The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2SEVENTY BIO INC COMMON STOCK 901384107   24,203,275 2,391,628 SH   DFND   667,300 0 1,724,328
ABCELLERA BIOLOGICS INC COM 00288U106   27,007,761 4,180,768 SH   SOLE   4,180,768 0 0
ACELYRIN INC COM 00445A100   111,319,712 5,326,302 SH   SOLE   5,326,302 0 0
ACUTUS MED INC COM 005111109   2,351,767 2,648,386 SH   SOLE   2,648,386 0 0
ADICET BIO INC COM 007002108   20,222,800 8,322,140 SH   SOLE   8,322,140 0 0
AEROVATE THERAPEUTICS INC COM 008064107   12,981,350 756,930 SH   DFND   215,100 0 541,830
AKERO THERAPEUTICS INC COM 00973Y108   9,314,655 199,500 SH   DFND   26,200 0 173,300
ALKERMES PLC SHS G01767105   4,738,820 151,400 SH   SOLE   0 0 151,400
ALPINE IMMUNE SCIENCES INC COM 02083G100   41,958,766 4,081,592 SH   SOLE   4,081,592 0 0
ALTIMMUNE INC COM NEW 02155H200   353,000 100,000 SH   DFND   35,500 0 64,500
ALX ONCOLOGY HLDGS INC COM 00166B105   21,561,210 2,871,000 SH   DFND   605,000 0 2,266,000
AMGEN INC COM 031162100   28,263,146 127,300 SH   SOLE   0 0 127,300
AMICUS THERAPEUTICS INC COM 03152W109   23,316,384 1,856,400 SH   DFND   490,400 0 1,366,000
APELLIS PHARMACEUTICALS INC COM 03753U106   82,919,220 910,200 SH   DFND   86,500 0 823,700
APOLLOMICS INC CL A SHS G0411D107   3,796,475 662,561 SH   SOLE   662,561 0 0
ARCUTIS BIOTHERAPEUTICS INC COM 03969K108   18,244,985 1,914,479 SH   SOLE   1,914,479 0 0
ARGENX SE SPONSORED ADR 04016X101   12,705,198 32,600 SH   SOLE   0 0 32,600
ARROWHEAD PHARMACEUTICALS IN COM 04280A100   4,172,220 117,000 SH   DFND   30,000 0 87,000
ARS PHARMACEUTICALS INC COM 82835W108   58,563,943 8,740,887 SH   DFND   7,788,510 0 952,377
BAXTER INTL INC COM 071813109   13,668,000 300,000 SH Call DFND   104,500 0 195,500
BAXTER INTL INC COM 071813109   153,765,000 3,375,000 SH   SOLE   0 0 3,375,000
BIOATLA INC COM 09077B104   3,468,525 1,156,175 SH   DFND   358,600 0 797,575
BIOGEN INC COM 09062X103   158,604,480 556,800 SH   DFND   51,400 0 505,400
BIOMARIN PHARMACEUTICAL INC COM 09061G101   140,006,403 1,615,210 SH   DFND   147,600 0 1,467,610
BIOMX INC COM 09090D103   1,639,256 4,553,489 SH   SOLE   4,553,489 0 0
BOLT BIOTHERAPEUTICS INC COM 097702104   1,972,480 1,541,000 SH   SOLE   1,541,000 0 0
BOSTON SCIENTIFIC CORP COM 101137107   182,818,791 3,379,900 SH   SOLE   0 0 3,379,900
BRIDGEBIO PHARMA INC NOTE 2.250% 2/0 10806XAD4   9,265,350 15,000,000 PRN   SOLE   15,000,000 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108   95,157,600 1,488,000 SH   SOLE   0 0 1,488,000
CALCIMEDICA INC COM NEW 38942Q202   1,192,494 297,380 SH   SOLE   297,380 0 0
CHEMOMAB THERAPEUTICS LTD SPONSORED ADS 16385C104   2,947,275 2,241,274 SH   SOLE   2,241,274 0 0
COMPASS THERAPEUTICS INC COM 20454B104   71,113,863 22,362,850 SH   DFND   18,791,422 0 3,571,428
CORVUS PHARMACEUTICALS INC COM 221015100   15,900,968 6,943,654 SH   SOLE   6,943,654 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107   71,193,344 3,950,796 SH   DFND   3,196,876 0 753,920
CULLINAN ONCOLOGY INC COM 230031106   5,862,564 544,848 SH   SOLE   544,848 0 0
CUTERA INC COM 232109108   5,856,823 387,100 SH   DFND   138,200 0 248,900
DECIBEL THERAPEUTICS INC COM 24343R106   19,038,989 4,945,192 SH   DFND   4,061,774 0 883,418
DISC MEDICINE INC COM 254604101   100,771,883 2,269,637 SH   SOLE   2,269,637 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105   112,895,614 14,567,176 SH   DFND   14,301,551 0 265,625
EDWARDS LIFESCIENCES CORP COM 28176E108   48,579,950 515,000 SH   SOLE   0 0 515,000
ELEVATION ONCOLOGY INC COM 28623U101   2,280,000 1,500,000 SH   SOLE   1,500,000 0 0
ENLIVEN THERAPEUTICS INC COM 29337E102   183,656,079 8,998,338 SH   DFND   8,951,463 0 46,875
ESSA PHARMA INC COM NEW 29668H708   2,489,238 921,940 SH   DFND   419,000 0 502,940
EVOLENT HEALTH INC CL A 30050B101   87,737,650 2,895,632 SH   DFND   214,700 0 2,680,932
FUSION PHARMACEUTICALS INC COM 36118A100   14,583,336 3,122,770 SH   DFND   2,930,670 0 192,100
GALECTO INC COM 36322Q107   9,662,277 3,834,237 SH   DFND   3,564,607 0 269,630
GH RESEARCH PLC ORDINARY SHARES G3855L106   8,736,377 736,315 SH   DFND   119,200 0 617,115
GILEAD SCIENCES INC COM 375558103   7,707,000 100,000 SH   SOLE   0 0 100,000
GOODRX HLDGS INC COM CL A 38246G108   9,873,072 1,788,600 SH   DFND   622,400 0 1,166,200
GRACELL BIOTECHNOLOGIES INC SPONSORED ADS 38406L103   34,418,496 9,033,726 SH   DFND   7,277,828 0 1,755,898
HARPOON THERAPEUTICS INC COM 41358P106   441,065 621,218 SH   SOLE   621,218 0 0
HERON THERAPEUTICS INC COM 427746102   931,132 802,700 SH   SOLE   0 0 802,700
HORIZON THERAPEUTICS PUB L SHS G46188101   32,541,740 316,400 SH   DFND   85,300 0 231,100
HORIZON THERAPEUTICS PUB L SHS G46188101   5,142,500 50,000 SH Put DFND   17,500 0 32,500
HUMANA INC COM 444859102   155,914,231 348,700 SH   SOLE   0 0 348,700
HUMANA INC COM 444859102   11,178,250 25,000 SH Call DFND   9,000 0 16,000
IKENA ONCOLOGY INC COM 45175G108   20,901,249 3,186,166 SH   DFND   2,189,111 0 997,055
IKENA ONCOLOGY INC NONVOTING 000000000   40,773,457 6,215,466 SH   DFND   5,586,311 0 629,155
IMMATICS N.V SHS N44445109   11,157,207 966,829 SH   DFND   447,629 0 519,200
INSPIREMD INC COM 45779A846   4,669,617 1,860,405 SH   SOLE   1,860,405 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602   212,173,770 620,500 SH   SOLE   0 0 620,500
INVIVYD INC COM 00534A102   5,533,920 5,270,400 SH   SOLE   5,270,400 0 0
IONIS PHARMACEUTICALS INC COM 462222100   89,014,585 2,169,500 SH   DFND   157,300 0 2,012,200
IOVANCE BIOTHERAPEUTICS INC COM 462260100   33,140,504 4,707,458 SH   SOLE   0 0 4,707,458
JANUX THERAPEUTICS INC COM 47103J105   33,667,902 2,836,386 SH   DFND   2,489,664 0 346,722
KEROS THERAPEUTICS INC COM 492327101   60,862,012 1,514,734 SH   DFND   1,268,734 0 246,000
KEZAR LIFE SCIENCES INC COM 49372L100   13,384,350 5,463,000 SH   DFND   1,339,000 0 4,124,000
KINNATE BIOPHARMA INC COM 49705R105   24,269,479 8,009,729 SH   DFND   7,559,729 0 450,000
LILLY ELI & CO COM 532457108   87,230,280 186,000 SH   SOLE   0 0 186,000
MADRIGAL PHARMACEUTICALS INC COM 558868105   74,282,439 321,569 SH   DFND   31,200 0 290,369
MERSANA THERAPEUTICS INC COM 59045L106   822,500 250,000 SH Call DFND   88,000 0 162,000
MERSANA THERAPEUTICS INC COM 59045L106   23,737,143 7,214,937 SH   DFND   1,569,600 0 5,645,337
MIRATI THERAPEUTICS INC COM 60468T105   33,010,175 913,650 SH   DFND   93,600 0 820,050
MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD 61559X104   5,967,000 117,000 SH   DFND   67,000 0 50,000
MORPHIC HLDG INC COM 61775R105   11,953,305 208,500 SH   DFND   52,900 0 155,600
NATERA INC COM 632307104   47,374,451 973,581 SH   DFND   88,600 0 884,981
NEKTAR THERAPEUTICS COM 640268108   296,228 515,000 SH Call DFND   182,000 0 333,000
NEUROCRINE BIOSCIENCES INC COM 64125C109   46,112,700 489,000 SH   SOLE   0 0 489,000
NEUROPACE INC COM 641288105   18,015,142 4,012,281 SH   SOLE   4,012,281 0 0
NEXTCURE INC COM 65343E108   4,879,823 2,711,013 SH   SOLE   2,711,013 0 0
ORIC PHARMACEUTICALS INC COM 68622P109   9,067,312 1,168,468 SH   SOLE   1,168,468 0 0
PASSAGE BIO INC COM 702712100   9,530,263 10,124,576 SH   DFND   8,034,000 0 2,090,576
PMV PHARMACEUTICALS INC COM 69353Y103   41,084,862 6,563,077 SH   SOLE   6,563,077 0 0
PRELUDE THERAPEUTICS INC COM 74065P101   49,091,652 10,909,256 SH   DFND   10,119,756 0 789,500
PRELUDE THERAPEUTICS INC NONVOTING 000000000   25,560,837 5,680,186 SH   DFND   5,596,886 0 83,300
PROTARA THERAPEUTICS INC COM STK 74365U107   1,846,476 772,584 SH   DFND   147,800 0 624,784
R1 RCM INC COM 77634L105   63,486,450 3,441,000 SH   SOLE   0 0 3,441,000
RAPT THERAPEUTICS INC COM 75382E109   23,395,009 1,251,070 SH   DFND   310,400 0 940,670
REGENERON PHARMACEUTICALS COM 75886F107   9,700,290 13,500 SH   SOLE   0 0 13,500
REPARE THERAPEUTICS INC COM 760273102   35,151,923 3,322,488 SH   DFND   3,177,041 0 145,447
REVANCE THERAPEUTICS INC COM 761330109   2,531,000 100,000 SH   SOLE   0 0 100,000
SAREPTA THERAPEUTICS INC COM 803607100   74,896,080 654,000 SH   DFND   53,400 0 600,600
SCHOLAR ROCK HLDG CORP COM 80706P103   5,546,763 735,645 SH   DFND   620,300 0 115,345
SCPHARMACEUTICALS INC COM 810648105   56,651,590 5,559,528 SH   SOLE   5,559,528 0 0
SI-BONE INC COM 825704109   61,852,486 2,292,531 SH   DFND   147,900 0 2,144,631
SINGULAR GENOMICS SYSTEMS IN COM 82933R100   448,779 540,697 SH   SOLE   540,697 0 0
SINOVAC BIOTECH LTD SHS P8696W104   340,000,000 2,718,735 SH   SOLE   0 0 2,718,735
SPRINGWORKS THERAPEUTICS INC COM 85205L107   109,562,577 4,178,588 SH   SOLE   4,178,588 0 0
STRYKER CORPORATION COM 863667101   82,801,426 271,400 SH   SOLE   0 0 271,400
SYNDAX PHARMACEUTICALS INC COM 87164F105   52,957,923 2,530,240 SH   DFND   614,800 0 1,915,440
SYNLOGIC INC COM 87166L100   2,592,898 6,029,995 SH   SOLE   6,029,995 0 0
TELA BIO INC COM 872381108   28,724,040 2,835,542 SH   SOLE   2,835,542 0 0
TENET HEALTHCARE CORP COM NEW 88033G407   78,165,490 960,500 SH   SOLE   0 0 960,500
TENET HEALTHCARE CORP COM NEW 88033G407   8,138,000 100,000 SH Call DFND   35,500 0 64,500
TERNS PHARMACEUTICALS INC COM 880881107   66,667,431 7,619,135 SH   SOLE   7,619,135 0 0
TG THERAPEUTICS INC COM 88322Q108   1,137,672 45,800 SH Call SOLE   0 0 45,800
THE CIGNA GROUP COM 125523100   45,176,600 161,000 SH   SOLE   0 0 161,000
THERMO FISHER SCIENTIFIC INC COM 883556102   84,940,900 162,800 SH   SOLE   0 0 162,800
THESEUS PHARMACEUTICALS INC COM 88369M101   160,790,122 17,233,668 SH   SOLE   17,233,668 0 0
THIRD HARMONIC BIO INC COM 88427A107   27,797,332 5,779,071 SH   SOLE   5,779,071 0 0
TRAVERE THERAPEUTICS INC COM 89422G107   32,534,016 2,118,100 SH   DFND   510,200 0 1,607,900
UNIQURE NV SHS N90064101   23,658,654 2,064,455 SH   DFND   98,000 0 1,966,455
UNITED THERAPEUTICS CORP DEL COM 91307C102   88,719,425 401,900 SH   DFND   49,000 0 352,900
UNITEDHEALTH GROUP INC COM 91324P102   117,276,160 244,000 SH   SOLE   0 0 244,000
VAXCYTE INC COM 92243G108   50,296,971 1,007,148 SH   DFND   122,700 0 884,448
VECTIVBIO HLDG AG ORD SHS H9060V101   87,661,537 5,156,561 SH   SOLE   5,156,561 0 0
VENTYX BIOSCIENCES INC COM 92332V107   17,744,275 540,984 SH   DFND   174,500 0 366,484
VERA THERAPEUTICS INC CL A 92337R101   28,196,640 1,756,800 SH   DFND   771,000 0 985,800
VERASTEM INC COM NEW 92337C203   11,376,616 1,529,115 SH   SOLE   1,529,115 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106   79,862,227 3,777,778 SH   SOLE   3,777,778 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100   58,205,914 165,400 SH   SOLE   0 0 165,400
VIGIL NEUROSCIENCE INC COM 92673K108   4,219,575 448,891 SH   SOLE   448,891 0 0
X4 PHARMACEUTICALS INC COM 98420X103   13,839,019 7,133,515 SH   SOLE   7,133,515 0 0
XENON PHARMACEUTICALS INC COM 98420N105   42,196,000 1,096,000 SH   DFND   230,000 0 866,000
XTANT MED HLDGS INC COM NEW 98420P308   67,989,259 73,114,592 SH   SOLE   73,114,592 0 0
YS BIOPHARMA CO LTD ORDINARY SHARES G9845F109   5,931,882 4,298,465 SH   DFND   1,590,652 0 2,707,813
ZIMMER BIOMET HOLDINGS INC COM 98956P102   35,672,000 245,000 SH   SOLE   0 0 245,000