The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
ABBOTT LABS | COM | 002824100 | 18,629 | 440,500 | SH | DFND | 1 | 185,300 | 0 | 255,200 | |
ABBVIE INC | COM | 00287Y109 | 266,780 | 4,229,900 | SH | DFND | 1 | 1,406,100 | 0 | 2,823,800 | |
ACHILLION PHARMACEUTICALS IN | COM | 00448Q201 | 106,168 | 13,107,200 | SH | DFND | 1 | 5,140,500 | 0 | 7,966,700 | |
ADAPTIMMUNE THERAPEUTICS PLC | SPONDS ADR | 00653A107 | 5,105 | 724,184 | SH | SOLE | 724,184 | 0 | 0 | ||
AEGLEA BIOTHERAPEUTICS INC | COM | 00773J103 | 8,719 | 1,360,224 | SH | SOLE | 1,360,224 | 0 | 0 | ||
AERIE PHARMACEUTICALS INC | COM | 00771V108 | 30,083 | 797,100 | SH | DFND | 1 | 320,300 | 0 | 476,800 | |
AETNA INC NEW | COM | 00817Y108 | 13,461 | 116,600 | SH | DFND | 1 | 46,200 | 0 | 70,400 | |
AFFIMED N V | COM | N01045108 | 9,383 | 3,375,000 | SH | SOLE | 3,375,000 | 0 | 0 | ||
AGILENT TECHNOLOGIES INC | COM | 00846U101 | 174,930 | 3,714,800 | SH | DFND | 1 | 1,590,200 | 0 | 2,124,600 | |
ALEXION PHARMACEUTICALS INC | COM | 015351109 | 323,262 | 2,638,011 | SH | DFND | 1 | 875,300 | 0 | 1,762,711 | |
ALIMERA SCIENCES INC | COM | 016259103 | 373 | 250,000 | SH | DFND | 1 | 98,300 | 0 | 151,700 | |
ALLERGAN PLC | SHS | G0177J108 | 179,340 | 778,690 | SH | DFND | 1 | 288,500 | 0 | 490,190 | |
ALLERGAN PLC | SHS | G0177J108 | 11,516 | 50,000 | SH | Call | DFND | 1 | 22,000 | 0 | 28,000 |
ALLERGAN PLC | PFD CONV SER A | G0177J116 | 72,455 | 88,200 | SH | DFND | 1 | 30,300 | 0 | 57,900 | |
AMARIN CORP PLC | SPONS ADR NEW | 023111206 | 1,117 | 350,000 | SH | SOLE | 350,000 | 0 | 0 | ||
AMEDISYS INC | COM | 023436108 | 3,392 | 71,500 | SH | DFND | 1 | 32,400 | 0 | 39,100 | |
AMGEN INC | COM | 031162100 | 406,466 | 2,436,700 | SH | DFND | 1 | 725,000 | 0 | 1,711,700 | |
ARALEZ PHARMACEUTICALS INC | COM | 03852X100 | 330 | 68,143 | SH | DFND | 1 | 27,339 | 0 | 40,804 | |
ARRAY BIOPHARMA INC | COM | 04269X105 | 95,714 | 14,179,900 | SH | DFND | 1 | 5,395,600 | 0 | 8,784,300 | |
ARROWHEAD PHARMACEUTICALS IN | COM | 04280A100 | 15,876 | 2,159,973 | SH | DFND | 1 | 987,200 | 0 | 1,172,773 | |
ASCENDIS PHARMA A S | SPONSORED ADR | 04351P101 | 44,039 | 2,191,000 | SH | SOLE | 2,191,000 | 0 | 0 | ||
ASSEMBLY BIOSCIENCES INC | COM | 045396108 | 10,073 | 1,397,100 | SH | DFND | 1 | 647,100 | 0 | 750,000 | |
AUDENTES THERAPEUTICS INC | COM | 05070R104 | 85,517 | 4,801,638 | SH | SOLE | 4,801,638 | 0 | 0 | ||
BARD C R INC | COM | 067383109 | 13,008 | 58,000 | SH | DFND | 1 | 26,300 | 0 | 31,700 | |
BIOGEN INC | COM | 09062X103 | 417,551 | 1,333,900 | SH | DFND | 1 | 403,600 | 0 | 930,300 | |
BIOLINERX LTD | SPONSORED ADR | 09071M106 | 1,194 | 1,038,600 | SH | SOLE | 1,038,600 | 0 | 0 | ||
BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 106,574 | 1,151,900 | SH | DFND | 1 | 331,700 | 0 | 820,200 | |
BIOMARIN PHARMACEUTICAL INC | NOTE 0.750%10/1 | 09061GAE1 | 600 | 500,000 | PRN | DFND | 1 | 215,000 | 0 | 285,000 | |
BIOMARIN PHARMACEUTICAL INC | NOTE 1.500%10/1 | 09061GAF8 | 624 | 500,000 | PRN | DFND | 1 | 215,000 | 0 | 285,000 | |
BLUEBIRD BIO INC | COM | 09609G100 | 80,374 | 1,185,800 | SH | DFND | 1 | 475,600 | 0 | 710,200 | |
BOSTON SCIENTIFIC CORP | COM | 101137107 | 409,638 | 17,211,700 | SH | DFND | 1 | 6,316,400 | 0 | 10,895,300 | |
BRISTOL MYERS SQUIBB CO | COM | 110122108 | 117,945 | 2,187,400 | SH | DFND | 1 | 730,200 | 0 | 1,457,200 | |
BRISTOL MYERS SQUIBB CO | COM | 110122108 | 5,392 | 100,000 | SH | Call | DFND | 1 | 45,500 | 0 | 54,500 |
CELGENE CORP | COM | 151020104 | 308,215 | 2,948,577 | SH | DFND | 1 | 1,062,200 | 0 | 1,886,377 | |
CELLECTIS S A | SPONSORED ADS | 15117K103 | 8,428 | 350,000 | SH | DFND | 1 | 162,100 | 0 | 187,900 | |
CIGNA CORPORATION | COM | 125509109 | 42,445 | 325,700 | SH | DFND | 1 | 143,300 | 0 | 182,400 | |
COGENTIX MED INC | COM | 19243A104 | 1,598 | 878,145 | SH | DFND | 1 | 386,807 | 0 | 491,338 | |
COHERUS BIOSCIENCES INC | COM | 19249H103 | 17,985 | 671,600 | SH | DFND | 1 | 139,300 | 0 | 532,300 | |
COOPER COS INC | COM NEW | 216648402 | 44,833 | 250,100 | SH | DFND | 1 | 83,500 | 0 | 166,600 | |
CORVUS PHARMACEUTICALS INC | COM | 221015100 | 88,490 | 5,379,349 | SH | SOLE | 5,379,349 | 0 | 0 | ||
CYNAPSUS THERAPEUTICS INC | COM PAR NO PAR | 23257Y859 | 20,114 | 499,999 | SH | SOLE | 499,999 | 0 | 0 | ||
DBV TECHNOLOGIES S A | SPONSORED ADR | 23306J101 | 12,559 | 345,700 | SH | SOLE | 345,700 | 0 | 0 | ||
DERMIRA INC | COM | 24983L104 | 14,394 | 425,600 | SH | SOLE | 425,600 | 0 | 0 | ||
DIMENSION THERAPEUTICS INC | COM | 25433V105 | 43,128 | 5,397,698 | SH | SOLE | 5,397,698 | 0 | 0 | ||
EAGLE PHARMACEUTICALS INC | COM | 269796108 | 72,527 | 1,036,100 | SH | DFND | 1 | 457,200 | 0 | 578,900 | |
EDWARDS LIFESCIENCES CORP | COM | 28176E108 | 165,553 | 1,373,200 | SH | DFND | 1 | 500,700 | 0 | 872,500 | |
EHEALTH INC | COM | 28238P109 | 20,346 | 1,815,000 | SH | DFND | 1 | 833,900 | 0 | 981,100 | |
EXACT SCIENCES CORP | COM | 30063P105 | 20,457 | 1,101,600 | SH | SOLE | 1,101,600 | 0 | 0 | ||
EXELIXIS INC | COM | 30161Q104 | 79,379 | 6,206,300 | SH | DFND | 1 | 2,430,400 | 0 | 3,775,900 | |
EXPRESS SCRIPTS HLDG CO | COM | 30219G108 | 102,403 | 1,451,900 | SH | DFND | 1 | 551,800 | 0 | 900,100 | |
FLUIDIGM CORP DEL | COM | 34385P108 | 13,986 | 1,746,100 | SH | DFND | 1 | 215,500 | 0 | 1,530,600 | |
FLUIDIGM CORP DEL | NOTE 2.750% 2/0 | 34385PAA6 | 6,213 | 10,000,000 | PRN | DFND | 1 | 4,466,000 | 0 | 5,534,000 | |
FORWARD PHARMA A/S | SPONSORED ADR | 34986J105 | 16,750 | 798,000 | SH | DFND | 1 | 226,500 | 0 | 571,500 | |
GALAPAGOS NV | SPON ADR | 36315X101 | 29,608 | 457,900 | SH | DFND | 1 | 32,000 | 0 | 425,900 | |
GILEAD SCIENCES INC | COM | 375558103 | 159,087 | 2,010,700 | SH | DFND | 1 | 618,400 | 0 | 1,392,300 | |
GLAUKOS CORP | COM | 377322102 | 82,273 | 2,180,000 | SH | SOLE | 2,180,000 | 0 | 0 | ||
GW PHARMACEUTICALS PLC | ADS | 36197T103 | 4,805 | 36,200 | SH | SOLE | 36,200 | 0 | 0 | ||
HCA HOLDINGS INC | COM | 40412C101 | 99,242 | 1,312,200 | SH | DFND | 1 | 344,800 | 0 | 967,400 | |
HUMANA INC | COM | 444859102 | 74,913 | 423,500 | SH | DFND | 1 | 132,800 | 0 | 290,700 | |
ILLUMINA INC | COM | 452327109 | 90,013 | 495,500 | SH | DFND | 1 | 108,100 | 0 | 387,400 | |
IMMUNOGEN INC | COM | 45253H101 | 16,336 | 6,095,647 | SH | DFND | 1 | 1,919,480 | 0 | 4,176,167 | |
IMMUNOMEDICS INC | COM | 452907108 | 12,357 | 3,802,000 | SH | DFND | 1 | 2,050,550 | 0 | 1,751,450 | |
IMMUNOMEDICS INC | NOTE 4.750% 2/1 | 452907AK4 | 25,479 | 30,000,000 | PRN | DFND | 1 | 16,014,000 | 0 | 13,986,000 | |
IMPAX LABORATORIES INC | COM | 45256B101 | 89,764 | 3,787,500 | SH | DFND | 1 | 1,348,300 | 0 | 2,439,200 | |
INCYTE CORP | COM | 45337C102 | 174,453 | 1,850,178 | SH | DFND | 1 | 475,200 | 0 | 1,374,978 | |
INCYTE CORP | NOTE 0.375%11/1 | 45337CAM4 | 8,090 | 4,250,000 | PRN | DFND | 1 | 1,816,000 | 0 | 2,434,000 | |
INCYTE CORP | NOTE 1.250%11/1 | 45337CAN2 | 8,267 | 4,250,000 | PRN | DFND | 1 | 1,816,000 | 0 | 2,434,000 | |
INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 5,070 | 3,250,300 | SH | DFND | 1 | 1,064,000 | 0 | 2,186,300 | |
INOTEK PHARMACEUTICALS CORP | COM | 45780V102 | 17,531 | 1,849,300 | SH | DFND | 1 | 846,500 | 0 | 1,002,800 | |
INOTEK PHARMACEUTICALS CORP | NOTE 5.750% 8/0 | 45780VAB8 | 9,547 | 7,000,000 | PRN | DFND | 1 | 3,200,000 | 0 | 3,800,000 | |
INSMED INC | COM PAR $.01 | 457669307 | 76,246 | 5,251,100 | SH | DFND | 1 | 2,329,260 | 0 | 2,921,840 | |
INSYS THERAPEUTICS INC NEW | COM NEW | 45824V209 | 64,871 | 5,502,240 | SH | DFND | 1 | 2,228,100 | 0 | 3,274,140 | |
INTELLIA THERAPEUTICS INC | COM | 45826J105 | 45,310 | 2,662,180 | SH | SOLE | 2,662,180 | 0 | 0 | ||
INTERCEPT PHARMACEUTICALS IN | COM | 45845P108 | 184,341 | 1,120,000 | SH | SOLE | 1,120,000 | 0 | 0 | ||
INTRA CELLULAR THERAPIES INC | COM | 46116X101 | 1,373 | 90,000 | SH | Call | DFND | 1 | 41,200 | 0 | 48,800 |
INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 136,123 | 187,800 | SH | DFND | 1 | 40,600 | 0 | 147,200 | |
INVITAE CORP | COM | 46185L103 | 4,000 | 456,666 | SH | SOLE | 456,666 | 0 | 0 | ||
IRONWOOD PHARMACEUTICALS INC | COM CL A | 46333X108 | 157,990 | 9,949,000 | SH | DFND | 1 | 3,595,700 | 0 | 6,353,300 | |
JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 | 29,993 | 246,900 | SH | DFND | 1 | 83,500 | 0 | 163,400 | |
JOHNSON & JOHNSON | COM | 478160104 | 101,356 | 858,000 | SH | DFND | 1 | 370,700 | 0 | 487,300 | |
LILLY ELI & CO | COM | 532457108 | 163,771 | 2,040,500 | SH | DFND | 1 | 671,000 | 0 | 1,369,500 | |
LILLY ELI & CO | COM | 532457108 | 20,065 | 250,000 | SH | Call | DFND | 1 | 112,500 | 0 | 137,500 |
LION BIOTECHNOLOGIES INC | COM | 53619R102 | 27,841 | 3,382,900 | SH | DFND | 1 | 1,446,500 | 0 | 1,936,400 | |
LOXO ONCOLOGY INC | COM | 548862101 | 45,239 | 1,728,000 | SH | SOLE | 1,728,000 | 0 | 0 | ||
MAGELLAN HEALTH INC | COM NEW | 559079207 | 37,595 | 699,700 | SH | DFND | 1 | 310,900 | 0 | 388,800 | |
MALLINCKRODT PUB LTD CO | SHS | G5785G107 | 81,657 | 1,170,200 | SH | DFND | 1 | 510,200 | 0 | 660,000 | |
MARINUS PHARMACEUTICALS INC | COM | 56854Q101 | 1,033 | 567,600 | SH | SOLE | 567,600 | 0 | 0 | ||
MEDIGUS LTD | SPONSORED ADR | 58471G102 | 756 | 600,000 | SH | SOLE | 600,000 | 0 | 0 | ||
MEDTRONIC PLC | SHS | G5960L103 | 66,234 | 766,600 | SH | DFND | 1 | 322,100 | 0 | 444,500 | |
MERCK & CO INC | COM | 58933Y105 | 218,859 | 3,506,800 | SH | DFND | 1 | 1,197,100 | 0 | 2,309,700 | |
MERCK & CO INC | COM | 58933Y105 | 21,847 | 350,000 | SH | Call | DFND | 1 | 160,500 | 0 | 189,500 |
MINERVA NEUROSCIENCES INC | COM | 603380106 | 7,851 | 556,200 | SH | SOLE | 556,200 | 0 | 0 | ||
MOLINA HEALTHCARE INC | COM | 60855R100 | 153,656 | 2,634,700 | SH | DFND | 1 | 900,000 | 0 | 1,734,700 | |
NABRIVA THERAPEUTICS AG | SPONSORED ADR | 62957M104 | 9,271 | 1,315,000 | SH | SOLE | 1,315,000 | 0 | 0 | ||
NATERA INC | COM | 632307104 | 14,178 | 1,276,190 | SH | SOLE | 1,276,190 | 0 | 0 | ||
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 91,936 | 1,815,474 | SH | DFND | 1 | 743,370 | 0 | 1,072,104 | |
NEWLINK GENETICS CORP | COM | 651511107 | 29,113 | 1,938,300 | SH | DFND | 1 | 721,200 | 0 | 1,217,100 | |
NIVALIS THERAPEUTICS INC | COM | 65481J109 | 480 | 59,000 | SH | SOLE | 59,000 | 0 | 0 | ||
NUVASIVE INC | COM | 670704105 | 8,233 | 123,500 | SH | SOLE | 123,500 | 0 | 0 | ||
OPHTHOTECH CORP | COM | 683745103 | 53,797 | 1,166,200 | SH | DFND | 1 | 419,460 | 0 | 746,740 | |
OREXIGEN THERAPEUTICS INC | NOTE 2.750%12/0 | 686164AB0 | 1,441 | 5,210,000 | PRN | DFND | 1 | 2,210,000 | 0 | 3,000,000 | |
OTONOMY INC | COM | 68906L105 | 33,653 | 1,850,094 | SH | SOLE | 1,850,094 | 0 | 0 | ||
PERNIX THERAPEUTICS HLDGS IN | COM | 71426V108 | 668 | 1,073,000 | SH | DFND | 1 | 485,000 | 0 | 588,000 | |
PERNIX THERAPEUTICS HLDGS IN | DBCV 4.250% 4/0 | 71426VAK4 | 3,514 | 12,000,000 | PRN | DFND | 1 | 6,500,000 | 0 | 5,500,000 | |
PFIZER INC | COM | 717081103 | 119,636 | 3,532,200 | SH | DFND | 1 | 1,486,000 | 0 | 2,046,200 | |
PIERIS PHARMACEUTICALS INC | COM | 720795103 | 13,267 | 7,259,620 | SH | SOLE | 7,259,620 | 0 | 0 | ||
PORTOLA PHARMACEUTICALS INC | COM | 737010108 | 8,423 | 370,900 | SH | SOLE | 370,900 | 0 | 0 | ||
PROQR THRAPEUTICS N V | SHS EURO | N71542109 | 15,377 | 2,305,446 | SH | DFND | 1 | 973,446 | 0 | 1,332,000 | |
PUMA BIOTECHNOLOGY INC | COM | 74587V107 | 159,815 | 2,383,525 | SH | DFND | 1 | 949,000 | 0 | 1,434,525 | |
QLT INC | COM | 746927102 | 1,030 | 500,000 | SH | DFND | 1 | 200,600 | 0 | 299,400 | |
REDHILL BIOPHARMA LTD | SPONSORED ADS | 757468103 | 7,846 | 564,900 | SH | SOLE | 564,900 | 0 | 0 | ||
REGENERON PHARMACEUTICALS | COM | 75886F107 | 142,838 | 355,300 | SH | DFND | 1 | 101,200 | 0 | 254,100 | |
ROKA BIOSCIENCE INC | COM | 775431109 | 2,238 | 3,220,429 | SH | SOLE | 3,220,429 | 0 | 0 | ||
SAGE THERAPEUTICS INC | COM | 78667J108 | 10,840 | 235,400 | SH | DFND | 1 | 107,500 | 0 | 127,900 | |
SANGAMO BIOSCIENCES INC | COM | 800677106 | 3,850 | 831,500 | SH | SOLE | 831,500 | 0 | 0 | ||
SAREPTA THERAPEUTICS INC | COM | 803607100 | 16,077 | 261,800 | SH | DFND | 1 | 116,300 | 0 | 145,500 | |
SELECTA BIOSCIENCES INC | COM | 816212104 | 26,260 | 1,842,797 | SH | SOLE | 1,842,797 | 0 | 0 | ||
SHIRE PLC | SPONSORED ADR | 82481R106 | 206,141 | 1,063,351 | SH | DFND | 1 | 368,100 | 0 | 695,251 | |
SIENTRA INC | COM | 82621J105 | 8,248 | 917,500 | SH | SOLE | 917,500 | 0 | 0 | ||
SINOVAC BIOTECH LTD | SHS | P8696W104 | 15,738 | 2,667,500 | SH | DFND | 1 | 1,219,500 | 0 | 1,448,000 | |
STEADYMED LTD | SHS | M84920103 | 11,029 | 3,072,196 | SH | SOLE | 3,072,196 | 0 | 0 | ||
STRYKER CORP | COM | 863667101 | 24,679 | 212,000 | SH | DFND | 1 | 77,000 | 0 | 135,000 | |
SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 11,482 | 757,365 | SH | SOLE | 757,365 | 0 | 0 | ||
SYNERGY PHARMACEUTICALS DEL | COM NEW | 871639308 | 32,931 | 5,976,648 | SH | DFND | 1 | 3,262,300 | 0 | 2,714,348 | |
TENET HEALTHCARE CORP | COM NEW | 88033G407 | 45,161 | 1,993,000 | SH | DFND | 1 | 888,900 | 0 | 1,104,100 | |
TEVA PHARMACEUTICAL INDS LTD | ADR | 881624209 | 84,263 | 1,831,400 | SH | DFND | 1 | 695,800 | 0 | 1,135,600 | |
THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 129,872 | 816,500 | SH | DFND | 1 | 308,200 | 0 | 508,300 | |
ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 | 12,010 | 169,300 | SH | DFND | 1 | 58,300 | 0 | 111,000 | |
UNIQURE NV | SHS | N90064101 | 3,741 | 489,000 | SH | SOLE | 489,000 | 0 | 0 | ||
UNITEDHEALTH GROUP INC | COM | 91324P102 | 85,652 | 611,800 | SH | DFND | 1 | 197,000 | 0 | 414,800 | |
VALEANT PHARMACEUTICALS INTL | COM | 91911K102 | 4,785 | 194,900 | SH | DFND | 1 | 76,800 | 0 | 118,100 | |
VANDA PHARMACEUTICALS INC | COM | 921659108 | 12,480 | 750,000 | SH | Call | DFND | 1 | 343,000 | 0 | 407,000 |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 140,583 | 1,612,000 | SH | DFND | 1 | 395,000 | 0 | 1,217,000 | |
VIEWRAY INC | COM | 92672L107 | 41,259 | 9,127,990 | SH | SOLE | 9,127,990 | 0 | 0 | ||
WELLCARE HEALTH PLANS INC | COM | 94946T106 | 146,128 | 1,248,000 | SH | DFND | 1 | 437,600 | 0 | 810,400 | |
WRIGHT MED GROUP N V | ORD SHS 0.03 PAR | N96617118 | 180,448 | 7,356,233 | SH | DFND | 1 | 2,456,550 | 0 | 4,899,683 | |
XENCOR INC | COM | 98401F105 | 18,233 | 744,522 | SH | SOLE | 744,522 | 0 | 0 | ||
XENON PHARMACEUTICALS INC | COM | 98420N105 | 8,100 | 1,000,000 | SH | SOLE | 1,000,000 | 0 | 0 | ||
XTANT MED HLDGS INC | COM | 98420P100 | 537 | 475,439 | SH | SOLE | 475,439 | 0 | 0 | ||
ZIMMER BIOMET HLDGS INC | COM | 98956P102 | 93,289 | 717,500 | SH | DFND | 1 | 315,700 | 0 | 401,800 |