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BAKER BROS. ADVISORS LP
> MDGL
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | MADRIGAL PHARMACEUTICALS, INC. | MDGL | 1,545,113 | 0 | 356,921,103,000 | -91,547,945,000 | $231,000.00 |
| 12/31/2022 | MADRIGAL PHARMACEUTICALS, INC. | MDGL | 1,545,113 | 45,900 | 448,469,048,000 | 448,371,614,000 | $290,250.00 |
| 09/30/2022 | MADRIGAL PHARMACEUTICALS, INC. | MDGL | 1,499,213 | 0 | 97,434,000 | -9,880,000 | $64.99 |
| 06/30/2022 | MADRIGAL PHARMACEUTICALS, INC. | MDGL | 1,499,213 | 0 | 107,314,000 | -39,789,000 | $71.58 |
| 03/31/2022 | MADRIGAL PHARMACEUTICALS, INC. | MDGL | 1,499,213 | 0 | 147,103,000 | 20,060,000 | $98.12 |
| 12/31/2021 | MADRIGAL PHARMACEUTICALS, INC. | MDGL | 1,499,213 | 0 | 127,043,000 | 7,421,000 | $84.74 |
| 09/30/2021 | MADRIGAL PHARMACEUTICALS, INC. | MDGL | 1,499,213 | 0 | 119,622,000 | -26,416,000 | $79.79 |
| 06/30/2021 | MADRIGAL PHARMACEUTICALS, INC. | MDGL | 1,499,213 | 0 | 146,038,000 | -29,325,000 | $97.41 |
| 03/31/2021 | MADRIGAL PHARMACEUTICALS, INC. | MDGL | 1,499,213 | 0 | 175,363,000 | 8,695,000 | $116.97 |
| 12/31/2020 | MADRIGAL PHARMACEUTICALS, INC. | MDGL | 1,499,213 | 0 | 166,667,509 | -11,334,491 | $111.17 |
| 09/30/2020 | MADRIGAL PHARMACEUTICALS, INC. | MDGL | 1,499,213 | 1 | 178,002,000 | 8,216,000 | $118.73 |
| 06/30/2020 | MADRIGAL PHARMACEUTICALS, INC. | MDGL | 1,499,212 | 0 | 169,786,000 | 69,699,000 | $113.25 |
| 03/31/2020 | MADRIGAL PHARMACEUTICALS, INC. | MDGL | 1,499,212 | 329,934 | 100,087,000 | -6,446,000 | $66.76 |
| 12/31/2019 | MADRIGAL PHARMACEUTICALS, INC. | MDGL | 1,169,278 | 0 | 106,533,000 | 5,718,000 | $91.11 |
| 09/30/2019 | MADRIGAL PHARMACEUTICALS, INC. | MDGL | 1,169,278 | 0 | 100,815,000 | -21,737,000 | $86.22 |
| 06/30/2019 | MADRIGAL PHARMACEUTICALS, INC. | MDGL | 1,169,278 | 0 | 122,552,000 | -23,912,000 | $104.81 |
| 03/31/2019 | MADRIGAL PHARMACEUTICALS, INC. | MDGL | 1,169,278 | 0 | 146,464,000 | 14,663,000 | $125.26 |
| 12/31/2018 | MADRIGAL PHARMACEUTICALS, INC. | MDGL | 1,169,278 | 0 | 131,801,016 | -118,575,984 | $112.72 |
| 09/30/2018 | MADRIGAL PHARMACEUTICALS, INC. | MDGL | 1,169,278 | 0 | 250,377,000 | -76,658,000 | $214.13 |
| 06/30/2018 | MADRIGAL PHARMACEUTICALS, INC. | MDGL | 1,169,278 | 553,594 | 327,035,000 | 270,521,000 | $279.69 |
| 12/31/2017 | MADRIGAL PHARMACEUTICALS, INC. | MDGL | 615,684 | 557,922 | 56,514,000 | 53,916,000 | $91.79 |
| 09/30/2017 | MADRIGAL PHARMACEUTICALS, INC. | MDGL | 57,762 | 0 | 2,598,000 | 1,659,000 | $44.98 |
| 06/30/2017 | MADRIGAL PHARMACEUTICALS, INC. | MDGL | 57,762 | 0 | 939,000 | 49,000 | $16.26 |
| 03/31/2017 | MADRIGAL PHARMACEUTICALS, INC. | MDGL | 57,762 | 0 | 890,000 | 29,000 | $15.41 |
| 12/31/2016 | MADRIGAL PHARMACEUTICALS, INC. | MDGL | 57,762 | 0 | 861,000 | 129,000 | $14.91 |
| 09/30/2016 | MADRIGAL PHARMACEUTICALS, INC. | MDGL | 57,762 | 57,762 | 732,000 | 732,000 | $12.67 |
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