The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2SEVENTY BIO INC COMMON STOCK 901384107   9,756,981 1,041,300 SH   DFND   337,000 0 704,300
89BIO INC COM 282559103   46,577,402 3,658,869 SH   SOLE   3,658,869 0 0
ABCELLERA BIOLOGICS INC COM 00288U106   42,351,180 4,180,768 SH   SOLE   4,180,768 0 0
ACLARIS THERAPEUTICS INC COM 00461U105   43,445,336 2,758,434 SH   DFND   488,400 0 2,270,034
ACUTUS MED INC COM 005111109   3,045,644 2,648,386 SH   SOLE   2,648,386 0 0
ADICET BIO INC COM 007002108   66,577,432 7,447,140 SH   SOLE   7,447,140 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103   808,570 1,797,221 SH   SOLE   1,797,221 0 0
AEROVATE THERAPEUTICS INC COM 008064107   22,254,522 759,540 SH   DFND   215,800 0 543,740
ALPINE IMMUNE SCIENCES INC COM 02083G100   29,999,701 4,081,592 SH   SOLE   4,081,592 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105   32,356,170 2,871,000 SH   DFND   605,000 0 2,266,000
AMICUS THERAPEUTICS INC COM 03152W109   6,300,360 516,000 SH   DFND   72,700 0 443,300
AMNEAL PHARMACEUTICALS INC COM STK CL A 03168L105   3,151,145 1,583,490 SH   DFND   471,800 0 1,111,690
APPLIED THERAPEUTICS INC COM 03828A101   2,318,700 3,050,921 SH   SOLE   3,050,921 0 0
ARCUTIS BIOTHERAPEUTICS INC COM 03969K108   36,409,598 2,460,108 SH   SOLE   2,460,108 0 0
ARGENX SE SPONSORED ADR 04016X101   6,137,046 16,200 SH   DFND   750 0 15,450
ARS PHARMACEUTICALS INC COM 82835W108   74,559,766 8,740,887 SH   DFND   7,788,510 0 952,377
BELLUS HEALTH INC NEW COM NEW 07987C204   38,658,842 4,708,900 SH   DFND   2,213,400 0 2,495,500
BIOATLA INC COM 09077B104   2,742,069 332,372 SH   SOLE   332,372 0 0
BIOGEN INC COM 09062X103   71,500,744 258,200 SH   DFND   37,000 0 221,200
BIOMARIN PHARMACEUTICAL INC COM 09061G101   167,158,083 1,615,210 SH   DFND   147,600 0 1,467,610
BIOMX INC COM 09090D103   525,278 2,813,489 SH   SOLE   2,813,489 0 0
BIONTECH SE SPONSORED ADS 09075V102   5,452,986 36,300 SH   SOLE   0 0 36,300
BOLT BIOTHERAPEUTICS INC COM 097702104   1,002,377 771,059 SH   SOLE   771,059 0 0
BOSTON SCIENTIFIC CORP COM 101137107   180,369,714 3,898,200 SH   SOLE   0 0 3,898,200
BRIDGEBIO PHARMA INC NOTE 2.250% 2/0 10806XAD4   12,600,000 30,000,000 PRN   SOLE   30,000,000 0 0
BRIDGEBIO PHARMA INC NOTE 2.500% 3/1 10806XAB8   7,950,000 20,000,000 PRN   SOLE   20,000,000 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108   185,983,555 2,584,900 SH   SOLE   0 0 2,584,900
CHEMOMAB THERAPEUTICS LTD SPONSORED ADS 16385C104   8,250,157 2,578,174 SH   SOLE   2,578,174 0 0
CHINOOK THERAPEUTICS INC COM 16961L106   53,167,660 2,029,300 SH   DFND   478,300 0 1,551,000
CINCOR PHARMA INC COM 17240Y109   23,424,740 1,906,000 SH   DFND   514,000 0 1,392,000
COMPASS THERAPEUTICS INC COM 20454B104   112,485,136 22,362,850 SH   DFND   18,791,422 0 3,571,428
CORVUS PHARMACEUTICALS INC COM 221015100   5,902,106 6,943,654 SH   SOLE   6,943,654 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107   58,502,831 3,196,876 SH   SOLE   3,196,876 0 0
CULLINAN ONCOLOGY INC COM 230031106   6,723,378 637,287 SH   SOLE   637,287 0 0
CYBIN INC COM 23256X100   1,651,629 5,386,299 SH   SOLE   0 0 5,386,299
DECIBEL THERAPEUTICS INC COM 24343R106   10,137,644 4,945,192 SH   DFND   4,061,774 0 883,418
DISC MEDICINE INC COM 254604101   42,981,116 2,160,941 SH   SOLE   2,160,941 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105   130,230,553 14,567,176 SH   DFND   14,301,551 0 265,625
EDWARDS LIFESCIENCES CORP COM 28176E108   64,201,905 860,500 SH   SOLE   0 0 860,500
ESSA PHARMA INC COM NEW 29668H708   920,556 365,300 SH   SOLE   365,300 0 0
EVOLENT HEALTH INC CL A 30050B101   79,321,283 2,824,832 SH   DFND   143,900 0 2,680,932
EYEPOINT PHARMACEUTICALS INC COM NEW 30233G209   1,706,747 487,642 SH   DFND   117,200 0 370,442
FUSION PHARMACEUTICALS INC COM 36118A100   10,158,026 3,224,770 SH   DFND   2,930,670 0 294,100
GALECTO INC COM 36322Q107   4,704,578 4,090,937 SH   DFND   3,803,255 0 287,682
GH RESEARCH PLC ORDINARY SHARES G3855L106   15,766,423 1,622,060 SH   DFND   239,100 0 1,382,960
GOODRX HLDGS INC COM CL A 38246G108   1,806,062 387,567 SH   DFND   125,600 0 261,967
GRACELL BIOTECHNOLOGIES INC SPONSORED ADS 38406L103   18,135,201 7,884,870 SH   DFND   5,970,672 0 1,914,198
GRAYBUG VISION INC COMMON 38942Q103   2,081,674 4,163,347 SH   SOLE   4,163,347 0 0
HARPOON THERAPEUTICS INC COM 41358P106   1,100,521 1,516,496 SH   DFND   804,206 0 712,290
HORIZON THERAPEUTICS PUB L SHS G46188101   19,459,800 171,000 SH   DFND   33,100 0 137,900
HUMANA INC COM 444859102   178,600,653 348,700 SH   SOLE   0 0 348,700
IKENA ONCOLOGY INC NONVOTING 000000000   17,204,058 6,467,691 SH   DFND   5,838,536 0 629,155
IKENA ONCOLOGY INC COM 45175G108   7,804,283 2,933,941 SH   DFND   1,936,886 0 997,055
IMARA INC COM 45249V107   17,941,063 4,386,568 SH   DFND   4,199,068 0 187,500
INTUITIVE SURGICAL INC COM NEW 46120E602   164,649,675 620,500 SH   SOLE   0 0 620,500
INVIVYD INC COM 00534A102   7,905,600 5,270,400 SH   SOLE   5,270,400 0 0
IONIS PHARMACEUTICALS INC COM 462222100   75,298,272 1,993,600 SH   DFND   136,300 0 1,857,300
IOVANCE BIOTHERAPEUTICS INC COM 462260100   12,827,657 2,007,458 SH   SOLE   0 0 2,007,458
JANUX THERAPEUTICS INC COM 47103J105   37,355,204 2,836,386 SH   DFND   2,489,664 0 346,722
KEROS THERAPEUTICS INC COM 492327101   80,645,604 1,679,417 SH   DFND   1,268,734 0 410,683
KEZAR LIFE SCIENCES INC COM 49372L100   32,273,627 4,584,322 SH   DFND   1,089,200 0 3,495,122
KINNATE BIOPHARMA INC COM 49705R105   24,666,137 4,043,629 SH   DFND   3,593,629 0 450,000
MEREO BIOPHARMA GROUP PLC SPON ADS 589492107   7,954,142 10,605,522 SH   DFND   5,777,210 0 4,828,312
MERRIMACK PHARMACEUTICALS IN COM NEW 590328209   843,456 73,600 SH   DFND   24,900 0 48,700
MERSANA THERAPEUTICS INC COM 59045L106   52,807,021 9,011,437 SH   DFND   1,928,600 0 7,082,837
MIRATI THERAPEUTICS INC COM 60468T105   58,164,085 1,283,692 SH   DFND   122,800 0 1,160,892
MODERNA INC COM 60770K107   14,827,631 82,550 SH   SOLE   0 0 82,550
MONTE ROSA THERAPEUTICS INC COM 61225M102   208,278 27,369 SH   SOLE   0 0 27,369
NATERA INC COM 632307104   78,185,000 1,946,353 SH   DFND   159,550 0 1,786,803
NEUROCRINE BIOSCIENCES INC COM 64125C109   82,138,888 687,700 SH   SOLE   0 0 687,700
NEUROPACE INC COM 641288105   5,978,299 4,012,281 SH   SOLE   4,012,281 0 0
NEXTCURE INC COM 65343E108   3,822,528 2,711,013 SH   SOLE   2,711,013 0 0
ORIC PHARMACEUTICALS INC COM 68622P109   9,468,576 1,607,568 SH   SOLE   1,607,568 0 0
PASSAGE BIO INC COM 702712100   12,326,159 8,931,999 SH   DFND   6,841,423 0 2,090,576
PFIZER INC COM 717081103   71,408,064 1,393,600 SH   SOLE   0 0 1,393,600
PMV PHARMACEUTICALS INC COM 69353Y103   57,098,770 6,563,077 SH   SOLE   6,563,077 0 0
PRELUDE THERAPEUTICS INC COM 74065P101   60,639,734 10,039,691 SH   DFND   9,250,191 0 789,500
PRELUDE THERAPEUTICS INC NONVOTING 000000000   34,308,323 5,680,186 SH   DFND   5,596,886 0 83,300
PROGYNY INC COM 74340E103   32,240,250 1,035,000 SH   SOLE   0 0 1,035,000
PROTARA THERAPEUTICS INC COM STK 74365U107   2,226,118 830,641 SH   DFND   158,900 0 671,741
PYXIS ONCOLOGY INC COMMON STOCK 747324101   1,136,658 848,252 SH   SOLE   0 0 848,252
RAPT THERAPEUTICS INC COM 75382E109   24,771,186 1,251,070 SH   DFND   310,400 0 940,670
REPARE THERAPEUTICS INC COM 760273102   48,873,798 3,322,488 SH   DFND   3,177,041 0 145,447
RXSIGHT INC COM 78349D107   15,239,894 1,202,833 SH   DFND   279,100 0 923,733
SANOFI SPONSORED ADR 80105N105   4,843,000 100,000 SH Call DFND   33,000 0 67,000
SAREPTA THERAPEUTICS INC COM 803607100   125,990,634 972,300 SH   DFND   56,900 0 915,400
SCHOLAR ROCK HLDG CORP COM 80706P103   7,954,977 879,003 SH   DFND   378,921 0 500,082
SCPHARMACEUTICALS INC COM 810648105   39,861,816 5,559,528 SH   SOLE   5,559,528 0 0
SEAGEN INC COM 81181C104   117,433,980 913,812 SH   DFND   59,800 0 854,012
SI-BONE INC COM 825704109   45,804,800 3,368,000 SH   DFND   166,900 0 3,201,100
SINGULAR GENOMICS SYSTEMS IN COM 82933R100   1,086,801 540,697 SH   SOLE   540,697 0 0
SINOVAC BIOTECH LTD COM P8696W104   340,000,000 2,718,735 SH   SOLE   0 0 2,718,735
SPDR SER TR S&P BIOTECH 78464A870   6,341,200 76,400 SH   DFND   24,000 0 52,400
SPRINGWORKS THERAPEUTICS INC COM 85205L107   136,552,500 5,250,000 SH   SOLE   5,250,000 0 0
STRYKER CORPORATION COM 863667101   117,599,690 481,000 SH   SOLE   0 0 481,000
SYNDAX PHARMACEUTICALS INC COM 87164F105   51,065,425 2,006,500 SH   DFND   444,000 0 1,562,500
SYNLOGIC INC COM 87166L100   4,582,796 6,029,995 SH   SOLE   6,029,995 0 0
TELA BIO INC COM 872381108   34,816,733 3,027,542 SH   SOLE   3,027,542 0 0
TENET HEALTHCARE CORP COM NEW 88033G407   59,538,437 1,220,300 SH   SOLE   0 0 1,220,300
TERNS PHARMACEUTICALS INC COM 880881107   77,562,794 7,619,135 SH   SOLE   7,619,135 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102   111,349,518 202,200 SH   SOLE   0 0 202,200
THESEUS PHARMACEUTICALS INC COM 88369M101   85,823,667 17,233,668 SH   SOLE   17,233,668 0 0
THIRD HARMONIC BIO INC COM 88427A107   24,850,005 5,779,071 SH   SOLE   5,779,071 0 0
TRAVERE THERAPEUTICS INC COM 89422G107   26,353,324 1,253,130 SH   DFND   267,700 0 985,430
UNIQURE NV SHS N90064101   39,617,072 1,747,555 SH   SOLE   0 0 1,747,555
UNITEDHEALTH GROUP INC COM 91324P102   201,733,490 380,500 SH   SOLE   0 0 380,500
VAXCYTE INC COM 92243G108   61,525,892 1,283,126 SH   DFND   157,800 0 1,125,326
VECTIVBIO HLDG AG ORD SHS H9060V101   60,714,451 7,006,861 SH   DFND   6,713,561 0 293,300
VENTYX BIOSCIENCES INC COM 92332V107   30,330,750 925,000 SH   DFND   297,888 0 627,112
VERASTEM INC COM 92337C104   6,642,553 16,503,237 SH   SOLE   16,503,237 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106   119,473,912 4,572,289 SH   DFND   4,260,691 0 311,598
VERTEX PHARMACEUTICALS INC COM 92532F100   78,403,770 271,500 SH   SOLE   0 0 271,500
VIGIL NEUROSCIENCE INC COM 92673K108   5,611,138 448,891 SH   SOLE   448,891 0 0
X4 PHARMACEUTICALS INC COM 98420X103   5,777,002 5,817,726 SH   SOLE   5,817,726 0 0
XENON PHARMACEUTICALS INC COM 98420N105   45,309,013 1,149,100 SH   DFND   230,000 0 919,100
XTANT MED HLDGS INC COM NEW 98420P308   48,255,631 73,114,592 SH   SOLE   73,114,592 0 0