The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109 174,610 1,965,000 SH   DFND 1 838,700 0 1,126,300
ACHILLION PHARMACEUTICALS IN COM 00448Q201 58,652 13,062,900 SH   DFND 1 5,123,100 0 7,939,800
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 15,681 1,914,660 SH   SOLE   1,914,660 0 0
AEGERION PHARMACEUTICALS INC NOTE 2.000% 8/1 00767EAB8 12,151 15,000,000 PRN   DFND 1 6,995,000 0 8,005,000
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 7,244 1,469,524 SH   SOLE   1,469,524 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 69,896 1,438,182 SH   DFND 1 470,875 0 967,307
AETNA INC NEW COM 00817Y108 222,057 1,396,500 SH   DFND 1 549,000 0 847,500
AFFIMED N V COM N01045108 735 326,650 SH   SOLE   326,650 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 233,617 3,638,900 SH   DFND 1 1,465,700 0 2,173,200
ALEXION PHARMACEUTICALS INC COM 015351109 511,425 3,645,486 SH   DFND 1 1,236,700 0 2,408,786
ALIMERA SCIENCES INC COM 016259103 338 250,000 SH   DFND 1 98,300 0 151,700
ALKERMES PLC SHS G01767105 7,372 145,000 SH   SOLE   0 0 145,000
ALLERGAN PLC SHS G0177J108 76,567 373,590 SH   DFND 1 143,600 0 229,990
ALLERGAN PLC PFD CONV SER A G0177J116 65,076 88,200 PRN   DFND 1 30,300 0 57,900
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 127,453 1,084,800 SH   DFND 1 331,600 0 753,200
ALPINE IMMUNE SCIENCES INC COM 02083G100 38,263 3,298,516 SH   SOLE   3,298,516 0 0
AMGEN INC COM 031162100 233,640 1,253,100 SH   DFND 1 377,100 0 876,000
ANTHEM INC COM 036752103 176,136 927,618 SH   DFND 1 309,700 0 617,918
ARGENX SE SPONSORED ADR 04016X101 11,305 500,000 SH   DFND 1 238,400 0 261,600
ARRAY BIOPHARMA INC COM 04269X105 174,450 14,182,900 SH   DFND 1 5,004,900 0 9,178,000
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 122,065 3,367,315 SH   DFND 1 3,026,915 0 340,400
ASSEMBLY BIOSCIENCES INC COM 045396108 26,121 748,026 SH   DFND 1 357,600 0 390,426
AUDENTES THERAPEUTICS INC COM 05070R104 115,671 4,129,638 SH   SOLE   4,129,638 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 11,270 1,797,400 SH   SOLE   0 0 1,797,400
BEIGENE LTD SPONSORED ADR 07725L102 135,925 1,313,788 SH   DFND 1 529,997 0 783,791
BIOGEN INC COM 09062X103 510,386 1,630,000 SH   DFND 1 551,100 0 1,078,900
BIOLINERX LTD SPONSORED ADR 09071M106 1,163 1,038,600 SH   SOLE   1,038,600 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 69,235 743,900 SH   DFND 1 247,100 0 496,800
BIOMARIN PHARMACEUTICAL INC NOTE 0.750%10/1 09061GAE1 558 500,000 PRN   DFND 1 215,000 0 285,000
BIOMARIN PHARMACEUTICAL INC NOTE 1.500%10/1 09061GAF8 602 500,000 PRN   DFND 1 215,000 0 285,000
BLUEBIRD BIO INC COM 09609G100 66,195 481,946 SH   DFND 1 146,800 0 335,146
BOSTON SCIENTIFIC CORP COM 101137107 390,790 13,397,000 SH   DFND 1 4,975,000 0 8,422,000
BRISTOL MYERS SQUIBB CO COM 110122108 55,753 874,700 SH   DFND 1 223,000 0 651,700
BRISTOL MYERS SQUIBB CO COM 110122108 9,561 150,000 SH Call DFND 1 70,000 0 80,000
CELGENE CORP COM 151020104 488,785 3,351,977 SH   DFND 1 1,105,200 0 2,246,777
CIGNA CORPORATION COM 125509109 236,685 1,266,100 SH   DFND 1 456,500 0 809,600
CLEMENTIA PHARMACEUTICALS IN COM 185575107 176,082 10,425,225 SH   SOLE   10,425,225 0 0
CLOVIS ONCOLOGY INC COM 189464100 196,826 2,388,670 SH   DFND 1 814,800 0 1,573,870
COHERUS BIOSCIENCES INC COM 19249H103 14,414 1,079,700 SH   SOLE   0 0 1,079,700
CORVUS PHARMACEUTICALS INC COM 221015100 85,747 5,379,349 SH   SOLE   5,379,349 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 6,651 372,191 SH   DFND 1 171,207 0 200,984
CTI BIOPHARMA CORP COM NEW 12648L601 15,950 5,000,000 SH   SOLE   5,000,000 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 21,767 512,900 SH   SOLE   0 0 512,900
DECIPHERA PHARMACEUTICALS IN COM 24344T101 7,487 394,270 SH   DFND 1 70,800 0 323,470
DERMIRA INC COM 24983L104 38,310 1,418,873 SH   DFND 1 413,570 0 1,005,303
DIMENSION THERAPEUTICS INC COM 25433V105 32,386 5,397,698 SH   SOLE   5,397,698 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 152,017 1,390,700 SH   DFND 1 436,400 0 954,300
EHEALTH INC COM 28238P109 43,831 1,834,700 SH   DFND 1 843,200 0 991,500
ENVISION HEALTHCARE CORP COM 29414D100 19,809 440,700 SH   DFND 1 200,500 0 240,200
FLUIDIGM CORP DEL COM 34385P108 8,800 1,746,100 SH   DFND 1 215,500 0 1,530,600
FLUIDIGM CORP DEL NOTE 2.750% 2/0 34385PAA6 7,390 10,000,000 PRN   DFND 1 4,466,000 0 5,534,000
GALAPAGOS NV SPON ADR 36315X101 53,296 523,790 SH   DFND 1 186,900 0 336,890
GILEAD SCIENCES INC COM 375558103 156,207 1,928,000 SH   DFND 1 681,000 0 1,247,000
GLAUKOS CORP COM 377322102 27,605 836,500 SH   SOLE   836,500 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 74,322 2,393,635 SH   DFND 1 1,182,700 0 1,210,935
GLYCOMIMETICS INC COM 38000Q102 4,723 337,588 SH   SOLE   0 0 337,588
GW PHARMACEUTICALS PLC ADS 36197T103 56,943 561,071 SH   DFND 1 204,000 0 357,071
HALOZYME THERAPEUTICS INC COM 40637H109 6,080 350,000 SH   DFND 1 159,000 0 191,000
HCA HEALTHCARE INC COM 40412C101 14,915 187,400 SH   DFND 1 78,200 0 109,200
HERON THERAPEUTICS INC COM 427746102 10,498 650,000 SH   DFND 1 311,000 0 339,000
ILLUMINA INC COM 452327109 79,381 398,500 SH   DFND 1 38,800 0 359,700
IMMUNOGEN INC COM 45253H101 41,697 5,450,581 SH   DFND 1 2,475,858 0 2,974,723
IMMUNOMEDICS INC COM 452907108 139,755 9,996,816 SH   DFND 1 5,704,876 0 4,291,940
INCYTE CORP COM 45337C102 23,348 200,000 SH Put DFND 1 93,000 0 107,000
INCYTE CORP COM 45337C102 172,308 1,476,000 SH   DFND 1 410,500 0 1,065,500
INFINITY PHARMACEUTICALS INC COM 45665G303 2,936 2,207,245 SH   DFND 1 722,900 0 1,484,345
INOTEK PHARMACEUTICALS CORP NOTE 5.750% 8/0 45780VAB8 5,547 7,000,000 PRN   DFND 1 3,200,000 0 3,800,000
INSMED INC COM PAR $.01 457669307 58,519 1,875,016 SH   DFND 1 859,700 0 1,015,316
INSYS THERAPEUTICS INC NEW COM NEW 45824V209 54,802 6,171,440 SH   DFND 1 2,583,300 0 3,588,140
INTEGRA LIFESCIENCES HLDGS C COM NEW 457985208 55,069 1,090,910 SH   DFND 1 435,500 0 655,410
INTELLIA THERAPEUTICS INC COM 45826J105 66,155 2,662,180 SH   SOLE   2,662,180 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 22,425 386,380 SH   SOLE   386,380 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 58,988 56,400 SH   SOLE   0 0 56,400
INVITAE CORP COM 46185L103 14,226 1,518,197 SH   SOLE   1,518,197 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 49,799 6,425,626 SH   DFND 1 3,246,226 0 3,179,400
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 90,823 5,759,200 SH   DFND 1 2,089,300 0 3,669,900
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 109,571 749,200 SH   DFND 1 312,600 0 436,600
JOHNSON & JOHNSON COM 478160104 146,183 1,124,400 SH   DFND 1 465,300 0 659,100
JUNO THERAPEUTICS INC COM 48205A109 91,587 2,041,608 SH   DFND 1 734,980 0 1,306,628
KALA PHARMACEUTICALS INC COM 483119103 54,251 2,375,279 SH   SOLE   2,375,279 0 0
LILLY ELI & CO COM 532457108 263,036 3,075,000 SH   DFND 1 1,014,800 0 2,060,200
LOXO ONCOLOGY INC COM 548862101 159,183 1,728,000 SH   SOLE   1,728,000 0 0
MAGELLAN HEALTH INC COM NEW 559079207 76,168 882,600 SH   DFND 1 357,800 0 524,800
MALLINCKRODT PUB LTD CO SHS G5785G107 55,035 1,472,700 SH   DFND 1 659,200 0 813,500
MARINUS PHARMACEUTICALS INC COM 56854Q101 3,332 567,600 SH   SOLE   567,600 0 0
MEDIGUS LTD SPONSORD ADR NEW 58471G201 134 60,000 SH   SOLE   60,000 0 0
MEDTRONIC PLC SHS G5960L103 68,360 879,000 SH   DFND 1 366,600 0 512,400
MERCK & CO INC COM 58933Y105 351,333 5,487,000 SH   DFND 1 2,038,200 0 3,448,800
MOMENTA PHARMACEUTICALS INC COM 60877T100 39,018 2,109,068 SH   DFND 1 613,300 0 1,495,768
MYLAN N V SHS EURO N59465109 112,967 3,601,100 SH   DFND 1 1,576,500 0 2,024,600
NABRIVA THERAPEUTICS PLC SHS G63637105 32,102 3,919,600 SH   SOLE   3,919,600 0 0
NATERA INC COM 632307104 20,317 1,576,190 SH   SOLE   1,576,190 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 17,455 284,841 SH   DFND 1 128,100 0 156,741
NEVRO CORP COM 64157F103 44,977 494,900 SH   DFND 1 141,000 0 353,900
NEWLINK GENETICS CORP COM 651511107 8,462 831,274 SH   DFND 1 309,000 0 522,274
NEWLINK GENETICS CORP COM 651511107 509 50,000 SH Call DFND 1 23,500 0 26,500
NOVELION THERAPEUTICS INC COM NEW 67001K202 703 100,000 SH   DFND 1 40,120 0 59,880
NOVO-NORDISK A S ADR 670100205 15,890 330,000 SH   SOLE   0 0 330,000
NOVUS THERAPEUTICS INC COM 67011N105 13,218 2,537,110 SH   SOLE   2,537,110 0 0
NUVASIVE INC COM 670704105 12,240 220,700 SH   SOLE   0 0 220,700
OBSEVA SA COM H5861P103 21,209 2,605,531 SH   SOLE   2,605,531 0 0
OREXIGEN THERAPEUTICS INC NOTE 2.750%12/0 686164AC8 2,042 5,210,000 PRN   DFND 1 2,210,000 0 3,000,000
OTONOMY INC COM 68906L105 2,093 644,074 SH   SOLE   644,074 0 0
PFIZER INC COM 717081103 87,779 2,458,800 SH   DFND 1 982,000 0 1,476,800
PIERIS PHARMACEUTICALS INC COM 720795103 41,815 7,259,620 SH   SOLE   7,259,620 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 11,132 2,295,346 SH   DFND 1 969,180 0 1,326,166
PUMA BIOTECHNOLOGY INC COM 74587V107 290,482 2,425,735 SH   DFND 1 877,289 0 1,548,446
RADIUS HEALTH INC COM NEW 750469207 43,284 1,122,800 SH   DFND 1 243,000 0 879,800
REDHILL BIOPHARMA LTD SPONSORED ADS 757468103 6,107 564,900 SH   SOLE   564,900 0 0
REGENERON PHARMACEUTICALS COM 75886F107 256,097 572,770 SH   DFND 1 154,800 0 417,970
ROKA BIOSCIENCE INC COM NEW 775431208 147 201,617 SH   SOLE   201,617 0 0
SAREPTA THERAPEUTICS INC COM 803607100 6,804 150,000 SH Call DFND 1 70,500 0 79,500
SELECT MED HLDGS CORP COM 81619Q105 107,107 5,578,500 SH   DFND 1 2,772,800 0 2,805,700
SELECTA BIOSCIENCES INC COM 816212104 33,631 1,842,797 SH   SOLE   1,842,797 0 0
SERES THERAPEUTICS INC COM 81750R102 1,203 75,000 SH Call DFND 1 35,000 0 40,000
SERES THERAPEUTICS INC COM 81750R102 3,520 219,458 SH   SOLE   0 0 219,458
SHIRE PLC SPONSORED ADR 82481R106 61,242 399,908 SH   DFND 1 179,800 0 220,108
SHIRE PLC SPONSORED ADR 82481R106 15,314 100,000 SH Put DFND 1 47,000 0 53,000
SIERRA ONCOLOGY INC COM 82640U107 5,741 3,703,704 SH   SOLE   3,703,704 0 0
SINOVAC BIOTECH LTD SHS P8696W104 18,806 2,667,500 SH   DFND 1 1,219,500 0 1,448,000
SPARK THERAPEUTICS INC COM 84652J103 38,340 430,016 SH   DFND 1 178,221 0 251,795
STEADYMED LTD SHS M84920103 14,225 4,246,196 SH   SOLE   4,246,196 0 0
STRYKER CORP COM 863667101 59,790 421,000 SH   DFND 1 77,000 0 344,000
SYNDAX PHARMACEUTICALS INC COM 87164F105 5,113 437,000 SH   SOLE   437,000 0 0
SYNERGY PHARMACEUTICALS DEL COM NEW 871639308 39,502 13,621,443 SH   DFND 1 6,253,043 0 7,368,400
SYNLOGIC INC COM 87166L100 25,005 1,314,996 SH   SOLE   1,314,996 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADR 881624209 7,137 405,500 SH   DFND 1 61,700 0 343,800
THERMO FISHER SCIENTIFIC INC COM 883556102 101,071 534,200 SH   DFND 1 197,600 0 336,600
UNITEDHEALTH GROUP INC COM 91324P102 74,423 380,000 SH   DFND 1 101,300 0 278,700
UNIVERSAL HLTH SVCS INC CL B 913903100 74,219 669,000 SH   DFND 1 301,000 0 368,000
VALEANT PHARMACEUTICALS INTL COM 91911K102 2,793 194,900 SH   DFND 1 76,800 0 118,100
VANDA PHARMACEUTICALS INC COM 921659108 17,325 967,859 SH   SOLE   0 0 967,859
VERONA PHARMA PLC SPONSORED ADS 925050106 10,233 666,666 SH   SOLE   666,666 0 0
VERSARTIS INC COM 92529L102 123 50,000 SH Call DFND 1 23,500 0 26,500
VERTEX PHARMACEUTICALS INC COM 92532F100 315,377 2,074,302 SH   DFND 1 638,600 0 1,435,702
VIEWRAY INC COM 92672L107 54,481 9,458,567 SH   SOLE   9,458,567 0 0
WRIGHT MED GROUP N V ORD SHS 0.03 PAR N96617118 231,439 8,946,234 SH   DFND 1 3,008,050 0 5,938,184
WRIGHT MED GROUP N V RIGHT 03/01/2019 N96617126 13,505 8,713,088 SH   SOLE   0 0 8,713,088
XENCOR INC COM 98401F105 17,127 747,244 SH   SOLE   0 0 747,244
XENON PHARMACEUTICALS INC COM 98420N105 1,873 634,812 SH   SOLE   634,812 0 0
XTANT MED HLDGS INC COM 98420P100 343 475,439 SH   SOLE   475,439 0 0
ZAI LAB LTD ADR 98887Q104 17,770 658,160 SH   SOLE   658,160 0 0
ZIMMER BIOMET HLDGS INC COM 98956P102 5,737 49,000 SH   DFND 1 20,600 0 28,400