,772
MERSANA THERAPEUTICS INC COM 59045L106 38,027 2,800,247 SH   DFND   375,400 0 2,424,847
MILESTONE PHARMACEUTICALS IN COM 59935V107 14,211 2,583,821 SH   SOLE   0 0 2,583,821
MIRATI THERAPEUTICS INC COM 60468T105 204,206 1,264,200 SH   DFND   213,900 0 1,050,300
MONTE ROSA THERAPEUTICS INC COM 61225M102 7,945 350,000 SH   DFND   80,500 0 269,500
NANOBIOTIX SA SPONSORED ADS 63009J107 6,890 500,000 SH   SOLE   0 0 500,000
NANOSTRING TECHNOLOGIES INC COM 63009R109 36,023 556,000 SH   DFND   62,900 0 493,100
NANOSTRING TECHNOLOGIES INC NOTE 2.625% 3/0 63009RAD1 9,705 6,000,000 PRN   SOLE   0 0 6,000,000
NATERA INC COM 632307104 233,622 2,057,800 SH   DFND   252,300 0 1,805,500
NAUTILUS BIOTECHNOLOGY INC COM 63909J108 15,622 1,546,700 SH   DFND   363,800 0 1,182,900
NEUROCRINE BIOSCIENCES INC COM 64125C109 119,812 1,231,115 SH   DFND   137,470 0 1,093,645
NEUROPACE INC COM 641288105 95,452 4,012,281 SH   SOLE   4,012,281 0 0
NEXTCURE INC COM 65343E108 21,769 2,711,013 SH   SOLE   2,711,013 0 0
NOVAVAX INC COM NEW 670002401 42,525 200,295 SH   DFND   34,275 0 166,020
NURIX THERAPEUTICS INC COM 67080M103 7,959 300,000 SH   SOLE   0 0 300,000
OAK STR HEALTH INC COM 67181A107 77,799 1,328,300 SH   DFND   136,700 0 1,191,600
OLEMA PHARMACEUTICALS INC COM 68062P106 22,602 807,792 SH   DFND   282,392 0 525,400
ONCOCYTE CORP COM 68235C107 12,054 2,100,000 SH   SOLE   0 0 2,100,000
ORGANON & CO COMMON STOCK 68622V106 5,052 166,939 SH   DFND   20,800 0 146,139
ORIC PHARMACEUTICALS INC COM 68622P109 41,352 2,337,574 SH   DFND   2,212,571 0 125,003
OTONOMY INC COM 68906L105 7,248 3,250,000 SH   DFND   769,200 0 2,480,800
PASSAGE BIO INC COM 702712100 92,189 6,962,899 SH   DFND   5,947,323 0 1,015,576
PMV PHARMACEUTICALS INC COM 69353Y103 250,407 7,330,423 SH   DFND   6,589,330 0 741,093
PRELUDE THERAPEUTICS INC COM 74065P101 287,436 10,039,691 SH   DFND   9,250,191 0 789,500
PRELUDE THERAPEUTICS INC NONVOTING 000000000 162,624 5,680,186 SH   DFND   5,596,886 0 83,300
PROGYNY INC COM 74340E103 80,561 1,365,445 SH   DFND   151,085 0 1,214,360
PROMETHEUS BIOSCIENCES INC COM 74349U108 6,140 250,000 SH   SOLE   0 0 250,000
PROTARA THERAPEUTICS INC COM STK 74365U107 4,383 450,000 SH   DFND   60,000 0 390,000
PULMONX CORP COM 745848101 5,515 125,000 SH   SOLE   0 0 125,000
PURPLE BIOTECH LTD SPONSORED ADS 74638P109 86 17,712 SH   SOLE   17,712 0 0
RELAY THERAPEUTICS INC COM 75943R102 12,807 350,000 SH   SOLE   0 0 350,000
REPARE THERAPEUTICS INC COM 760273102 106,833 3,426,325 SH   DFND   3,276,325 0 150,000
SAREPTA THERAPEUTICS INC COM 803607100 5,030 64,700 SH   SOLE   64,700 0 0
SCPHARMACEUTICALS INC COM 810648105 29,311 4,797,148 SH   SOLE   4,797,148 0 0
SELECT MED HLDGS CORP COM 81619Q105 53,717 1,271,100 SH   DFND   135,900 0 1,135,200
SI-BONE INC COM 825704109 41,078 1,305,300 SH   SOLE   0 0 1,305,300
SIERRA ONCOLOGY INC COM NEW 82640U404 28,763 1,477,320 SH   DFND   1,306,860 0 170,460
SILVERBACK THERAPEUTICS INC COM 82835W108 270,006 8,740,887 SH   DFND   7,788,510 0 952,377
SINGULAR GENOMICS SYSTEMS IN COM 82933R100 54,919 1,998,521 SH   DFND   683,626 0 1,314,895
SINOVAC BIOTECH LTD SHS P8696W104 76,800 2,839,500 SH   SOLE   0 0 2,839,500
SPDR SER TR S&P BIOTECH 78464A870 126,694 935,700 SH   DFND   167,800 0 767,900
SPRINGWORKS THERAPEUTICS INC COM 85205L107 498,108 6,044,266 SH   SOLE   6,044,266 0 0
STRONGBRIDGE BIOPHARMA PLC SHS USD G85347105 5,182 1,744,669 SH   DFND   251,200 0 1,493,469
STRYKER CORPORATION COM 863667101 87,633 337,400 SH   DFND   53,200 0 284,200
SUTRO BIOPHARMA INC COM 869367102 8,062 433,700 SH   SOLE   0 0 433,700
SYNLOGIC INC COM 87166L100 14,380 3,696,662 SH   SOLE   3,696,662 0 0
SYROS PHARMACEUTICALS INC COM 87184Q107 10,014 1,837,500 SH   SOLE   0 0 1,837,500
TALARIS THERAPEUTICS INC COM 87410C104 3,632 247,240 SH   SOLE   0 0 247,240
TELA BIO INC COM 872381108 48,774 3,027,542 SH   SOLE   3,027,542 0 0
TERNS PHARMACEUTICALS INC COM 880881107 46,480 3,791,204 SH   SOLE   3,791,204 0 0
THERAVANCE BIOPHARMA INC COM G8807B106 66,270 4,564,045 SH   DFND   558,385 0 4,005,660
THERMO FISHER SCIENTIFIC INC COM 883556102 55,643 110,300 SH   DFND   16,800 0 93,500
TRICIDA INC COM 89610F101 41,534 9,614,280 SH   SOLE   9,614,280 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 32,226 3,322,300 SH   DFND   364,000 0 2,958,300
TURNING POINT THERAPEUTICS I COM 90041T108 184,231 2,361,327 SH   DFND   1,743,950 0 617,377
UNIQURE NV SHS N90064101 14,512 471,174 SH   DFND   94,400 0 376,774
UNITEDHEALTH GROUP INC COM 91324P102 156,051 389,700 SH   DFND   56,500 0 333,200
VAXCYTE INC COM 92243G108 21,281 945,400 SH   SOLE   0 0 945,400
VECTIVBIO HLDG AG ORD SHS H9060V101 59,738 5,123,304 SH   DFND   4,830,004 0 293,300
VERONA PHARMA PLC SPONSORED ADS 925050106 37,244 5,694,841 SH   DFND   5,028,174 0 666,667
VERRICA PHARMACEUTICALS INC COM 92511W108 16,721 1,479,733 SH   SOLE   1,479,733 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 214,817 1,065,400 SH   DFND   171,200 0 894,200
VERVE THERAPEUTICS INC COM 92539P101 6,025 100,000 SH   SOLE   0 0 100,000
VISTAGEN THERAPEUTICS INC COM NEW 92840H202 45,574 14,467,872 SH   DFND   2,917,743 0 11,550,129
VOR BIOPHARMA INC COM 929033108 15,542 833,333 SH   SOLE   0 0 833,333
WM TECHNOLOGY INC *W EXP 06/16/202 92971A117 954 150,200 SH Call SOLE   0 0 150,200
WM TECHNOLOGY INC COM 92971A109 12,509 700,400 SH   SOLE   0 0 700,400
X4 PHARMACEUTICALS INC COM 98420X103 8,930 1,373,849 SH   SOLE   1,373,849 0 0
XENON PHARMACEUTICALS INC COM 98420N105 24,843 1,334,217 SH   DFND   527,029 0 807,188
XTANT MED HLDGS INC COM NEW 98420P308 118,784 72,873,494 SH   SOLE   72,873,494 0 0