The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109 159,348 2,197,600 SH   DFND 1 971,800 0 1,225,800
ACHILLION PHARMACEUTICALS IN COM 00448Q201 60,162 13,107,200 SH   DFND 1 5,140,500 0 7,966,700
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 8,597 1,914,660 SH   SOLE   1,914,660 0 0
AEGERION PHARMACEUTICALS INC NOTE 2.000% 8/1 00767EAB8 12,269 15,000,000 PRN   DFND 1 6,995,000 0 8,005,000
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 5,658 1,469,524 SH   SOLE   1,469,524 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 96,253 1,831,647 SH   DFND 1 599,700 0 1,231,947
AETNA INC NEW COM 00817Y108 134,810 887,900 SH   DFND 1 332,200 0 555,700
AFFIMED N V COM N01045108 3,689 1,799,700 SH   SOLE   1,799,700 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 226,214 3,814,100 SH   DFND 1 1,558,200 0 2,255,900
ALEXION PHARMACEUTICALS INC COM 015351109 471,080 3,871,786 SH   DFND 1 1,317,400 0 2,554,386
ALIMERA SCIENCES INC COM 016259103 348 250,000 SH   DFND 1 98,300 0 151,700
ALKERMES PLC SHS G01767105 8,406 145,000 SH   SOLE   0 0 145,000
ALLERGAN PLC SHS G0177J108 90,816 373,590 SH   DFND 1 143,600 0 229,990
ALLERGAN PLC PFD CONV SER A G0177J116 76,506 88,200 PRN   DFND 1 30,300 0 57,900
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 50,983 639,200 SH   DFND 1 184,800 0 454,400
AMARIN CORP PLC SPONS ADR NEW 023111206 826 204,857 SH   SOLE   204,857 0 0
AMGEN INC COM 031162100 224,364 1,302,700 SH   DFND 1 403,800 0 898,900
ANTHEM INC COM 036752103 173,196 920,618 SH   DFND 1 342,400 0 578,218
ARGENX SE SPONSORED ADR 04016X101 10,605 500,000 SH   DFND 1 238,400 0 261,600
ARRAY BIOPHARMA INC COM 04269X105 118,711 14,182,900 SH   DFND 1 5,004,900 0 9,178,000
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 93,477 3,367,315 SH   DFND 1 3,026,915 0 340,400
ASSEMBLY BIOSCIENCES INC COM 045396108 18,346 888,426 SH   DFND 1 423,600 0 464,826
ASTRAZENECA PLC SPONSORED ADR 046353108 8,523 250,000 SH Put DFND 1 116,500 0 133,500
AUDENTES THERAPEUTICS INC COM 05070R104 91,855 4,801,638 SH   SOLE   4,801,638 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 11,018 1,797,400 SH   SOLE   0 0 1,797,400
BEIGENE LTD SPONSORED ADR 07725L102 57,941 1,287,588 SH   DFND 1 529,997 0 757,591
BIOGEN INC COM 09062X103 442,317 1,630,000 SH   DFND 1 551,100 0 1,078,900
BIOLINERX LTD SPONSORED ADR 09071M106 878 1,038,600 SH   SOLE   1,038,600 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 89,240 982,600 SH   DFND 1 331,400 0 651,200
BIOMARIN PHARMACEUTICAL INC NOTE 0.750%10/1 09061GAE1 556 500,000 PRN   DFND 1 215,000 0 285,000
BIOMARIN PHARMACEUTICAL INC NOTE 1.500%10/1 09061GAF8 598 500,000 PRN   DFND 1 215,000 0 285,000
BLUEBIRD BIO INC COM 09609G100 41,999 399,800 SH   DFND 1 113,900 0 285,900
BOSTON SCIENTIFIC CORP COM 101137107 399,168 14,400,000 SH   DFND 1 5,227,600 0 9,172,400
BRISTOL MYERS SQUIBB CO COM 110122108 48,738 874,700 SH   DFND 1 223,000 0 651,700
CELGENE CORP COM 151020104 444,906 3,425,777 SH   DFND 1 1,130,300 0 2,295,477
CELLECTIS S A SPONSORED ADS 15117K103 1,725 66,799 SH   DFND 1 30,499 0 36,300
CIGNA CORPORATION COM 125509109 204,567 1,222,100 SH   DFND 1 456,500 0 765,600
CLOVIS ONCOLOGY INC COM 189464100 197,032 2,104,370 SH   DFND 1 673,700 0 1,430,670
COHERUS BIOSCIENCES INC COM 19249H103 15,494 1,079,700 SH   SOLE   0 0 1,079,700
CORVUS PHARMACEUTICALS INC COM 221015100 65,090 5,379,349 SH   SOLE   5,379,349 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 5,963 372,191 SH   DFND 1 171,207 0 200,984
CTI BIOPHARMA CORP COM NEW 12648L601 16,550 5,000,000 SH   SOLE   5,000,000 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 18,316 512,900 SH   SOLE   0 0 512,900
DERMIRA INC COM 24983L104 41,346 1,418,873 SH   DFND 1 413,570 0 1,005,303
DIMENSION THERAPEUTICS INC COM 25433V105 7,827 5,397,698 SH   SOLE   5,397,698 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 217,479 1,839,300 SH   DFND 1 630,000 0 1,209,300
EHEALTH INC COM 28238P109 34,492 1,834,700 SH   DFND 1 843,200 0 991,500
ENVISION HEALTHCARE CORP COM 29414D100 36,230 578,100 SH   DFND 1 200,500 0 377,600
FLUIDIGM CORP DEL COM 34385P108 7,054 1,746,100 SH   DFND 1 215,500 0 1,530,600
FLUIDIGM CORP DEL NOTE 2.750% 2/0 34385PAA6 6,298 10,000,000 PRN   DFND 1 4,466,000 0 5,534,000
GALAPAGOS NV SPON ADR 36315X101 21,693 283,500 SH   DFND 1 82,400 0 201,100
GILEAD SCIENCES INC COM 375558103 146,755 2,073,400 SH   DFND 1 765,000 0 1,308,400
GLAUKOS CORP COM 377322102 72,228 1,741,700 SH   SOLE   1,741,700 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 59,402 2,171,935 SH   DFND 1 1,045,900 0 1,126,035
GLYCOMIMETICS INC COM 38000Q102 3,767 337,588 SH   SOLE   0 0 337,588
GW PHARMACEUTICALS PLC ADS 36197T103 56,247 561,071 SH   DFND 1 204,000 0 357,071
HALOZYME THERAPEUTICS INC COM 40637H109 4,487 350,000 SH   DFND 1 159,000 0 191,000
HCA HEALTHCARE INC COM 40412C101 52,093 597,400 SH   DFND 1 78,200 0 519,200
HERON THERAPEUTICS INC COM 427746102 9,003 650,000 SH   DFND 1 311,000 0 339,000
HUMANA INC COM 444859102 185,494 770,900 SH   DFND 1 287,400 0 483,500
ILLUMINA INC COM 452327109 69,148 398,500 SH   DFND 1 38,800 0 359,700
IMMUNOGEN INC COM 45253H101 28,001 3,938,272 SH   DFND 1 1,240,500 0 2,697,772
IMMUNOGEN INC NOTE 4.500% 7/0 45253HAB7 18,260 10,000,000 PRN   DFND 1 5,925,000 0 4,075,000
IMMUNOMEDICS INC COM 452907108 43,523 4,928,958 SH   DFND 1 3,026,059 0 1,902,899
IMMUNOMEDICS INC NOTE 4.750% 2/1 452907AK4 54,794 30,000,000 PRN   DFND 1 16,014,000 0 13,986,000
INCYTE CORP COM 45337C102 209,439 1,663,400 SH   DFND 1 456,700 0 1,206,700
INFINITY PHARMACEUTICALS INC COM 45665G303 5,103 3,250,300 SH   DFND 1 1,064,000 0 2,186,300
INOTEK PHARMACEUTICALS CORP NOTE 5.750% 8/0 45780VAB8 4,261 7,000,000 PRN   DFND 1 3,200,000 0 3,800,000
INSMED INC COM PAR $.01 457669307 75,393 4,393,509 SH   DFND 1 2,001,260 0 2,392,249
INSYS THERAPEUTICS INC NEW COM NEW 45824V209 78,069 6,171,440 SH   DFND 1 2,583,300 0 3,588,140
INTEGRA LIFESCIENCES HLDGS C COM NEW 457985208 23,271 426,910 SH   DFND 1 147,900 0 279,010
INTELLIA THERAPEUTICS INC COM 45826J105 42,595 2,662,180 SH   SOLE   2,662,180 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 103,703 856,554 SH   SOLE   856,554 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 45,085 48,200 SH   SOLE   0 0 48,200
INVITAE CORP COM 46185L103 4,366 456,666 SH   SOLE   456,666 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 25,203 3,382,900 SH   DFND 1 1,446,500 0 1,936,400
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 108,734 5,759,200 SH   DFND 1 2,089,300 0 3,669,900
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 84,887 545,900 SH   DFND 1 220,800 0 325,100
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 15,550 100,000 SH Call DFND 1 46,500 0 53,500
JOHNSON & JOHNSON COM 478160104 148,747 1,124,400 SH   DFND 1 465,300 0 659,100
JUNO THERAPEUTICS INC COM 48205A109 27,356 915,208 SH   DFND 1 309,300 0 605,908
LILLY ELI & CO COM 532457108 253,073 3,075,000 SH   DFND 1 1,014,800 0 2,060,200
LOXO ONCOLOGY INC COM 548862101 138,568 1,728,000 SH   SOLE   1,728,000 0 0
MAGELLAN HEALTH INC COM NEW 559079207 88,581 1,215,100 SH   DFND 1 492,600 0 722,500
MALLINCKRODT PUB LTD CO SHS G5785G107 8,962 200,000 SH Put DFND 1 93,000 0 107,000
MALLINCKRODT PUB LTD CO SHS G5785G107 65,992 1,472,700 SH   DFND 1 659,200 0 813,500
MARINUS PHARMACEUTICALS INC COM 56854Q101 778 567,600 SH   SOLE   567,600 0 0
MEDIGUS LTD SPONSORD ADR NEW 58471G201 131 60,000 SH   SOLE   60,000 0 0
MEDTRONIC PLC SHS G5960L103 78,011 879,000 SH   DFND 1 366,600 0 512,400
MERCK & CO INC COM 58933Y105 351,662 5,487,000 SH   DFND 1 2,038,200 0 3,448,800
MINERVA NEUROSCIENCES INC COM 603380106 3,046 344,173 SH   SOLE   0 0 344,173
MOMENTA PHARMACEUTICALS INC COM 60877T100 35,643 2,109,068 SH   DFND 1 613,300 0 1,495,768
MYLAN N V SHS EURO N59465109 115,653 2,979,200 SH   DFND 1 1,212,900 0 1,766,300
NABRIVA THERAPEUTICS PLC SHS G63637105 41,077 3,919,600 SH   SOLE   3,919,600 0 0
NATERA INC COM 632307104 13,859 1,276,190 SH   SOLE   1,276,190 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 13,103 284,841 SH   DFND 1 128,100 0 156,741
NEVRO CORP COM 64157F103 33,590 451,300 SH   DFND 1 141,000 0 310,300
NEVRO CORP COM 64157F103 5,582 75,000 SH Call DFND 1 34,500 0 40,500
NEWLINK GENETICS CORP COM 651511107 13,568 1,846,000 SH   DFND 1 686,100 0 1,159,900
NOVELION THERAPEUTICS INC COM NEW 67001K202 923 100,000 SH   DFND 1 40,120 0 59,880
NOVUS THERAPEUTICS INC COM 67011N105 14,842 2,537,110 SH   SOLE   2,537,110 0 0
NUVASIVE INC COM 670704105 5,046 65,600 SH   SOLE   0 0 65,600
OBSEVA SA COM H5861P103 22,277 2,605,531 SH   SOLE   2,605,531 0 0
OREXIGEN THERAPEUTICS INC NOTE 2.750%12/0 686164AC8 2,443 5,210,000 PRN   DFND 1 2,210,000 0 3,000,000
OTONOMY INC COM 68906L105 29,389 1,559,074 SH   SOLE   1,559,074 0 0
PFIZER INC COM 717081103 82,591 2,458,800 SH   DFND 1 982,000 0 1,476,800
PIERIS PHARMACEUTICALS INC COM 720795103 36,734 7,259,620 SH   SOLE   7,259,620 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 11,988 2,305,446 SH   DFND 1 973,446 0 1,332,000
PUMA BIOTECHNOLOGY INC COM 74587V107 212,009 2,425,735 SH   DFND 1 877,289 0 1,548,446
RADIUS HEALTH INC COM NEW 750469207 31,846 704,100 SH   DFND 1 243,000 0 461,100
REDHILL BIOPHARMA LTD SPONSORED ADS 757468103 4,869 564,900 SH   SOLE   564,900 0 0
REGENERON PHARMACEUTICALS COM 75886F107 229,249 466,770 SH   DFND 1 112,800 0 353,970
ROKA BIOSCIENCE INC COM NEW 775431208 2,306 893,470 SH   SOLE   893,470 0 0
SELECT MED HLDGS CORP COM 81619Q105 56,602 3,687,400 SH   DFND 1 1,664,700 0 2,022,700
SELECTA BIOSCIENCES INC COM 816212104 36,598 1,842,797 SH   SOLE   1,842,797 0 0
SHIRE PLC SPONSORED ADR 82481R106 90,701 548,808 SH   DFND 1 247,400 0 301,408
SIENTRA INC COM 82621J105 4,698 483,347 SH   SOLE   483,347 0 0
SIERRA ONCOLOGY INC COM 82640U107 4,333 3,703,704 SH   SOLE   3,703,704 0 0
SINOVAC BIOTECH LTD SHS P8696W104 18,006 2,667,500 SH   DFND 1 1,219,500 0 1,448,000
STEADYMED LTD SHS M84920103 26,751 4,246,196 SH   SOLE   4,246,196 0 0
STRYKER CORP COM 863667101 43,896 316,300 SH   DFND 1 77,000 0 239,300
SYNDAX PHARMACEUTICALS INC COM 87164F105 6,105 437,000 SH   SOLE   437,000 0 0
SYNERGY PHARMACEUTICALS DEL COM NEW 871639308 94,132 21,153,343 SH   DFND 1 9,710,743 0 11,442,600
TESARO INC COM 881569107 4,238 30,301 SH   DFND 1 17,601 0 12,700
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADR 881624209 17,484 526,300 SH   DFND 1 123,400 0 402,900
THERMO FISHER SCIENTIFIC INC COM 883556102 93,202 534,200 SH   DFND 1 197,600 0 336,600
UNITEDHEALTH GROUP INC COM 91324P102 79,471 428,600 SH   DFND 1 124,400 0 304,200
VALEANT PHARMACEUTICALS INTL COM 91911K102 3,372 194,900 SH   DFND 1 76,800 0 118,100
VANDA PHARMACEUTICALS INC COM 921659108 15,776 967,859 SH   SOLE   0 0 967,859
VERONA PHARMA PLC SPONSORED ADS 925050106 7,770 666,666 SH   SOLE   666,666 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 261,155 2,026,502 SH   DFND 1 638,600 0 1,387,902
VIEWRAY INC COM 92672L107 61,197 9,458,567 SH   SOLE   9,458,567 0 0
WRIGHT MED GROUP N V ORD SHS 0.03 PAR N96617118 245,932 8,946,234 SH   DFND 1 3,008,050 0 5,938,184
WRIGHT MED GROUP N V RIGHT 03/01/2019 N96617126 12,673 8,679,975 SH   SOLE   0 0 8,679,975
XENCOR INC COM 98401F105 15,774 747,244 SH   SOLE   0 0 747,244
XENON PHARMACEUTICALS INC COM 98420N105 2,000 634,812 SH   SOLE   634,812 0 0
XTANT MED HLDGS INC COM 98420P100 314 475,439 SH   SOLE   475,439 0 0
ZIMMER BIOMET HLDGS INC COM 98956P102 6,292 49,000 SH   DFND 1 20,600 0 28,400