The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACADIA Pharmaceuticals Inc. COM 004225108 1,728,564 41,904,586 SH   SOLE   41,904,586 0 0
Acceleron Pharma Inc. COM 00434H108 2,885 25,640 SH   SOLE   25,640 0 0
Adamas Pharmaceuticals, Inc. COM 00548A106 675 163,830 SH   SOLE   163,830 0 0
Adaptive Biotechnologies Corporation COM 00650F109 21,423 440,539 SH   SOLE   440,539 0 0
Adaptimmune Therapeutics plc SPONSORED ADR 00653A107 50,516 6,330,354 SH   SOLE   6,330,354 0 0
ADC Therapeutics SA SHS H0036K147 55,671 1,687,500 SH   SOLE   1,687,500 0 0
Aeglea BioTherapeutics, Inc. COM 00773J103 31,051 4,379,592 SH   SOLE   4,379,592 0 0
Affimed N.V. COM N01045108 643 189,800 SH   SOLE   189,800 0 0
Akero Therapeutics, Inc. COM 00973Y108 4,058 131,788 SH   SOLE   131,788 0 0
Albireo Pharma, Inc. COM 01345P106 18,322 549,047 SH   SOLE   549,047 0 0
Alector, Inc. COM 014442107 2,798 265,600 SH   SOLE   265,600 0 0
Alexion Pharmaceuticals, Inc. COM 015351109 1,002,498 8,760,794 SH   SOLE   8,760,794 0 0
Alkermes plc SHS G01767105 22,519 1,359,001 SH   SOLE   1,359,001 0 0
Allakos Inc. COM 01671P100 56,890 698,469 SH   SOLE   698,469 0 0
Altimmune, Inc. COM 02155H200 29,132 2,206,955 SH   SOLE   2,206,955 0 0
Amarin Corporation plc SPONSORED ADR 023111206 134,799 32,018,867 SH   SOLE   32,018,867 0 0
AnaptysBio, Inc. COM 032724106 7,187 487,243 SH   SOLE   487,243 0 0
Apellis Pharmaceuticals, Inc. COM 03753U106 27,049 896,551 SH   SOLE   896,551 0 0
Applied Therapeutics, Inc. COM 03828A101 790 38,034 SH   SOLE   38,034 0 0
Aravive, Inc. COM 03890D108 357 75,854 SH   SOLE   75,854 0 0
Arcus Biosciences, Inc. COM 03969F109 1,978 115,425 SH   SOLE   115,425 0 0
argenx SE SPONSORED ADR 04016X101 267,654 1,019,557 SH   SOLE   1,019,557 0 0
Ascendis Pharma A/S SPONSORED ADR 04351P101 546,334 3,540,270 SH   SOLE   3,540,270 0 0
Assembly Biosciences, Inc. COM 045396108 25,341 1,541,418 SH   SOLE   1,541,418 0 0
Athira Pharma, Inc. COM 04746L104 16,288 882,352 SH   SOLE   882,352 0 0
Atreca, Inc. CL A COM 04965G109 49,353 3,532,760 SH   SOLE   3,532,760 0 0
Aurinia Pharmaceuticals Inc. COM 05156V102 23,834 1,618,029 SH   SOLE   1,618,029 0 0
Autolus Therapeutics plc SPONSORED ADS 05280R100 5,370 461,324 SH   SOLE   461,324 0 0
Axsome Therapeutics, Inc. COM 05464T104 68,383 959,757 SH   SOLE   959,757 0 0
BeiGene, Ltd. SPONSORED ADR 07725L102 3,810,109 13,301,597 SH   SOLE   13,301,597 0 0
Bellicum Pharmaceuticals, Inc. COM 079481404 1,637 249,123 SH   SOLE   249,123 0 0
BioCryst Pharmaceuticals, Inc. COM 09058V103 43,610 12,695,818 SH   SOLE   12,695,818 0 0
BioMarin Pharmaceutical Inc. COM 09061G101 577,393 7,589,294 SH   SOLE   7,589,294 0 0
bluebird bio, Inc. COM 09609G100 13,595 252,000 SH   SOLE   252,000 0 0
Burning Rock Biotech Limited SPONSORED ADS 12233L107 5,951 237,300 SH   SOLE   237,300 0 0
Cabaletta Bio, Inc. COM 12674W109 6,898 636,363 SH   SOLE   636,363 0 0
Catalyst Pharmaceuticals, Inc. COM 14888U101 1,409 474,400 SH   SOLE   474,400 0 0
Cerus Corporation COM 157085101 85,845 13,713,195 SH   SOLE   13,713,195 0 0
ChemoCentryx, Inc. COM 16383L106 49,310 899,821 SH   SOLE   899,821 0 0
Chiasma, Inc. COM 16706W102 3,191 742,133 SH   SOLE   742,133 0 0
Constellation Pharmaceuticals, Inc. COM 210373106 2,701 133,333 SH   SOLE   133,333 0 0
Crinetics Pharmaceuticals, Inc. COM 22663K107 4,737 302,320 SH   SOLE   302,320 0 0
Cymabay Therapeutics, Inc. COM 23257D103 23,548 3,252,542 SH   SOLE   3,252,542 0 0
DBV Technologies S.A. SPONSORED ADR 23306J101 25,283 14,614,264 SH   SOLE   14,614,264 0 0
Denali Therapeutics Inc. COM 24823R105 3,562 99,400 SH   SOLE   99,400 0 0
Dicerna Pharmaceuticals, Inc. COM 253031108 2,035 113,135 SH   SOLE   113,135 0 0
Exact Sciences Corporation COM 30063P105 188,214 1,846,139 SH   SOLE   1,846,139 0 0
Evofem Biosciences, Inc. COM 30048L104 1,022 433,048 SH   SOLE   433,048 0 0
Frequency Therapeutics, Inc. COM 35803L108 18,241 949,555 SH   SOLE   949,555 0 0
Forma Therapeutics Holdings, Inc. SHS 34633R104 88,292 1,771,509 SH   SOLE   1,771,509 0 0
Fulgent Genetics, Inc. COM 359664109 21,869 546,189 SH   SOLE   546,189 0 0
Galapagos NV SPONSORED ADR 36315X101 1,761 12,412 SH   SOLE   12,412 0 0
Galmed Pharmaceuticals Ltd. SHS M47238106 725 205,375 SH   SOLE   205,375 0 0
Gamida Cell Ltd. SHS M47364100 2,628 633,324 SH   SOLE   633,324 0 0
Genetron Holdings Limited ADS 37186H100 1,194 100,000 SH   SOLE   100,000 0 0
Genfit SA ADS 372279109 150 28,396 SH   SOLE   28,396 0 0
Global Blood Therapeutics, Inc. COM 37890U108 50,749 920,375 SH   SOLE   920,375 0 0
GW Pharmaceuticals plc ADS 36197T103 13,507 138,745 SH   SOLE   138,745 0 0
Harmony Biosciences Holdings, Inc. COM 413197104 13,560 400,000 SH   SOLE   400,000 0 0
Heron Therapeutics, Inc. COM 427746102 88,842 5,994,704 SH   SOLE   5,994,704 0 0
HOOKIPA Pharma Inc. COM 43906K100 6,634 700,481 SH   SOLE   700,481 0 0
Horizon Therapeutics Public Ltd Co SHS G46188101 51,774 666,500 SH   SOLE   666,500 0 0
Idera Pharmaceuticals, Inc. COM PAR 45168K405 9,863 4,608,786 SH   SOLE   4,608,786 0 0
IGM Biosciences, Inc. COM 449585108 232,092 3,144,446 SH   SOLE   3,144,446 0 0
Immatics N.V. SHS N44445109 10,625 1,001,414 SH   SOLE   1,001,414 0 0
Immunomedics, Inc. COM 452907108 20,211 237,694 SH   SOLE   237,694 0 0
Incyte Corporation COM 45337C102 2,871,626 31,999,398 SH   SOLE   31,999,398 0 0
Infinity Pharmaceuticals, Inc. COM 45665G303 679 580,400 SH   SOLE   580,400 0 0
Inflarx N.V. COM N44821101 4,292 1,007,559 SH   SOLE   1,007,559 0 0
Inozyme Pharma, Inc. COM 45790W108 3,115 118,500 SH   SOLE   118,500 0 0
Insmed Incorporated COM PAR $.01 457669307 73,045 2,272,712 SH   SOLE   2,272,712 0 0
Intellia Therapeutics, Inc. COM 45826J105 2,430 122,238 SH   SOLE   122,238 0 0
Invitae Corporation COM 46185L103 513,739 11,850,962 SH   SOLE   11,850,962 0 0
Iteos Therapeutics, Inc. COM 46565G104 4,134 167,562 SH   SOLE   167,562 0 0
IVERIC bio, Inc. COM 46583P102 7,930 1,406,037 SH   SOLE   1,406,037 0 0
Karuna Therapeutics, Inc. COM 48576A100 6,014 77,776 SH   SOLE   77,776 0 0
Kezar Life Sciences, Inc. COM 49372L100 2,783 574,958 SH   SOLE   574,958 0 0
Kiniksa Pharmaceuticals, Ltd. COM CL A G5269C101 42,890 2,799,577 SH   SOLE   2,799,577 0 0
Kymera Therapeutics, Inc. COM 501575104 63,302 1,959,211 SH   SOLE   1,959,211 0 0
Kodiak Sciences Inc. COM 50015M109 731,372 12,352,175 SH   SOLE   12,352,175 0 0
Krystal Biotech, Inc. COM 501147102 33,372 775,192 SH   SOLE   775,192 0 0
Leap Therapeutics, Inc. COM 52187K101 1,108 559,705 SH   SOLE   559,705 0 0
Legend Biotech Corporation SPONSORED ADS 52490G102 3,958 128,200 SH   SOLE   128,200 0 0
Madrigal Pharmaceuticals, Inc. COM 558868105 178,002 1,499,213 SH   SOLE   1,499,213 0 0
Merus N.V. COM N5749R100 24,450 2,037,469 SH   SOLE   2,037,469 0 0
Mirati Therapeutics, Inc. COM 60468T105 234,095 1,409,784 SH   SOLE   1,409,784 0 0
Mirum Pharmaceuticals, Inc. COM 604749101 10,656 553,009 SH   SOLE   553,009 0 0
Molecular Templates, Inc. COM 608550109 1,625 148,817 SH   SOLE   148,817 0 0
MyoKardia, Inc. COM 62857M105 410,264 3,009,344 SH   SOLE   3,009,344 0 0
Neoleukin Therapeutics, Inc. COM 64049K104 45,861 3,821,740 SH   SOLE   3,821,740 0 0
Neurocrine Biosciences, Inc. COM 64125C109 65,098 676,975 SH   SOLE   676,975 0 0
NGM Biopharmaceuticals, Inc. COM 62921N105 1,879 118,100 SH   SOLE   118,100 0 0
Novavax, Inc. COM 670002401 20,302 187,376 SH   SOLE   187,376 0 0
Nurix Therapeutics, Inc. COM 67080M103 62,451 1,788,921 SH   SOLE   1,788,921 0 0
Orchard Therapeutics plc ADS 68570P101 1,411 343,202 SH   SOLE   343,202 0 0
Ovid Therapeutics Inc. COM 690469101 3,391 590,761 SH   SOLE   590,761 0 0
Oyster Point Pharma, Inc. COM 69242L106 1,440 68,228 SH   SOLE   68,228 0 0
Pacific Biosciences of California, Inc. COM 69404D108 32,078 3,250,000 SH   SOLE   3,250,000 0 0
Passage Bio, Inc. COM 702712100 3,423 261,066 SH   SOLE   261,066 0 0
Prelude Therapeutics Incorporated COM 74065P101 304,875 10,118,636 SH   SOLE   10,118,636 0 0
Protagonist Therapeutics, Inc. COM 74366E102 31,206 1,596,198 SH   SOLE   1,596,198 0 0
Protara Therapeutics, Inc. COM STK 74365U107 3,360 199,671 SH   SOLE   199,671 0 0
Reata Pharmaceuticals, Inc. CL A 75615P103 5,181 53,183 SH   SOLE   53,183 0 0
Replimune Group, Inc. COM 76029N106 4,756 206,586 SH   SOLE   206,586 0 0
Rhythm Pharmaceuticals, Inc. COM 76243J105 53,550 2,471,155 SH   SOLE   2,471,155 0 0
Sangamo Therapeutics, Inc. COM 800677106 8,976 949,823 SH   SOLE   949,823 0 0
Seagen Inc. COM 81181C104 9,250,154 47,269,424 SH   SOLE   47,269,424 0 0
Sunesis Pharmaceuticals, Inc. COM PAR 867328700 66 53,066 SH   SOLE   53,066 0 0
Syros Pharmaceuticals, Inc. COM 87184Q107 6,101 690,167 SH   SOLE   690,167 0 0
TCR2 Therapeutics Inc. COM 87808K106 2,490 122,532 SH   SOLE   122,532 0 0
uniQure N.V. SHS N90064101 7,159 194,383 SH   SOLE   194,383 0 0
Urovant Sciences Ltd. SHS G9381B108 9,139 978,505 SH   SOLE   978,505 0 0
Vaxart, Inc. COM 92243A200 10,415 1,566,121 SH   SOLE   1,566,121 0 0
Viking Therapeutics, Inc. COM 92686J106 2,352 404,200 SH   SOLE   404,200 0 0
Xencor, Inc. COM 98401F105 15,909 410,142 SH   SOLE   410,142 0 0
Xenon Pharmaceuticals Inc. COM 98420N105 8,417 760,308 SH   SOLE   760,308 0 0
Zymeworks Inc. COM 98985W102 79,581 1,708,472 SH   SOLE   1,708,472 0 0
BioMarin Pharmaceutical Inc. NOTE 0.599% 8/1/2024 09061GAH4 15,650 15,000,000 PRN   SOLE   15,000,000 0 0
Invitae Corporation NOTE 2.0% 9/1/2024 46185LAB9 16,905 10,300,000 PRN   SOLE   10,300,000 0 0
Neurocrine Biosciences, Inc. NOTE 2.25% 5/15/2024 64125CAD1 42,342 30,770,000 PRN   SOLE   30,770,000 0 0