The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
ABBOTT LABS | COM | 002824100 | 68,810 | 822,400 | SH | DFND | 1 | 194,000 | 0 | 628,400 | |
ACADIA PHARMACEUTICALS INC | COM | 004225108 | 3,460 | 96,143 | SH | SOLE | 0 | 0 | 96,143 | ||
ADAPTIMMUNE THERAPEUTICS PLC | SPONDS ADR | 00653A107 | 2,039 | 1,350,655 | SH | SOLE | 1,350,655 | 0 | 0 | ||
ADVERUM BIOTECHNOLOGIES INC | COM | 00773U108 | 21,871 | 4,012,969 | SH | DFND | 1 | 341,300 | 0 | 3,671,669 | |
AEGLEA BIOTHERAPEUTICS INC | COM | 00773J103 | 22,036 | 2,865,524 | SH | SOLE | 2,865,524 | 0 | 0 | ||
AERPIO PHARMACEUTICALS INC | COM | 00810B105 | 3,531 | 5,193,946 | SH | SOLE | 5,193,946 | 0 | 0 | ||
ALCON INC | ORD SHS | H01301128 | 20,493 | 351,380 | SH | DFND | 1 | 125,800 | 0 | 225,580 | |
ALDER BIOPHARMACEUTICALS INC | COM | 014339105 | 6,601 | 350,000 | SH | Put | DFND | 1 | 66,500 | 0 | 283,500 |
ALECTOR INC | COM | 014442107 | 180,716 | 12,532,329 | SH | DFND | 1 | 12,240,829 | 0 | 291,500 | |
ALEXION PHARMACEUTICALS INC | COM | 015351109 | 162,902 | 1,663,285 | SH | DFND | 1 | 270,000 | 0 | 1,393,285 | |
ALPINE IMMUNE SCIENCES INC | COM | 02083G100 | 14,537 | 3,670,955 | SH | SOLE | 3,670,955 | 0 | 0 | ||
AMARIN CORP PLC | SPONS ADR NEW | 023111206 | 3,352 | 221,100 | SH | SOLE | 0 | 0 | 221,100 | ||
AMGEN INC | COM | 031162100 | 23,628 | 122,100 | SH | SOLE | 0 | 0 | 122,100 | ||
ANTHEM INC | COM | 036752103 | 61,129 | 254,600 | SH | DFND | 1 | 39,000 | 0 | 215,600 | |
APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 15,029 | 623,859 | SH | SOLE | 0 | 0 | 623,859 | ||
ARENA PHARMACEUTICALS INC | COM NEW | 040047607 | 5,035 | 110,000 | SH | SOLE | 0 | 0 | 110,000 | ||
ARGENX SE | SPONSORED ADR | 04016X101 | 35,373 | 310,400 | SH | SOLE | 0 | 0 | 310,400 | ||
ARQULE INC | COM | 04269E107 | 26,538 | 3,701,273 | SH | DFND | 1 | 261,200 | 0 | 3,440,073 | |
ARVINAS INC | COM | 04335A105 | 45,153 | 2,095,283 | SH | DFND | 1 | 1,517,183 | 0 | 578,100 | |
ASCENDIS PHARMA A S | SPONSORED ADR | 04351P101 | 358,231 | 3,719,173 | SH | DFND | 1 | 3,397,673 | 0 | 321,500 | |
ATHENEX INC | COM | 04685N103 | 40,253 | 3,308,920 | SH | SOLE | 0 | 0 | 3,308,920 | ||
AUDENTES THERAPEUTICS INC | COM | 05070R104 | 44,609 | 1,588,069 | SH | SOLE | 1,588,069 | 0 | 0 | ||
AURINIA PHARMACEUTICALS INC | COM | 05156V102 | 18,856 | 3,531,002 | SH | SOLE | 0 | 0 | 3,531,002 | ||
AVEDRO INC | COM | 05355N109 | 96,251 | 4,240,128 | SH | SOLE | 4,240,128 | 0 | 0 | ||
AVROBIO INC | COM | 05455M100 | 8,058 | 570,700 | SH | SOLE | 0 | 0 | 570,700 | ||
BAUSCH HEALTH COS INC | COM | 071734107 | 72,374 | 3,312,300 | SH | DFND | 1 | 675,000 | 0 | 2,637,300 | |
BELLUS HEALTH INC NEW | COM NEW | 07987C204 | 45,129 | 7,025,832 | SH | DFND | 1 | 4,943,416 | 0 | 2,082,416 | |
BIOGEN INC | COM | 09062X103 | 8,428 | 36,200 | SH | SOLE | 0 | 0 | 36,200 | ||
BIOLINERX LTD | SPONSORED ADS | 09071M205 | 183 | 69,240 | SH | SOLE | 69,240 | 0 | 0 | ||
BOSTON SCIENTIFIC CORP | COM | 101137107 | 214,383 | 5,268,700 | SH | DFND | 1 | 1,017,800 | 0 | 4,250,900 | |
CEL SCI CORP | COM PAR NEW | 150837607 | 1,118 | 125,000 | SH | Put | DFND | 1 | 24,000 | 0 | 101,000 |
CIGNA CORP NEW | COM | 125523100 | 44,262 | 291,600 | SH | DFND | 1 | 73,000 | 0 | 218,600 | |
CONSTELLATION PHARMCETICLS I | COM | 210373106 | 5,400 | 835,842 | SH | SOLE | 835,842 | 0 | 0 | ||
CORVUS PHARMACEUTICALS INC | COM | 221015100 | 20,370 | 6,767,584 | SH | SOLE | 6,767,584 | 0 | 0 | ||
CRINETICS PHARMACEUTICALS IN | COM | 22663K107 | 30,671 | 2,039,282 | SH | SOLE | 2,039,282 | 0 | 0 | ||
CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 21,167 | 516,400 | SH | DFND | 1 | 27,400 | 0 | 489,000 | |
CTI BIOPHARMA CORP | COM | 12648L601 | 4,185 | 5,000,000 | SH | SOLE | 5,000,000 | 0 | 0 | ||
CURIS INC | COM NEW | 231269200 | 2,781 | 1,241,494 | SH | SOLE | 0 | 0 | 1,241,494 | ||
DECIPHERA PHARMACEUTICALS IN | COM | 24344T101 | 83,512 | 2,460,571 | SH | DFND | 1 | 384,800 | 0 | 2,075,771 | |
DEXCOM INC | COM | 252131107 | 57,308 | 384,000 | SH | DFND | 1 | 61,000 | 0 | 323,000 | |
EDWARDS LIFESCIENCES CORP | COM | 28176E108 | 111,670 | 507,800 | SH | DFND | 1 | 77,000 | 0 | 430,800 | |
EHEALTH INC | COM | 28238P109 | 6,679 | 100,000 | SH | Call | DFND | 1 | 19,000 | 0 | 81,000 |
EHEALTH INC | COM | 28238P109 | 74,632 | 1,117,414 | SH | DFND | 1 | 124,800 | 0 | 992,614 | |
ESSA PHARMA INC | COM NEW | 29668H708 | 4,960 | 1,471,853 | SH | SOLE | 1,471,853 | 0 | 0 | ||
EXELIXIS INC | COM | 30161Q104 | 69,200 | 3,912,900 | SH | DFND | 1 | 555,200 | 0 | 3,357,700 | |
FOAMIX PHARMACEUTICALS LTD | SHS | M46135105 | 14,558 | 4,788,896 | SH | SOLE | 0 | 0 | 4,788,896 | ||
GILEAD SCIENCES INC | COM | 375558103 | 20,668 | 326,100 | SH | SOLE | 0 | 0 | 326,100 | ||
HARPOON THERAPEUTICS INC | COM | 41358P106 | 33,418 | 2,446,409 | SH | DFND | 1 | 1,360,704 | 0 | 1,085,705 | |
HEALTH CATALYST INC | COM | 42225T107 | 5,682 | 179,598 | SH | SOLE | 179,598 | 0 | 0 | ||
HUMANA INC | COM | 444859102 | 46,481 | 181,800 | SH | DFND | 1 | 32,000 | 0 | 149,800 | |
INSMED INC | COM PAR $.01 | 457669307 | 9,919 | 562,300 | SH | SOLE | 0 | 0 | 562,300 | ||
INSPIRE MED SYS INC | COM | 457730109 | 89,760 | 1,471,000 | SH | SOLE | 1,471,000 | 0 | 0 | ||
INTELLIA THERAPEUTICS INC | COM | 45826J105 | 4,373 | 327,600 | SH | SOLE | 327,600 | 0 | 0 | ||
INTERCEPT PHARMACEUTICALS IN | COM | 45845P108 | 2,137 | 32,200 | SH | SOLE | 0 | 0 | 32,200 | ||
INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 111,010 | 205,600 | SH | DFND | 1 | 32,000 | 0 | 173,600 | |
IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 100,980 | 5,548,326 | SH | DFND | 1 | 1,337,800 | 0 | 4,210,526 | |
IQVIA HLDGS INC | COM | 46266C105 | 26,142 | 175,000 | SH | SOLE | 0 | 0 | 175,000 | ||
ISHARES TR | NASDAQ BIOTECH | 464287556 | 19,900 | 200,000 | SH | Put | DFND | 1 | 38,000 | 0 | 162,000 |
KALA PHARMACEUTICALS INC | COM | 483119103 | 13,119 | 3,447,840 | SH | SOLE | 3,447,840 | 0 | 0 | ||
KALVISTA PHARMACEUTICALS INC | COM | 483497103 | 449 | 38,733 | SH | SOLE | 0 | 0 | 38,733 | ||
KARYOPHARM THERAPEUTICS INC | COM | 48576U106 | 10,254 | 1,065,900 | SH | SOLE | 0 | 0 | 1,065,900 | ||
KRYSTAL BIOTECH INC | COM | 501147102 | 20,903 | 601,950 | SH | SOLE | 0 | 0 | 601,950 | ||
LOGICBIO THERAPEUTICS INC | COM | 54142F102 | 69,906 | 6,466,783 | SH | SOLE | 6,466,783 | 0 | 0 | ||
MEDIGUS LTD | SPONSORED ADS | 58471G300 | 26 | 15,000 | SH | SOLE | 15,000 | 0 | 0 | ||
MEIRAGTX HOLDINGS PLC | COM | G59665102 | 53,418 | 3,349,060 | SH | SOLE | 0 | 0 | 3,349,060 | ||
MENLO THERAPEUTICS INC | COM | 586858102 | 2,968 | 662,600 | SH | SOLE | 0 | 0 | 662,600 | ||
MERCK & CO INC | COM | 58933Y105 | 164,496 | 1,954,100 | SH | DFND | 1 | 290,000 | 0 | 1,664,100 | |
MERSANA THERAPEUTICS INC | COM | 59045L106 | 2,988 | 1,891,119 | SH | SOLE | 0 | 0 | 1,891,119 | ||
MIRATI THERAPEUTICS INC | COM | 60468T105 | 41,693 | 535,143 | SH | DFND | 1 | 65,400 | 0 | 469,743 | |
MYOKARDIA INC | COM | 62857M105 | 40,835 | 783,032 | SH | DFND | 1 | 140,400 | 0 | 642,632 | |
NABRIVA THERAPEUTICS PLC | SHS | G63637105 | 9,289 | 4,644,600 | SH | SOLE | 4,644,600 | 0 | 0 | ||
NATERA INC | COM | 632307104 | 98,404 | 3,000,128 | SH | DFND | 1 | 978,786 | 0 | 2,021,342 | |
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 141,939 | 1,575,170 | SH | DFND | 1 | 235,170 | 0 | 1,340,000 | |
NEXTCURE INC | COM | 65343E108 | 83,635 | 2,711,013 | SH | SOLE | 2,711,013 | 0 | 0 | ||
NOVO-NORDISK A S | ADR | 670100205 | 17,061 | 330,000 | SH | SOLE | 0 | 0 | 330,000 | ||
NOVUS THERAPEUTICS INC | COM | 67011N105 | 1,974 | 3,183,314 | SH | SOLE | 3,183,314 | 0 | 0 | ||
OBSEVA SA | COM | H5861P103 | 21,704 | 2,605,531 | SH | SOLE | 2,605,531 | 0 | 0 | ||
PERSONALIS INC | COM | 71535D106 | 7,100 | 483,842 | SH | SOLE | 0 | 0 | 483,842 | ||
PREVAIL THERAPEUTICS INC | COM | 74140Y101 | 169,740 | 13,822,463 | SH | SOLE | 13,822,463 | 0 | 0 | ||
PRINCIPIA BIOPHARMA INC | COM | 74257L108 | 45,345 | 1,605,713 | SH | SOLE | 1,605,713 | 0 | 0 | ||
PROTHENA CORP PLC | SHS | G72800108 | 23,693 | 3,022,117 | SH | DFND | 1 | 613,800 | 0 | 2,408,317 | |
PTC THERAPEUTICS INC | COM | 69366J200 | 66,250 | 1,958,900 | SH | DFND | 1 | 302,600 | 0 | 1,656,300 | |
PUMA BIOTECHNOLOGY INC | COM | 74587V107 | 6,853 | 636,600 | SH | SOLE | 0 | 0 | 636,600 | ||
PUMA BIOTECHNOLOGY INC | COM | 74587V107 | 1,615 | 150,000 | SH | Call | DFND | 1 | 28,500 | 0 | 121,500 |
RA PHARMACEUTICALS INC | COM | 74933V108 | 8,914 | 376,894 | SH | SOLE | 0 | 0 | 376,894 | ||
REATA PHARMACEUTICALS INC | CL A | 75615P103 | 12,044 | 150,000 | SH | Put | DFND | 1 | 28,500 | 0 | 121,500 |
REGENERON PHARMACEUTICALS | COM | 75886F107 | 63,275 | 228,100 | SH | DFND | 1 | 54,000 | 0 | 174,100 | |
RESTORBIO INC | COM | 76133L103 | 42,701 | 4,830,387 | SH | SOLE | 4,830,387 | 0 | 0 | ||
RUBIUS THERAPEUTICS INC | COM | 78116T103 | 785 | 100,000 | SH | Put | DFND | 1 | 39,000 | 0 | 61,000 |
SAREPTA THERAPEUTICS INC | COM | 803607100 | 63,069 | 837,349 | SH | DFND | 1 | 134,800 | 0 | 702,549 | |
SAREPTA THERAPEUTICS INC | COM | 803607100 | 3,766 | 50,000 | SH | Call | DFND | 1 | 9,500 | 0 | 40,500 |
SCPHARMACEUTICALS INC | COM | 810648105 | 20,016 | 3,409,865 | SH | SOLE | 3,409,865 | 0 | 0 | ||
SELECTA BIOSCIENCES INC | COM | 816212104 | 5,038 | 2,879,064 | SH | SOLE | 2,879,064 | 0 | 0 | ||
SI BONE INC | COM | 825704109 | 7,457 | 422,000 | SH | SOLE | 422,000 | 0 | 0 | ||
SINOVAC BIOTECH LTD | SHS | P8696W104 | 16,611 | 2,839,500 | SH | SOLE | 0 | 0 | 2,839,500 | ||
SPARK THERAPEUTICS INC | COM | 84652J103 | 23,750 | 244,900 | SH | DFND | 1 | 38,500 | 0 | 206,400 | |
SPERO THERAPEUTICS INC | COM | 84833T103 | 1,492 | 140,709 | SH | SOLE | 0 | 0 | 140,709 | ||
SPRINGWORKS THERAPEUTICS INC | COM | 85205L107 | 160,569 | 7,406,307 | SH | SOLE | 7,406,307 | 0 | 0 | ||
SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 1,584 | 212,000 | SH | SOLE | 212,000 | 0 | 0 | ||
SYNLOGIC INC | COM | 87166L100 | 4,649 | 2,029,996 | SH | SOLE | 2,029,996 | 0 | 0 | ||
SYNTHORX INC | COM | 87167A103 | 86,497 | 5,316,355 | SH | SOLE | 5,316,355 | 0 | 0 | ||
TAKEDA PHARMACEUTICAL CO LTD | SPONSORED ADS | 874060205 | 12,900 | 750,000 | SH | DFND | 1 | 172,000 | 0 | 578,000 | |
TANDEM DIABETES CARE INC | COM NEW | 875372203 | 39,186 | 664,390 | SH | DFND | 1 | 134,200 | 0 | 530,190 | |
THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 102,498 | 351,900 | SH | DFND | 1 | 68,000 | 0 | 283,900 | |
TRICIDA INC | COM | 89610F101 | 343,098 | 11,114,280 | SH | SOLE | 11,114,280 | 0 | 0 | ||
TURNING POINT THERAPEUTICS I | COM | 90041T108 | 103,224 | 2,745,327 | SH | DFND | 1 | 2,027,550 | 0 | 717,777 | |
ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 | 35,692 | 834,313 | SH | DFND | 1 | 136,100 | 0 | 698,213 | |
UNIQURE NV | SHS | N90064101 | 33,047 | 839,600 | SH | DFND | 1 | 137,300 | 0 | 702,300 | |
VERONA PHARMA PLC | SPONSORED ADS | 925050106 | 5,714 | 1,250,396 | SH | SOLE | 1,250,396 | 0 | 0 | ||
VERRICA PHARMACEUTICALS INC | COM | 92511W108 | 21,841 | 1,479,733 | SH | SOLE | 1,479,733 | 0 | 0 | ||
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 143,397 | 846,400 | SH | DFND | 1 | 113,100 | 0 | 733,300 | |
WRIGHT MED GROUP N V | ORD SHS | N96617118 | 79,162 | 3,837,250 | SH | DFND | 1 | 745,000 | 0 | 3,092,250 | |
X4 PHARMACEUTICALS INC | COM | 98420X103 | 11,903 | 936,493 | SH | SOLE | 936,493 | 0 | 0 | ||
XENON PHARMACEUTICALS INC | COM | 98420N105 | 5,720 | 634,812 | SH | SOLE | 634,812 | 0 | 0 | ||
XTANT MED HLDGS INC | COM NEW | 98420P308 | 26,148 | 9,207,012 | SH | SOLE | 9,207,012 | 0 | 0 | ||
ZAI LAB LTD | ADR | 98887Q104 | 16,628 | 514,000 | SH | SOLE | 514,000 | 0 | 0 |