The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number: 3235-0006
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hours per response: 23.8

COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Abeona Therapeutics Inc. COM 00289Y107 4,637 1,590,686 SH   SOLE   1,590,686 0 0
ACADIA Pharmaceuticals Inc. COM 004225108 2,031,115 41,904,586 SH   SOLE   41,904,586 0 0
Acceleron Pharma Inc. COM 00434H108 2,572 27,000 SH   SOLE   27,000 0 0
Adamas Pharmaceuticals, Inc. COM 00548A106 442 172,630 SH   SOLE   172,630 0 0
Adaptive Biotechnologies Corporation COM 00650F109 22,426 463,539 SH   SOLE   463,539 0 0
Adaptimmune Therapeutics plc SPONSORED ADR 00653A107 66,819 6,675,181 SH   SOLE   6,675,181 0 0
ADC Therapeutics SA SHS H0036K147 78,992 1,687,500 SH   SOLE   1,687,500 0 0
Aeglea BioTherapeutics, Inc. COM 00773J103 40,511 4,379,592 SH   SOLE   4,379,592 0 0
Affimed N.V. COM N01045108 923 200,000 SH   SOLE   200,000 0 0
Aimmune Therapeutics, Inc. COM 00900T107 11,261 673,908 SH   SOLE   673,908 0 0
Albireo Pharma, Inc. COM 01345P106 9,776 369,047 SH   SOLE   369,047 0 0
Alector, Inc. COM 014442107 6,843 280,000 SH   SOLE   280,000 0 0
Alexion Pharmaceuticals, Inc. COM 015351109 983,312 8,760,794 SH   SOLE   8,760,794 0 0
Alkermes plc SHS G01767105 24,154 1,244,744 SH   SOLE   1,244,744 0 0
Allakos Inc. COM 01671P100 52,851 735,469 SH   SOLE   735,469 0 0
Altimmune, Inc. COM 02155H200 22,572 2,107,600 SH   SOLE   2,107,600 0 0
Amarin Corporation plc SPONSORED ADR 023111206 238,717 34,496,685 SH   SOLE   34,496,685 0 0
AnaptysBio, Inc. COM 032724106 11,476 513,677 SH   SOLE   513,677 0 0
Apellis Pharmaceuticals, Inc. COM 03753U106 29,281 896,551 SH   SOLE   896,551 0 0
Applied Therapeutics, Inc. COM 03828A101 2,384 65,934 SH   SOLE   65,934 0 0
Aravive, Inc. COM 03890D108 2,841 244,055 SH   SOLE   244,055 0 0
Arcus Biosciences, Inc. COM 03969F109 3,007 121,534 SH   SOLE   121,534 0 0
argenx SE SPONSORED ADR 04016X101 229,635 1,019,557 SH   SOLE   1,019,557 0 0
ARYA Sciences Acquisition Corp. SHS CL A G3165V109 2,361 150,000 SH   SOLE   150,000 0 0
Ascendis Pharma A/S SPONSORED ADR 04351P101 501,421 3,390,270 SH   SOLE   3,390,270 0 0
Assembly Biosciences, Inc. COM 045396108 35,951 1,541,618 SH   SOLE   1,541,618 0 0
Atreca, Inc. CL A COM 04965G109 75,177 3,532,760 SH   SOLE   3,532,760 0 0
Aurinia Pharmaceuticals Inc. COM 05156V102 27,656 1,701,929 SH   SOLE   1,701,929 0 0
Autolus Therapeutics plc SPON ADS 05280R100 7,785 485,624 SH   SOLE   485,624 0 0
Axsome Therapeutics, Inc. COM 05464T104 83,083 1,009,757 SH   SOLE   1,009,757 0 0
BeiGene, Ltd. SPONSORED ADR 07725L102 2,218,840 11,777,285 SH   SOLE   11,777,285 0 0
Bellicum Pharmaceuticals, Inc. COM 079481404 1,851 249,123 SH   SOLE   249,123 0 0
BioCryst Pharmaceuticals, Inc. COM 09058V103 65,597 13,766,405 SH   SOLE   13,766,405 0 0
BioMarin Pharmaceutical Inc. COM 09061G101 936,064 7,589,294 SH   SOLE   7,589,294 0 0
bluebird bio, Inc. COM 09609G100 16,176 265,000 SH   SOLE   265,000 0 0
Burning Rock Biotech Limited SPONSORED ADS 12233L107 6,753 250,000 SH   SOLE   250,000 0 0
Cabaletta Bio, Inc. COM 12674W109 7,089 636,363 SH   SOLE   636,363 0 0
Catalyst Pharmaceuticals, Inc. COM 14888U101 2,310 500,000 SH   SOLE   500,000 0 0
Cerus Corporation COM 157085101 90,507 13,713,195 SH   SOLE   13,713,195 0 0
ChemoCentryx, Inc. COM 16383L106 54,388 945,221 SH   SOLE   945,221 0 0
Chiasma, Inc. COM 16706W102 5,093 946,701 SH   SOLE   946,701 0 0
Constellation Pharmaceuticals, Inc. COM 210373106 4,007 133,333 SH   SOLE   133,333 0 0
Crinetics Pharmaceuticals, Inc. COM 22663K107 5,569 317,857 SH   SOLE   317,857 0 0
CymaBay Therapeutics, Inc. COM 23257D103 5,315 1,522,792 SH   SOLE   1,522,792 0 0
DBV Technologies S.A. SPONSORED ADR 23306J101 64,157 14,614,264 SH   SOLE   14,614,264 0 0
Denali Therapeutics Inc. COM 24823R105 2,536 104,900 SH   SOLE   104,900 0 0
Dicerna Pharmaceuticals, Inc. COM 253031108 3,031 119,335 SH   SOLE   119,335 0 0
Exact Sciences Corporation COM 30063P105 160,503 1,846,139 SH   SOLE   1,846,139 0 0
Evofem Biosciences, Inc. COM 30048L104 4,033 1,425,000 SH   SOLE   1,425,000 0 0
Frequency Therapeutics, Inc. COM 35803L108 21,988 945,719 SH   SOLE   945,719 0 0
Forma Therapeutics Holdings, Inc. SHS 34633R104 92,980 2,000,000 SH   SOLE   2,000,000 0 0
Fulgent Genetics, Inc. COM 359664109 9,111 569,444 SH   SOLE   569,444 0 0
Galapagos NV SPON ADR 36315X101 2,579 13,072 SH   SOLE   13,072 0 0
Galmed Pharmaceuticals Ltd. SHS M47238106 1,031 215,594 SH   SOLE   215,594 0 0
Gamida Cell Ltd. SHS M47364100 3,047 666,666 SH   SOLE   666,666 0 0
Genfit SA ADS 372279109 156 28,396 SH   SOLE   28,396 0 0
Global Blood Therapeutics, Inc. COM 37890U108 2,967 47,000 SH   SOLE   47,000 0 0
GW Pharmaceuticals plc ADS 36197T103 22,709 185,045 SH   SOLE   185,045 0 0
Heron Therapeutics, Inc. COM 427746102 88,526 6,018,104 SH   SOLE   6,018,104 0 0
HOOKIPA Pharma Inc. COM 43906K100 8,140 700,481 SH   SOLE   700,481 0 0
Horizon Therapeutics Public Ltd Co SHS G46188101 11,116 200,000 SH   SOLE   200,000 0 0
Idera Pharmaceuticals, Inc. COM PAR 45168K405 8,250 4,608,786 SH   SOLE   4,608,786 0 0
IGM Biosciences, Inc. COM 449585108 229,528 3,144,223 SH   SOLE   3,144,223 0 0
Immunomedics, Inc. COM 452907108 11,695 330,000 SH   SOLE   330,000 0 0
Incyte Corporation COM 45337C102 3,326,944 31,999,081 SH   SOLE   31,999,081 0 0
Infinity Pharmaceuticals, Inc. COM 45665G303 525 580,400 SH   SOLE   580,400 0 0
Inflarx N.V. COM N44821101 4,859 1,058,555 SH   SOLE   1,058,555 0 0
Insmed Incorporated COM PAR $.01 457669307 83,319 3,025,384 SH   SOLE   3,025,384 0 0
Intellia Therapeutics, Inc. COM 45826J105 2,702 128,538 SH   SOLE   128,538 0 0
Invitae Corporation COM 46185L103 358,966 11,850,962 SH   SOLE   11,850,962 0 0
IVERIC bio, Inc. COM 46583P102 8,341 1,635,501 SH   SOLE   1,635,501 0 0
Karuna Therapeutics, Inc. COM 48576A100 9,137 81,976 SH   SOLE   81,976 0 0
Kezar Life Sciences, Inc. COM 49372L100 3,108 600,000 SH   SOLE   600,000 0 0
Kiniksa Pharmaceuticals, Ltd. COM CL A G5269C101 71,333 2,799,577 SH   SOLE   2,799,577 0 0
Kodiak Sciences Inc. COM 50015M109 626,414 11,574,538 SH   SOLE   11,574,538 0 0
Krystal Biotech, Inc. COM 501147102 33,866 817,631 SH   SOLE   817,631 0 0
Leap Therapeutics, Inc. COM 52187K101 2,045 978,454 SH   SOLE   978,454 0 0
Legend Biotech Corporation SPONSORED ADS 52490G102 5,746 135,000 SH   SOLE   135,000 0 0
Madrigal Pharmaceuticals, Inc. COM 558868105 169,786 1,499,212 SH   SOLE   1,499,212 0 0
Marker Therapeutics, Inc. COM 57055L107 498 240,505 SH   SOLE   240,505 0 0
Matinas BioPharma Holdings, Inc. COM 576810105 1,620 2,096,375 SH   SOLE   2,096,375 0 0
Merus N.V. COM N5749R100 32,783 2,037,469 SH   SOLE   2,037,469 0 0
Mirati Therapeutics, Inc. COM 60468T105 160,955 1,409,784 SH   SOLE   1,409,784 0 0
Mirum Pharmaceuticals, Inc. COM 604749101 11,352 583,333 SH   SOLE   583,333 0 0
Molecular Templates, Inc. COM 608550109 2,182 158,217 SH   SOLE   158,217 0 0
MyoKardia, Inc. COM 62857M105 305,728 3,164,234 SH   SOLE   3,164,234 0 0
Neoleukin Therapeutics, Inc. COM 64049K104 56,402 3,397,740 SH   SOLE   3,397,740 0 0
Neurocrine Biosciences, Inc. COM 64125C109 110,652 906,986 SH   SOLE   906,986 0 0
NGM Biopharmaceuticals, Inc. COM 62921N105 2,456 124,400 SH   SOLE   124,400 0 0
Novavax, Inc. COM 670002401 20,119 241,376 SH   SOLE   241,376 0 0
Orchard Therapeutics plc ADS 68570P101 2,434 405,702 SH   SOLE   405,702 0 0
Ovid Therapeutics Inc. COM 690469101 3,377 458,253 SH   SOLE   458,253 0 0
Oyster Point Pharma, Inc. COM 69242L106 2,063 71,428 SH   SOLE   71,428 0 0
Passage Bio, Inc. COM 702712100 7,516 275,000 SH   SOLE   275,000 0 0
Principia Biopharma Inc. COM 74257L108 94,520 1,580,873 SH   SOLE   1,580,873 0 0
Protagonist Therapeutics, Inc. COM 74366E102 33,756 1,911,446 SH   SOLE   1,911,446 0 0
Protara Therapeutics, Inc. COM STK 74365U107 5,854 199,671 SH   SOLE   199,671 0 0
Reata Pharmaceuticals, Inc. CL A 75615P103 8,734 55,983 SH   SOLE   55,983 0 0
Replimune Group, Inc. COM 76029N106 128 5,141 SH   SOLE   5,141 0 0
Rhythm Pharmaceuticals, Inc. COM 76243J105 60,211 2,700,055 SH   SOLE   2,700,055 0 0
Sangamo Therapeutics, Inc. COM 800677106 8,958 999,823 SH   SOLE   999,823 0 0
Seattle Genetics, Inc. COM 812578102 8,032,021 47,269,424 SH   SOLE   47,269,424 0 0
Sunesis Pharmaceuticals, Inc. COM 867328700 147 556,665 SH   SOLE   556,665 0 0
Syros Pharmaceuticals, Inc. COM 87184Q107 7,357 690,167 SH   SOLE   690,167 0 0
Tricida, Inc. COM 89610F101 21,643 787,582 SH   SOLE   787,582 0 0
uniQure N.V. SHS N90064101 10,404 230,883 SH   SOLE   230,883 0 0
Urovant Sciences Ltd. SHS G9381B108 9,840 1,000,000 SH   SOLE   1,000,000 0 0
Vaxart, Inc. COM 92243A200 14,506 1,639,121 SH   SOLE   1,639,121 0 0
Viking Therapeutics, Inc. COM 92686J106 3,064 425,000 SH   SOLE   425,000 0 0
Xencor, Inc. COM 98401F105 13,867 428,120 SH   SOLE   428,120 0 0
Xenon Pharmaceuticals Inc. COM 98420N105 10,021 799,102 SH   SOLE   799,102 0 0
Zymeworks Inc. COM 98985W102 61,625 1,708,472 SH   SOLE   1,708,472 0 0
BioMarin Pharmaceutical Inc. NOTE 0.599% 8/1/2024 09061GAH4 18,340 15,000,000 PRN   SOLE   15,000,000 0 0
Neurocrine Biosciences, Inc. NOTE 2.25% 5/15/2024 64125CAD1 51,144 30,770,000 PRN   SOLE   30,770,000 0 0