The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103 95,697 3,729,442 SH   SOLE   3,729,442 0 0
9 METERS BIOPHARMA INC COM 654405109 20,489 25,716,755 SH   SOLE   25,716,755 0 0
ABBVIE INC COM 00287Y109 40,642 464,000 SH   DFND 1 65,100 0 398,900
ACADIA HEALTHCARE COMPANY IN COM 00404A109 32,854 1,114,466 SH   DFND 1 133,000 0 981,466
ACADIA PHARMACEUTICALS INC COM 004225108 4,414 107,000 SH   SOLE   0 0 107,000
ACCELERON PHARMA INC COM 00434H108 67,638 601,066 SH   DFND 1 51,300 0 549,766
ACUTUS MED INC COM 005111109 163,243 5,477,958 SH   SOLE   5,477,958 0 0
ADICET BIO INC COM 007002108 79,764 6,708,507 SH   SOLE   6,708,507 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 47,219 4,584,344 SH   DFND 1 546,597 0 4,037,747
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 28,470 4,015,524 SH   SOLE   4,015,524 0 0
AERPIO PHARMACEUTICALS INC COM 00810B105 7,791 5,193,946 SH   SOLE   5,193,946 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 77,256 2,207,321 SH   DFND 1 258,200 0 1,949,121
AKOUOS INC COM 00973J101 7,204 315,000 SH   SOLE   0 0 315,000
ALBIREO PHARMA INC COM 01345P106 10,958 328,385 SH   DFND 1 56,300 0 272,085
ALCON AG ORD SHS H01301128 19,945 351,380 SH   DFND 1 125,800 0 225,580
ALECTOR INC COM 014442107 28,711 2,725,313 SH   SOLE   2,725,313 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 249,972 2,184,500 SH   DFND 1 311,300 0 1,873,200
ALEXION PHARMACEUTICALS INC COM 015351109 14,304 125,000 SH Call DFND 1 38,000 0 87,000
ALPINE IMMUNE SCIENCES INC COM 02083G100 32,268 3,670,955 SH   SOLE   3,670,955 0 0
AMGEN INC COM 031162100 23,256 91,500 SH   SOLE   0 0 91,500
ANAPTYSBIO INC COM 032724106 2,662 180,442 SH   DFND 1 17,200 0 163,242
ANNEXON INC COM 03589W102 11,486 379,947 SH   SOLE   0 0 379,947
APPLIED THERAPEUTICS INC COM 03828A101 32,109 1,546,687 SH   DFND 1 97,806 0 1,448,881
APTOSE BIOSCIENCES INC COM NEW 03835T200 5,385 897,541 SH   SOLE   0 0 897,541
ARCTURUS THERAPEUTICS HLDGS COM 03969T109 26,537 618,586 SH   DFND 1 48,726 0 569,860
ARCUTIS BIOTHERAPEUTICS INC COM 03969K108 136,944 4,673,850 SH   DFND 1 4,067,564 0 606,286
ARENA PHARMACEUTICALS INC COM NEW 040047607 4,988 66,700 SH   SOLE   0 0 66,700
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 113,348 734,500 SH   DFND 1 459,000 0 275,500
ATHENEX INC COM 04685N103 48,133 3,977,950 SH   DFND 1 227,400 0 3,750,550
ATRICURE INC COM 04963C209 49,005 1,228,189 SH   DFND 1 187,000 0 1,041,189
AURINIA PHARMACEUTICALS INC COM 05156V102 70,026 4,754,000 SH   DFND 1 590,000 0 4,164,000
AVIDITY BIOSCIENCES INC COM 05370A108 1,798 63,860 SH   SOLE   0 0 63,860
AVROBIO INC COM 05455M100 10,334 793,712 SH   DFND 1 129,000 0 664,712
BELLUS HEALTH INC NEW COM NEW 07987C204 11,728 5,137,216 SH   DFND 1 3,954,800 0 1,182,416
BIOGEN INC COM 09062X103 203,087 715,900 SH   DFND 1 79,200 0 636,700
BIOLINERX LTD SPONSORED ADS 09071M205 114 69,240 SH   SOLE   69,240 0 0
BIOMX INC COM 09090D103 14,668 2,313,489 SH   SOLE   2,313,489 0 0
BOSTON SCIENTIFIC CORP COM 101137107 185,215 4,847,300 SH   DFND 1 939,400 0 3,907,900
BRISTOL-MYERS SQUIBB CO COM 110122108 213,975 3,549,100 SH   DFND 1 545,300 0 3,003,800
BRISTOL-MYERS SQUIBB CO RIGHT 99/99/9999 110122157 900 400,000 SH   DFND 1 135,306 0 264,694
BURNING ROCK BIOTECH LTD SPONSORED ADS 12233L107 119,032 4,746,075 SH   DFND 1 523,599 0 4,222,476
CALLIDITAS THERAPEUTICS AB SPONSERED ADS 13124Q106 425 17,696 SH   SOLE   0 0 17,696
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 9,269 625,000 SH   DFND 1 84,800 0 540,200
CENTENE CORP DEL COM 15135B101 77,911 1,335,700 SH   DFND 1 179,300 0 1,156,400
CHANGE HEALTHCARE INC COM 15912K100 44,890 3,093,700 SH   DFND 1 398,000 0 2,695,700
COMPASS PATHWAYS PLC SPONSORED ADS 20451W101 12,215 350,000 SH   DFND 1 106,300 0 243,700
CORVUS PHARMACEUTICALS INC COM 221015100 27,138 6,767,584 SH   SOLE   6,767,584 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 43,148 2,753,567 SH   SOLE   2,753,567 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 52,694 630,004 SH   DFND 1 56,200 0 573,804
CTI BIOPHARMA CORP COM 12648L601 20,469 9,520,600 SH   SOLE   9,520,600 0 0
CURIS INC COM NEW 231269200 1,453 1,241,494 SH   SOLE   0 0 1,241,494
DECIPHERA PHARMACEUTICALS IN COM 24344T101 57,748 1,125,700 SH   DFND 1 190,100 0 935,600
DEXCOM INC COM 252131107 93,329 226,400 SH   DFND 1 33,500 0 192,900
DYNE THERAPEUTICS INC COM 26818M108 7,067 350,000 SH   SOLE   0 0 350,000
EDWARDS LIFESCIENCES CORP COM 28176E108 56,393 706,500 SH   DFND 1 106,500 0 600,000
EHEALTH INC COM 28238P109 50,446 638,558 SH   DFND 1 86,021 0 552,537
ESSA PHARMA INC COM NEW 29668H708 8,125 1,177,483 SH   SOLE   1,177,483 0 0
EXELIXIS INC COM 30161Q104 58,780 2,404,100 SH   DFND 1 288,800 0 2,115,300
FLEXION THERAPEUTICS INC COM 33938J106 17,530 1,684,000 SH   DFND 1 84,100 0 1,599,900
FLUIDIGM CORP DEL COM 34385P108 26,404 3,553,703 SH   DFND 1 348,600 0 3,205,103
FORTE BIOSCIENCES INC COM 34962G109 16,517 340,480 SH   DFND 1 71,789 0 268,691
FUSION PHARMACEUTICALS INC COM 36118A100 38,762 3,224,770 SH   DFND 1 2,930,670 0 294,100
GILEAD SCIENCES INC COM 375558103 12,145 192,200 SH   SOLE   0 0 192,200
GRAYBUG VISION INC COM SHS 38942Q103 56,888 4,475,847 SH   DFND 1 4,163,347 0 312,500
GUARDANT HEALTH INC COM 40131M109 17,248 154,300 SH   DFND 1 17,300 0 137,000
HARPOON THERAPEUTICS INC COM 41358P106 31,189 1,835,704 SH   DFND 1 1,020,704 0 815,000
HEALTH CATALYST INC COM 42225T107 6,573 179,598 SH   SOLE   179,598 0 0
HEALTH SCIENCES ACQ CORP 2 ORD SHS G4411D109 5,500 500,000 SH   DFND 1 100,000 0 400,000
HERON THERAPEUTICS INC COM 427746102 17,663 1,191,846 SH   SOLE   0 0 1,191,846
HORIZON THERAPEUTICS PUB L SHS G46188101 233,720 3,008,755 SH   DFND 1 357,500 0 2,651,255
HUMANA INC COM 444859102 116,013 280,300 SH   DFND 1 42,300 0 238,000
I MAB SPONSORED ADS 44975P103 28,503 606,070 SH   DFND 1 136,360 0 469,710
IMARA INC COM 45249V107 55,323 2,719,902 SH   DFND 1 2,532,402 0 187,500
INFLARX NV COM N44821101 2,891 678,525 SH   DFND 1 122,500 0 556,025
INOZYME PHARMA INC COM 45790W108 10,527 400,400 SH   SOLE   0 0 400,400
INTUITIVE SURGICAL INC COM NEW 46120E602 80,036 112,800 SH   DFND 1 18,500 0 94,300
IOVANCE BIOTHERAPEUTICS INC COM 462260100 218,757 6,645,100 SH   DFND 1 1,337,800 0 5,307,300
IVERIC BIO INC COM 46583P102 19,243 3,411,806 SH   DFND 1 505,756 0 2,906,050
KALA PHARMACEUTICALS INC COM 483119103 40,988 5,465,030 SH   DFND 1 4,714,195 0 750,835
KEROS THERAPEUTICS INC COM 492327101 64,775 1,679,417 SH   DFND 1 1,268,734 0 410,683
KITOV PHARMA LTD SPONSORD ADS NEW 49803V206 1,527 346,197 SH   SOLE   346,197 0 0
KYMERA THERAPEUTICS INC COM 501575104 3,231 100,000 SH   SOLE   0 0 100,000
LARIMAR THERAPEUTICS INC COM 517125100 13,449 886,560 SH   DFND 1 154,237 0 732,323
LOGICBIO THERAPEUTICS INC COM 54142F102 58,718 6,466,783 SH   SOLE   6,466,783 0 0
MEIRAGTX HLDGS PLC COM G59665102 49,171 3,713,820 SH   DFND 1 133,500 0 3,580,320
MERCK & CO. INC COM 58933Y105 214,766 2,589,100 SH   DFND 1 382,100 0 2,207,000
MERSANA THERAPEUTICS INC COM 59045L106 24,743 1,328,852 SH   DFND 1 52,550 0 1,276,302
MILESTONE PHARMACEUTICALS IN COM 59935V107 2,824 385,791 SH   SOLE   0 0 385,791
MIRATI THERAPEUTICS INC COM 60468T105 218,688 1,317,000 SH   DFND 1 188,400 0 1,128,600
MYOVANT SCIENCES LTD COM G637AM102 703 50,000 SH Call DFND 1 18,500 0 31,500
MYOVANT SCIENCES LTD COM G637AM102 5,121 364,500 SH   DFND 1 59,500 0 305,000
NABRIVA THERAPEUTICS PLC SHS G63637105 1,410 2,644,600 SH   SOLE   2,644,600 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109 52,885 1,183,100 SH   DFND 1 147,100 0 1,036,000
NATERA INC COM 632307104 152,477 2,110,700 SH   DFND 1 273,300 0 1,837,400
NEUROCRINE BIOSCIENCES INC COM 64125C109 125,173 1,301,715 SH   DFND 1 137,470 0 1,164,245
NEXTCURE INC COM 65343E108 23,857 2,711,013 SH   SOLE   2,711,013 0 0
NOVO-NORDISK A S ADR 670100205 22,912 330,000 SH   SOLE   0 0 330,000
NOVUS THERAPEUTICS INC COM 67011N105 54,435 3,183,314 SH   SOLE   3,183,314 0 0
NURIX THERAPEUTICS INC COM 67080M103 10,473 300,000 SH   SOLE   0 0 300,000
OAK STR HEALTH INC COM 67181A107 17,870 334,400 SH   DFND 1 35,900 0 298,500
OBSEVA SA COM H5861P103 3,231 1,303,000 SH   SOLE   1,303,000 0 0
ORIC PHARMACEUTICALS INC COM 68622P109 73,078 2,921,967 SH   DFND 1 2,765,717 0 156,250
OTONOMY INC COM 68906L105 13,163 3,250,000 SH   DFND 1 769,200 0 2,480,800
OUTSET MED INC COM 690145107 6,250 125,000 SH   DFND 1 16,000 0 109,000
PANDION THERAPEUTICS INC COM 698340106 16,972 1,480,940 SH   DFND 1 1,040,825 0 440,115
PASSAGE BIO INC COM 702712100 91,284 6,962,899 SH   DFND 1 5,947,323 0 1,015,576
PFIZER INC COM 717081103 27,525 750,000 SH Call DFND 1 232,500 0 517,500
PMV PHARMACEUTICALS INC COM 69353Y103 260,230 7,330,423 SH   DFND 1 6,589,330 0 741,093
PRELUDE THERAPEUTICS INC COM 74065P101 469,874 15,594,877 SH   DFND 1 14,805,377 0 789,500
PREVAIL THERAPEUTICS INC COM 74140Y101 140,713 13,822,463 SH   SOLE   13,822,463 0 0
PROGYNY INC COM 74340E103 49,310 1,675,500 SH   DFND 1 189,700 0 1,485,800
PROTARA THERAPEUTICS INC COM STK 74365U107 7,574 450,000 SH   DFND 1 60,000 0 390,000
PROTHENA CORP PLC SHS G72800108 35,409 3,544,475 SH   DFND 1 613,800 0 2,930,675
RELAY THERAPEUTICS INC COM 75943R102 14,907 350,000 SH   SOLE   0 0 350,000
REPARE THERAPEUTICS INC COM 760273102 105,428 3,426,325 SH   DFND 1 3,276,325 0 150,000
ROCKET PHARMACEUTICALS INC COM 77313F106 5,786 253,108 SH   DFND 1 37,430 0 215,678
SAREPTA THERAPEUTICS INC COM 803607100 75,699 539,049 SH   DFND 1 68,000 0 471,049
SCPHARMACEUTICALS INC COM 810648105 35,739 4,797,148 SH   SOLE   4,797,148 0 0
SELECTA BIOSCIENCES INC COM 816212104 5,193 2,093,869 SH   SOLE   2,093,869 0 0
SI BONE INC COM 825704109 32,461 1,368,500 SH   DFND 1 63,200 0 1,305,300
SIERRA ONCOLOGY INC COM NEW 82640U404 15,763 1,477,320 SH   DFND 1 1,306,860 0 170,460
SINOVAC BIOTECH LTD SHS P8696W104 27,300 2,839,500 SH   SOLE   0 0 2,839,500
SPRINGWORKS THERAPEUTICS INC COM 85205L107 353,059 7,406,307 SH   SOLE   7,406,307 0 0
STRONGBRIDGE BIOPHARMA PLC SHS USD G85347105 7,328 3,489,369 SH   DFND 1 502,500 0 2,986,869
STRYKER CORPORATION COM 863667101 48,967 235,000 SH   DFND 1 42,200 0 192,800
SYNDAX PHARMACEUTICALS INC COM 87164F105 16,149 1,094,100 SH   DFND 1 78,600 0 1,015,500
SYNLOGIC INC COM 87166L100 4,101 2,029,996 SH   SOLE   2,029,996 0 0
TELA BIO INC COM 872381108 50,076 3,027,542 SH   SOLE   3,027,542 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 17,436 1,935,200 SH   DFND 1 269,500 0 1,665,700
THERAVANCE BIOPHARMA INC COM G8807B106 91,950 6,219,110 SH   DFND 1 674,898 0 5,544,212
THERMO FISHER SCIENTIFIC INC COM 883556102 48,700 110,300 SH   DFND 1 16,800 0 93,500
TRICIDA INC COM 89610F101 87,105 9,614,280 SH   SOLE   9,614,280 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 17,799 1,252,600 SH   DFND 1 283,400 0 969,200
TURNING POINT THERAPEUTICS I COM 90041T108 239,832 2,745,327 SH   DFND 1 2,027,550 0 717,777
UNIQURE NV SHS N90064101 35,691 969,079 SH   DFND 1 138,100 0 830,979
VAXCYTE INC COM 92243G108 31,641 640,760 SH   SOLE   0 0 640,760
VERONA PHARMA PLC SPONSORED ADS 925050106 35,536 5,694,841 SH   DFND 1 5,028,174 0 666,667
VERRICA PHARMACEUTICALS INC COM 92511W108 11,453 1,479,733 SH   SOLE   1,479,733 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 181,259 666,100 SH   DFND 1 113,100 0 553,000
X4 PHARMACEUTICALS INC COM 98420X103 7,356 1,086,493 SH   SOLE   1,086,493 0 0
XENON PHARMACEUTICALS INC COM 98420N105 27,652 2,497,917 SH   DFND 1 786,612 0 1,711,305
XTANT MED HLDGS INC COM NEW 98420P308 7,618 9,248,678 SH   SOLE   9,248,678 0 0
ZYMEWORKS INC COM 98985W102 15,889 341,102 SH   SOLE   0 0 341,102