The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103 13,794 3,658,869 SH   SOLE   3,658,869 0 0
9 METERS BIOPHARMA INC COM 654405109 6,158 10,275,887 SH   SOLE   10,275,887 0 0
ABBVIE INC COM 00287Y109 148,428 915,600 SH   DFND   93,200 0 822,400
ABCELLERA BIOLOGICS INC COM 00288U106 40,762 4,180,768 SH   SOLE   4,180,768 0 0
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 4,659 1,584,845 SH   DFND   178,735 0 1,406,110
ACLARIS THERAPEUTICS INC COM 00461U105 27,237 1,579,900 SH   DFND   258,400 0 1,321,500
ACUTUS MED INC COM 005111109 3,681 2,648,386 SH   SOLE   2,648,386 0 0
ADAGIO THERAPEUTICS INC COM 00534A102 23,055 5,056,000 SH   SOLE   5,056,000 0 0
ADICET BIO INC COM 007002108 148,719 7,447,141 SH   SOLE   7,447,141 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 6,799 2,956,124 SH   SOLE   2,956,124 0 0
AEROVATE THERAPEUTICS INC COM 008064107 9,347 509,949 SH   DFND   107,114 0 402,835
ALBIREO PHARMA INC COM 01345P106 5,787 194,000 SH   SOLE   194,000 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100 36,612 4,081,592 SH   SOLE   4,081,592 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105 10,507 621,700 SH   DFND   178,700 0 443,000
AMGEN INC COM 031162100 13,808 57,100 SH   SOLE   0 0 57,100
APTINYX INC COM 03836N103 1,222 538,500 SH   SOLE   538,500 0 0
ARCUTIS BIOTHERAPEUTICS INC COM 03969K108 116,982 6,073,850 SH   DFND   4,267,564 0 1,806,286
ARGENX SE SPONSORED ADR 04016X101 53,540 169,800 SH   SOLE   0 0 169,800
ASLAN PHARMACEUTICALS LTD ADS 04522R101 1,747 1,941,219 SH   SOLE   0 0 1,941,219
BELLUS HEALTH INC NEW COM NEW 07987C204 10,068 1,454,800 SH   SOLE   1,454,800 0 0
BIOGEN INC COM 09062X103 24,830 117,900 SH   DFND   13,300 0 104,600
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 85,256 719,034 SH   SOLE   719,034 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 126,986 1,647,030 SH   DFND   125,350 0 1,521,680
BIOMX INC COM 09090D103 5,430 2,813,489 SH   SOLE   2,813,489 0 0
BOSTON SCIENTIFIC CORP COM 101137107 203,712 4,599,500 SH   DFND   480,000 0 4,119,500
BRIDGEBIO PHARMA INC NOTE 2.250% 2/0 10806XAD4 14,416 30,000,000 PRN   SOLE   30,000,000 0 0
BRIDGEBIO PHARMA INC NOTE 2.500% 3/1 10806XAB8 12,000 20,000,000 PRN   SOLE   20,000,000 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 190,440 2,607,700 SH   DFND   186,000 0 2,421,700
BURNING ROCK BIOTECH LTD SPONSORED ADS 12233L107 13,493 1,452,402 SH   DFND   125,678 0 1,326,724
CABALETTA BIO INC COM 12674W109 1,172 577,509 SH   DFND   275,000 0 302,509
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 13,832 406,100 SH   DFND   49,600 0 356,500
CHEMOMAB THERAPEUTICS LTD SPONSORED ADS 16385C104 12,375 2,578,174 SH   SOLE   2,578,174 0 0
CHINOOK THERAPEUTICS INC COM 16961L106 23,203 1,418,300 SH   DFND   478,300 0 940,000
COMPASS THERAPEUTICS INC COM 20454B104 29,651 21,642,975 SH   DFND   18,071,547 0 3,571,428
CORVUS PHARMACEUTICALS INC COM 221015100 11,388 6,943,654 SH   SOLE   6,943,654 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 70,171 3,196,876 SH   SOLE   3,196,876 0 0
CULLINAN ONCOLOGY INC COM 230031106 7,023 670,787 SH   SOLE   670,787 0 0
CYBIN INC COM 23256X100 8,598 10,524,300 SH   SOLE   0 0 10,524,300
CYTOMX THERAPEUTICS INC COM 23284F105 5,674 2,124,975 SH   DFND   544,559 0 1,580,416
DANAHER CORPORATION 5% CONV PFD B 235851409 12,696 8,039 PRN   SOLE   0 0 8,039
DECIBEL THERAPEUTICS INC COM 24343R106 15,033 4,945,192 SH   DFND   4,061,774 0 883,418
DEXCOM INC COM 252131107 76,689 149,900 SH   DFND   9,600 0 140,300
EDGEWISE THERAPEUTICS INC COM 28036F105 135,263 13,944,680 SH   DFND   13,679,055 0 265,625
EDWARDS LIFESCIENCES CORP COM 28176E108 123,759 1,051,300 SH   DFND   85,000 0 966,300
ERASCA INC COM 29479A108 14,342 1,667,693 SH   SOLE   0 0 1,667,693
EVOLENT HEALTH INC CL A 30050B101 45,220 1,400,000 SH   SOLE   0 0 1,400,000
EXSCIENTIA PLC ADS 30223G102 1,800 125,000 SH   SOLE   125,000 0 0
FIELD TRIP HEALTH LTD COM 31656R102 762 576,930 SH   SOLE   0 0 576,930
FUSION PHARMACEUTICALS INC COM 36118A100 25,056 3,224,770 SH   DFND   2,930,670 0 294,100
GALAPAGOS NV SPON ADR 36315X101 12,914 208,225 SH   DFND   11,800 0 196,425
GALECTO INC COM 36322Q107 9,000 4,090,937 SH   DFND   3,803,255 0 287,682
GEMINI THERAPEUTICS INC COM 36870G105 8,098 5,826,224 SH   SOLE   5,826,224 0 0
GH RESEARCH PLC ORDINARY SHARES G3855L106 26,132 1,428,732 SH   DFND   125,000 0 1,303,732
GILEAD SCIENCES INC COM 375558103 17,098 287,600 SH   SOLE   0 0 287,600
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 54,613 1,576,600 SH   DFND   52,700 0 1,523,900
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 1,732 50,000 SH Call DFND   24,000 0 26,000
GRACELL BIOTECHNOLOGIES INC SPONSORED ADS 38406L103 18,372 7,884,870 SH   DFND   5,970,672 0 1,914,198
GRAPHITE BIO INC COM 38870X104 7,986 1,565,812 SH   DFND   430,000 0 1,135,812
GRAYBUG VISION INC COM SHS 38942Q103 5,121 4,163,347 SH   SOLE   4,163,347 0 0
GUARDANT HEALTH INC COM 40131M109 87,794 1,325,400 SH   DFND   108,700 0 1,216,700
HARPOON THERAPEUTICS INC COM 41358P106 15,106 3,039,508 SH   DFND   1,371,608 0 1,667,900
HORIZON THERAPEUTICS PUB L SHS G46188101 231,100 2,196,555 SH   DFND   185,000 0 2,011,555
HUMANA INC COM 444859102 166,104 381,700 SH   DFND   33,000 0 348,700
I MAB SPONSORED ADS 44975P103 1,805 111,120 SH   DFND   25,000 0 86,120
IKENA ONCOLOGY INC COM 45175G108 17,897 2,933,941 SH   DFND   1,936,886 0 997,055
IKENA ONCOLOGY INC NONVOTING 000000000 37,914 6,215,466 SH   DFND   5,586,311 0 629,155
ILLUMINA INC COM 452327109 15,758 45,100 SH   SOLE   0 0 45,100
IMARA INC COM 45249V107 8,247 4,386,568 SH   DFND   4,199,068 0 187,500
IMMUNOCORE HLDGS PLC ADS 45258D105 3,830 128,100 SH   SOLE   128,100 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 161,157 534,200 SH   DFND   36,000 0 498,200
IOVANCE BIOTHERAPEUTICS INC COM 462260100 110,440 6,633,006 SH   DFND   1,263,700 0 5,369,306
JANUX THERAPEUTICS INC COM 47103J105 40,674 2,836,386 SH   DFND   2,489,664 0 346,722
JOUNCE THERAPEUTICS INC COM 481116101 19,419 2,859,900 SH   DFND   659,700 0 2,200,200
KEROS THERAPEUTICS INC COM 492327101 91,327 1,679,417 SH   DFND   1,268,734 0 410,683
KINNATE BIOPHARMA INC COM 49705R105 45,531 4,043,629 SH   DFND   3,593,629 0 450,000
LANDOS BIOPHARMA INC COM 515069102 418 283,217 SH   SOLE   0 0 283,217
LOGICBIO THERAPEUTICS INC COM 54142F102 5,758 8,466,783 SH   DFND   7,948,265 0 518,518
LONGBOARD PHARMACEUTICALS IN COM 54300N103 606 113,500 SH   SOLE   0 0 113,500
MAGENTA THERAPEUTICS INC COM 55910K108 6,528 2,250,953 SH   DFND   543,000 0 1,707,953
MEIRAGTX HLDGS PLC COM G59665102 45,659 3,296,666 SH   DFND   133,500 0 3,163,166
MEREO BIOPHARMA GROUP PLC ADS 589492107 11,373 10,154,810 SH   DFND   4,471,023 0 5,683,787
MEREO BIOPHARMA GROUP PLC ADS 589492107 7,963 7,109,954 PRN   DFND   4,739,969 0 2,369,985
MERSANA THERAPEUTICS INC COM 59045L106 19,108 4,788,900 SH   DFND   1,353,000 0 3,435,900
MILESTONE PHARMACEUTICALS IN COM 59935V107 16,588 2,583,821 SH   SOLE   0 0 2,583,821
MIRATI THERAPEUTICS INC COM 60468T105 134,060 1,630,500 SH   DFND   220,600 0 1,409,900
MIRUM PHARMACEUTICALS INC COM 604749101 595 27,000 SH   SOLE   27,000 0 0
NANOSTRING TECHNOLOGIES INC NOTE 2.625% 3/0 63009RAD1 6,086 6,000,000 PRN   SOLE   0 0 6,000,000
NANOSTRING TECHNOLOGIES INC COM 63009R109 40,219 1,157,387 SH   DFND   67,400 0 1,089,987
NATERA INC COM 632307104 6,102 150,000 SH Call DFND   72,500 0 77,500
NATERA INC COM 632307104 64,900 1,595,385 SH   DFND   125,000 0 1,470,385
NEUROCRINE BIOSCIENCES INC COM 64125C109 82,080 875,515 SH   DFND   52,970 0 822,545
NEUROPACE INC COM 641288105 32,941 4,012,281 SH   SOLE   4,012,281 0 0
NEXTCURE INC COM 65343E108 13,176 2,711,013 SH   SOLE   2,711,013 0 0
ONCOCYTE CORP COM 68235C107 5,206 3,493,800 SH   DFND   1,188,800 0 2,305,000
ORIC PHARMACEUTICALS INC COM 68622P109 11,148 2,087,568 SH   SOLE   2,087,568 0 0
OWLET INC *W EXP 09/14/202 69120X115 170 220,704 SH   DFND   82,544 0 138,160
PASSAGE BIO INC COM 702712100 22,729 7,331,999 SH   DFND   6,316,423 0 1,015,576
PFIZER INC COM 717081103 202,188 3,905,500 SH   DFND   275,000 0 3,630,500
PMV PHARMACEUTICALS INC COM 69353Y103 142,730 6,855,423 SH   DFND   6,589,330 0 266,093
PRELUDE THERAPEUTICS INC COM 74065P101 69,274 10,039,691 SH   DFND   9,250,191 0 789,500
PRELUDE THERAPEUTICS INC NONVOTING 000000000 39,193 5,680,186 SH   DFND   5,596,886 0 83,300
PROTARA THERAPEUTICS INC COM STK 74365U107 4,245 830,641 SH   DFND   158,900 0 671,741
PULMONX CORP COM 745848101 10,792 435,000 SH   DFND   83,600 0 351,400
PYXIS ONCOLOGY INC COMMON STOCK 747324101 580 143,640 SH   DFND   49,540 0 94,100
RAPT THERAPEUTICS INC COM 75382E109 7,945 361,300 SH   DFND   144,300 0 217,000
REPARE THERAPEUTICS INC COM 760273102 47,312 3,322,488 SH   DFND   3,177,041 0 145,447
RXSIGHT INC COM 78349D107 17,128 1,383,500 SH   DFND   321,000 0 1,062,500
SAREPTA THERAPEUTICS INC COM 803607100 3,054 39,100 SH   SOLE   39,100 0 0
SCPHARMACEUTICALS INC COM 810648105 27,248 4,797,148 SH   SOLE   4,797,148 0 0
SEAGEN INC COM 81181C104 96,182 667,700 SH   DFND   66,100 0 601,600
SI-BONE INC COM 825704109 70,947 3,139,247 SH   SOLE   0 0 3,139,247
SIERRA ONCOLOGY INC COM NEW 82640U404 62,971 1,964,770 SH   DFND   1,738,066 0 226,704
SIGHT SCIENCES INC COM 82657M105 2,312 200,000 SH   SOLE   0 0 200,000
SIGNIFY HEALTH INC CL A COM 82671G100 11,266 620,700 SH   SOLE   0 0 620,700
SILVERBACK THERAPEUTICS INC COM 82835W108 30,681 8,740,887 SH   DFND   7,788,510 0 952,377
SINGULAR GENOMICS SYSTEMS IN COM 82933R100 14,518 2,300,792 SH   DFND   985,897 0 1,314,895
SONENDO INC COM 835431107 7,892 1,968,180 SH   SOLE   1,968,180 0 0
SPDR SER TR S&P BIOTECH 78464A870 10,049 111,800 SH   SOLE   111,800 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 340,238 6,028,307 SH   SOLE   6,028,307 0 0
STRYKER CORPORATION COM 863667101 122,206 457,100 SH   DFND   34,000 0 423,100
SYNDAX PHARMACEUTICALS INC COM 87164F105 37,511 2,158,300 SH   DFND   387,000 0 1,771,300
SYNLOGIC INC COM 87166L100 14,472 6,029,995 SH   SOLE   6,029,995 0 0
TALARIS THERAPEUTICS INC COM 87410C104 2,433 247,240 SH   SOLE   0 0 247,240
TELA BIO INC COM 872381108 35,210 3,027,542 SH   SOLE   3,027,542 0 0
TENET HEALTHCARE CORP COM NEW 88033G407 54,009 628,300 SH   DFND   51,000 0 577,300
TERNS PHARMACEUTICALS INC COM 880881107 11,260 3,791,204 SH   SOLE   3,791,204 0 0
THERAVANCE BIOPHARMA INC COM G8807B106 31,115 3,254,713 SH   DFND   34,280 0 3,220,433
THERMO FISHER SCIENTIFIC INC COM 883556102 71,232 120,600 SH   DFND   12,200 0 108,400
THESEUS PHARMACEUTICALS INC COM 88369M101 196,490 17,041,668 SH   SOLE   17,041,668 0 0
TRICIDA INC COM 89610F101 84,509 10,280,947 SH   SOLE   10,280,947 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 54,209 2,018,950 SH   DFND   1,656,450 0 362,500
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 16,528 227,600 SH   DFND   60,300 0 167,300
UNIQURE NV SHS N90064101 16,611 919,249 SH   DFND   94,400 0 824,849
UNITEDHEALTH GROUP INC COM 91324P102 150,033 294,200 SH   DFND   27,000 0 267,200
VAXCYTE INC COM 92243G108 36,555 1,513,659 SH   DFND   207,945 0 1,305,714
VECTIVBIO HLDG AG ORD SHS H9060V101 25,108 5,330,704 SH   DFND   5,037,404 0 293,300
VENTYX BIOSCIENCES INC COM 92332V107 17,496 1,289,280 SH   SOLE   1,289,280 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 28,417 5,694,841 SH   DFND   5,028,174 0 666,667
VERTEX PHARMACEUTICALS INC COM 92532F100 104,440 400,200 SH   DFND   27,000 0 373,200
VIGIL NEUROSCIENCE INC COM 92673K108 2,891 411,191 SH   SOLE   411,191 0 0
VISTAGEN THERAPEUTICS INC COM NEW 92840H202 16,008 12,909,283 SH   DFND   2,390,043 0 10,519,240
VOR BIOPHARMA INC COM 929033108 5,033 833,333 SH   SOLE   0 0 833,333
X4 PHARMACEUTICALS INC COM 98420X103 2,404 1,373,849 SH   SOLE   1,373,849 0 0
XENON PHARMACEUTICALS INC COM 98420N105 20,971 686,000 SH   DFND   55,000 0 631,000
XTANT MED HLDGS INC COM NEW 98420P308 49,602 72,943,918 SH   SOLE   72,943,918 0 0