The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2SEVENTY BIO INC COMMON STOCK 901384107 15,151 1,041,300 SH   DFND   337,000 0 704,300
89BIO INC COM 282559103 21,185 3,658,869 SH   SOLE   3,658,869 0 0
ABBVIE INC COM 00287Y109 80,526 600,000 SH   SOLE   0 0 600,000
ABCELLERA BIOLOGICS INC COM 00288U106 41,348 4,180,768 SH   SOLE   4,180,768 0 0
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 3,307 1,463,251 SH   DFND   165,001 0 1,298,250
ACLARIS THERAPEUTICS INC COM 00461U105 43,418 2,758,434 SH   DFND   488,400 0 2,270,034
ACUTUS MED INC COM 005111109 2,331 2,648,386 SH   SOLE   2,648,386 0 0
ADICET BIO INC COM 007002108 105,898 7,447,140 SH   SOLE   7,447,140 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 945 1,797,221 SH   SOLE   1,797,221 0 0
AEROVATE THERAPEUTICS INC COM 008064107 13,181 795,000 SH   DFND   227,000 0 568,000
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 50,140 250,500 SH   DFND   23,000 0 227,500
ALPINE IMMUNE SCIENCES INC COM 02083G100 29,387 4,081,592 SH   SOLE   4,081,592 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105 27,475 2,871,000 SH   DFND   605,000 0 2,266,000
AMNEAL PHARMACEUTICALS INC COM STK CL A 03168L105 3,199 1,583,490 SH   DFND   471,800 0 1,111,690
APPLIED THERAPEUTICS INC COM 03828A101 3,953 4,250,000 SH   SOLE   4,250,000 0 0
ARCUS BIOSCIENCES INC COM 03969F109 7,926 303,000 SH   DFND   152,000 0 151,000
ARCUTIS BIOTHERAPEUTICS INC COM 03969K108 53,508 2,800,000 SH   SOLE   2,800,000 0 0
ARGENX SE SPONSORED ADR 04016X101 95,218 269,700 SH   DFND   10,200 0 259,500
BELLUS HEALTH INC NEW COM NEW 07987C204 48,971 4,634,900 SH   DFND   2,139,400 0 2,495,500
BIOGEN INC COM 09062X103 59,968 224,600 SH   DFND   37,000 0 187,600
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 25,815 170,769 SH   SOLE   170,769 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 145,576 1,717,310 SH   DFND   122,200 0 1,595,110
BIOMX INC COM 09090D103 957 2,813,489 SH   SOLE   2,813,489 0 0
BOLT BIOTHERAPEUTICS INC COM 097702104 1,141 771,059 SH   SOLE   771,059 0 0
BOSTON SCIENTIFIC CORP COM 101137107 150,977 3,898,200 SH   SOLE   0 0 3,898,200
BRIDGEBIO PHARMA INC NOTE 2.500% 3/1 10806XAB8 11,760 20,000,000 PRN   SOLE   20,000,000 0 0
BRIDGEBIO PHARMA INC NOTE 2.250% 2/0 10806XAD4 12,509 30,000,000 PRN   SOLE   30,000,000 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 183,761 2,584,900 SH   SOLE   0 0 2,584,900
BURNING ROCK BIOTECH LTD SPONSORED ADS 12233L107 3,066 1,282,816 SH   DFND   58,222 0 1,224,594
CHEMOMAB THERAPEUTICS LTD SPONSORED ADS 16385C104 6,420 2,578,174 SH   SOLE   2,578,174 0 0
CHINOOK THERAPEUTICS INC COM 16961L106 39,896 2,029,300 SH   DFND   478,300 0 1,551,000
CINCOR PHARMA INC COM 17240Y109 10,312 314,202 SH   DFND   93,700 0 220,502
COMPASS THERAPEUTICS INC COM 20454B104 50,071 21,960,850 SH   DFND   18,389,422 0 3,571,428
CORVUS PHARMACEUTICALS INC COM 221015100 5,683 6,943,654 SH   SOLE   6,943,654 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 62,787 3,196,876 SH   SOLE   3,196,876 0 0
CULLINAN ONCOLOGY INC COM 230031106 8,170 637,287 SH   SOLE   637,287 0 0
CYBIN INC COM 23256X100 5,082 10,453,600 SH   SOLE   0 0 10,453,600
DECIBEL THERAPEUTICS INC COM 24343R106 17,110 4,945,192 SH   DFND   4,061,774 0 883,418
DYNE THERAPEUTICS INC COM 26818M108 2,799 220,400 SH   SOLE   0 0 220,400
EDGEWISE THERAPEUTICS INC COM 28036F105 143,341 14,567,176 SH   DFND   14,301,551 0 265,625
EDWARDS LIFESCIENCES CORP COM 28176E108 79,845 966,300 SH   SOLE   0 0 966,300
ESSA PHARMA INC COM NEW 29668H708 1,166 640,645 SH   SOLE   640,645 0 0
EVOLENT HEALTH INC CL A 30050B101 71,670 1,994,717 SH   SOLE   0 0 1,994,717
EYEPOINT PHARMACEUTICALS INC COM NEW 30233G209 7,680 970,860 SH   DFND   232,000 0 738,860
FUSION PHARMACEUTICALS INC COM 36118A100 9,707 3,224,770 SH   DFND   2,930,670 0 294,100
GALECTO INC COM 36322Q107 7,732 4,090,937 SH   DFND   3,803,255 0 287,682
GEMINI THERAPEUTICS INC COM 36870G105 9,555 5,826,223 SH   SOLE   5,826,223 0 0
GH RESEARCH PLC ORDINARY SHARES G3855L106 18,848 1,622,060 SH   DFND   239,100 0 1,382,960
GRACELL BIOTECHNOLOGIES INC SPONSORED ADS 38406L103 25,389 7,884,870 SH   DFND   5,970,672 0 1,914,198
GRAPHITE BIO INC COM 38870X104 2,689 848,412 SH   SOLE   0 0 848,412
GRAYBUG VISION INC COMMON 38942Q103 3,915 4,163,347 SH   SOLE   4,163,347 0 0
GUARDANT HEALTH INC COM 40131M109 53,421 992,400 SH   SOLE   0 0 992,400
HARPOON THERAPEUTICS INC COM 41358P106 2,935 3,025,908 SH   DFND   1,368,808 0 1,657,100
HERON THERAPEUTICS INC COM 427746102 4,739 1,123,000 SH   SOLE   0 0 1,123,000
HUMANA INC COM 444859102 169,186 348,700 SH   SOLE   0 0 348,700
IKENA ONCOLOGY INC COM 45175G108 10,415 2,933,941 SH   DFND   1,936,886 0 997,055
IKENA ONCOLOGY INC NONVOTING 000000000 22,960 6,467,691 SH   DFND   5,838,536 0 629,155
IMARA INC COM 45249V107 10,001 4,386,568 SH   DFND   4,199,068 0 187,500
INTUITIVE SURGICAL INC COM NEW 46120E602 107,347 572,700 SH   SOLE   0 0 572,700
INVIVYD INC COM 00534A102 16,496 5,270,400 SH   SOLE   5,270,400 0 0
IONIS PHARMACEUTICALS INC COM 462222100 34,008 768,900 SH   SOLE   0 0 768,900
IOVANCE BIOTHERAPEUTICS INC COM 462260100 19,231 2,007,458 SH   SOLE   0 0 2,007,458
JANUX THERAPEUTICS INC COM 47103J105 38,405 2,836,386 SH   DFND   2,489,664 0 346,722
JOUNCE THERAPEUTICS INC COM 481116101 6,854 2,928,900 SH   DFND   728,700 0 2,200,200
KALVISTA PHARMACEUTICALS INC COM 483497103 15,119 1,042,000 SH   DFND   243,000 0 799,000
KEROS THERAPEUTICS INC COM 492327101 63,180 1,679,417 SH   DFND   1,268,734 0 410,683
KEZAR LIFE SCIENCES INC COM 49372L100 15,254 1,771,700 SH   DFND   452,000 0 1,319,700
KINNATE BIOPHARMA INC COM 49705R105 48,321 4,043,629 SH   DFND   3,593,629 0 450,000
LILLY ELI & CO COM 532457108 4,850 15,000 SH Call DFND   4,500 0 10,500
LOGICBIO THERAPEUTICS INC COM 54142F102 2,307 8,466,783 SH   DFND   7,948,265 0 518,518
LONGBOARD PHARMACEUTICALS IN COM 54300N103 422 113,500 SH   SOLE   0 0 113,500
MAGENTA THERAPEUTICS INC COM 55910K108 3,174 2,250,953 SH   DFND   543,000 0 1,707,953
MEIRAGTX HLDGS PLC COM G59665102 17,729 2,108,143 SH   DFND   87,800 0 2,020,343
MEREO BIOPHARMA GROUP PLC SPON ADS 589492107 9,132 10,605,522 SH   DFND   5,777,210 0 4,828,312
MERSANA THERAPEUTICS INC COM 59045L106 60,917 9,011,437 SH   DFND   1,928,600 0 7,082,837
MIRATI THERAPEUTICS INC COM 60468T105 99,095 1,418,892 SH   DFND   131,500 0 1,287,392
MIRUM PHARMACEUTICALS INC COM 604749101 10,965 521,891 SH   DFND   279,500 0 242,391
MONTE ROSA THERAPEUTICS INC COM 61225M102 960 117,455 SH   SOLE   0 0 117,455
NATERA INC COM 632307104 65,956 1,505,153 SH   DFND   15,400 0 1,489,753
NEUROCRINE BIOSCIENCES INC COM 64125C109 95,222 896,545 SH   SOLE   0 0 896,545
NEUROPACE INC COM 641288105 15,046 4,012,281 SH   SOLE   4,012,281 0 0
NEXTCURE INC COM 65343E108 7,455 2,711,013 SH   SOLE   2,711,013 0 0
ONCOCYTE CORP COM 68235C107 1,374 1,882,768 SH   DFND   438,600 0 1,444,168
ORIC PHARMACEUTICALS INC COM 68622P109 6,680 2,087,568 SH   SOLE   2,087,568 0 0
PASSAGE BIO INC COM 702712100 11,165 8,931,999 SH   DFND   6,841,423 0 2,090,576
PFIZER INC COM 717081103 113,732 2,599,000 SH   SOLE   0 0 2,599,000
PMV PHARMACEUTICALS INC COM 69353Y103 78,101 6,563,077 SH   SOLE   6,563,077 0 0
PRELUDE THERAPEUTICS INC COM 74065P101 66,362 10,039,691 SH   DFND   9,250,191 0 789,500
PRELUDE THERAPEUTICS INC NONVOTING 000000000 37,546 5,680,186 SH   DFND   5,596,886 0 83,300
PROGYNY INC COM 74340E103 42,028 1,134,053 SH   SOLE   0 0 1,134,053
PROTARA THERAPEUTICS INC COM STK 74365U107 2,459 830,641 SH   DFND   158,900 0 671,741
PULMONX CORP COM 745848101 7,247 435,000 SH   DFND   83,600 0 351,400
PYXIS ONCOLOGY INC COMMON STOCK 747324101 1,671 848,252 SH   SOLE   0 0 848,252
RAPT THERAPEUTICS INC COM 75382E109 30,101 1,251,070 SH   DFND   310,400 0 940,670
REPARE THERAPEUTICS INC COM 760273102 40,302 3,322,488 SH   DFND   3,177,041 0 145,447
RXSIGHT INC COM 78349D107 14,434 1,202,833 SH   DFND   279,100 0 923,733
SAREPTA THERAPEUTICS INC COM 803607100 101,531 918,500 SH   DFND   43,000 0 875,500
SCHOLAR ROCK HLDG CORP COM 80706P103 4,629 667,943 SH   DFND   267,689 0 400,254
SCPHARMACEUTICALS INC COM 810648105 31,277 4,797,148 SH   SOLE   4,797,148 0 0
SEAGEN INC COM 81181C104 3,421 25,000 SH Call DFND   8,000 0 17,000
SEAGEN INC COM 81181C104 104,347 762,600 SH   DFND   59,800 0 702,800
SI-BONE INC COM 825704109 58,805 3,368,000 SH   DFND   166,900 0 3,201,100
SILVERBACK THERAPEUTICS INC COM 82835W108 46,152 8,740,887 SH   DFND   7,788,510 0 952,377
SINGULAR GENOMICS SYSTEMS IN COM 82933R100 1,352 540,697 SH   SOLE   540,697 0 0
SINOVAC BIOTECH LTD SHS P8696W104 340,500 2,718,735 SH   SOLE   0 0 2,718,735
SPDR SER TR S&P BIOTECH 78464A870 6,060 76,400 SH   DFND   24,000 0 52,400
SPRINGWORKS THERAPEUTICS INC COM 85205L107 157,655 5,525,926 SH   SOLE   5,525,926 0 0
STRYKER CORPORATION COM 863667101 85,695 423,100 SH   SOLE   0 0 423,100
SYNDAX PHARMACEUTICALS INC COM 87164F105 48,216 2,006,500 SH   DFND   444,000 0 1,562,500
SYNLOGIC INC COM 87166L100 5,728 6,029,995 SH   SOLE   6,029,995 0 0
TELA BIO INC COM 872381108 25,795 3,027,542 SH   SOLE   3,027,542 0 0
TENET HEALTHCARE CORP COM NEW 88033G407 33,181 643,300 SH   SOLE   0 0 643,300
TERNS PHARMACEUTICALS INC COM 880881107 44,064 7,481,204 SH   SOLE   7,481,204 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 102,554 202,200 SH   SOLE   0 0 202,200
THESEUS PHARMACEUTICALS INC COM 88369M101 98,842 17,041,668 SH   SOLE   17,041,668 0 0
THIRD HARMONIC BIO INC COM 88427A107 109,629 5,779,071 SH   SOLE   5,779,071 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 30,877 1,253,130 SH   DFND   267,700 0 985,430
TRICIDA INC COM 89610F101 107,744 10,280,947 SH   SOLE   10,280,947 0 0
UNIQURE NV SHS N90064101 29,960 1,597,000 SH   SOLE   0 0 1,597,000
UNITEDHEALTH GROUP INC COM 91324P102 134,947 267,200 SH   SOLE   0 0 267,200
VAXCYTE INC COM 92243G108 6,000 250,000 SH Call DFND   76,000 0 174,000
VAXCYTE INC COM 92243G108 17,230 717,900 SH   DFND   161,000 0 556,900
VECTIVBIO HLDG AG ORD SHS H9060V101 38,841 6,473,561 SH   DFND   6,180,261 0 293,300
VENTYX BIOSCIENCES INC COM 92332V107 7,855 225,000 SH   DFND   103,788 0 121,212
VERASTEM INC COM 92337C104 14,620 17,200,000 SH   SOLE   17,200,000 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 58,201 5,694,841 SH   DFND   5,028,174 0 666,667
VERTEX PHARMACEUTICALS INC COM 92532F100 108,056 373,200 SH   SOLE   0 0 373,200
VIGIL NEUROSCIENCE INC COM 92673K108 3,742 411,191 SH   SOLE   411,191 0 0
VOR BIOPHARMA INC COM 929033108 445 111,808 SH   SOLE   0 0 111,808
X4 PHARMACEUTICALS INC COM 98420X103 8,596 5,026,817 SH   SOLE   5,026,817 0 0
XENON PHARMACEUTICALS INC COM 98420N105 41,057 1,137,300 SH   DFND   218,200 0 919,100
XTANT MED HLDGS INC COM NEW 98420P308 52,628 73,114,592 SH   SOLE   73,114,592 0 0