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The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2seventy bio, Inc. COM 901384107   19,327,911 2,062,744 SH   SOLE   2,062,744 0 0
Aadi Bioscience, Inc. COM 00032Q104   12,700,776 989,928 SH   SOLE   989,928 0 0
AbCellera Biologics Inc. COM 00288U106   105,860,323 10,450,180 SH   SOLE   10,450,180 0 0
ACADIA Pharmaceuticals Inc. COM 004225108   667,421,897 41,923,486 SH   SOLE   41,923,486 0 0
Achilles Therapeutics plc SPONSORED ADS 00449L102   2,332,229 2,591,366 SH   SOLE   2,591,366 0 0
Adaptimmune Therapeutics plc SPONSORED ADR 00653A107   14,353,080 9,830,877 SH   SOLE   9,830,877 0 0
Aeglea BioTherapeutics, Inc. COM 00773J103   1,534,207 3,410,106 SH   SOLE   3,410,106 0 0
Aerovate Therapeutics, Inc. COM 008064107   57,922,232 1,976,868 SH   SOLE   1,976,868 0 0
Affimed N.V. COM N01045108   8,180,069 6,596,830 SH   SOLE   6,596,830 0 0
Akero Therapeutics, Inc. COM 00973Y108   129,787,114 2,368,378 SH   SOLE   2,368,378 0 0
Alector, Inc. COM 014442107   6,294,777 681,991 SH   SOLE   681,991 0 0
Aligos Therapeutics, Inc. COM 01626L105   1,978,602 2,076,400 SH   SOLE   2,076,400 0 0
Altimmune, Inc. COM 02155H200   10,751,095 653,562 SH   SOLE   653,562 0 0
AnaptysBio, Inc. COM 032724106   24,045,885 775,924 SH   SOLE   775,924 0 0
Aravive, Inc. COM 03890D108   4,304,816 3,261,224 SH   SOLE   3,261,224 0 0
argenx SE SPONSORED ADR 04016X101   106,132,634 280,159 SH   SOLE   280,159 0 0
ARS Pharmaceuticals, Inc. COM 82835W108   17,115,027 2,006,451 SH   SOLE   2,006,451 0 0
Ascendis Pharma A/S SPONSORED ADR 04351P101   605,136,441 4,954,855 SH   SOLE   4,954,855 0 0
Atara Biotherapeutics, Inc. COM 046513107   2,440,930 744,186 SH   SOLE   744,186 0 0
Athira Pharma, Inc. COM 04746L104   5,959,080 1,879,836 SH   SOLE   1,879,836 0 0
Atreca, Inc. CL A COM 04965G109   2,828,328 3,532,760 SH   SOLE   3,532,760 0 0
aTyr Pharma, Inc. COM 002120202   18,757 8,565 SH   SOLE   8,565 0 0
Avidity Biosciences, Inc. COM 05370A108   9,647,813 434,782 SH   SOLE   434,782 0 0
BeiGene, Ltd. SPONSORED ADR 07725L102   2,566,457,206 11,668,897 SH   SOLE   11,668,897 0 0
Bellicum Pharmaceuticals, Inc. COM 079481404   179,369 249,123 SH   SOLE   249,123 0 0
Bicycle Therapeutics plc SPONSORED ADS 088786108   24,976,894 843,814 SH   SOLE   843,814 0 0
BioCryst Pharmaceuticals, Inc. COM 09058V103   145,920,191 12,710,818 SH   SOLE   12,710,818 0 0
Biohaven Ltd. COM G1110E107   6,609,517 476,190 SH   SOLE   476,190 0 0
BioMarin Pharmaceutical Inc. COM 09061G101   788,644,924 7,620,494 SH   SOLE   7,620,494 0 0
Biomea Fusion, Inc. COM 09077A106   17,741,432 2,104,559 SH   SOLE   2,104,559 0 0
bluebird bio, Inc. COM 09609G100   17,298,028 2,499,715 SH   SOLE   2,499,715 0 0
Cabaletta Bio, Inc. COM 12674W109   12,432,000 1,344,000 SH   SOLE   1,344,000 0 0
Century Therapeutics, Inc. COM 15673T100   5,896,114 1,149,340 SH   SOLE   1,149,340 0 0
Cerus Corporation COM 157085101   58,646,587 16,067,558 SH   SOLE   16,067,558 0 0
Chinook Therapeutics, Inc. COM 16961L106   66,393,472 2,534,102 SH   SOLE   2,534,102 0 0
CinCor Pharma, Inc. COM 17240Y109   9,920,635 807,212 SH   SOLE   807,212 0 0
Compass Therapeutics, Inc. COM 20454B104   7,834,879 1,557,630 SH   SOLE   1,557,630 0 0
CymaBay Therapeutics, Inc. COM 23257D103   13,608,809 2,170,464 SH   SOLE   2,170,464 0 0
Cyteir Therapeutics, Inc. COM 23284P103   4,111,995 2,492,118 SH   SOLE   2,492,118 0 0
DBV Technologies S.A. SPONSORED ADR 23306J101   22,359,824 14,614,264 SH   SOLE   14,614,264 0 0
Denali Therapeutics Inc. COM 24823R105   30,277,804 1,088,738 SH   SOLE   1,088,738 0 0
Design Therapeutics, Inc. COM 25056L103   7,101,264 692,131 SH   SOLE   692,131 0 0
DICE Therapeutics, Inc. COM 23345J104   26,900,858 862,207 SH   SOLE   862,207 0 0
Edgewise Therapeutics, Inc. COM 28036F105   4,470,000 500,000 SH   SOLE   500,000 0 0
Entrada Therapeutics, Inc. COM 29384C108   65,785,873 4,865,819 SH   SOLE   4,865,819 0 0
Fate Therapeutics, Inc. COM 31189P102   2,176,363 215,695 SH   SOLE   215,695 0 0
FibroGen, Inc. COM 31572Q808   22,030,880 1,375,211 SH   SOLE   1,375,211 0 0
Foghorn Therapeutics Inc. COM 344174107   287,272 45,027 SH   SOLE   45,027 0 0
Genetron Holdings Limited ADS 37186H100   509,943 455,306 SH   SOLE   455,306 0 0
Heron Therapeutics, Inc. COM 427746102   20,329,195 8,131,678 SH   SOLE   8,131,678 0 0
HOOKIPA Pharma Inc. COM 43906K100   2,815,183 3,475,535 SH   SOLE   3,475,535 0 0
Horizon Therapeutics Public Ltd Co SHS G46188101   110,354,933 969,727 SH   SOLE   969,727 0 0
IDEAYA Biosciences, Inc. COM 45166A102   30,314,010 1,668,355 SH   SOLE   1,668,355 0 0
IGM Biosciences, Inc. COM 449585108   53,685,295 3,156,102 SH   SOLE   3,156,102 0 0
Immatics N.V. SHS N44445109   45,179,476 5,187,081 SH   SOLE   5,187,081 0 0
Immunocore Holdings plc ADS 45258D105   143,858,118 2,520,731 SH   SOLE   2,520,731 0 0
Incyte Corporation COM 45337C102   2,903,967,271 36,154,971 SH   SOLE   36,154,971 0 0
Insmed Incorporated COM PAR $.01 457669307   398,601 19,950 SH   SOLE   19,950 0 0
Instil Bio, Inc. COM 45783C101   3,322,487 5,273,789 SH   SOLE   5,273,789 0 0
Invitae Corporation COM 46185L103   15,627,785 8,402,035 SH   SOLE   8,402,035 0 0
iTeos Therapeutics, Inc. COM 46565G104   2,936,257 150,346 SH   SOLE   150,346 0 0
Kala Pharmaceuticals, Inc. COM 483119202   2,930,416 76,813 SH   SOLE   76,813 0 0
Kezar Life Sciences, Inc. COM 49372L100   436,100 61,946 SH   SOLE   61,946 0 0
Kiniksa Pharmaceuticals, Ltd. COM CL A G5269C101   41,937,663 2,799,577 SH   SOLE   2,799,577 0 0
Kodiak Sciences Inc. COM 50015M109   123,943,108 17,310,490 SH   SOLE   17,310,490 0 0
Kronos Bio, Inc. COM 50107A104   1,941,005 1,198,151 SH   SOLE   1,198,151 0 0
Krystal Biotech, Inc. COM 501147102   23,981,162 302,716 SH   SOLE   302,716 0 0
Kymera Therapeutics, Inc. COM 501575104   71,880,432 2,879,825 SH   SOLE   2,879,825 0 0
Leap Therapeutics, Inc. COM 52187K101   251,867 559,705 SH   SOLE   559,705 0 0
MacroGenics, Inc. COM 556099109   5,989,205 892,579 SH   SOLE   892,579 0 0
Madrigal Pharmaceuticals, Inc. COM 558868105   448,469,048 1,545,113 SH   SOLE   1,545,113 0 0
Mirati Therapeutics, Inc. COM 60468T105   63,877,313 1,409,784 SH   SOLE   1,409,784 0 0
Natera, Inc. COM 632307104   4,017,000 100,000 SH   SOLE   100,000 0 0
Neoleukin Therapeutics, Inc. COM 64049K104   1,945,266 3,821,740 SH   SOLE   3,821,740 0 0
Nkarta, Inc. COM 65487U108   2,396,000 400,000 SH   SOLE   400,000 0 0
Nurix Therapeutics, Inc. COM 67080M103   42,625,733 3,882,125 SH   SOLE   3,882,125 0 0
Opthea Limited SPONSORED ADS 68386J208   14,425,856 2,691,391 SH   SOLE   2,691,391 0 0
Pacific Biosciences of California, Inc. COM 69404D108   9,225,257 1,127,782 SH   SOLE   1,127,782 0 0
PMV Pharmaceuticals, Inc. COM 69353Y103   2,801,609 322,024 SH   SOLE   322,024 0 0
POINT Biopharma Global Inc. COM 730541109   8,522,761 1,169,103 SH   SOLE   1,169,103 0 0
Praxis Precision Medicines, Inc. COM 74006W108   4,356,150 1,830,315 SH   SOLE   1,830,315 0 0
Prelude Therapeutics Inc. COM 74065P101   61,147,897 10,123,824 SH   SOLE   10,123,824 0 0
Prime Medicine, Inc. COM 74168J101   19,108,898 1,028,466 SH   SOLE   1,028,466 0 0
Protara Therapeutics, Inc. COM STK 74365U107   535,118 199,671 SH   SOLE   199,671 0 0
Reata Pharmaceuticals, Inc. CL A 75615P103   8,508,848 223,976 SH   SOLE   223,976 0 0
Replimune Group, Inc. COM 76029N106   124,529,216 4,578,280 SH   SOLE   4,578,280 0 0
Revolution Medicines, Inc. COM 76155X100   5,293,328 222,222 SH   SOLE   222,222 0 0
Rhythm Pharmaceuticals, Inc. COM 76243J105   185,046,185 6,354,608 SH   SOLE   6,354,608 0 0
Roivant Sciences Ltd. SHS G76279101   5,726,057 716,653 SH   SOLE   716,653 0 0
Seagen Inc. COM 81181C104   6,028,695,304 46,912,266 SH   SOLE   46,912,266 0 0
Sera Prognostics, Inc. CLASS A COM 81749D107   253,968 201,562 SH   SOLE   201,562 0 0
SpringWorks Therapeutics, Inc. COM 85205L107   39,757,273 1,528,538 SH   SOLE   1,528,538 0 0
Stoke Therapeutics, Inc. COM 86150R107   10,235,267 1,108,913 SH   SOLE   1,108,913 0 0
Summit Therapeutics Inc. COM 86627T108   8,500,000 2,000,000 SH   SOLE   2,000,000 0 0
Surrozen, Inc. W EXP 8/11/2026 86889P117   45,917 833,333 SH   SOLE   833,333 0 0
Talis Biomedical Corporation COM 87424L108   3,398,389 7,624,835 SH   SOLE   7,624,835 0 0
Tango Therapeutics, Inc. COM 87583X109   5,437,500 750,000 SH   SOLE   750,000 0 0
TCR2 Therapeutics Inc. COM 87808K106   752,160 753,064 SH   SOLE   753,064 0 0
Travere Therapeutics, Inc. COM 89422G107   25,767,113 1,225,255 SH   SOLE   1,225,255 0 0
TScan Therapeutics, Inc. COM 89854M101   4,316,428 2,784,792 SH   SOLE   2,784,792 0 0
Ultragenyx Pharmaceutical Inc. COM 90400D108   21,820,225 470,974 SH   SOLE   470,974 0 0
Vaxcyte, Inc. COM 92243G108   2,344,036 48,885 SH   SOLE   48,885 0 0
Vera Therapeutics, Inc. CL A 92337R101   6,449,994 333,333 SH   SOLE   333,333 0 0
Verastem, Inc. COM 92337C104   10,863,032 26,988,898 SH   SOLE   26,988,898 0 0
Veru Inc. COM 92536C103   8,498,577 1,609,579 SH   SOLE   1,609,579 0 0
Verve Therapeutics, Inc. COM 92539P101   27,409,856 1,416,530 SH   SOLE   1,416,530 0 0
Vincerx Pharma, Inc. COM 92731L106   246,207 241,379 SH   SOLE   241,379 0 0
Vor Biopharma Inc. COM 929033108   9,748,401 1,465,925 SH   SOLE   1,465,925 0 0
Xencor, Inc. COM 98401F105   3,206,227 123,127 SH   SOLE   123,127 0 0
Xenon Pharmaceuticals Inc. COM 98420N105   29,637,126 751,639 SH   SOLE   751,639 0 0
Zymeworks Inc. COM 98985Y108   13,428,590 1,708,472 SH   SOLE   1,708,472 0 0
Insmed Incorporated Note 0.75% 6/1/2028 457669AB5   19,229,604 23,500,000 PRN   SOLE   23,500,000 0 0
Invitae Corporation Note 2.0% 9/1/2024 46185LAB9   8,058,143 10,300,000 PRN   SOLE   10,300,000 0 0