The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103 11,782 3,658,869 SH   SOLE   3,658,869 0 0
9 METERS BIOPHARMA INC COM 654405109 2,218 8,505,729 SH   SOLE   8,505,729 0 0
ABBVIE INC COM 00287Y109 122,497 799,800 SH   DFND   28,000 0 771,800
ABCELLERA BIOLOGICS INC COM 00288U106 44,525 4,180,768 SH   SOLE   4,180,768 0 0
ABCELLERA BIOLOGICS INC COM 00288U106 2,663 250,000 SH Call DFND   69,000 0 181,000
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 3,994 1,584,845 SH   DFND   178,735 0 1,406,110
ACLARIS THERAPEUTICS INC COM 00461U105 32,464 2,325,500 SH   DFND   420,400 0 1,905,100
ACUTUS MED INC COM 005111109 2,966 2,648,386 SH   SOLE   2,648,386 0 0
ADAGIO THERAPEUTICS INC COM 00534A102 16,584 5,056,000 SH   SOLE   5,056,000 0 0
ADICET BIO INC COM 007002108 108,728 7,447,141 SH   SOLE   7,447,141 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 908 1,797,221 SH   SOLE   1,797,221 0 0
AEROVATE THERAPEUTICS INC COM 008064107 7,480 478,579 SH   DFND   124,779 0 353,800
ALPINE IMMUNE SCIENCES INC COM 02083G100 34,734 4,081,592 SH   SOLE   4,081,592 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105 17,687 2,186,269 SH   DFND   448,700 0 1,737,569
AMGEN INC COM 031162100 13,892 57,100 SH   SOLE   0 0 57,100
APPLIED THERAPEUTICS INC COM 03828A101 4,030 4,250,000 SH   SOLE   4,250,000 0 0
APTINYX INC COM 03836N103 300 538,500 SH   SOLE   538,500 0 0
ARCUTIS BIOTHERAPEUTICS INC COM 03969K108 101,897 4,781,646 SH   DFND   3,534,537 0 1,247,109
ARGENX SE SPONSORED ADR 04016X101 73,503 194,000 SH   SOLE   0 0 194,000
BELLUS HEALTH INC NEW COM NEW 07987C204 13,391 1,454,800 SH   SOLE   1,454,800 0 0
BIOGEN INC COM 09062X103 22,760 111,600 SH   DFND   7,000 0 104,600
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 104,770 719,034 SH   SOLE   719,034 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 140,855 1,699,710 SH   DFND   155,200 0 1,544,510
BIOMX INC COM 09090D103 2,054 2,813,489 SH   SOLE   2,813,489 0 0
BOSTON SCIENTIFIC CORP COM 101137107 162,851 4,369,500 SH   DFND   250,000 0 4,119,500
BRIDGEBIO PHARMA INC NOTE 2.250% 2/0 10806XAD4 12,150 30,000,000 PRN   SOLE   30,000,000 0 0
BRIDGEBIO PHARMA INC NOTE 2.500% 3/1 10806XAB8 9,000 20,000,000 PRN   SOLE   20,000,000 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 193,940 2,518,700 SH   DFND   97,000 0 2,421,700
BURNING ROCK BIOTECH LTD SPONSORED ADS 12233L107 4,044 1,389,802 SH   DFND   63,078 0 1,326,724
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 3,038 112,700 SH   DFND   12,700 0 100,000
CHEMOMAB THERAPEUTICS LTD SPONSORED ADS 16385C104 9,539 2,578,174 SH   SOLE   2,578,174 0 0
CHINOOK THERAPEUTICS INC COM 16961L106 33,166 1,896,300 SH   DFND   478,300 0 1,418,000
COMPASS THERAPEUTICS INC COM 20454B104 58,196 21,960,850 SH   DFND   18,389,422 0 3,571,428
CORVUS PHARMACEUTICALS INC COM 221015100 6,875 6,943,654 SH   SOLE   6,943,654 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 59,622 3,196,876 SH   SOLE   3,196,876 0 0
CULLINAN ONCOLOGY INC COM 230031106 8,599 670,787 SH   SOLE   670,787 0 0
CYBIN INC COM 23256X100 5,886 10,524,300 SH   SOLE   0 0 10,524,300
CYTOMX THERAPEUTICS INC COM 23284F105 3,889 2,124,975 SH   DFND   544,559 0 1,580,416
DANAHER CORPORATION 5% CONV PFD B 235851409 10,637 8,039 PRN   SOLE   0 0 8,039
DECIBEL THERAPEUTICS INC COM 24343R106 20,819 4,945,192 SH   DFND   4,061,774 0 883,418
EDGEWISE THERAPEUTICS INC COM 28036F105 112,098 14,082,680 SH   DFND   13,817,055 0 265,625
EDWARDS LIFESCIENCES CORP COM 28176E108 96,165 1,011,300 SH   DFND   45,000 0 966,300
ERASCA INC COM 29479A108 9,289 1,667,693 SH   SOLE   0 0 1,667,693
EVOLENT HEALTH INC CL A 30050B101 54,602 1,778,000 SH   SOLE   0 0 1,778,000
EYEPOINT PHARMACEUTICALS INC COM NEW 30233G209 1,685 214,100 SH   SOLE   0 0 214,100
FUSION PHARMACEUTICALS INC COM 36118A100 8,030 3,224,770 SH   DFND   2,930,670 0 294,100
GALECTO INC COM 36322Q107 7,077 4,090,937 SH   DFND   3,803,255 0 287,682
GEMINI THERAPEUTICS INC COM 36870G105 9,846 5,826,224 SH   SOLE   5,826,224 0 0
GH RESEARCH PLC ORDINARY SHARES G3855L106 16,188 1,622,060 SH   DFND   239,100 0 1,382,960
GILEAD SCIENCES INC COM 375558103 17,777 287,600 SH   SOLE   0 0 287,600
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 65,306 2,044,000 SH   DFND   185,000 0 1,859,000
GRACELL BIOTECHNOLOGIES INC SPONSORED ADS 38406L103 43,367 7,884,870 SH   DFND   5,970,672 0 1,914,198
GRAPHITE BIO INC COM 38870X104 2,333 848,412 SH   SOLE   0 0 848,412
GRAYBUG VISION INC COM SHS 38942Q103 4,538 4,163,347 SH   SOLE   4,163,347 0 0
GUARDANT HEALTH INC COM 40131M109 2,017 50,000 SH Call DFND   13,500 0 36,500
GUARDANT HEALTH INC COM 40131M109 41,687 1,033,400 SH   DFND   41,000 0 992,400
HARPOON THERAPEUTICS INC COM 41358P106 5,805 3,039,508 SH   DFND   1,371,608 0 1,667,900
HORIZON THERAPEUTICS PUB L SHS G46188101 168,178 2,108,555 SH   DFND   97,000 0 2,011,555
HUMANA INC COM 444859102 171,173 365,700 SH   DFND   17,000 0 348,700
IKENA ONCOLOGY INC COM 45175G108 12,997 2,933,941 SH   DFND   1,936,886 0 997,055
IKENA ONCOLOGY INC NONVOTING 000000000 28,652 6,467,691 SH   DFND   5,838,536 0 629,155
IMARA INC COM 45249V107 5,352 4,386,568 SH   DFND   4,199,068 0 187,500
IMMUNOCORE HLDGS PLC ADS 45258D105 4,891 131,100 SH   SOLE   131,100 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 103,807 517,200 SH   DFND   19,000 0 498,200
IONIS PHARMACEUTICALS INC COM 462222100 16,785 453,400 SH   SOLE   0 0 453,400
IOVANCE BIOTHERAPEUTICS INC COM 462260100 30,895 2,798,441 SH   DFND   400,000 0 2,398,441
IVERIC BIO INC COM 46583P102 13,097 1,361,400 SH   DFND   164,000 0 1,197,400
JANUX THERAPEUTICS INC COM 47103J105 34,632 2,836,386 SH   DFND   2,489,664 0 346,722
JOUNCE THERAPEUTICS INC COM 481116101 8,875 2,928,900 SH   DFND   728,700 0 2,200,200
KALVISTA PHARMACEUTICALS INC COM 483497103 1,824 185,400 SH   SOLE   0 0 185,400
KEROS THERAPEUTICS INC COM 492327101 46,402 1,679,417 SH   DFND   1,268,734 0 410,683
KEZAR LIFE SCIENCES INC COM 49372L100 11,743 1,419,900 SH   DFND   391,200 0 1,028,700
KINNATE BIOPHARMA INC COM 49705R105 50,990 4,043,629 SH   DFND   3,593,629 0 450,000
LOGICBIO THERAPEUTICS INC COM 54142F102 2,967 8,466,783 SH   DFND   7,948,265 0 518,518
LONGBOARD PHARMACEUTICALS IN COM 54300N103 351 113,500 SH   SOLE   0 0 113,500
MAGENTA THERAPEUTICS INC COM 55910K108 2,701 2,250,953 SH   DFND   543,000 0 1,707,953
MEIRAGTX HLDGS PLC COM G59665102 18,937 2,501,618 SH   DFND   103,100 0 2,398,518
MEREO BIOPHARMA GROUP PLC ADS 589492107 7,963 7,109,954 PRN   DFND   4,739,969 0 2,369,985
MEREO BIOPHARMA GROUP PLC ADS 589492107 2,914 2,601,468 SH   DFND   441,174 0 2,160,294
MERSANA THERAPEUTICS INC COM 59045L106 41,633 9,011,437 SH   DFND   1,928,600 0 7,082,837
MILESTONE PHARMACEUTICALS IN COM 59935V107 11,178 1,817,521 SH   SOLE   0 0 1,817,521
MIRATI THERAPEUTICS INC COM 60468T105 73,199 1,090,400 SH   DFND   139,800 0 950,600
MIRUM PHARMACEUTICALS INC COM 604749101 5,439 279,500 SH   SOLE   279,500 0 0
NANOSTRING TECHNOLOGIES INC NOTE 2.625% 3/0 63009RAD1 4,851 6,000,000 PRN   SOLE   0 0 6,000,000
NATERA INC COM 632307104 5,316 150,000 SH Call DFND   72,500 0 77,500
NATERA INC COM 632307104 58,878 1,661,353 SH   DFND   102,700 0 1,558,653
NEUROCRINE BIOSCIENCES INC COM 64125C109 82,814 849,545 SH   DFND   27,000 0 822,545
NEUROPACE INC COM 641288105 19,861 4,012,281 SH   SOLE   4,012,281 0 0
NEXTCURE INC COM 65343E108 12,742 2,711,013 SH   SOLE   2,711,013 0 0
NOVAVAX INC COM NEW 670002401 3,857 75,000 SH Call DFND   21,000 0 54,000
ONCOCYTE CORP COM 68235C107 2,553 2,837,800 SH   DFND   710,700 0 2,127,100
ORIC PHARMACEUTICALS INC COM 68622P109 9,352 2,087,568 SH   SOLE   2,087,568 0 0
PASSAGE BIO INC COM 702712100 21,080 8,931,999 SH   DFND   6,841,423 0 2,090,576
PFIZER INC COM 717081103 143,868 2,744,000 SH   DFND   145,000 0 2,599,000
PMV PHARMACEUTICALS INC COM 69353Y103 93,524 6,563,077 SH   SOLE   6,563,077 0 0
PRELUDE THERAPEUTICS INC COM 74065P101 52,407 10,039,691 SH   DFND   9,250,191 0 789,500
PRELUDE THERAPEUTICS INC NONVOTING 000000000 29,651 5,680,186 SH   DFND   5,596,886 0 83,300
PROGYNY INC COM 74340E103 18,156 625,000 SH   SOLE   0 0 625,000
PROTARA THERAPEUTICS INC COM STK 74365U107 2,434 830,641 SH   DFND   158,900 0 671,741
PULMONX CORP COM 745848101 6,403 435,000 SH   DFND   83,600 0 351,400
RAPT THERAPEUTICS INC COM 75382E109 15,812 866,396 SH   DFND   231,800 0 634,596
REGENERON PHARMACEUTICALS COM 75886F107 13,123 22,200 SH   SOLE   0 0 22,200
REPARE THERAPEUTICS INC COM 760273102 46,482 3,322,488 SH   DFND   3,177,041 0 145,447
RXSIGHT INC COM 78349D107 19,480 1,383,500 SH   DFND   321,000 0 1,062,500
SAREPTA THERAPEUTICS INC COM 803607100 1,499 20,000 SH   SOLE   20,000 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 5,910 1,076,540 SH   DFND   294,400 0 782,140
SCPHARMACEUTICALS INC COM 810648105 23,122 4,797,148 SH   SOLE   4,797,148 0 0
SEAGEN INC COM 81181C104 121,646 687,500 SH   DFND   61,700 0 625,800
SEAGEN INC COM 81181C104 8,847 50,000 SH Call DFND   14,000 0 36,000
SI-BONE INC COM 825704109 44,458 3,368,000 SH   DFND   166,900 0 3,201,100
SIERRA ONCOLOGY INC COM NEW 82640U404 108,043 1,964,770 SH   DFND   1,738,066 0 226,704
SIGHT SCIENCES INC COM 82657M105 1,798 200,000 SH   SOLE   0 0 200,000
SIGNIFY HEALTH INC CL A COM 82671G100 12,420 900,000 SH   SOLE   0 0 900,000
SILVERBACK THERAPEUTICS INC COM 82835W108 37,061 8,740,887 SH   DFND   7,788,510 0 952,377
SINGULAR GENOMICS SYSTEMS IN COM 82933R100 2,065 540,697 SH   SOLE   540,697 0 0
SINOVAC BIOTECH LTD SHS P8696W104 349,500 2,718,735 SH   SOLE   0 0 2,718,735
SONENDO INC COM 835431107 1,244 723,478 SH   SOLE   723,478 0 0
SPDR SER TR S&P BIOTECH 78464A870 8,303 111,800 SH   SOLE   111,800 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 148,417 6,028,307 SH   SOLE   6,028,307 0 0
STRYKER CORPORATION COM 863667101 87,748 441,100 SH   DFND   18,000 0 423,100
SYNDAX PHARMACEUTICALS INC COM 87164F105 44,700 2,323,300 SH   DFND   552,000 0 1,771,300
SYNLOGIC INC COM 87166L100 6,934 6,029,995 SH   SOLE   6,029,995 0 0
TALARIS THERAPEUTICS INC COM 87410C104 1,064 235,995 SH   SOLE   0 0 235,995
TELA BIO INC COM 872381108 21,223 3,027,542 SH   SOLE   3,027,542 0 0
TENET HEALTHCARE CORP COM NEW 88033G407 34,495 656,300 SH   DFND   13,000 0 643,300
TERNS PHARMACEUTICALS INC COM 880881107 9,402 3,791,204 SH   SOLE   3,791,204 0 0
THERAVANCE BIOPHARMA INC COM G8807B106 12,414 1,370,250 SH   SOLE   0 0 1,370,250
THERMO FISHER SCIENTIFIC INC COM 883556102 61,608 113,400 SH   DFND   5,000 0 108,400
THESEUS PHARMACEUTICALS INC COM 88369M101 94,240 17,041,668 SH   SOLE   17,041,668 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 18,710 772,200 SH   DFND   138,200 0 634,000
TRICIDA INC COM 89610F101 99,520 10,280,947 SH   SOLE   10,280,947 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 151,422 2,012,250 SH   DFND   1,548,350 0 463,900
UNIQURE NV SHS N90064101 16,307 874,849 SH   DFND   50,000 0 824,849
UNITEDHEALTH GROUP INC COM 91324P102 144,433 281,200 SH   DFND   14,000 0 267,200
VAXCYTE INC COM 92243G108 32,937 1,513,659 SH   DFND   207,945 0 1,305,714
VECTIVBIO HLDG AG ORD SHS H9060V101 34,957 6,473,561 SH   DFND   6,180,261 0 293,300
VENTYX BIOSCIENCES INC COM 92332V107 15,768 1,289,280 SH   SOLE   1,289,280 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 23,861 5,694,841 SH   DFND   5,028,174 0 666,667
VERTEX PHARMACEUTICALS INC COM 92532F100 109,109 387,200 SH   DFND   14,000 0 373,200
VIGIL NEUROSCIENCE INC COM 92673K108 1,061 411,191 SH   SOLE   411,191 0 0
VISTAGEN THERAPEUTICS INC COM NEW 92840H202 11,811 13,421,283 SH   DFND   2,902,043 0 10,519,240
VOR BIOPHARMA INC COM 929033108 4,142 833,333 SH   SOLE   0 0 833,333
X4 PHARMACEUTICALS INC COM 98420X103 1,326 1,373,849 SH   SOLE   1,373,849 0 0
XENON PHARMACEUTICALS INC COM 98420N105 40,434 1,329,200 SH   DFND   218,200 0 1,111,000
XTANT MED HLDGS INC COM NEW 98420P308 37,894 72,943,918 SH   SOLE   72,943,918 0 0