The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABS COM 002824100 8,486 211,000 SH   DFND 1 53,000 0 158,000
ABBVIE INC COM 00287Y109 377,780 6,943,200 SH   DFND 1 3,098,500 0 3,844,700
ACHILLION PHARMACEUTICALS IN COM 00448Q201 36,087 5,222,500 SH   DFND 1 2,142,200 0 3,080,300
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 2,112 176,470 SH   SOLE   176,470 0 0
ADURO BIOTECH INC COM 00739L101 20,639 1,065,522 SH   SOLE   1,065,522 0 0
ADVAXIS INC COM NEW 007624208 6,512 636,600 SH   DFND 1 0 0 636,600
AETNA INC NEW COM 00817Y108 7,330 67,000 SH   DFND 1 18,000 0 49,000
AFFIMED N V COM N01045108 28,275 4,582,616 SH   SOLE   4,582,616 0 0
AFFYMETRIX INC COM 00826T108 64,144 7,511,000 SH   DFND 1 2,295,000 0 5,216,000
AGILENT TECHNOLOGIES INC COM 00846U101 121,494 3,539,000 SH   DFND 1 1,457,800 0 2,081,200
ALEXION PHARMACEUTICALS INC COM 015351109 348,218 2,226,600 SH   DFND 1 826,400 0 1,400,200
ALIMERA SCIENCES INC COM 016259103 3,315 1,500,000 SH   DFND 1 670,000 0 830,000
ALIMERA SCIENCES INC COM 016259103 442 200,000 SH Call DFND 1 80,300 0 119,700
ALLERGAN PLC PFD CONV SER A G0177J116 98,309 104,200 SH   DFND 1 30,300 0 73,900
ALLERGAN PLC SHS G0177J108 392,307 1,443,315 SH   DFND 1 682,025 0 761,290
AMARIN CORP PLC SPONS ADR NEW 023111206 676 350,000 SH   SOLE   350,000 0 0
AMGEN INC COM 031162100 416,758 3,013,000 SH   DFND 1 1,110,000 0 1,903,000
ANACOR PHARMACEUTICALS INC COM 032420101 6,274 53,300 SH   DFND 1 0 0 53,300
ARRAY BIOPHARMA INC COM 04269X105 45,876 10,060,500 SH   DFND 1 3,969,700 0 6,090,800
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 3,933 222,223 SH   SOLE   222,223 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 13,356 1,397,100 SH   DFND 1 647,100 0 750,000
BAXALTA INC COM 07177M103 8,980 285,000 SH   DFND 1 80,000 0 205,000
BAXTER INTL INC COM 071813109 10,479 319,000 SH   DFND 1 90,000 0 229,000
BIOGEN INC COM 09062X103 381,512 1,307,400 SH   DFND 1 464,600 0 842,800
BIOLINERX LTD SPONSORED ADR 09071M106 1,589 1,038,600 SH   SOLE   1,038,600 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 19,800 188,000 SH   DFND 1 0 0 188,000
BIOMARIN PHARMACEUTICAL INC NOTE 0.750%10/1 09061GAE1 653 500,000 PRN   DFND 1 215,000 0 285,000
BIOMARIN PHARMACEUTICAL INC NOTE 1.500%10/1 09061GAF8 653 500,000 PRN   DFND 1 215,000 0 285,000
BIOTIE THERAPIES OYJ SPONSORED ADR 09074D103 3,517 268,672 SH   SOLE   268,672 0 0
BLUEBIRD BIO INC COM 09609G100 101,710 1,188,900 SH   DFND 1 404,000 0 784,900
BOSTON SCIENTIFIC CORP COM 101137107 393,958 24,007,200 SH   DFND 1 10,627,200 0 13,380,000
BRISTOL MYERS SQUIBB CO COM 110122108 513,152 8,668,100 SH   DFND 1 3,684,500 0 4,983,600
CARDINAL HEALTH INC COM 14149Y108 11,216 146,000 SH   DFND 1 40,000 0 106,000
CELGENE CORP COM 151020104 388,655 3,593,000 SH   DFND 1 1,361,000 0 2,232,000
CELLECTIS S A SPONSORED ADS 15117K103 9,226 350,000 SH   DFND 1 162,100 0 187,900
CERUS CORP COM 157085101 29,530 6,504,400 SH   DFND 1 2,683,900 0 3,820,500
CHIMERIX INC COM 16934W106 39,025 1,021,600 SH   DFND 1 418,980 0 602,620
CLOVIS ONCOLOGY INC COM 189464100 101,699 1,105,900 SH   DFND 1 449,100 0 656,800
COGENTIX MED INC COM 19243A104 1,229 990,745 SH   DFND 1 436,407 0 554,338
COMMUNITY HEALTH SYS INC NEW COM 203668108 116,343 2,720,200 SH   DFND 1 1,098,200 0 1,622,000
CONNECTURE INC COM 20786J106 7,934 1,740,000 SH   DFND 1 795,000 0 945,000
COOPER COS INC COM NEW 216648402 193,726 1,301,400 SH   DFND 1 600,000 0 701,400
CYNAPSUS THERAPEUTICS INC COM PAR NO PAR 23257Y859 18,439 1,140,325 SH   SOLE   1,140,325 0 0
DYAX CORP COM 26746E103 21,324 1,117,000 SH   DFND 1 300,200 0 816,800
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 60,668 2,472,200 SH   DFND 1 770,800 0 1,701,400
EHEALTH INC COM 28238P109 16,653 1,300,000 SH   DFND 1 600,000 0 700,000
ENSIGN GROUP INC COM 29358P101 10,555 247,600 SH   DFND 1 101,600 0 146,000
EXACT SCIENCES CORP COM 30063P105 31,986 1,778,000 SH   DFND 1 824,000 0 954,000
EXPRESS SCRIPTS HLDG CO COM 30219G108 108,648 1,342,000 SH   DFND 1 578,000 0 764,000
FATE THERAPEUTICS INC COM 31189P102 3,693 692,900 SH   DFND 1 296,100 0 396,800
FLUIDIGM CORP DEL COM 34385P108 19,869 2,449,900 SH   DFND 1 888,000 0 1,561,900
FLUIDIGM CORP DEL NOTE 2.750% 2/0 34385PAA6 7,154 10,000,000 PRN   DFND 1 4,466,000 0 5,534,000
FORWARD PHARMA A/S SPONSORED ADR 34986J105 22,632 960,600 SH   DFND 1 389,100 0 571,500
GALAPAGOS NV SPON ADR 36315X101 20,880 512,900 SH   DFND 1 279,800 0 233,100
GILEAD SCIENCES INC COM 375558103 214,486 2,184,400 SH   DFND 1 721,900 0 1,462,500
GLAUKOS CORP COM 377322102 70,101 2,897,937 SH   SOLE   2,897,937 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 34,456 377,100 SH   DFND 1 0 0 377,100
HCA HOLDINGS INC COM 40412C101 451,620 5,837,900 SH   DFND 1 2,636,400 0 3,201,500
HEALTH NET INC COM 42222G108 15,055 250,000 SH Call DFND 1 100,400 0 149,600
HEALTH NET INC COM 42222G108 204,616 3,397,800 SH   DFND 1 1,563,600 0 1,834,200
HORIZON PHARMA PLC SHS G4617B105 4,043 204,000 SH   DFND 1 0 0 204,000
ILLUMINA INC COM 452327109 202,369 1,151,000 SH   DFND 1 432,000 0 719,000
IMMUNOGEN INC COM 45253H101 34,502 3,594,000 SH   DFND 1 1,273,900 0 2,320,100
IMMUNOMEDICS INC COM 452907108 5,716 3,323,000 SH   DFND 1 1,795,300 0 1,527,700
IMPAX LABORATORIES INC COM 45256B101 234,643 6,664,100 SH   DFND 1 2,653,500 0 4,010,600
INCYTE CORP COM 45337C102 302,412 2,740,978 SH   DFND 1 1,030,500 0 1,710,478
INCYTE CORP NOTE 0.375%11/1 45337CAM4 8,979 4,250,000 PRN   DFND 1 1,816,000 0 2,434,000
INCYTE CORP NOTE 1.250%11/1 45337CAN2 9,403 4,250,000 PRN   DFND 1 1,816,000 0 2,434,000
INFINITY PHARMACEUTICALS INC COM 45665G303 37,318 4,416,300 SH   DFND 1 1,742,000 0 2,674,300
INOTEK PHARMACEUTICALS CORP COM 45780V102 3,995 425,000 SH   DFND 1 197,000 0 228,000
INSMED INC COM PAR $.01 457669307 58,408 3,145,301 SH   DFND 1 1,268,200 0 1,877,101
INSYS THERAPEUTICS INC NEW COM NEW 45824V209 116,168 4,081,800 SH   DFND 1 1,463,200 0 2,618,600
INTERCEPT PHARMACEUTICALS IN COM 45845P108 185,763 1,120,000 SH   SOLE   1,120,000 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 109,840 239,000 SH   DFND 1 116,600 0 122,400
INVITAE CORP COM 46185L103 3,297 456,666 SH   SOLE   456,666 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 116,979 11,226,400 SH   DFND 1 4,509,500 0 6,716,900
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 15,273 115,000 SH   DFND 1 0 0 115,000
JOHNSON & JOHNSON COM 478160104 27,258 292,000 SH   DFND 1 80,000 0 212,000
LILLY ELI & CO COM 532457108 106,454 1,272,000 SH   DFND 1 553,000 0 719,000
LION BIOTECHNOLOGIES INC COM 53619R102 5,887 1,022,100 SH   DFND 1 272,000 0 750,100
LOXO ONCOLOGY INC COM 548862101 38,034 2,175,857 SH   SOLE   2,175,857 0 0
MACROGENICS INC COM 556099109 6,790 317,000 SH   DFND 1 146,800 0 170,200
MAGELLAN HEALTH INC COM NEW 559079207 101,603 1,833,000 SH   DFND 1 751,300 0 1,081,700
MALLINCKRODT PUB LTD CO SHS G5785G107 75,002 1,173,000 SH   DFND 1 484,000 0 689,000
MANNKIND CORP COM 56400P201 1,445 450,000 SH Put DFND 1 226,800 0 223,200
MCKESSON CORP COM 58155Q103 129,521 700,000 SH   DFND 1 294,000 0 406,000
MEDIGUS LTD SPONSORED ADR 58471G102 2,688 600,000 SH   SOLE   600,000 0 0
MEDTRONIC PLC SHS G5960L103 39,381 588,299 SH   DFND 1 156,199 0 432,100
MERCK & CO INC NEW COM 58933Y105 20,497 415,000 SH   DFND 1 110,000 0 305,000
MIRATI THERAPEUTICS INC COM 60468T105 8,261 240,000 SH   SOLE   240,000 0 0
MOLINA HEALTHCARE INC COM 60855R100 222,819 3,236,300 SH   DFND 1 1,410,300 0 1,826,000
NABRIVA THERAPEUTICS AG SPONSORED ADR 62957M104 12,493 1,315,000 SH   SOLE   1,315,000 0 0
NATERA INC COM 632307104 13,847 1,276,190 SH   SOLE   1,276,190 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 151,841 3,816,050 SH   DFND 1 1,497,040 0 2,319,010
NEWLINK GENETICS CORP COM 651511107 25,529 712,306 SH   DFND 1 329,600 0 382,706
NUVASIVE INC COM 670704105 71,703 1,487,000 SH   DFND 1 806,000 0 681,000
OCULAR THERAPEUTIX INC COM 67576A100 2,937 208,900 SH   DFND 1 0 0 208,900
OPHTHOTECH CORP COM 683745103 77,940 1,923,500 SH   DFND 1 881,580 0 1,041,920
OREXIGEN THERAPEUTICS INC NOTE 2.750%12/0 686164AB0 3,621 5,210,000 PRN   DFND 1 2,210,000 0 3,000,000
OTONOMY INC COM 68906L105 40,186 2,256,398 SH   SOLE   2,256,398 0 0
PERNIX THERAPEUTICS HLDGS IN COM 71426V108 3,391 1,073,000 SH   DFND 1 485,000 0 588,000
PFIZER INC COM 717081103 118,196 3,763,000 SH   DFND 1 1,048,000 0 2,715,000
PIERIS PHARMACEUTICALS INC COM 720795103 13,285 7,259,620 SH   SOLE   7,259,620 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 41,968 984,700 SH   DFND 1 475,700 0 509,000
PRONAI THERAPEUTICS INC COM 74346L101 40,834 1,989,949 SH   SOLE   1,989,949 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 26,829 1,841,400 SH   DFND 1 839,500 0 1,001,900
PUMA BIOTECHNOLOGY INC COM 74587V107 90,093 1,195,500 SH   DFND 1 439,600 0 755,900
QLT INC COM 746927102 1,330 500,000 SH   DFND 1 200,600 0 299,400
REDHILL BIOPHARMA LTD SPONSORED ADS 757468103 7,293 564,900 SH   SOLE   564,900 0 0
REGENERON PHARMACEUTICALS COM 75886F107 226,849 487,700 SH   DFND 1 184,700 0 303,000
RELYPSA INC COM 759531106 136,974 7,400,000 SH   SOLE   7,400,000 0 0
ROKA BIOSCIENCE INC COM 775431109 6,280 3,220,429 SH   SOLE   3,220,429 0 0
SAGE THERAPEUTICS INC COM 78667J108 6,348 149,999 SH   SOLE   149,999 0 0
SERES THERAPEUTICS INC COM 81750R102 7,311 246,645 SH   SOLE   246,645 0 0
SHIRE PLC SPONSORED ADR 82481R106 136,355 664,400 SH   DFND 1 267,803 0 396,597
SIENTRA INC COM 82621J105 30,247 2,980,000 SH   SOLE   2,980,000 0 0
SINOVAC BIOTECH LTD SHS P8696W104 13,551 2,667,500 SH   DFND 1 1,219,500 0 1,448,000
STRYKER CORP COM 863667101 17,503 186,000 SH   DFND 1 51,000 0 135,000
SYNERGY PHARMACEUTICALS DEL COM NEW 871639308 12,066 2,276,648 SH   DFND 1 1,114,300 0 1,162,348
TESARO INC COM 881569107 69,582 1,735,200 SH   DFND 1 719,600 0 1,015,600
TEVA PHARMACEUTICAL INDS LTD ADR 881624209 124,156 2,199,000 SH   DFND 1 1,002,000 0 1,197,000
THERMO FISHER SCIENTIFIC INC COM 883556102 166,790 1,364,000 SH   DFND 1 579,000 0 785,000
UNITEDHEALTH GROUP INC COM 91324P102 27,610 238,000 SH   DFND 1 63,000 0 175,000
VALEANT PHARMACEUTICALS INTL COM 91911K102 29,433 165,000 SH   DFND 1 44,000 0 121,000
VERTEX PHARMACEUTICALS INC COM 92532F100 11,976 115,000 SH   DFND 1 0 0 115,000
VITAE PHARMACEUTICALS INC COM 92847N103 3,980 361,500 SH   DFND 1 0 0 361,500
WELLCARE HEALTH PLANS INC COM 94946T106 9,825 114,000 SH   DFND 1 48,700 0 65,300
WRIGHT MED GROUP INC COM 98235T107 166,015 8,142,000 SH   DFND 1 3,731,000 0 4,411,000
XENCOR INC COM 98401F105 13,820 1,130,022 SH   DFND 1 0 0 1,130,022
XENOPORT INC COM 98411C100 20,016 5,768,400 SH   DFND 1 2,321,000 0 3,447,400
XTANT MEDICAL HOLDINGS INC COM 98420P100 1,550 475,439 SH   SOLE   475,439 0 0
ZIMMER BIOMET HLDGS INC COM 98956P102 19,941 212,300 SH   DFND 1 90,500 0 121,800