The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109 101,604 1,050,600 SH   DFND 1 710,000 0 340,600
ACADIA PHARMACEUTICALS INC COM 004225108 25,566 849,100 SH   DFND 1 229,700 0 619,400
ACHILLION PHARMACEUTICALS IN COM 00448Q201 23,532 8,170,973 SH   DFND 1 3,234,800 0 4,936,173
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 12,790 1,914,660 SH   SOLE   1,914,660 0 0
AEGERION PHARMACEUTICALS INC NOTE 2.000% 8/1 00767EAB8 12,006 15,000,000 PRN   DFND 1 6,995,000 0 8,005,000
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 7,950 1,469,524 SH   SOLE   1,469,524 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 79,444 1,329,600 SH   DFND 1 530,200 0 799,400
AETNA INC NEW COM 00817Y108 80,734 447,552 SH   DFND 1 196,400 0 251,152
AFFIMED N V COM N01045108 425 326,650 SH   SOLE   326,650 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 173,499 2,590,700 SH   DFND 1 1,465,700 0 1,125,000
ALEXION PHARMACEUTICALS INC COM 015351109 344,368 2,879,575 SH   DFND 1 1,437,200 0 1,442,375
ALIMERA SCIENCES INC COM 016259103 333 250,000 SH   DFND 1 98,300 0 151,700
ALKERMES PLC SHS G01767105 7,936 145,000 SH   SOLE   0 0 145,000
ALLERGAN PLC SHS G0177J108 46,995 287,290 SH   DFND 1 143,600 0 143,690
ALLERGAN PLC 5.5% CNV PFD A G0177J116 42,034 71,700 PRN   DFND 1 30,300 0 41,400
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 119,630 941,600 SH   DFND 1 305,100 0 636,500
ALPINE IMMUNE SCIENCES INC COM 02083G100 36,943 3,298,516 SH   SOLE   3,298,516 0 0
AMEDISYS INC COM 023436108 10,937 207,500 SH   DFND 1 63,100 0 144,400
AMGEN INC COM 031162100 225,566 1,297,100 SH   DFND 1 488,800 0 808,300
AMICUS THERAPEUTICS INC COM 03152W109 80,188 5,572,500 SH   DFND 1 1,966,900 0 3,605,600
ANTHEM INC COM 036752103 148,218 658,718 SH   DFND 1 298,400 0 360,318
ARGENX SE SPONSORED ADR 04016X101 31,570 500,000 SH   DFND 1 238,400 0 261,600
ARRAY BIOPHARMA INC COM 04269X105 97,554 7,621,400 SH   DFND 1 3,322,200 0 4,299,200
ARSANIS INC COM 042873109 23,848 1,868,966 SH   SOLE   1,868,966 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 134,895 3,367,315 SH   DFND 1 3,026,915 0 340,400
ASSEMBLY BIOSCIENCES INC COM 045396108 54,211 1,198,026 SH   DFND 1 572,726 0 625,300
AUDENTES THERAPEUTICS INC COM 05070R104 129,051 4,129,638 SH   SOLE   4,129,638 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 8,142 1,797,400 SH   SOLE   0 0 1,797,400
BEIGENE LTD SPONSORED ADR 07725L102 101,774 1,041,488 SH   DFND 1 412,797 0 628,691
BIOGEN INC COM 09062X103 392,064 1,230,700 SH   DFND 1 523,100 0 707,600
BIOLINERX LTD SPONSORED ADR 09071M106 1,132 1,038,600 SH   SOLE   1,038,600 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 8,971 100,600 SH   SOLE   0 0 100,600
BIOMARIN PHARMACEUTICAL INC NOTE 0.750%10/1 09061GAE1 540 500,000 PRN   DFND 1 215,000 0 285,000
BIOMARIN PHARMACEUTICAL INC NOTE 1.500%10/1 09061GAF8 594 500,000 PRN   DFND 1 215,000 0 285,000
BLUEBIRD BIO INC COM 09609G100 68,399 384,046 SH   DFND 1 131,800 0 252,246
BOSTON SCIENTIFIC CORP COM 101137107 257,484 10,386,600 SH   DFND 1 5,109,500 0 5,277,100
BRISTOL MYERS SQUIBB CO COM 110122108 42,161 688,000 SH   DFND 1 345,500 0 342,500
CELGENE CORP COM 151020104 319,639 3,062,850 SH   DFND 1 1,254,900 0 1,807,950
CELGENE CORP COM 151020104 15,654 150,000 SH Call DFND 1 69,000 0 81,000
CIGNA CORPORATION COM 125509109 196,855 969,300 SH   DFND 1 456,500 0 512,800
CLEMENTIA PHARMACEUTICALS IN COM 185575107 197,871 10,425,225 SH   SOLE   10,425,225 0 0
CLOVIS ONCOLOGY INC COM 189464100 134,074 1,971,670 SH   DFND 1 961,800 0 1,009,870
COHERUS BIOSCIENCES INC COM 19249H103 12,949 1,471,500 SH   SOLE   0 0 1,471,500
CORVUS PHARMACEUTICALS INC COM 221015100 55,730 5,379,349 SH   SOLE   5,379,349 0 0
CTI BIOPHARMA CORP COM NEW 12648L601 13,400 5,000,000 SH   SOLE   5,000,000 0 0
DAVITA INC COM 23918K108 34,492 477,400 SH   DFND 1 305,300 0 172,100
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 14,231 578,500 SH   SOLE   0 0 578,500
DECIPHERA PHARMACEUTICALS IN COM 24344T101 26,662 1,176,070 SH   DFND 1 423,200 0 752,870
DERMIRA INC COM 24983L104 32,848 1,181,168 SH   DFND 1 413,570 0 767,598
EDWARDS LIFESCIENCES CORP COM 28176E108 126,697 1,124,100 SH   DFND 1 503,300 0 620,800
EHEALTH INC COM 28238P109 31,869 1,834,700 SH   DFND 1 843,200 0 991,500
ENDO INTL PLC SHS G30401106 7,939 1,024,386 SH   DFND 1 678,400 0 345,986
ENVISION HEALTHCARE CORP COM 29414D100 30,254 875,400 SH   DFND 1 515,100 0 360,300
FLUIDIGM CORP DEL COM 34385P108 9,328 1,583,700 SH   DFND 1 215,500 0 1,368,200
FLUIDIGM CORP DEL NOTE 2.750% 2/0 34385PAA6 8,302 10,000,000 PRN   DFND 1 4,466,000 0 5,534,000
GALAPAGOS NV SPON ADR 36315X101 45,660 486,990 SH   DFND 1 186,900 0 300,090
GILEAD SCIENCES INC COM 375558103 37,367 521,600 SH   DFND 1 157,000 0 364,600
GLAUKOS CORP COM 377322102 21,456 836,500 SH   SOLE   836,500 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 84,907 2,157,730 SH   DFND 1 1,182,700 0 975,030
GW PHARMACEUTICALS PLC ADS 36197T103 5,861 44,400 SH   SOLE   0 0 44,400
HERON THERAPEUTICS INC COM 427746102 11,765 650,000 SH   DFND 1 311,000 0 339,000
ILLUMINA INC COM 452327109 71,774 328,500 SH   DFND 1 38,800 0 289,700
IMMUNOGEN INC COM 45253H101 18,167 2,834,126 SH   DFND 1 1,318,554 0 1,515,572
IMMUNOMEDICS INC COM 452907108 136,742 8,461,727 SH   DFND 1 5,019,776 0 3,441,951
INOTEK PHARMACEUTICALS CORP NOTE 5.750% 8/0 45780VAB8 5,918 7,000,000 PRN   DFND 1 3,200,000 0 3,800,000
INSMED INC COM PAR $.01 457669307 46,670 1,496,791 SH   DFND 1 859,700 0 637,091
INSYS THERAPEUTICS INC NEW COM NEW 45824V209 52,014 5,406,844 SH   DFND 1 2,914,000 0 2,492,844
INTEGRA LIFESCIENCES HLDGS C COM NEW 457985208 34,062 711,710 SH   DFND 1 333,300 0 378,410
INTELLIA THERAPEUTICS INC COM 45826J105 44,930 2,337,684 SH   SOLE   2,337,684 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 56,055 153,600 SH   SOLE   0 0 153,600
INVITAE CORP COM 46185L103 13,785 1,518,197 SH   SOLE   1,518,197 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 44,387 5,548,326 SH   DFND 1 3,246,226 0 2,302,100
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 5,996 400,000 SH Call DFND 1 186,500 0 213,500
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 67,833 4,525,200 SH   DFND 1 2,089,300 0 2,435,900
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 81,854 607,900 SH   DFND 1 342,300 0 265,600
JOHNSON & JOHNSON COM 478160104 65,012 465,300 SH   SOLE   465,300 0 0
JUNO THERAPEUTICS INC COM 48205A109 83,886 1,835,188 SH   DFND 1 734,980 0 1,100,208
KALA PHARMACEUTICALS INC COM 483119103 43,919 2,375,279 SH   SOLE   2,375,279 0 0
LILLY ELI & CO COM 532457108 193,244 2,288,000 SH   DFND 1 1,014,800 0 1,273,200
LOXO ONCOLOGY INC COM 548862101 79,213 94,100,036 SH   SOLE   94,100,036 0 0
MAGELLAN HEALTH INC COM NEW 559079207 82,632 855,843 SH   DFND 1 404,900 0 450,943
MARINUS PHARMACEUTICALS INC COM 56854Q101 4,632 567,600 SH   SOLE   567,600 0 0
MEDIGUS LTD SPONSORD ADR NEW 58471G201 79 60,000 SH   SOLE   60,000 0 0
MEDTRONIC PLC SHS G5960L103 20,527 254,200 SH   SOLE   254,200 0 0
MERCK & CO INC COM 58933Y105 204,001 3,625,400 SH   DFND 1 1,859,500 0 1,765,900
MOMENTA PHARMACEUTICALS INC COM 60877T100 15,706 1,125,900 SH   SOLE   0 0 1,125,900
MYLAN N V SHS EURO N59465109 77,609 1,834,300 SH   DFND 1 843,100 0 991,200
NABRIVA THERAPEUTICS PLC SHS G63637105 23,439 3,919,600 SH   SOLE   3,919,600 0 0
NATERA INC COM 632307104 14,170 1,576,190 SH   SOLE   1,576,190 0 0
NEVRO CORP COM 64157F103 61,983 897,791 SH   DFND 1 281,100 0 616,691
NOVELION THERAPEUTICS INC COM NEW 67001K202 312 100,000 SH   DFND 1 40,120 0 59,880
NOVO-NORDISK A S ADR 670100205 17,711 330,000 SH   SOLE   0 0 330,000
NOVUS THERAPEUTICS INC COM 67011N105 10,301 2,537,110 SH   SOLE   2,537,110 0 0
NUVASIVE INC COM 670704105 12,909 220,700 SH   SOLE   0 0 220,700
OBSEVA SA COM H5861P103 25,430 2,605,531 SH   SOLE   2,605,531 0 0
OREXIGEN THERAPEUTICS INC NOTE 2.750%12/0 686164AC8 1,787 5,210,000 PRN   DFND 1 2,210,000 0 3,000,000
ORTHOPEDIATRICS CORP COM 68752L100 8,160 425,200 SH   DFND 1 202,100 0 223,100
PFIZER INC COM 717081103 35,568 982,000 SH   SOLE   982,000 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 54,810 7,259,620 SH   SOLE   7,259,620 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 4,202 1,302,955 SH   DFND 1 640,668 0 662,287
PUMA BIOTECHNOLOGY INC COM 74587V107 215,941 2,184,535 SH   DFND 1 945,689 0 1,238,846
RADIUS HEALTH INC COM NEW 750469207 43,579 1,371,700 SH   DFND 1 243,000 0 1,128,700
REDHILL BIOPHARMA LTD SPONSORED ADS 757468103 2,904 564,900 SH   SOLE   564,900 0 0
REGENERON PHARMACEUTICALS COM 75886F107 321,295 854,600 SH   DFND 1 351,200 0 503,400
RHYTHM PHARMACEUTICALS INC COM 76243J105 43,519 2,901,295 SH   SOLE   2,901,295 0 0
SAREPTA THERAPEUTICS INC COM 803607100 2,782 50,000 SH Call DFND 1 23,500 0 26,500
SAREPTA THERAPEUTICS INC COM 803607100 5,531 99,400 SH   SOLE   0 0 99,400
SCPHARMACEUTICALS INC COM 810648105 41,225 3,409,865 SH   SOLE   3,409,865 0 0
SELECT MED HLDGS CORP COM 81619Q105 89,560 5,074,200 SH   DFND 1 3,066,500 0 2,007,700
SELECTA BIOSCIENCES INC COM 816212104 18,078 1,842,797 SH   SOLE   1,842,797 0 0
SERES THERAPEUTICS INC COM 81750R102 2,225 219,458 SH   SOLE   0 0 219,458
SHIRE PLC SPONSORED ADR 82481R106 42,271 272,508 SH   DFND 1 173,900 0 98,608
SIERRA ONCOLOGY INC COM 82640U107 11,950 3,203,704 SH   SOLE   3,203,704 0 0
SINOVAC BIOTECH LTD SHS P8696W104 22,375 2,839,500 SH   DFND 1 1,301,200 0 1,538,300
STEADYMED LTD SHS M84920103 15,711 4,246,196 SH   SOLE   4,246,196 0 0
STRYKER CORP COM 863667101 44,284 286,000 SH   DFND 1 77,000 0 209,000
SYNDAX PHARMACEUTICALS INC COM 87164F105 3,828 437,000 SH   SOLE   437,000 0 0
SYNLOGIC INC COM 87166L100 12,755 1,314,996 SH   SOLE   1,314,996 0 0
TESARO INC COM 881569107 5,576 67,281 SH   DFND 1 41,395 0 25,886
THERMO FISHER SCIENTIFIC INC COM 883556102 73,939 389,400 SH   DFND 1 197,600 0 191,800
UNITEDHEALTH GROUP INC COM 91324P102 52,800 239,500 SH   DFND 1 101,300 0 138,200
UNIVERSAL HLTH SVCS INC CL B 913903100 19,814 174,800 SH   DFND 1 107,000 0 67,800
VALEANT PHARMACEUTICALS INTL COM 91911K102 1,596 76,800 SH   SOLE   76,800 0 0
VANDA PHARMACEUTICALS INC COM 921659108 14,711 967,859 SH   SOLE   0 0 967,859
VERONA PHARMA PLC SPONSORED ADS 925050106 14,843 1,250,396 SH   SOLE   1,250,396 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 260,951 1,741,300 SH   DFND 1 714,000 0 1,027,300
VIEWRAY INC COM 92672L107 87,586 9,458,567 SH   SOLE   9,458,567 0 0
WRIGHT MED GROUP N V ORD SHS 0.03 PAR N96617118 152,116 6,852,068 SH   DFND 1 2,778,004 0 4,074,064
WRIGHT MED GROUP N V RIGHT 03/01/2019 N96617126 13,207 8,746,583 SH   SOLE   0 0 8,746,583
XENCOR INC COM 98401F105 22,404 1,022,100 SH   SOLE   0 0 1,022,100
XENON PHARMACEUTICALS INC COM 98420N105 1,793 634,812 SH   SOLE   634,812 0 0
XTANT MED HLDGS INC COM 98420P100 272 4,754,386 SH   SOLE   4,754,386 0 0
ZAI LAB LTD ADR 98887Q104 13,973 658,160 SH   SOLE   658,160 0 0