The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABS COM 002824100 9,476 211,000 SH   DFND 1 53,000 0 158,000
ABBVIE INC COM 00287Y109 441,249 7,448,500 SH   DFND 1 3,288,500 0 4,160,000
ACHILLION PHARMACEUTICALS IN COM 00448Q201 104,122 9,649,900 SH   DFND 1 3,952,800 0 5,697,100
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 5,292 438,784 SH   SOLE   438,784 0 0
ADURO BIOTECH INC COM 00739L101 1,688 60,000 SH   SOLE   60,000 0 0
ADVAXIS INC COM NEW 007624208 6,404 636,600 SH   DFND 1 0 0 636,600
AETNA INC NEW COM 00817Y108 7,244 67,000 SH   DFND 1 18,000 0 49,000
AFFIMED N V COM N01045108 32,628 4,582,616 SH   SOLE   4,582,616 0 0
AFFYMETRIX INC COM 00826T108 75,786 7,511,000 SH   DFND 1 2,295,000 0 5,216,000
AGILENT TECHNOLOGIES INC COM 00846U101 139,060 3,326,000 SH   DFND 1 1,341,800 0 1,984,200
ALEXION PHARMACEUTICALS INC COM 015351109 433,975 2,275,100 SH   DFND 1 850,400 0 1,424,700
ALIMERA SCIENCES INC COM 016259103 3,630 1,500,000 SH   DFND 1 670,000 0 830,000
ALIMERA SCIENCES INC COM 016259103 484 200,000 SH Call DFND 1 80,300 0 119,700
ALLERGAN PLC SHS G0177J108 445,223 1,424,715 SH   DFND 1 697,025 0 727,690
ALLERGAN PLC PFD CONV SER A G0177J116 107,221 104,200 SH   DFND 1 30,300 0 73,900
AMARIN CORP PLC SPONS ADR NEW 023111206 662 350,000 SH   SOLE   350,000 0 0
AMGEN INC COM 031162100 474,166 2,921,000 SH   DFND 1 1,079,000 0 1,842,000
ANACOR PHARMACEUTICALS INC COM 032420101 6,021 53,300 SH   SOLE   53,300 0 0
ARRAY BIOPHARMA INC COM 04269X105 45,108 10,689,000 SH   DFND 1 4,249,700 0 6,439,300
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 4,071 222,223 SH   SOLE   222,223 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 10,492 1,397,100 SH   DFND 1 647,100 0 750,000
BAXALTA INC COM 07177M103 11,124 285,000 SH   DFND 1 80,000 0 205,000
BIOGEN INC COM 09062X103 441,910 1,442,500 SH   DFND 1 533,700 0 908,800
BIOLINERX LTD SPONSORED ADR 09071M106 1,350 1,038,600 SH   SOLE   1,038,600 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 15,609 149,000 SH   DFND 1 0 0 149,000
BIOMARIN PHARMACEUTICAL INC NOTE 0.750%10/1 09061GAE1 645 500,000 PRN   DFND 1 215,000 0 285,000
BIOMARIN PHARMACEUTICAL INC NOTE 1.500%10/1 09061GAF8 672 500,000 PRN   DFND 1 215,000 0 285,000
BIOTIE THERAPIES OYJ SPONSORED ADR 09074D103 3,855 268,672 SH   SOLE   268,672 0 0
BLUEBIRD BIO INC COM 09609G100 60,476 941,700 SH   DFND 1 375,200 0 566,500
BOSTON SCIENTIFIC CORP COM 101137107 450,506 24,430,900 SH   DFND 1 10,751,000 0 13,679,900
BRISTOL MYERS SQUIBB CO COM 110122108 577,492 8,395,000 SH   DFND 1 3,488,400 0 4,906,600
CARDINAL HEALTH INC COM 14149Y108 13,033 146,000 SH   DFND 1 40,000 0 106,000
CELGENE CORP COM 151020104 438,974 3,665,450 SH   DFND 1 1,276,000 0 2,389,450
CELLECTIS S A SPONSORED ADS 15117K103 10,861 350,000 SH   DFND 1 162,100 0 187,900
CERUS CORP COM 157085101 41,108 6,504,400 SH   DFND 1 2,683,900 0 3,820,500
CIGNA CORPORATION COM 125509109 41,265 282,000 SH   DFND 1 117,000 0 165,000
CLOVIS ONCOLOGY INC COM 189464100 25,536 729,600 SH   DFND 1 289,700 0 439,900
COGENTIX MED INC COM 19243A104 1,278 990,745 SH   DFND 1 436,407 0 554,338
COMMUNITY HEALTH SYS INC NEW COM 203668108 89,730 3,382,200 SH   DFND 1 1,707,200 0 1,675,000
CONNECTURE INC COM 20786J106 6,281 1,740,000 SH   DFND 1 795,000 0 945,000
COOPER COS INC COM NEW 216648402 122,780 914,900 SH   DFND 1 446,000 0 468,900
CYNAPSUS THERAPEUTICS INC COM PAR NO PAR 23257Y859 17,604 1,140,325 SH   SOLE   1,140,325 0 0
DIMENSION THERAPEUTICS INC COM 25433V105 60,886 5,397,698 SH   SOLE   5,397,698 0 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 59,728 2,472,200 SH   DFND 1 770,800 0 1,701,400
EHEALTH INC COM 28238P109 12,974 1,300,000 SH   DFND 1 600,000 0 700,000
ENANTA PHARMACEUTICALS INC COM 29251M106 16,652 504,300 SH   DFND 1 218,000 0 286,300
ENSIGN GROUP INC COM 29358P101 11,206 495,200 SH   DFND 1 203,200 0 292,000
EXPRESS SCRIPTS HLDG CO COM 30219G108 190,729 2,182,000 SH   DFND 1 942,000 0 1,240,000
FATE THERAPEUTICS INC COM 31189P102 2,335 692,900 SH   DFND 1 296,100 0 396,800
FLUIDIGM CORP DEL COM 34385P108 26,483 2,449,900 SH   DFND 1 888,000 0 1,561,900
FLUIDIGM CORP DEL NOTE 2.750% 2/0 34385PAA6 6,424 10,000,000 PRN   DFND 1 4,466,000 0 5,534,000
FORWARD PHARMA A/S SPONSORED ADR 34986J105 18,251 960,600 SH   DFND 1 389,100 0 571,500
GALAPAGOS NV SPON ADR 36315X101 14,462 230,000 SH   DFND 1 0 0 230,000
GILEAD SCIENCES INC COM 375558103 346,211 3,421,400 SH   DFND 1 1,226,700 0 2,194,700
GLAUKOS CORP COM 377322102 71,550 2,897,937 SH   SOLE   2,897,937 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 21,117 304,100 SH   DFND 1 0 0 304,100
HCA HOLDINGS INC COM 40412C101 402,777 5,955,600 SH   DFND 1 2,659,100 0 3,296,500
HEALTH NET INC COM 42222G108 204,613 2,988,800 SH   DFND 1 1,374,600 0 1,614,200
ILLUMINA INC COM 452327109 168,336 877,000 SH   DFND 1 348,000 0 529,000
IMMUNOGEN INC COM 45253H101 82,718 6,095,647 SH   DFND 1 1,919,480 0 4,176,167
IMMUNOMEDICS INC COM 452907108 11,672 3,802,000 SH   DFND 1 2,050,550 0 1,751,450
IMPAX LABORATORIES INC COM 45256B101 284,957 6,664,100 SH   DFND 1 2,653,500 0 4,010,600
INCYTE CORP COM 45337C102 307,236 2,832,978 SH   DFND 1 1,022,500 0 1,810,478
INCYTE CORP NOTE 0.375%11/1 45337CAM4 9,195 4,250,000 PRN   DFND 1 1,816,000 0 2,434,000
INCYTE CORP NOTE 1.250%11/1 45337CAN2 9,292 4,250,000 PRN   DFND 1 1,816,000 0 2,434,000
INFINITY PHARMACEUTICALS INC COM 45665G303 34,668 4,416,300 SH   DFND 1 1,742,000 0 2,674,300
INOTEK PHARMACEUTICALS CORP COM 45780V102 4,815 425,000 SH   DFND 1 197,000 0 228,000
INSMED INC COM PAR $.01 457669307 62,979 3,469,900 SH   DFND 1 1,375,200 0 2,094,700
INSYS THERAPEUTICS INC NEW COM NEW 45824V209 125,020 4,366,740 SH   DFND 1 1,563,200 0 2,803,540
INTERCEPT PHARMACEUTICALS IN COM 45845P108 167,272 1,120,000 SH   SOLE   1,120,000 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 130,532 239,000 SH   DFND 1 116,600 0 122,400
INVITAE CORP COM 46185L103 3,749 456,666 SH   SOLE   456,666 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 130,114 11,226,400 SH   DFND 1 4,509,500 0 6,716,900
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 12,650 90,000 SH   DFND 1 0 0 90,000
JOHNSON & JOHNSON COM 478160104 29,994 292,000 SH   DFND 1 80,000 0 212,000
LILLY ELI & CO COM 532457108 135,911 1,613,000 SH   DFND 1 797,000 0 816,000
LION BIOTECHNOLOGIES INC COM 53619R102 7,891 1,022,100 SH   DFND 1 272,000 0 750,100
LOXO ONCOLOGY INC COM 548862101 61,903 2,175,857 SH   SOLE   2,175,857 0 0
MACROGENICS INC COM 556099109 9,817 317,000 SH   DFND 1 146,800 0 170,200
MAGELLAN HEALTH INC COM NEW 559079207 113,023 1,833,000 SH   DFND 1 751,300 0 1,081,700
MALLINCKRODT PUB LTD CO SHS G5785G107 94,183 1,262,000 SH   DFND 1 511,000 0 751,000
MANNKIND CORP COM 56400P201 653 450,000 SH Put DFND 1 226,800 0 223,200
MARINUS PHARMACEUTICALS INC COM 56854Q101 7,373 965,000 SH   SOLE   965,000 0 0
MCKESSON CORP COM 58155Q103 68,907 349,372 SH   DFND 1 132,000 0 217,372
MEDIGUS LTD SPONSORED ADR 58471G102 52 600,000 SH   SOLE   600,000 0 0
MEDIVATION INC COM 58501N101 7,879 163,000 SH   DFND 1 0 0 163,000
MEDTRONIC PLC SHS G5960L103 45,252 588,299 SH   DFND 1 156,199 0 432,100
MIRATI THERAPEUTICS INC COM 60468T105 1,018 32,200 SH   SOLE   32,200 0 0
MOLINA HEALTHCARE INC COM 60855R100 34,205 568,850 SH   DFND 1 253,700 0 315,150
MYLAN N V SHS EURO N59465109 170,699 3,157,000 SH   DFND 1 1,406,000 0 1,751,000
NABRIVA THERAPEUTICS AG SPONSORED ADR 62957M104 12,650 1,315,000 SH   SOLE   1,315,000 0 0
NATERA INC COM 632307104 13,783 1,276,190 SH   SOLE   1,276,190 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 142,272 2,514,974 SH   DFND 1 944,070 0 1,570,904
NEWLINK GENETICS CORP COM 651511107 34,764 955,306 SH   DFND 1 398,600 0 556,706
NUVASIVE INC COM 670704105 80,462 1,487,000 SH   DFND 1 806,000 0 681,000
OCULAR THERAPEUTIX INC COM 67576A100 1,452 155,000 SH   DFND 1 0 0 155,000
OPHTHOTECH CORP COM 683745103 157,963 2,011,500 SH   DFND 1 918,280 0 1,093,220
OREXIGEN THERAPEUTICS INC NOTE 2.750%12/0 686164AB0 3,104 5,210,000 PRN   DFND 1 2,210,000 0 3,000,000
OTONOMY INC COM 68906L105 51,340 1,850,094 SH   SOLE   1,850,094 0 0
PERNIX THERAPEUTICS HLDGS IN COM 71426V108 3,165 1,073,000 SH   DFND 1 485,000 0 588,000
PFIZER INC COM 717081103 133,123 4,124,000 SH   DFND 1 1,159,000 0 2,965,000
PIERIS PHARMACEUTICALS INC COM 720795103 16,625 7,259,620 SH   SOLE   7,259,620 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 66,972 1,301,700 SH   DFND 1 725,700 0 576,000
PRONAI THERAPEUTICS INC COM 74346L101 29,929 1,989,949 SH   SOLE   1,989,949 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 19,717 2,271,500 SH   DFND 1 961,820 0 1,309,680
PUMA BIOTECHNOLOGY INC COM 74587V107 175,524 2,238,825 SH   DFND 1 890,600 0 1,348,225
QLT INC COM 746927102 1,330 500,000 SH   DFND 1 200,600 0 299,400
REDHILL BIOPHARMA LTD SPONSORED ADS 757468103 7,276 564,900 SH   SOLE   564,900 0 0
REGENERON PHARMACEUTICALS COM 75886F107 262,206 483,000 SH   DFND 1 183,500 0 299,500
RELYPSA INC COM 759531106 209,716 7,400,000 SH   SOLE   7,400,000 0 0
ROKA BIOSCIENCE INC COM 775431109 3,961 3,220,429 SH   SOLE   3,220,429 0 0
SERES THERAPEUTICS INC COM 81750R102 5,848 166,645 SH   SOLE   166,645 0 0
SHIRE PLC SPONSORED ADR 82481R106 51,449 250,971 SH   DFND 1 114,428 0 136,543
SIENTRA INC COM 82621J105 8,036 1,357,500 SH   SOLE   1,357,500 0 0
SINOVAC BIOTECH LTD SHS P8696W104 15,258 2,667,500 SH   DFND 1 1,219,500 0 1,448,000
STRYKER CORP COM 863667101 17,287 186,000 SH   DFND 1 51,000 0 135,000
SYNERGY PHARMACEUTICALS DEL COM NEW 871639308 12,909 2,276,648 SH   DFND 1 1,114,300 0 1,162,348
TESARO INC COM 881569107 92,329 1,764,700 SH   DFND 1 731,600 0 1,033,100
TEVA PHARMACEUTICAL INDS LTD ADR 881624209 160,555 2,446,000 SH   DFND 1 1,093,000 0 1,353,000
THERMO FISHER SCIENTIFIC INC COM 883556102 195,753 1,380,000 SH   DFND 1 579,000 0 801,000
UNITEDHEALTH GROUP INC COM 91324P102 27,998 238,000 SH   DFND 1 63,000 0 175,000
VALEANT PHARMACEUTICALS INTL COM 91911K102 39,644 390,000 SH   DFND 1 141,000 0 249,000
VERTEX PHARMACEUTICALS INC COM 92532F100 84,684 673,000 SH   DFND 1 206,000 0 467,000
VITAE PHARMACEUTICALS INC COM 92847N103 8,822 487,400 SH   DFND 1 0 0 487,400
WELLCARE HEALTH PLANS INC COM 94946T106 105,286 1,346,200 SH   DFND 1 556,900 0 789,300
WRIGHT MED GROUP N V ORD SHS 0.03 PAR N96617118 199,367 8,245,111 SH   DFND 1 3,781,397 0 4,463,714
XENCOR INC COM 98401F105 16,185 1,107,022 SH   DFND 1 0 0 1,107,022
XENOPORT INC COM 98411C100 31,669 5,768,400 SH   DFND 1 2,321,000 0 3,447,400
XTANT MED HLDGS INC COM 98420P100 1,331 475,439 SH   SOLE   475,439 0 0
ZIMMER BIOMET HLDGS INC COM 98956P102 15,060 146,800 SH   DFND 1 25,000 0 121,800