The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103 88,313 3,729,442 SH   SOLE   3,729,442 0 0
9 METERS BIOPHARMA INC COM 654405109 30,089 25,716,755 SH   SOLE   25,716,755 0 0
ABBVIE INC COM 00287Y109 131,293 1,213,200 SH   DFND   228,100 0 985,100
ABCELLERA BIOLOGICS INC COM 00288U106 278,498 8,200,768 SH   SOLE   8,200,768 0 0
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 26,229 1,584,845 SH   DFND   178,735 0 1,406,110
ACUTUS MED INC COM 005111109 73,240 5,477,958 SH   SOLE   5,477,958 0 0
ADAGENE INC ADS 005329107 4,936 275,000 SH   SOLE   275,000 0 0
ADICET BIO INC COM 007002108 94,606 7,232,856 SH   SOLE   7,232,856 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 54,241 5,501,144 SH   DFND   655,897 0 4,845,247
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 31,803 4,015,524 SH   SOLE   4,015,524 0 0
AERPIO PHARMACEUTICALS INC COM 00810B105 6,700 5,193,946 SH   SOLE   5,193,946 0 0
ALECTOR INC COM 014442107 12,315 611,478 SH   SOLE   611,478 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 15,612 102,100 SH   SOLE   0 0 102,100
ALEXION PHARMACEUTICALS INC COM 015351109 22,937 150,000 SH Call DFND   42,500 0 107,500
ALIGNMENT HEALTHCARE INC COM 01625V104 17,544 800,000 SH   DFND   124,500 0 675,500
ALPINE IMMUNE SCIENCES INC COM 02083G100 32,552 3,070,955 SH   SOLE   3,070,955 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105 11,061 150,000 SH   SOLE   0 0 150,000
AMGEN INC COM 031162100 22,766 91,500 SH   SOLE   0 0 91,500
ANTHEM INC COM 036752103 102,875 286,600 SH   DFND   39,800 0 246,800
APPLIED THERAPEUTICS INC COM 03828A101 42,337 2,257,387 SH   DFND   156,706 0 2,100,681
APTOSE BIOSCIENCES INC COM NEW 03835T200 47,979 8,030,000 SH   SOLE   0 0 8,030,000
ARCTURUS THERAPEUTICS HLDGS COM 03969T109 49,844 1,206,886 SH   DFND   159,626 0 1,047,260
ARCUTIS BIOTHERAPEUTICS INC COM 03969K108 175,716 6,073,850 SH   DFND   4,267,564 0 1,806,286
ARYA SCIENCES ACQUISITION CO COM CL A G3166W106 680 49,375 SH   DFND   20,900 0 28,475
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 65,105 505,159 SH   DFND   61,000 0 444,159
ASLAN PHARMACEUTICALS LTD ADS 04522R101 8,442 2,520,000 SH   SOLE   0 0 2,520,000
AURINIA PHARMACEUTICALS INC COM 05156V102 78,806 6,069,032 SH   DFND   585,300 0 5,483,732
AXSOME THERAPEUTICS INC COM 05464T104 2,831 50,000 SH Put DFND   18,000 0 32,000
BELLUS HEALTH INC NEW COM NEW 07987C204 15,100 3,954,800 SH   SOLE   3,954,800 0 0
BIOGEN INC COM 09062X103 22,940 82,000 SH   SOLE   0 0 82,000
BIOMX INC COM 09090D103 16,472 2,313,489 SH   SOLE   2,313,489 0 0
BOSTON SCIENTIFIC CORP COM 101137107 267,481 6,920,600 SH   DFND   939,400 0 5,981,200
BRISTOL-MYERS SQUIBB CO COM 110122108 285,057 4,515,400 SH   DFND   569,100 0 3,946,300
BURNING ROCK BIOTECH LTD SPONSORED ADS 12233L107 51,085 1,897,663 SH   DFND   201,999 0 1,695,664
CATALYST BIOSCIENCES INC COM NEW 14888D208 10,678 2,118,600 SH   SOLE   0 0 2,118,600
CEL-SCI CORP COM PAR NEW 150837607 1,521 100,000 SH Put DFND   35,500 0 64,500
CHEMOMAB THERAPEUTICS LTD SPONSORED ADS 16385C104 74,019 2,578,174 SH   SOLE   2,578,174 0 0
CHINOOK THERAPEUTICS INC COM 16961L106 19,425 1,250,001 SH   DFND   250,000 0 1,000,001
COMPASS PATHWAYS PLC SPONSORED ADS 20451W101 4,706 127,816 SH   DFND   38,816 0 89,000
CORVUS PHARMACEUTICALS INC COM 221015100 24,804 8,053,298 SH   SOLE   8,053,298 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 42,075 2,753,567 SH   SOLE   2,753,567 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 67,322 552,500 SH   DFND   47,500 0 505,000
CTI BIOPHARMA CORP COM 12648L601 21,885 7,520,600 SH   SOLE   7,520,600 0 0
CULLINAN ONCOLOGY INC COM 230031106 47,760 1,146,145 SH   DFND   959,245 0 186,900
CURIS INC COM NEW 231269200 49,429 4,366,494 SH   DFND   195,900 0 4,170,594
DECIBEL THERAPEUTICS INC COM 24343R106 56,177 4,945,192 SH   DFND   4,061,774 0 883,418
DECIPHERA PHARMACEUTICALS IN COM 24344T101 61,920 1,380,900 SH   DFND   190,100 0 1,190,800
DEXCOM INC COM 252131107 106,883 297,400 SH   DFND   37,000 0 260,400
DYNE THERAPEUTICS INC COM 26818M108 5,436 350,000 SH   SOLE   0 0 350,000
EDGEWISE THERAPEUTICS INC COM 28036F105 453,202 13,944,680 SH   DFND   13,679,055 0 265,625
EDWARDS LIFESCIENCES CORP COM 28176E108 94,212 1,126,400 SH   DFND   151,600 0 974,800
FLEXION THERAPEUTICS INC COM 33938J106 20,657 2,308,083 SH   DFND   84,100 0 2,223,983
FLUIDIGM CORP DEL COM 34385P108 2,260 500,000 SH Call DFND   175,500 0 324,500
FLUIDIGM CORP DEL COM 34385P108 20,790 4,599,571 SH   DFND   484,800 0 4,114,771
FORTE BIOSCIENCES INC COM 34962G109 5,472 159,664 SH   DFND   55,530 0 104,134
FUSION PHARMACEUTICALS INC COM 36118A100 34,570 3,224,770 SH   DFND   2,930,670 0 294,100
GALAPAGOS NV SPON ADR 36315X101 17,800 230,905 SH   DFND   25,700 0 205,205
GALECTO INC COM 36322Q107 24,852 4,090,937 SH   DFND   3,803,255 0 287,682
GEMINI THERAPEUTICS INC COM 36870G105 78,945 5,826,224 SH   SOLE   5,826,224 0 0
GILEAD SCIENCES INC COM 375558103 18,588 287,600 SH   SOLE   0 0 287,600
GRACELL BIOTECHNOLOGIES INC SPONSORED ADS 38406L103 121,427 7,884,870 SH   DFND   5,970,672 0 1,914,198
GRAYBUG VISION INC COM SHS 38942Q103 23,107 4,163,347 SH   SOLE   4,163,347 0 0
GUARDANT HEALTH INC COM 40131M109 149,200 977,400 SH   DFND   108,700 0 868,700
HAEMONETICS CORP MASS COM 405024100 94,581 852,000 SH   DFND   90,500 0 761,500
HARPOON THERAPEUTICS INC COM 41358P106 47,817 2,285,704 SH   DFND   1,020,704 0 1,265,000
HEALTH CATALYST INC COM 42225T107 8,400 179,598 SH   SOLE   179,598 0 0
HEALTH SCIENCES ACQ CORP 2 ORD SHS G4411D109 5,595 500,000 SH   DFND   100,000 0 400,000
HORIZON THERAPEUTICS PUB L SHS G46188101 289,406 3,144,355 SH   DFND   357,500 0 2,786,855
HUMANA INC COM 444859102 131,477 313,600 SH   DFND   48,100 0 265,500
I MAB SPONSORED ADS 44975P103 900 18,565 SH   DFND   1,900 0 16,665
IKENA ONCOLOGY INC COM 45175G108 82,884 2,933,941 SH   DFND   1,936,886 0 997,055
IKENA ONCOLOGY INC NONVOTING 000000000 175,587 6,215,466 SH   DFND   5,586,311 0 629,155
IMARA INC COM 45249V107 22,956 2,719,902 SH   DFND   2,532,402 0 187,500
IMMUNOGEN INC COM 45253H101 73,968 9,131,822 SH   DFND   573,800 0 8,558,022
INFLARX NV COM N44821101 4,150 1,064,118 SH   SOLE   0 0 1,064,118
INNOVAGE HLDG CORP COM 45784A104 5,158 200,000 SH   SOLE   0 0 200,000
INTELLIA THERAPEUTICS INC COM 45826J105 5,818 72,500 SH   SOLE   0 0 72,500
INTUITIVE SURGICAL INC COM NEW 46120E602 103,156 139,600 SH   DFND   20,800 0 118,800
IOVANCE BIOTHERAPEUTICS INC COM 462260100 210,384 6,645,100 SH   DFND   1,337,800 0 5,307,300
JOUNCE THERAPEUTICS INC COM 481116101 18,728 1,823,600 SH   DFND   335,900 0 1,487,700
KALA PHARMACEUTICALS INC COM 483119103 36,834 5,465,030 SH   DFND   4,714,195 0 750,835
KEROS THERAPEUTICS INC COM 492327101 103,368 1,679,417 SH   DFND   1,268,734 0 410,683
KINNATE BIOPHARMA INC COM 49705R105 119,901 3,847,929 SH   DFND   3,397,929 0 450,000
LANDOS BIOPHARMA INC COM 515069102 6,558 681,000 SH   SOLE   0 0 681,000
LARIMAR THERAPEUTICS INC COM 517125100 9,018 617,245 SH   DFND   107,384 0 509,861
LOGICBIO THERAPEUTICS INC COM 54142F102 61,638 8,466,783 SH   DFND   7,948,265 0 518,518
LONGBOARD PHARMACEUTICALS IN COM 54300N103 4,914 300,000 SH   SOLE   0 0 300,000
MAGENTA THERAPEUTICS INC COM 55910K108 11,237 949,048 SH   SOLE   0 0 949,048
MEIRAGTX HLDGS PLC COM G59665102 59,205 4,102,925 SH   DFND   133,500 0 3,969,425
MERCK & CO. INC COM 58933Y105 287,731 3,732,400 SH   DFND   465,000 0 3,267,400
MEREO BIOPHARMA GROUP PLC ADS 589492107 58,183 17,264,763 PRN   DFND   9,210,992 0 8,053,771
MERSANA THERAPEUTICS INC COM 59045L106 30,621 1,892,500 SH   DFND   77,900 0 1,814,600
MILESTONE PHARMACEUTICALS IN COM 59935V107 14,960 2,583,821 SH   SOLE   0 0 2,583,821
MIRATI THERAPEUTICS INC COM 60468T105 209,192 1,221,200 SH   DFND   170,900 0 1,050,300
MOLINA HEALTHCARE INC COM 60855R100 37,963 162,400 SH   DFND   20,600 0 141,800
NANOBIOTIX SA SPONSORED ADS 63009J107 7,520 500,000 SH   SOLE   0 0 500,000
NANOSTRING TECHNOLOGIES INC COM 63009R109 40,931 622,900 SH   DFND   62,900 0 560,000
NATERA INC COM 632307104 222,972 2,195,900 SH   DFND   273,300 0 1,922,600
NEUROCRINE BIOSCIENCES INC COM 64125C109 126,592 1,301,715 SH   DFND   137,470 0 1,164,245
NEXTCURE INC COM 65343E108 27,137 2,711,013 SH   SOLE   2,711,013 0 0
NOVAVAX INC COM NEW 670002401 28,254 155,833 SH   DFND   20,210 0 135,623
NURIX THERAPEUTICS INC COM 67080M103 9,327 300,000 SH   SOLE   0 0 300,000
NUVATION BIO INC COM CL A 67080N101 8,360 800,000 SH   SOLE   0 0 800,000
OAK STR HEALTH INC COM 67181A107 52,479 967,000 SH   DFND   108,000 0 859,000
OLEMA PHARMACEUTICALS INC COM 68062P106 21,770 656,126 SH   DFND   227,792 0 428,334
OLINK HLDG AB SPONSORED ADS 680710100 10,800 300,000 SH   SOLE   0 0 300,000
ONCOCYTE CORP COM 68235C107 10,899 2,100,000 SH   SOLE   0 0 2,100,000
ORIC PHARMACEUTICALS INC COM 68622P109 57,271 2,337,574 SH   DFND   2,212,571 0 125,003
OTONOMY INC COM 68906L105 8,288 3,250,000 SH   DFND   769,200 0 2,480,800
PANDION THERAPEUTICS INC COM 698340106 31,720 528,229 SH   SOLE   528,229 0 0
PASSAGE BIO INC COM 702712100 121,711 6,962,899 SH   DFND   5,947,323 0 1,015,576
PMV PHARMACEUTICALS INC COM 69353Y103 241,098 7,330,423 SH   DFND   6,589,330 0 741,093
PRELUDE THERAPEUTICS INC COM 74065P101 435,020 10,039,691 SH   DFND   9,250,191 0 789,500
PRELUDE THERAPEUTICS INC NONVOTING 000000000 246,122 5,680,186 SH   DFND   5,596,886 0 83,300
PROGYNY INC COM 74340E103 85,693 1,925,260 SH   DFND   200,900 0 1,724,360
PROMETHEUS BIOSCIENCES INC COM 74349U108 4,565 250,000 SH   SOLE   0 0 250,000
PROTARA THERAPEUTICS INC COM STK 74365U107 7,083 450,000 SH   DFND   60,000 0 390,000
PULMONX CORP COM 745848101 5,718 125,000 SH   SOLE   0 0 125,000
PURPLE BIOTECH LTD SPONSORED ADS 74638P109 130 31,418 SH   SOLE   31,418 0 0
RELAY THERAPEUTICS INC COM 75943R102 12,100 350,000 SH   SOLE   0 0 350,000
REPARE THERAPEUTICS INC COM 760273102 105,154 3,426,325 SH   DFND   3,276,325 0 150,000
SANA BIOTECHNOLOGY INC COM 799566104 2,008 60,000 SH   SOLE   0 0 60,000
SAREPTA THERAPEUTICS INC COM 803607100 14,927 200,278 SH   DFND   64,700 0 135,578
SCPHARMACEUTICALS INC COM 810648105 31,901 4,797,148 SH   SOLE   4,797,148 0 0
SELECTA BIOSCIENCES INC COM 816212104 1,535 339,169 SH   SOLE   339,169 0 0
SI BONE INC COM 825704109 41,522 1,305,300 SH   SOLE   0 0 1,305,300
SIERRA ONCOLOGY INC COM NEW 82640U404 25,454 1,477,320 SH   DFND   1,306,860 0 170,460
SIGNIFY HEALTH INC CL A COM 82671G100 6,584 225,000 SH   SOLE   0 0 225,000
SILVER SPIKE ACQUISITION COR *W EXP 08/02/202 G8136L114 1,057 150,200 SH   SOLE   0 0 150,200
SILVER SPIKE ACQUISITION COR CL A SHS G8136L106 12,859 700,400 SH   SOLE   0 0 700,400
SILVERBACK THERAPEUTICS INC COM 82835W108 381,365 8,740,887 SH   DFND   7,788,510 0 952,377
SINOVAC BIOTECH LTD SHS P8696W104 72,000 2,839,500 SH   SOLE   0 0 2,839,500
SPRINGWORKS THERAPEUTICS INC COM 85205L107 455,127 6,186,307 SH   SOLE   6,186,307 0 0
STRONGBRIDGE BIOPHARMA PLC SHS USD G85347105 4,815 1,744,669 SH   DFND   251,200 0 1,493,469
STRYKER CORPORATION COM 863667101 82,184 337,400 SH   DFND   53,200 0 284,200
SUTRO BIOPHARMA INC COM 869367102 7,966 350,000 SH   SOLE   0 0 350,000
SYNLOGIC INC COM 87166L100 7,267 2,029,996 SH   SOLE   2,029,996 0 0
SYROS PHARMACEUTICALS INC COM 87184Q107 13,745 1,837,500 SH   SOLE   0 0 1,837,500
TCR2 THERAPEUTICS INC COM 87808K106 5,504 249,279 SH   SOLE   0 0 249,279
TELA BIO INC COM 872381108 45,110 3,027,542 SH   SOLE   3,027,542 0 0
TERNS PHARMACEUTICALS INC COM 880881107 83,406 3,791,204 SH   SOLE   3,791,204 0 0
THERAVANCE BIOPHARMA INC COM G8807B106 126,932 6,219,110 SH   DFND   674,898 0 5,544,212
THERMO FISHER SCIENTIFIC INC COM 883556102 50,339 110,300 SH   DFND   16,800 0 93,500
TRAVERE THERAPEUTICS INC COM 89422G107 13,187 528,100 SH   DFND   64,700 0 463,400
TRICIDA INC COM 89610F101 50,860 9,614,280 SH   SOLE   9,614,280 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 18 1,700 SH Call DFND   700 0 1,000
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 33,994 3,165,200 SH   DFND   206,900 0 2,958,300
TURNING POINT THERAPEUTICS I COM 90041T108 223,358 2,361,327 SH   DFND   1,743,950 0 617,377
UNIQURE NV SHS N90064101 32,648 969,079 SH   DFND   138,100 0 830,979
UNITEDHEALTH GROUP INC COM 91324P102 149,944 403,000 SH   DFND   56,500 0 346,500
VAXCYTE INC COM 92243G108 12,813 648,774 SH   SOLE   0 0 648,774
VERONA PHARMA PLC SPONSORED ADS 925050106 47,609 5,694,841 SH   DFND   5,028,174 0 666,667
VERRICA PHARMACEUTICALS INC COM 92511W108 22,418 1,479,733 SH   SOLE   1,479,733 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 244,094 1,135,900 SH   DFND   136,200 0 999,700
VISTAGEN THERAPEUTICS INC COM NEW 92840H202 18,327 8,604,000 SH   DFND   979,000 0 7,625,000
VOR BIOPHARMA INC COM 929033108 35,917 833,333 SH   SOLE   0 0 833,333
X4 PHARMACEUTICALS INC COM 98420X103 11,829 1,373,849 SH   SOLE   1,373,849 0 0
XENON PHARMACEUTICALS INC COM 98420N105 44,713 2,497,917 SH   DFND   786,612 0 1,711,305
XTANT MED HLDGS INC COM NEW 98420P308 171,981 72,873,494 SH   SOLE   72,873,494 0 0