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ORBIMED ADVISORS LLC
> IOVA
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | IOVANCE BIOTHERAPEUTICS, INC. | IOVA | 4,707,458 | 0 | 33,140,504,000 | 4,377,936,000 | $7,040.00 |
| 03/31/2023 | IOVANCE BIOTHERAPEUTICS, INC. | IOVA | 4,707,458 | 2,700,000 | 28,762,568,000 | 15,934,911,000 | $6,110.00 |
| 12/31/2022 | IOVANCE BIOTHERAPEUTICS, INC. | IOVA | 2,007,458 | 0 | 12,827,657,000 | 12,808,426,000 | $6,390.00 |
| 09/30/2022 | IOVANCE BIOTHERAPEUTICS, INC. | IOVA | 2,007,458 | -790,983 | 19,231,000 | -11,664,000 | $9.58 |
| 06/30/2022 | IOVANCE BIOTHERAPEUTICS, INC. | IOVA | 2,798,441 | -3,834,565 | 30,895,000 | -79,545,000 | $11.04 |
| 03/31/2022 | IOVANCE BIOTHERAPEUTICS, INC. | IOVA | 6,633,006 | 295,306 | 110,440,000 | -10,547,000 | $16.65 |
| 12/31/2021 | IOVANCE BIOTHERAPEUTICS, INC. | IOVA | 6,337,700 | -307,400 | 120,987,000 | -51,919,000 | $19.09 |
| 06/30/2021 | IOVANCE BIOTHERAPEUTICS, INC. | IOVA | 6,645,100 | 0 | 172,906,000 | -37,478,000 | $26.02 |
| 03/31/2021 | IOVANCE BIOTHERAPEUTICS, INC. | IOVA | 6,645,100 | 0 | 210,384,000 | -97,949,000 | $31.66 |
| 12/31/2020 | IOVANCE BIOTHERAPEUTICS, INC. | IOVA | 6,645,100 | 0 | 308,333,000 | 89,576,000 | $46.40 |
| 09/30/2020 | IOVANCE BIOTHERAPEUTICS, INC. | IOVA | 6,645,100 | 0 | 218,757,000 | 36,349,000 | $32.92 |
| 06/30/2020 | IOVANCE BIOTHERAPEUTICS, INC. | IOVA | 6,645,100 | 1,096,774 | 182,408,000 | 16,319,000 | $27.45 |
| 03/31/2020 | IOVANCE BIOTHERAPEUTICS, INC. | IOVA | 5,548,326 | 0 | 166,089,000 | 12,511,000 | $29.93 |
| 12/31/2019 | IOVANCE BIOTHERAPEUTICS, INC. | IOVA | 5,548,326 | 0 | 153,578,000 | 52,598,000 | $27.68 |
| 09/30/2019 | IOVANCE BIOTHERAPEUTICS, INC. | IOVA | 5,548,326 | 0 | 100,980,000 | -35,065,000 | $18.20 |
| 06/30/2019 | IOVANCE BIOTHERAPEUTICS, INC. | IOVA | 5,548,326 | 0 | 136,045,000 | 83,280,000 | $24.52 |
| 03/31/2019 | IOVANCE BIOTHERAPEUTICS, INC. | IOVA | 5,548,326 | 0 | 52,765,000 | 3,662,000 | $9.51 |
| 12/31/2018 | IOVANCE BIOTHERAPEUTICS, INC. | IOVA | 5,548,326 | 0 | 49,103,000 | -13,316,000 | $8.85 |
| 09/30/2018 | IOVANCE BIOTHERAPEUTICS, INC. | IOVA | 5,548,326 | 0 | 62,419,000 | -8,600,000 | $11.25 |
| 06/30/2018 | IOVANCE BIOTHERAPEUTICS, INC. | IOVA | 5,548,326 | 0 | 71,019,000 | -22,748,000 | $12.80 |
| 03/31/2018 | IOVANCE BIOTHERAPEUTICS, INC. | IOVA | 5,548,326 | 0 | 93,767,000 | 49,380,000 | $16.90 |
| 12/31/2017 | IOVANCE BIOTHERAPEUTICS, INC. | IOVA | 5,548,326 | -877,300 | 44,387,000 | -5,412,000 | $8.00 |
| 09/30/2017 | IOVANCE BIOTHERAPEUTICS, INC. | IOVA | 6,425,626 | 3,042,726 | 49,799,000 | 24,596,000 | $7.75 |
| 06/30/2017 | IOVANCE BIOTHERAPEUTICS, INC. | IOVA | 3,382,900 | 3,382,900 | 25,203,000 | 25,203,000 | $7.45 |
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