The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABS COM 002824100 9,426 245,400 SH   DFND 1 103,200 0 142,200
ABBVIE INC COM 00287Y109 183,164 2,925,000 SH   DFND 1 1,082,100 0 1,842,900
ACHILLION PHARMACEUTICALS IN COM 00448Q201 54,133 13,107,200 SH   DFND 1 5,140,500 0 7,966,700
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 2,933 724,184 SH   SOLE   724,184 0 0
AEGERION PHARMACEUTICALS INC NOTE 2.000% 8/1 00767EAB8 5,976 8,000,000 PRN   DFND 1 3,725,000 0 4,275,000
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 5,917 1,360,224 SH   SOLE   1,360,224 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 56,624 1,496,000 SH   DFND 1 501,700 0 994,300
AETNA INC NEW COM 00817Y108 99,940 805,900 SH   DFND 1 308,500 0 497,400
AFFIMED N V COM N01045108 6,075 3,375,000 SH   SOLE   3,375,000 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 165,378 3,629,900 SH   DFND 1 1,590,200 0 2,039,700
ALEXION PHARMACEUTICALS INC COM 015351109 414,569 3,388,386 SH   DFND 1 1,131,800 0 2,256,586
ALEXION PHARMACEUTICALS INC COM 015351109 12,235 100,000 SH Call DFND 1 46,500 0 53,500
ALIMERA SCIENCES INC COM 016259103 270 250,000 SH   DFND 1 98,300 0 151,700
ALLERGAN PLC SHS G0177J108 161,643 769,690 SH   DFND 1 288,500 0 481,190
ALLERGAN PLC PFD CONV SER A G0177J116 67,249 88,200 PRN   DFND 1 30,300 0 57,900
AMARIN CORP PLC SPONS ADR NEW 023111206 1,078 350,000 SH   SOLE   350,000 0 0
AMEDISYS INC COM 023436108 3,048 71,500 SH   DFND 1 32,400 0 39,100
AMGEN INC COM 031162100 340,932 2,331,800 SH   DFND 1 732,100 0 1,599,700
ANTHEM INC COM 036752103 146,875 1,021,600 SH   DFND 1 421,900 0 599,700
ARALEZ PHARMACEUTICALS INC COM 03852X100 301 68,143 SH   DFND 1 27,339 0 40,804
ARRAY BIOPHARMA INC COM 04269X105 141,421 16,088,800 SH   DFND 1 5,667,500 0 10,421,300
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 54,998 2,717,315 SH   SOLE   2,717,315 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 16,975 1,397,100 SH   DFND 1 647,100 0 750,000
AUDENTES THERAPEUTICS INC COM 05070R104 87,726 4,801,638 SH   SOLE   4,801,638 0 0
BARD C R INC COM 067383109 13,030 58,000 SH   DFND 1 26,300 0 31,700
BEIGENE LTD SPONSORED ADR 07725L102 27,436 903,700 SH   DFND 1 381,600 0 522,100
BIOGEN INC COM 09062X103 363,323 1,281,200 SH   DFND 1 391,800 0 889,400
BIOLINERX LTD SPONSORED ADR 09071M106 956 1,038,600 SH   SOLE   1,038,600 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 105,546 1,274,100 SH   DFND 1 428,400 0 845,700
BIOMARIN PHARMACEUTICAL INC NOTE 0.750%10/1 09061GAE1 562 500,000 PRN   DFND 1 215,000 0 285,000
BIOMARIN PHARMACEUTICAL INC NOTE 1.500%10/1 09061GAF8 589 500,000 PRN   DFND 1 215,000 0 285,000
BLUEBIRD BIO INC COM 09609G100 17,510 283,800 SH   DFND 1 113,900 0 169,900
BOSTON SCIENTIFIC CORP COM 101137107 357,044 16,506,900 SH   DFND 1 6,240,900 0 10,266,000
BRISTOL MYERS SQUIBB CO COM 110122108 87,280 1,493,500 SH   DFND 1 481,500 0 1,012,000
CELGENE CORP COM 151020104 359,609 3,106,777 SH   DFND 1 1,071,600 0 2,035,177
CELLECTIS S A SPONSORED ADS 15117K103 5,933 350,000 SH   DFND 1 162,100 0 187,900
CLEARSIDE BIOMEDICAL INC COM 185063104 2,682 300,000 SH   SOLE   0 0 300,000
COHERUS BIOSCIENCES INC COM 19249H103 23,930 850,100 SH   DFND 1 139,300 0 710,800
COOPER COS INC COM NEW 216648402 43,750 250,100 SH   DFND 1 83,500 0 166,600
CORVUS PHARMACEUTICALS INC COM 221015100 76,925 5,379,349 SH   SOLE   5,379,349 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 7,541 372,191 SH   DFND 1 171,207 0 200,984
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 12,144 345,700 SH   SOLE   0 0 345,700
DERMIRA INC COM 24983L104 12,908 425,600 SH   SOLE   0 0 425,600
DIMENSION THERAPEUTICS INC COM 25433V105 23,480 5,397,698 SH   SOLE   5,397,698 0 0
EAGLE PHARMACEUTICALS INC COM 269796108 53,237 671,000 SH   DFND 1 306,300 0 364,700
EDWARDS LIFESCIENCES CORP COM 28176E108 126,626 1,351,400 SH   DFND 1 500,700 0 850,700
EHEALTH INC COM 28238P109 19,383 1,820,000 SH   DFND 1 836,200 0 983,800
EXACT SCIENCES CORP COM 30063P105 12,692 950,000 SH   SOLE   0 0 950,000
FLUIDIGM CORP DEL COM 34385P108 12,712 1,746,100 SH   DFND 1 215,500 0 1,530,600
FLUIDIGM CORP DEL NOTE 2.750% 2/0 34385PAA6 7,013 10,000,000 PRN   DFND 1 4,466,000 0 5,534,000
FORWARD PHARMA A/S SPONSORED ADR 34986J105 11,970 798,000 SH   DFND 1 226,500 0 571,500
GALAPAGOS NV SPON ADR 36315X101 18,198 283,500 SH   DFND 1 82,400 0 201,100
GILEAD SCIENCES INC COM 375558103 75,556 1,055,100 SH   DFND 1 269,000 0 786,100
GLAUKOS CORP COM 377322102 74,774 2,180,000 SH   SOLE   2,180,000 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 44,320 396,600 SH   DFND 1 134,200 0 262,400
HCA HOLDINGS INC COM 40412C101 148,203 2,002,200 SH   DFND 1 587,700 0 1,414,500
HUMANA INC COM 444859102 170,651 836,400 SH   DFND 1 292,500 0 543,900
HUMANA INC COM 444859102 20,403 100,000 SH Call DFND 1 46,000 0 54,000
ILLUMINA INC COM 452327109 23,329 182,200 SH   DFND 1 38,800 0 143,400
IMMUNOGEN INC COM 45253H101 12,435 6,095,647 SH   DFND 1 1,919,480 0 4,176,167
IMMUNOMEDICS INC COM 452907108 13,953 3,802,000 SH   DFND 1 2,050,550 0 1,751,450
IMMUNOMEDICS INC NOTE 4.750% 2/1 452907AK4 29,769 30,000,000 PRN   DFND 1 16,014,000 0 13,986,000
INCYTE CORP COM 45337C102 208,842 2,082,800 SH   DFND 1 548,400 0 1,534,400
INCYTE CORP NOTE 0.375%11/1 45337CAM4 8,496 4,250,000 PRN   DFND 1 1,816,000 0 2,434,000
INCYTE CORP NOTE 1.250%11/1 45337CAN2 8,670 4,250,000 PRN   DFND 1 1,816,000 0 2,434,000
INFINITY PHARMACEUTICALS INC COM 45665G303 4,388 3,250,300 SH   DFND 1 1,064,000 0 2,186,300
INOTEK PHARMACEUTICALS CORP COM 45780V102 11,281 1,849,300 SH   DFND 1 846,500 0 1,002,800
INOTEK PHARMACEUTICALS CORP NOTE 5.750% 8/0 45780VAB8 7,354 7,000,000 PRN   DFND 1 3,200,000 0 3,800,000
INSMED INC COM PAR $.01 457669307 70,143 5,301,805 SH   DFND 1 2,351,360 0 2,950,445
INSYS THERAPEUTICS INC NEW COM NEW 45824V209 55,857 6,071,440 SH   DFND 1 2,538,600 0 3,532,840
INTELLIA THERAPEUTICS INC COM 45826J105 34,901 2,662,180 SH   SOLE   2,662,180 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 121,688 1,120,000 SH   SOLE   1,120,000 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 92,272 145,500 SH   DFND 1 38,000 0 107,500
INVITAE CORP COM 46185L103 3,626 456,666 SH   SOLE   456,666 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 110,719 7,241,300 SH   DFND 1 2,524,000 0 4,717,300
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 40,494 371,400 SH   DFND 1 140,100 0 231,300
JOHNSON & JOHNSON COM 478160104 98,850 858,000 SH   DFND 1 370,700 0 487,300
LILLY ELI & CO COM 532457108 201,453 2,739,000 SH   DFND 1 988,900 0 1,750,100
LILLY ELI & CO COM 532457108 11,033 150,000 SH Call DFND 1 68,500 0 81,500
LION BIOTECHNOLOGIES INC COM 53619R102 23,511 3,382,900 SH   DFND 1 1,446,500 0 1,936,400
LOXO ONCOLOGY INC COM 548862101 55,495 1,728,000 SH   SOLE   1,728,000 0 0
MAGELLAN HEALTH INC COM NEW 559079207 60,320 801,600 SH   DFND 1 362,400 0 439,200
MALLINCKRODT PUB LTD CO SHS G5785G107 73,370 1,472,700 SH   DFND 1 659,200 0 813,500
MARINUS PHARMACEUTICALS INC COM 56854Q101 573 567,600 SH   SOLE   567,600 0 0
MEDIGUS LTD SPONSORED ADR 58471G102 339 600,000 SH   SOLE   600,000 0 0
MEDTRONIC PLC SHS G5960L103 54,605 766,600 SH   DFND 1 322,100 0 444,500
MERCK & CO INC COM 58933Y105 271,697 4,615,200 SH   DFND 1 1,619,400 0 2,995,800
MINERVA NEUROSCIENCES INC COM 603380106 6,535 556,200 SH   SOLE   0 0 556,200
MOLINA HEALTHCARE INC COM 60855R100 26,924 496,200 SH   SOLE   0 0 496,200
MOMENTA PHARMACEUTICALS INC COM 60877T100 44,427 2,951,968 SH   DFND 1 1,069,500 0 1,882,468
NABRIVA THERAPEUTICS AG SPONSORED ADR 62957M104 10,001 1,677,940 SH   SOLE   1,677,940 0 0
NATERA INC COM 632307104 14,944 1,276,190 SH   SOLE   1,276,190 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 82,384 2,128,774 SH   DFND 1 900,670 0 1,228,104
NEWLINK GENETICS CORP COM 651511107 20,475 1,991,700 SH   DFND 1 740,300 0 1,251,400
NOVELION THERAPEUTICS INC COM NEW 67001K202 842 100,000 SH   DFND 1 40,120 0 59,880
NUVASIVE INC COM 670704105 8,319 123,500 SH   SOLE   0 0 123,500
OREXIGEN THERAPEUTICS INC NOTE 2.750%12/0 686164AB0 1,465 5,210,000 PRN   DFND 1 2,210,000 0 3,000,000
OTONOMY INC COM 68906L105 29,416 1,850,094 SH   SOLE   1,850,094 0 0
PFIZER INC COM 717081103 167,853 5,167,900 SH   DFND 1 2,212,500 0 2,955,400
PIERIS PHARMACEUTICALS INC COM 720795103 10,201 7,259,620 SH   SOLE   7,259,620 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 12,376 551,500 SH   SOLE   0 0 551,500
PROQR THRAPEUTICS N V SHS EURO N71542109 11,297 2,305,446 SH   DFND 1 973,446 0 1,332,000
PTC THERAPEUTICS INC COM 69366J200 2,230 204,400 SH   SOLE   0 0 204,400
PUMA BIOTECHNOLOGY INC COM 74587V107 69,868 2,275,825 SH   DFND 1 868,500 0 1,407,325
REDHILL BIOPHARMA LTD SPONSORED ADS 757468103 5,909 564,900 SH   SOLE   564,900 0 0
REGENERON PHARMACEUTICALS COM 75886F107 130,427 355,300 SH   DFND 1 101,200 0 254,100
ROKA BIOSCIENCE INC COM NEW 775431208 3,788 893,470 SH   SOLE   893,470 0 0
SANGAMO BIOSCIENCES INC COM 800677106 2,158 707,400 SH   SOLE   0 0 707,400
SELECT MED HLDGS CORP COM 81619Q105 11,023 831,900 SH   DFND 1 373,200 0 458,700
SELECTA BIOSCIENCES INC COM 816212104 31,604 1,842,797 SH   SOLE   1,842,797 0 0
SHIRE PLC SPONSORED ADR 82481R106 205,027 1,203,351 SH   DFND 1 368,100 0 835,251
SIENTRA INC COM 82621J105 6,327 742,574 SH   SOLE   742,574 0 0
SINOVAC BIOTECH LTD SHS P8696W104 15,738 2,667,500 SH   DFND 1 1,219,500 0 1,448,000
STEADYMED LTD SHS M84920103 7,988 3,072,196 SH   SOLE   3,072,196 0 0
STRYKER CORP COM 863667101 37,896 316,300 SH   DFND 1 77,000 0 239,300
SYNDAX PHARMACEUTICALS INC COM 87164F105 5,430 757,365 SH   SOLE   757,365 0 0
SYNERGY PHARMACEUTICALS DEL COM NEW 871639308 111,090 18,241,398 SH   DFND 1 9,439,098 0 8,802,300
TENET HEALTHCARE CORP COM NEW 88033G407 55,156 3,716,700 SH   DFND 1 1,703,000 0 2,013,700
TESARO INC COM 881569107 6,347 47,200 SH   SOLE   0 0 47,200
TEVA PHARMACEUTICAL INDS LTD ADR 881624209 22,276 614,500 SH   DFND 1 183,900 0 430,600
THERMO FISHER SCIENTIFIC INC COM 883556102 112,809 799,500 SH   DFND 1 308,200 0 491,300
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 11,903 169,300 SH   DFND 1 58,300 0 111,000
UNITEDHEALTH GROUP INC COM 91324P102 47,436 296,400 SH   DFND 1 59,900 0 236,500
VALEANT PHARMACEUTICALS INTL COM 91911K102 2,830 194,900 SH   DFND 1 76,800 0 118,100
VANDA PHARMACEUTICALS INC COM 921659108 11,963 750,000 SH Call DFND 1 343,000 0 407,000
VERTEX PHARMACEUTICALS INC COM 92532F100 159,083 2,159,400 SH   DFND 1 658,600 0 1,500,800
VIEWRAY INC COM 92672L107 28,571 9,127,990 SH   SOLE   9,127,990 0 0
WRIGHT MED GROUP N V ORD SHS 0.03 PAR N96617118 174,288 7,584,334 SH   DFND 1 2,456,550 0 5,127,784
XENCOR INC COM 98401F105 22,115 840,237 SH   SOLE   0 0 840,237
XENON PHARMACEUTICALS INC COM 98420N105 7,700 1,000,000 SH   SOLE   1,000,000 0 0
XTANT MED HLDGS INC COM 98420P100 261 475,439 SH   SOLE   475,439 0 0
ZIMMER BIOMET HLDGS INC COM 98956P102 5,057 49,000 SH   DFND 1 20,600 0 28,400