The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2SEVENTY BIO INC COMMON STOCK 901384107   24,394,606 2,391,628 SH   DFND   667,300 0 1,724,328
ABCELLERA BIOLOGICS INC COM 00288U106   31,522,991 4,180,768 SH   SOLE   4,180,768 0 0
ACUTUS MED INC COM 005111109   1,996,883 2,648,386 SH   SOLE   2,648,386 0 0
ADICET BIO INC COM 007002108   42,895,526 7,447,140 SH   SOLE   7,447,140 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103   521,194 1,797,221 SH   SOLE   1,797,221 0 0
AEROVATE THERAPEUTICS INC COM 008064107   15,267,278 756,930 SH   DFND   215,100 0 541,830
ALPINE IMMUNE SCIENCES INC COM 02083G100   31,509,890 4,081,592 SH   SOLE   4,081,592 0 0
ALTIMMUNE INC COM NEW 02155H200   422,000 100,000 SH Call DFND   35,500 0 64,500
ALTIMMUNE INC COM NEW 02155H200   213,532 50,600 SH   DFND   18,000 0 32,600
ALX ONCOLOGY HLDGS INC COM 00166B105   12,976,920 2,871,000 SH   DFND   605,000 0 2,266,000
AMGEN INC COM 031162100   18,542,225 76,700 SH   SOLE   0 0 76,700
AMICUS THERAPEUTICS INC COM 03152W109   12,986,390 1,171,000 SH   DFND   333,000 0 838,000
AMYLYX PHARMACEUTICALS INC COM 03237H101   23,868,090 813,500 SH   DFND   202,000 0 611,500
APELLIS PHARMACEUTICALS INC COM 03753U106   60,036,792 910,200 SH   DFND   86,500 0 823,700
APOLLOMICS INC CL A SHS G0411D107   16,033,976 662,561 SH   SOLE   662,561 0 0
ARCUTIS BIOTHERAPEUTICS INC COM 03969K108   21,059,269 1,914,479 SH   SOLE   1,914,479 0 0
ARGENX SE SPONSORED ADR 04016X101   16,579,810 44,500 SH   SOLE   0 0 44,500
ARS PHARMACEUTICALS INC COM 82835W108   56,903,174 8,740,887 SH   DFND   7,788,510 0 952,377
BAXTER INTL INC COM 071813109   14,196,000 350,000 SH Call DFND   123,500 0 226,500
BAXTER INTL INC COM 071813109   63,354,720 1,562,000 SH   SOLE   0 0 1,562,000
BELLUS HEALTH INC NEW COM NEW 07987C204   36,755,893 5,108,900 SH   DFND   2,333,300 0 2,775,600
BIOATLA INC COM 09077B104   10,347,480 3,861,000 SH   DFND   1,197,000 0 2,664,000
BIOGEN INC COM 09062X103   140,405,150 505,000 SH   DFND   44,800 0 460,200
BIOMARIN PHARMACEUTICAL INC COM 09061G101   157,063,020 1,615,210 SH   DFND   147,600 0 1,467,610
BIOMX INC COM 09090D103   964,254 3,161,489 SH   SOLE   3,161,489 0 0
BOLT BIOTHERAPEUTICS INC COM 097702104   2,141,990 1,541,000 SH   SOLE   1,541,000 0 0
BOSTON SCIENTIFIC CORP COM 101137107   189,613,700 3,790,000 SH   SOLE   0 0 3,790,000
BRIDGEBIO PHARMA INC NOTE 2.250% 2/0 10806XAD4   12,853,200 20,000,000 PRN   SOLE   20,000,000 0 0
BRIDGEBIO PHARMA INC NOTE 2.500% 3/1 10806XAB8   9,468,750 12,500,000 PRN   SOLE   12,500,000 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108   162,185,400 2,340,000 SH   SOLE   0 0 2,340,000
CHEMOMAB THERAPEUTICS LTD SPONSORED ADS 16385C104   3,563,626 2,241,274 SH   SOLE   2,241,274 0 0
CHINOOK THERAPEUTICS INC COM 16961L106   46,978,295 2,029,300 SH   DFND   478,300 0 1,551,000
COMPASS THERAPEUTICS INC COM 20454B104   73,126,520 22,362,850 SH   DFND   18,791,422 0 3,571,428
CORVUS PHARMACEUTICALS INC COM 221015100   6,318,725 6,943,654 SH   SOLE   6,943,654 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107   63,449,784 3,950,796 SH   DFND   3,196,876 0 753,920
CULLINAN ONCOLOGY INC COM 230031106   6,193,109 605,387 SH   SOLE   605,387 0 0
DECIBEL THERAPEUTICS INC COM 24343R106   14,934,480 4,945,192 SH   DFND   4,061,774 0 883,418
DISC MEDICINE INC COM 254604101   48,093,608 2,269,637 SH   SOLE   2,269,637 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105   97,163,064 14,567,176 SH   DFND   14,301,551 0 265,625
EDWARDS LIFESCIENCES CORP COM 28176E108   52,119,900 630,000 SH   SOLE   0 0 630,000
ENLIVEN THERAPEUTICS INC COM 29337E102   197,017,065 8,996,213 SH   DFND   8,949,338 0 46,875
ESSA PHARMA INC COM NEW 29668H708   3,559,061 1,198,337 SH   DFND   542,900 0 655,437
EVOLENT HEALTH INC CL A 30050B101   93,963,258 2,895,632 SH   DFND   214,700 0 2,680,932
FUSION PHARMACEUTICALS INC COM 36118A100   11,772,843 3,122,770 SH   DFND   2,930,670 0 192,100
GALECTO INC COM 36322Q107   8,140,965 4,090,937 SH   DFND   3,803,255 0 287,682
GH RESEARCH PLC ORDINARY SHARES G3855L106   13,255,530 1,659,015 SH   DFND   239,100 0 1,419,915
GOODRX HLDGS INC COM CL A 38246G108   10,625,000 1,700,000 SH   DFND   600,000 0 1,100,000
GRACELL BIOTECHNOLOGIES INC SPONSORED ADS 38406L103   17,665,860 9,497,774 SH   DFND   7,583,576 0 1,914,198
HARPOON THERAPEUTICS INC COM 41358P106   462,310 621,218 SH   SOLE   621,218 0 0
HERON THERAPEUTICS INC COM 427746102   1,212,077 802,700 SH   SOLE   0 0 802,700
HORIZON THERAPEUTICS PUB L SHS G46188101   21,828,000 200,000 SH   DFND   70,700 0 129,300
HORIZON THERAPEUTICS PUB L SHS G46188101   5,457,000 50,000 SH Put DFND   17,500 0 32,500
HUMANA INC COM 444859102   169,279,902 348,700 SH   SOLE   0 0 348,700
IKENA ONCOLOGY INC COM 45175G108   10,992,273 3,186,166 SH   DFND   2,189,111 0 997,055
IKENA ONCOLOGY INC NONVOTING 000000000   21,443,358 6,215,466 SH   DFND   5,586,311 0 629,155
IMMATICS N.V SHS N44445109   6,536,011 947,248 SH   DFND   436,248 0 511,000
INTELLIA THERAPEUTICS INC COM 45826J105   6,135,648 164,627 SH   DFND   35,200 0 129,427
INTUITIVE SURGICAL INC COM NEW 46120E602   158,519,135 620,500 SH   SOLE   0 0 620,500
INVIVYD INC COM 00534A102   6,324,480 5,270,400 SH   SOLE   5,270,400 0 0
IONIS PHARMACEUTICALS INC COM 462222100   75,929,630 2,124,500 SH   DFND   136,300 0 1,988,200
IOVANCE BIOTHERAPEUTICS INC COM 462260100   28,762,568 4,707,458 SH   SOLE   0 0 4,707,458
JANUX THERAPEUTICS INC COM 47103J105   34,320,271 2,836,386 SH   DFND   2,489,664 0 346,722
KEROS THERAPEUTICS INC COM 492327101   71,711,106 1,679,417 SH   DFND   1,268,734 0 410,683
KEZAR LIFE SCIENCES INC COM 49372L100   17,099,190 5,463,000 SH   DFND   1,339,000 0 4,124,000
KINNATE BIOPHARMA INC COM 49705R105   32,147,681 5,143,629 SH   DFND   4,693,629 0 450,000
LILLY ELI & CO COM 532457108   63,876,120 186,000 SH   SOLE   0 0 186,000
MEREO BIOPHARMA GROUP PLC SPON ADS 589492107   5,476,984 7,747,891 SH   DFND   4,220,555 0 3,527,336
MERSANA THERAPEUTICS INC COM 59045L106   865,977 210,700 SH Call DFND   73,500 0 137,200
MERSANA THERAPEUTICS INC COM 59045L106   37,037,006 9,011,437 SH   DFND   1,928,600 0 7,082,837
MIRATI THERAPEUTICS INC COM 60468T105   5,577,000 150,000 SH Call DFND   51,500 0 98,500
MIRATI THERAPEUTICS INC COM 60468T105   33,969,507 913,650 SH   DFND   93,600 0 820,050
NATERA INC COM 632307104   54,053,217 973,581 SH   DFND   88,600 0 884,981
NEKTAR THERAPEUTICS COM 640268108   726,840 1,034,059 SH   DFND   258,300 0 775,759
NEKTAR THERAPEUTICS COM 640268108   383,081 545,000 SH Call DFND   192,500 0 352,500
NEUROCRINE BIOSCIENCES INC COM 64125C109   49,496,580 489,000 SH   SOLE   0 0 489,000
NEUROPACE INC COM 641288105   18,616,984 4,012,281 SH   SOLE   4,012,281 0 0
NEXTCURE INC COM 65343E108   4,012,299 2,711,013 SH   SOLE   2,711,013 0 0
ORIC PHARMACEUTICALS INC COM 68622P109   7,834,468 1,374,468 SH   SOLE   1,374,468 0 0
PASSAGE BIO INC COM 702712100   8,554,175 8,931,999 SH   DFND   6,841,423 0 2,090,576
PMV PHARMACEUTICALS INC COM 69353Y103   31,305,877 6,563,077 SH   SOLE   6,563,077 0 0
PRELUDE THERAPEUTICS INC COM 74065P101   57,226,239 10,039,691 SH   DFND   9,250,191 0 789,500
PRELUDE THERAPEUTICS INC NONVOTING 000000000   32,377,060 5,680,186 SH   DFND   5,596,886 0 83,300
PROGYNY INC COM 74340E103   33,337,733 1,037,912 SH   SOLE   0 0 1,037,912
PROTAGONIST THERAPEUTICS INC COM 74366E102   6,923,000 301,000 SH   DFND   105,000 0 196,000
PROTARA THERAPEUTICS INC COM STK 74365U107   2,483,837 793,558 SH   DFND   151,800 0 641,758
R1 RCM INC COM 77634L105   26,250,000 1,750,000 SH   SOLE   0 0 1,750,000
RAPT THERAPEUTICS INC COM 75382E109   22,957,135 1,251,070 SH   DFND   310,400 0 940,670
REGENERON PHARMACEUTICALS COM 75886F107   19,720,080 24,000 SH   SOLE   0 0 24,000
REPARE THERAPEUTICS INC COM 760273102   32,693,282 3,322,488 SH   DFND   3,177,041 0 145,447
REVANCE THERAPEUTICS INC COM 761330109   1,610,500 50,000 SH   SOLE   0 0 50,000
RXSIGHT INC COM 78349D107   20,063,254 1,202,833 SH   DFND   279,100 0 923,733
SAREPTA THERAPEUTICS INC COM 803607100   10,337,250 75,000 SH Call DFND   26,000 0 49,000
SAREPTA THERAPEUTICS INC COM 803607100   119,236,733 865,100 SH   DFND   56,900 0 808,200
SCHOLAR ROCK HLDG CORP COM 80706P103   4,120,000 515,000 SH   SOLE   515,000 0 0
SCPHARMACEUTICALS INC COM 810648105   50,424,919 5,559,528 SH   SOLE   5,559,528 0 0
SI-BONE INC COM 825704109   57,425,660 2,919,454 SH   DFND   166,900 0 2,752,554
SINGULAR GENOMICS SYSTEMS IN COM 82933R100   654,243 540,697 SH   SOLE   540,697 0 0
SINOVAC BIOTECH LTD SHS P8696W104   340,000,000 2,718,735 SH   SOLE   0 0 2,718,735
SPDR SER TR S&P BIOTECH 78464A870   20,881,540 274,000 SH   DFND   96,900 0 177,100
SPDR SER TR S&P BIOTECH 78464A870   7,621,000 100,000 SH Call DFND   34,000 0 66,000
SPRINGWORKS THERAPEUTICS INC COM 85205L107   115,801,686 4,498,900 SH   SOLE   4,498,900 0 0
STRYKER CORPORATION COM 863667101   104,938,772 367,600 SH   SOLE   0 0 367,600
SYNDAX PHARMACEUTICALS INC COM 87164F105   36,150,576 1,711,675 SH   DFND   401,200 0 1,310,475
SYNLOGIC INC COM 87166L100   3,810,957 6,029,995 SH   SOLE   6,029,995 0 0
TELA BIO INC COM 872381108   32,213,047 3,027,542 SH   SOLE   3,027,542 0 0
TENET HEALTHCARE CORP COM NEW 88033G407   72,510,226 1,220,300 SH   SOLE   0 0 1,220,300
TERNS PHARMACEUTICALS INC COM 880881107   90,210,558 7,619,135 SH   SOLE   7,619,135 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102   85,187,486 147,800 SH   SOLE   0 0 147,800
THESEUS PHARMACEUTICALS INC COM 88369M101   153,034,972 17,233,668 SH   SOLE   17,233,668 0 0
THIRD HARMONIC BIO INC COM 88427A107   23,809,773 5,779,071 SH   SOLE   5,779,071 0 0
TRAVERE THERAPEUTICS INC COM 89422G107   39,229,307 1,744,300 SH   DFND   419,700 0 1,324,600
UNIQURE NV SHS N90064101   41,578,124 2,064,455 SH   DFND   98,000 0 1,966,455
UNITEDHEALTH GROUP INC COM 91324P102   130,434,840 276,000 SH   SOLE   0 0 276,000
VAXCYTE INC COM 92243G108   27,339,374 729,439 SH   DFND   90,600 0 638,839
VECTIVBIO HLDG AG ORD SHS H9060V101   43,882,334 5,156,561 SH   SOLE   5,156,561 0 0
VENTYX BIOSCIENCES INC COM 92332V107   19,597,500 585,000 SH   DFND   195,000 0 390,000
VERA THERAPEUTICS INC CL A 92337R101   10,572,224 1,362,400 SH   DFND   620,200 0 742,200
VERASTEM INC COM 92337C104   6,852,144 16,503,237 SH   SOLE   16,503,237 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106   85,554,675 4,260,691 SH   SOLE   4,260,691 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100   55,956,432 177,600 SH   SOLE   0 0 177,600
VIGIL NEUROSCIENCE INC COM 92673K108   4,394,643 448,891 SH   SOLE   448,891 0 0
X4 PHARMACEUTICALS INC COM 98420X103   5,061,422 5,817,726 SH   SOLE   5,817,726 0 0
XENON PHARMACEUTICALS INC COM 98420N105   41,126,289 1,149,100 SH   DFND   230,000 0 919,100
XTANT MED HLDGS INC COM NEW 98420P308   46,610,552 73,114,592 SH   SOLE   73,114,592 0 0
YS BIOPHARMA CO LTD ORDINARY SHARES G9845F109   6,877,542 4,298,464 SH   DFND   1,590,652 0 2,707,812