The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103 48,744 3,729,442 SH   SOLE   3,729,442 0 0
9 METERS BIOPHARMA INC COM 654405109 10,057 10,275,887 SH   SOLE   10,275,887 0 0
AADI BIOSCIENCE INC COM 00032Q104 3,082 127,600 SH   SOLE   127,600 0 0
ABBVIE INC COM 00287Y109 144,716 1,068,800 SH   DFND   135,300 0 933,500
ABCELLERA BIOLOGICS INC COM 00288U106 59,785 4,180,768 SH   SOLE   4,180,768 0 0
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 7,940 1,584,845 SH   DFND   178,735 0 1,406,110
ACLARIS THERAPEUTICS INC COM 00461U105 14,335 985,900 SH   SOLE   0 0 985,900
ACUTUS MED INC COM 005111109 9,031 2,648,386 SH   SOLE   2,648,386 0 0
ADAGENE INC ADS 005329107 2,123 263,176 SH   SOLE   263,176 0 0
ADAGIO THERAPEUTICS INC COM 00534A102 36,180 4,983,500 SH   SOLE   4,983,500 0 0
ADICET BIO INC COM 007002108 130,250 7,447,141 SH   SOLE   7,447,141 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 14,042 2,956,124 SH   SOLE   2,956,124 0 0
AEROVATE THERAPEUTICS INC COM 008064107 6,316 535,714 SH   DFND   107,114 0 428,600
ALPINE IMMUNE SCIENCES INC COM 02083G100 56,530 4,081,592 SH   SOLE   4,081,592 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105 4,461 207,600 SH   SOLE   0 0 207,600
AMGEN INC COM 031162100 12,846 57,100 SH   SOLE   0 0 57,100
APPLIED THERAPEUTICS INC COM 03828A101 20,707 2,313,681 SH   DFND   213,000 0 2,100,681
APTINYX INC COM 03836N103 2,001 749,500 SH   SOLE   749,500 0 0
ARCUTIS BIOTHERAPEUTICS INC COM 03969K108 125,972 6,073,850 SH   DFND   4,267,564 0 1,806,286
ASLAN PHARMACEUTICALS LTD ADS 04522R101 2,206 1,970,000 SH   SOLE   0 0 1,970,000
AUGMEDIX INC COM 05105P107 278 88,363 SH   SOLE   88,363 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 11,698 1,454,800 SH   SOLE   1,454,800 0 0
BIOGEN INC COM 09062X103 55,230 230,200 SH   DFND   13,300 0 216,900
BIOMARIN PHARMACEUTICAL INC COM 09061G101 76,059 860,880 SH   DFND   92,650 0 768,230
BIOMX INC COM 09090D103 4,502 2,813,489 SH   SOLE   2,813,489 0 0
BOSTON SCIENTIFIC CORP COM 101137107 235,862 5,552,300 SH   DFND   615,800 0 4,936,500
BRIGHT MINDS BIOSCIENCES INC COM 10919W108 2,131 660,600 SH   SOLE   0 0 660,600
BRISTOL-MYERS SQUIBB CO COM 110122108 270,587 4,339,800 SH   DFND   424,400 0 3,915,400
BURNING ROCK BIOTECH LTD SPONSORED ADS 12233L107 13,841 1,452,402 SH   DFND   125,678 0 1,326,724
CABALETTA BIO INC COM 12674W109 1,147 302,509 SH   SOLE   0 0 302,509
CATALYST BIOSCIENCES INC COM NEW 14888D208 1,581 1,729,402 SH   DFND   378,800 0 1,350,602
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 15,692 406,100 SH   DFND   49,600 0 356,500
CENTURY THERAPEUTICS INC COM 15673T100 4,870 307,047 SH   DFND   92,114 0 214,933
CHEMOMAB THERAPEUTICS LTD SPONSORED ADS 16385C104 17,789 2,578,174 SH   SOLE   2,578,174 0 0
CHINOOK THERAPEUTICS INC COM 16961L106 23,132 1,418,300 SH   DFND   478,300 0 940,000
COMPASS THERAPEUTICS INC COM 20454B104 68,608 21,642,975 SH   DFND   18,071,547 0 3,571,428
CORVUS PHARMACEUTICALS INC COM 221015100 16,734 6,943,654 SH   SOLE   6,943,654 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 90,823 3,196,876 SH   SOLE   3,196,876 0 0
CULLINAN ONCOLOGY INC COM 230031106 12,422 805,041 SH   DFND   751,741 0 53,300
CURIS INC COM NEW 231269200 17,302 3,634,800 SH   DFND   485,000 0 3,149,800
CVRX INC COM 126638105 8,843 723,055 SH   DFND   134,100 0 588,955
CYBIN INC COM 23256X100 12,481 10,524,300 SH   SOLE   0 0 10,524,300
CYTEK BIOSCIENCES INC COM 23285D109 31,386 1,923,139 SH   DFND   961,569 0 961,570
CYTOMX THERAPEUTICS INC COM 23284F105 13,919 3,214,509 SH   DFND   823,615 0 2,390,894
DANAHER CORPORATION 5% CONV PFD B 235851409 17,382 10,000 PRN   DFND   1,961 0 8,039
DECIBEL THERAPEUTICS INC COM 24343R106 22,995 4,945,192 SH   DFND   4,061,774 0 883,418
DEXCOM INC COM 252131107 82,100 152,900 SH   DFND   12,600 0 140,300
EDGEWISE THERAPEUTICS INC COM 28036F105 213,075 13,944,680 SH   DFND   13,679,055 0 265,625
EDWARDS LIFESCIENCES CORP COM 28176E108 139,422 1,076,200 SH   DFND   109,900 0 966,300
ERASCA INC COM 29479A108 25,983 1,667,693 SH   SOLE   0 0 1,667,693
EVOLENT HEALTH INC CL A 30050B101 25,954 938,000 SH   SOLE   0 0 938,000
EXSCIENTIA PLC ADS 30223G102 2,470 125,000 SH   SOLE   125,000 0 0
FIELD TRIP HEALTH LTD COM 31656R102 3,722 1,538,470 SH   SOLE   0 0 1,538,470
FLUIDIGM CORP DEL COM 34385P108 14,972 3,819,348 SH   DFND   402,477 0 3,416,871
FUSION PHARMACEUTICALS INC COM 36118A100 13,447 3,224,770 SH   DFND   2,930,670 0 294,100
GALAPAGOS NV SPON ADR 36315X101 39,542 717,257 SH   DFND   94,700 0 622,557
GALECTO INC COM 36322Q107 12,396 4,090,937 SH   DFND   3,803,255 0 287,682
GEMINI THERAPEUTICS INC COM 36870G105 16,954 5,826,224 SH   SOLE   5,826,224 0 0
GH RESEARCH PLC ORDINARY SHARES G3855L106 33,332 1,428,732 SH   DFND   125,000 0 1,303,732
GILEAD SCIENCES INC COM 375558103 20,883 287,600 SH   SOLE   0 0 287,600
GOSSAMER BIO INC COM 38341P102 7,725 683,000 SH   SOLE   0 0 683,000
GRACELL BIOTECHNOLOGIES INC SPONSORED ADS 38406L103 47,625 7,884,870 SH   DFND   5,970,672 0 1,914,198
GRAPHITE BIO INC COM 38870X104 19,463 1,565,812 SH   DFND   430,000 0 1,135,812
GRAYBUG VISION INC COM SHS 38942Q103 7,619 4,163,347 SH   SOLE   4,163,347 0 0
GUARDANT HEALTH INC COM 40131M109 122,765 1,227,400 SH   DFND   108,700 0 1,118,700
HARPOON THERAPEUTICS INC COM 41358P106 21,921 2,903,508 SH   DFND   1,235,608 0 1,667,900
HCA HEALTHCARE INC COM 40412C101 100,070 389,500 SH   DFND   31,400 0 358,100
HEALTH SCIENCES ACQ CORP 2 ORD SHS G4411D109 5,040 500,000 SH   DFND   100,000 0 400,000
HORIZON THERAPEUTICS PUB L SHS G46188101 269,406 2,500,055 SH   DFND   223,500 0 2,276,555
HUMANA INC COM 444859102 147,647 318,300 SH   DFND   41,400 0 276,900
I MAB SPONSORED ADS 44975P103 5,266 111,120 SH   DFND   25,000 0 86,120
IKENA ONCOLOGY INC COM 45175G108 36,792 2,933,941 SH   DFND   1,936,886 0 997,055
IKENA ONCOLOGY INC NONVOTING 000000000 77,942 6,215,466 SH   DFND   5,586,311 0 629,155
ILLUMINA INC COM 452327109 17,158 45,100 SH   SOLE   0 0 45,100
IMARA INC COM 45249V107 9,870 4,386,568 SH   DFND   4,199,068 0 187,500
IMMUNOGEN INC COM 45253H101 28,706 3,868,786 SH   DFND   612,200 0 3,256,586
INFLARX NV COM N44821101 4,166 875,297 SH   SOLE   0 0 875,297
INOZYME PHARMA INC COM 45790W108 3,591 526,600 SH   SOLE   526,600 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 6,290 53,200 SH   SOLE   0 0 53,200
INTUITIVE SURGICAL INC COM NEW 46120E602 134,306 373,800 SH   DFND   47,100 0 326,700
IOVANCE BIOTHERAPEUTICS INC COM 462260100 120,987 6,337,700 SH   DFND   1,263,700 0 5,074,000
JANUX THERAPEUTICS INC COM 47103J105 55,962 2,836,386 SH   DFND   2,489,664 0 346,722
JOUNCE THERAPEUTICS INC COM 481116101 23,880 2,859,900 SH   DFND   659,700 0 2,200,200
KEROS THERAPEUTICS INC COM 492327101 98,263 1,679,417 SH   DFND   1,268,734 0 410,683
KINNATE BIOPHARMA INC COM 49705R105 68,185 3,847,929 SH   DFND   3,397,929 0 450,000
LANDOS BIOPHARMA INC COM 515069102 1,359 283,217 SH   SOLE   0 0 283,217
LOGICBIO THERAPEUTICS INC COM 54142F102 19,558 8,466,783 SH   DFND   7,948,265 0 518,518
LONGBOARD PHARMACEUTICALS IN COM 54300N103 554 113,500 SH   SOLE   0 0 113,500
MAGENTA THERAPEUTICS INC COM 55910K108 9,972 2,250,953 SH   DFND   543,000 0 1,707,953
MEIRAGTX HLDGS PLC COM G59665102 88,490 3,727,466 SH   DFND   133,500 0 3,593,966
MERCK & CO INC COM 58933Y105 136,366 1,779,300 SH   DFND   171,200 0 1,608,100
MEREO BIOPHARMA GROUP PLC ADS 589492107 27,624 17,264,764 PRN   DFND   9,210,992 0 8,053,772
MERSANA THERAPEUTICS INC COM 59045L106 17,969 2,888,847 SH   DFND   464,000 0 2,424,847
MILESTONE PHARMACEUTICALS IN COM 59935V107 16,924 2,583,821 SH   SOLE   0 0 2,583,821
MIRATI THERAPEUTICS INC COM 60468T105 209,239 1,426,400 SH   DFND   220,600 0 1,205,800
NANOSTRING TECHNOLOGIES INC COM 63009R109 34,084 807,100 SH   DFND   67,400 0 739,700
NANOSTRING TECHNOLOGIES INC NOTE 2.625% 3/0 63009RAD1 7,172 6,000,000 PRN   SOLE   0 0 6,000,000
NATERA INC COM 632307104 132,052 1,413,985 SH   DFND   128,400 0 1,285,585
NAUTILUS BIOTECHNOLOGY INC COM 63909J108 7,525 1,452,774 SH   DFND   353,674 0 1,099,100
NEUROCRINE BIOSCIENCES INC COM 64125C109 79,371 931,915 SH   DFND   68,770 0 863,145
NEUROPACE INC COM 641288105 40,444 4,012,281 SH   SOLE   4,012,281 0 0
NEXTCURE INC COM 65343E108 16,266 2,711,013 SH   SOLE   2,711,013 0 0
NURIX THERAPEUTICS INC COM 67080M103 5,340 184,468 SH   DFND   33,200 0 151,268
OAK STR HEALTH INC COM 67181A107 42,761 1,290,300 SH   DFND   98,700 0 1,191,600
ONCOCYTE CORP COM 68235C107 7,582 3,493,800 SH   DFND   1,188,800 0 2,305,000
ORIC PHARMACEUTICALS INC COM 68622P109 34,362 2,337,574 SH   DFND   2,212,571 0 125,003
OWLET INC *W EXP 09/14/202 69120X115 86 220,704 SH   DFND   82,544 0 138,160
PASSAGE BIO INC COM 702712100 44,214 6,962,899 SH   DFND   5,947,323 0 1,015,576
PFIZER INC COM 717081103 154,439 2,615,400 SH   DFND   259,500 0 2,355,900
PMV PHARMACEUTICALS INC COM 69353Y103 169,333 7,330,423 SH   DFND   6,589,330 0 741,093
PRELUDE THERAPEUTICS INC COM 74065P101 124,994 10,039,691 SH   DFND   9,250,191 0 789,500
PRELUDE THERAPEUTICS INC NONVOTING 000000000 70,718 5,680,186 SH   DFND   5,596,886 0 83,300
PROMETHEUS BIOSCIENCES INC COM 74349U108 9,885 250,000 SH   SOLE   0 0 250,000
PROTARA THERAPEUTICS INC COM STK 74365U107 5,607 830,641 SH   DFND   158,900 0 671,741
PULMONX CORP COM 745848101 13,950 435,000 SH   DFND   83,600 0 351,400
PYXIS ONCOLOGY INC COMMON STOCK 747324101 1,576 143,640 SH   DFND   49,540 0 94,100
RAPT THERAPEUTICS INC COM 75382E109 7,970 217,000 SH   SOLE   0 0 217,000
REPARE THERAPEUTICS INC COM 760273102 70,071 3,322,488 SH   DFND   3,177,041 0 145,447
RXSIGHT INC COM 78349D107 15,564 1,383,500 SH   DFND   321,000 0 1,062,500
SAREPTA THERAPEUTICS INC COM 803607100 5,286 58,700 SH   SOLE   58,700 0 0
SCPHARMACEUTICALS INC COM 810648105 24,082 4,797,148 SH   SOLE   4,797,148 0 0
SEAGEN INC COM 81181C104 101,356 655,600 SH   DFND   63,300 0 592,300
SELECT MED HLDGS CORP COM 81619Q105 36,268 1,233,600 SH   DFND   98,400 0 1,135,200
SI-BONE INC COM 825704109 51,201 2,305,300 SH   SOLE   0 0 2,305,300
SIERRA ONCOLOGY INC COM NEW 82640U404 32,117 1,477,320 SH   DFND   1,306,860 0 170,460
SIGHT SCIENCES INC COM 82657M105 3,514 200,000 SH   SOLE   0 0 200,000
SILVERBACK THERAPEUTICS INC COM 82835W108 58,214 8,740,887 SH   DFND   7,788,510 0 952,377
SINGULAR GENOMICS SYSTEMS IN COM 82933R100 24,326 2,104,359 SH   DFND   789,464 0 1,314,895
SINOVAC BIOTECH LTD SHS P8696W104 72,700 2,839,500 SH   SOLE   0 0 2,839,500
SONENDO INC COM 835431107 11,337 1,968,180 SH   SOLE   1,968,180 0 0
SPDR SER TR S&P BIOTECH 78464A870 113,046 1,009,700 SH   DFND   111,800 0 897,900
SPRINGWORKS THERAPEUTICS INC COM 85205L107 373,634 6,028,307 SH   SOLE   6,028,307 0 0
STRYKER CORPORATION COM 863667101 124,431 465,300 SH   DFND   42,200 0 423,100
SURFACE ONCOLOGY INC COM 86877M209 2,237 467,945 SH   DFND   162,755 0 305,190
SYNDAX PHARMACEUTICALS INC COM 87164F105 43,371 1,981,300 SH   DFND   210,000 0 1,771,300
SYNLOGIC INC COM 87166L100 14,593 6,029,995 SH   SOLE   6,029,995 0 0
SYROS PHARMACEUTICALS INC COM 87184Q107 5,990 1,837,500 SH   SOLE   0 0 1,837,500
TALARIS THERAPEUTICS INC COM 87410C104 3,780 247,240 SH   SOLE   0 0 247,240
TELA BIO INC COM 872381108 38,753 3,027,542 SH   SOLE   3,027,542 0 0
TENET HEALTHCARE CORP COM NEW 88033G407 24,425 299,000 SH   DFND   31,500 0 267,500
TERNS PHARMACEUTICALS INC COM 880881107 26,804 3,791,204 SH   SOLE   3,791,204 0 0
THERAVANCE BIOPHARMA INC COM G8807B106 66,019 5,974,535 SH   DFND   517,755 0 5,456,780
THERMO FISHER SCIENTIFIC INC COM 883556102 63,188 94,700 SH   DFND   12,200 0 82,500
THESEUS PHARMACEUTICALS INC COM 88369M101 213,514 16,838,668 SH   SOLE   16,838,668 0 0
TRICIDA INC COM 89610F101 98,286 10,280,947 SH   SOLE   10,280,947 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 100,478 2,106,450 SH   DFND   1,743,950 0 362,500
UNIQURE NV SHS N90064101 12,145 585,574 SH   DFND   94,400 0 491,174
UNITEDHEALTH GROUP INC COM 91324P102 136,080 271,000 SH   DFND   33,500 0 237,500
VAXCYTE INC COM 92243G108 26,090 1,096,700 SH   SOLE   0 0 1,096,700
VECTIVBIO HLDG AG ORD SHS H9060V101 25,649 5,223,804 SH   DFND   4,930,504 0 293,300
VENTYX BIOSCIENCES INC COM 92332V107 25,605 1,289,280 SH   SOLE   1,289,280 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 38,269 5,694,841 SH   DFND   5,028,174 0 666,667
VERTEX PHARMACEUTICALS INC COM 92532F100 144,519 658,100 SH   DFND   68,900 0 589,200
VISTAGEN THERAPEUTICS INC COM NEW 92840H202 25,173 12,909,283 SH   DFND   2,390,043 0 10,519,240
VOR BIOPHARMA INC COM 929033108 9,683 833,333 SH   SOLE   0 0 833,333
X4 PHARMACEUTICALS INC COM 98420X103 3,146 1,373,849 SH   SOLE   1,373,849 0 0
XENON PHARMACEUTICALS INC COM 98420N105 19,712 631,000 SH   SOLE   0 0 631,000
XTANT MED HLDGS INC COM NEW 98420P308 40,809 72,873,494 SH   SOLE   72,873,494 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 71,689 564,300 SH   DFND   46,100 0 518,200