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The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Abeona Therapeutics Inc. COM 00289Y107 3,340 1,590,686 SH   SOLE   1,590,686 0 0
ACADIA Pharmaceuticals Inc. COM 004225108 1,770,469 41,904,586 SH   SOLE   41,904,586 0 0
Acceleron Pharma Inc. COM 00434H108 2,426 27,000 SH   SOLE   27,000 0 0
Adamas Pharmaceuticals, Inc. COM 00548A106 499 172,630 SH   SOLE   172,630 0 0
Adaptive Biotechnologies Corporation COM 00650F109 20,661 743,734 SH   SOLE   743,734 0 0
Adaptimmune Therapeutics plc SPONSORED ADR 00653A107 10,038 3,690,307 SH   SOLE   3,690,307 0 0
Aeglea BioTherapeutics, Inc. COM 00773J103 7,985 1,713,604 SH   SOLE   1,713,604 0 0
Affimed N.V. COM N01045108 316 200,000 SH   SOLE   200,000 0 0
Aimmune Therapeutics, Inc. COM 00900T107 9,718 673,908 SH   SOLE   673,908 0 0
Albireo Pharma, Inc. COM 01345P106 6,041 369,047 SH   SOLE   369,047 0 0
Alector, Inc. COM 014442107 6,756 280,000 SH   SOLE   280,000 0 0
Alexion Pharmaceuticals, Inc. COM 015351109 786,632 8,760,794 SH   SOLE   8,760,794 0 0
Alkermes plc SHS G01767105 17,949 1,244,744 SH   SOLE   1,244,744 0 0
Allakos Inc. COM 01671P100 32,721 735,469 SH   SOLE   735,469 0 0
Amarin Corporation plc SPONSORED ADR 023111206 137,987 34,496,685 SH   SOLE   34,496,685 0 0
AnaptysBio, Inc. COM 032724106 3,315 234,592 SH   SOLE   234,592 0 0
Apellis Pharmaceuticals, Inc. COM 03753U106 24,019 896,551 SH   SOLE   896,551 0 0
Applied Therapeutics, Inc. COM 03828A101 2,155 65,934 SH   SOLE   65,934 0 0
Aravive, Inc. COM 03890D108 2,801 486,333 SH   SOLE   486,333 0 0
Arcus Biosciences, Inc. COM 03969F109 1,687 121,534 SH   SOLE   121,534 0 0
argenx SE SPONSORED ADR 04016X101 134,306 1,019,557 SH   SOLE   1,019,557 0 0
ArTara Therapeutics, Inc. COM 04300J107 4,592 199,671 SH   SOLE   199,671 0 0
ARYA Sciences Acquisition Corp. SHS CL A G3165V109 1,527 150,000 SH   SOLE   150,000 0 0
Ascendis Pharma A/S SPONSORED ADR 04351P101 381,778 3,390,270 SH   SOLE   3,390,270 0 0
Assembly Biosciences, Inc. COM 045396108 22,862 1,541,618 SH   SOLE   1,541,618 0 0
Atreca, Inc. CL A COM 04965G109 58,467 3,532,760 SH   SOLE   3,532,760 0 0
Aurinia Pharmaceuticals Inc. COM 05156V102 24,695 1,701,929 SH   SOLE   1,701,929 0 0
Autolus Therapeutics plc SPON ADS 05280R100 939 156,773 SH   SOLE   156,773 0 0
Axsome Therapeutics, Inc. COM 05464T104 52,344 889,757 SH   SOLE   889,757 0 0
BeiGene, Ltd. SPONSORED ADR 07725L102 1,449,902 11,777,285 SH   SOLE   11,777,285 0 0
Bellicum Pharmaceuticals, Inc. COM 079481404 1,173 249,123 SH   SOLE   249,123 0 0
BioCryst Pharmaceuticals, Inc. COM 09058V103 21,892 10,946,166 SH   SOLE   10,946,166 0 0
BioDelivery Sciences International, Inc. COM 09060J106 6,209 1,638,334 SH   SOLE   1,638,334 0 0
BioMarin Pharmaceutical Inc. COM 09061G101 641,295 7,589,294 SH   SOLE   7,589,294 0 0
bluebird bio, Inc. COM 09609G100 1,838 40,000 SH   SOLE   40,000 0 0
Cabaletta Bio, Inc. COM 12674W109 4,645 636,363 SH   SOLE   636,363 0 0
Catalyst Pharmaceuticals, Inc. COM 14888U101 4,084 1,060,714 SH   SOLE   1,060,714 0 0
Cerus Corporation COM 157085101 63,766 13,713,195 SH   SOLE   13,713,195 0 0
ChemoCentryx, Inc. COM 16383L106 34,515 859,015 SH   SOLE   859,015 0 0
Constellation Pharmaceuticals, Inc. COM 210373106 4,191 133,333 SH   SOLE   133,333 0 0
Crinetics Pharmaceuticals, Inc. COM 22663K107 2,573 175,000 SH   SOLE   175,000 0 0
CytomX Therapeutics, Inc. COM 23284F105 153 20,000 SH   SOLE   20,000 0 0
DBV Technologies S.A. SPONSORED ADR 23306J101 57,288 14,614,264 SH   SOLE   14,614,264 0 0
Denali Therapeutics Inc. COM 24823R105 1,837 104,900 SH   SOLE   104,900 0 0
Dicerna Pharmaceuticals, Inc. COM 253031108 1,505 81,935 SH   SOLE   81,935 0 0
Exact Sciences Corporation COM 30063P105 107,076 1,846,139 SH   SOLE   1,846,139 0 0
Evofem Biosciences, Inc. COM 30048L104 3,305 621,297 SH   SOLE   621,297 0 0
Frequency Therapeutics, Inc. COM 35803L108 21,019 1,180,162 SH   SOLE   1,180,162 0 0
Fulgent Genetics, Inc. COM 359664109 6,127 569,444 SH   SOLE   569,444 0 0
G1 Therapeutics, Inc. COM 3621LQ109 970 88,026 SH   SOLE   88,026 0 0
Galapagos NV SPONSORED ADR 36315X101 2,561 13,072 SH   SOLE   13,072 0 0
Galmed Pharmaceuticals Ltd. SHS M47238106 746 215,594 SH   SOLE   215,594 0 0
Genfit SA ADS 372279109 395 26,696 SH   SOLE   26,696 0 0
Global Blood Therapeutics, Inc. COM 37890U108 2,401 47,000 SH   SOLE   47,000 0 0
GW Pharmaceuticals plc ADS 36197T103 32,475 370,845 SH   SOLE   370,845 0 0
Harpoon Therapeutics, Inc. COM 41358P106 2,368 204,467 SH   SOLE   204,467 0 0
Heron Therapeutics, Inc. COM 427746102 70,653 6,018,104 SH   SOLE   6,018,104 0 0
HOOKIPA Pharma Inc. COM 43906K100 5,779 700,481 SH   SOLE   700,481 0 0
Horizon Therapeutics Public Ltd Co SHS G46188101 5,924 200,000 SH   SOLE   200,000 0 0
IDEAYA Biosciences, Inc. COM 45166A102 522 126,611 SH   SOLE   126,611 0 0
Idera Pharmaceuticals, Inc. COM PAR 45168K405 6,084 4,608,786 SH   SOLE   4,608,786 0 0
IGM Biosciences, Inc. COM 449585108 176,536 3,144,000 SH   SOLE   3,144,000 0 0
Immunomedics, Inc. COM 452907108 4,179 310,000 SH   SOLE   310,000 0 0
Incyte Corporation COM 45337C102 2,341,806 31,978,785 SH   SOLE   31,978,785 0 0
Infinity Pharmaceuticals, Inc. COM 45665G303 486 580,400 SH   SOLE   580,400 0 0
Inflarx N.V. COM N44821101 6,794 1,778,415 SH   SOLE   1,778,415 0 0
Insmed Incorporated COM PAR $.01 457669307 48,497 3,025,384 SH   SOLE   3,025,384 0 0
Intellia Therapeutics, Inc. COM 45826J105 1,572 128,538 SH   SOLE   128,538 0 0
Invitae Corporation COM 46185L103 124,405 9,100,615 SH   SOLE   9,100,615 0 0
IVERIC bio, Inc. COM 46583P102 5,626 1,635,501 SH   SOLE   1,635,501 0 0
Karuna Therapeutics, Inc. COM 48576A100 3,022 41,976 SH   SOLE   41,976 0 0
Kiniksa Pharmaceuticals, Ltd. COM CL A G5269C101 43,337 2,799,577 SH   SOLE   2,799,577 0 0
Kodiak Sciences Inc. COM 50015M109 552,105 11,574,538 SH   SOLE   11,574,538 0 0
Krystal Biotech, Inc. COM 501147102 40,925 946,471 SH   SOLE   946,471 0 0
Leap Therapeutics, Inc. COM 52187K101 1,546 978,454 SH   SOLE   978,454 0 0
Madrigal Pharmaceuticals, Inc. COM 558868105 100,087 1,499,212 SH   SOLE   1,499,212 0 0
Marker Therapeutics, Inc. COM 57055L107 2,793 1,470,198 SH   SOLE   1,470,198 0 0
Matinas BioPharma Holdings, Inc. COM 576810105 2,253 3,754,221 SH   SOLE   3,754,221 0 0
Menlo Therapeutics Inc. COM 586858102 1,676 625,345 SH   SOLE   625,345 0 0
Merus N.V. COM N5749R100 24,653 2,037,469 SH   SOLE   2,037,469 0 0
Millendo Therapeutics, Inc. COM 60040X103 4,400 833,333 SH   SOLE   833,333 0 0
Minerva Neurosciences, Inc. COM 603380106 4,145 688,531 SH   SOLE   688,531 0 0
Mirati Therapeutics, Inc. COM 60468T105 108,370 1,409,784 SH   SOLE   1,409,784 0 0
Mirum Pharmaceuticals, Inc. COM 604749101 8,167 583,333 SH   SOLE   583,333 0 0
Molecular Templates, Inc. COM 608550109 3,162 237,917 SH   SOLE   237,917 0 0
MyoKardia, Inc. COM 62857M105 83,176 1,774,234 SH   SOLE   1,774,234 0 0
Neoleukin Therapeutics, Inc. COM 64049K104 38,666 3,397,740 SH   SOLE   3,397,740 0 0
Neurocrine Biosciences, Inc. COM 64125C109 107,343 1,240,243 SH   SOLE   1,240,243 0 0
NGM Biopharmaceuticals, Inc. COM 62921N105 3,083 250,000 SH   SOLE   250,000 0 0
Orchard Therapeutics plc ADS 68570P101 3,055 405,702 SH   SOLE   405,702 0 0
Ovid Therapeutics Inc. COM 690469101 207 69,471 SH   SOLE   69,471 0 0
Passage Bio, Inc. COM 702712100 4,331 275,000 SH   SOLE   275,000 0 0
Principia Biopharma Inc. COM 74257L108 116,112 1,955,413 SH   SOLE   1,955,413 0 0
Protagonist Therapeutics, Inc. COM 74366E102 11,855 1,679,164 SH   SOLE   1,679,164 0 0
Ra Pharmaceuticals, Inc. COM 74933V108 100,525 2,093,839 SH   SOLE   2,093,839 0 0
Reata Pharmaceuticals, Inc. CL A 75615P103 8,081 55,983 SH   SOLE   55,983 0 0
Rhythm Pharmaceuticals, Inc. COM 76243J105 41,219 2,708,200 SH   SOLE   2,708,200 0 0
Sangamo Therapeutics, Inc. COM 800677106 6,369 999,823 SH   SOLE   999,823 0 0
Seattle Genetics, Inc. COM 812578102 5,775,950 50,060,240 SH   SOLE   50,060,240 0 0
Sunesis Pharmaceuticals, Inc. COM PAR 867328700 231 556,665 SH   SOLE   556,665 0 0
Syros Pharmaceuticals, Inc. COM 87184Q107 4,093 690,167 SH   SOLE   690,167 0 0
Tricida, Inc. COM 89610F101 58,652 2,666,015 SH   SOLE   2,666,015 0 0
uniQure N.V. SHS N90064101 16,944 357,083 SH   SOLE   357,083 0 0
UroGen Pharma Ltd. COM M96088105 12,005 672,912 SH   SOLE   672,912 0 0
Urovant Sciences Ltd. SHS G9381B108 9,220 1,000,000 SH   SOLE   1,000,000 0 0
Viking Therapeutics, Inc. COM 92686J106 1,989 425,000 SH   SOLE   425,000 0 0
Xencor, Inc. COM 98401F105 12,792 428,120 SH   SOLE   428,120 0 0
Zymeworks Inc. COM 98985W102 60,600 1,708,472 SH   SOLE   1,708,472 0 0
BioMarin Pharmaceutical Inc. NOTE 0.599% 8/1/2024 09061GAH4 15,576 15,000,000 PRN   SOLE   15,000,000 0 0
Neurocrine Biosciences, Inc. NOTE 2.25% 5/15/2024 64125CAD1 39,321 30,770,000 PRN   SOLE   30,770,000 0 0