The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2seventy bio, Inc. COMMON STOCK 901384107 21,356 833,236 SH   SOLE   833,236 0 0
AbCellera Biologics Inc. COM 00288U106 149,438 10,450,180 SH   SOLE   10,450,180 0 0
ACADIA Pharmaceuticals Inc. COM 004225108 978,196 41,910,704 SH   SOLE   41,910,704 0 0
Achilles Therapeutics plc SPONSORED ADS 00449L102 12,983 2,591,366 SH   SOLE   2,591,366 0 0
Adaptimmune Therapeutics plc SPONSORED ADR 00653A107 36,866 9,830,877 SH   SOLE   9,830,877 0 0
Aeglea BioTherapeutics, Inc. COM 00773J103 16,198 3,410,106 SH   SOLE   3,410,106 0 0
Aerovate Therapeutics, Inc. COM 008064107 21,597 1,831,789 SH   SOLE   1,831,789 0 0
Affimed N.V. COM N01045108 14,645 2,653,169 SH   SOLE   2,653,169 0 0
Akero Therapeutics, Inc. COM 00973Y108 2,504 118,378 SH   SOLE   118,378 0 0
Albireo Pharma, Inc. COM 01345P106 2,434 104,521 SH   SOLE   104,521 0 0
Alector, Inc. COM 014442107 4,940 239,228 SH   SOLE   239,228 0 0
Aligos Therapeutics, Inc. COM 01626L105 24,647 2,076,400 SH   SOLE   2,076,400 0 0
Alkermes plc SHS G01767105 34,890 1,500,000 SH   SOLE   1,500,000 0 0
Allakos Inc. COM 01671P100 6,883 703,050 SH   SOLE   703,050 0 0
Altimmune, Inc. COM 02155H200 9,820 1,072,038 SH   SOLE   1,072,038 0 0
Amarin Corporation plc SPONSORED ADR 023111206 71,342 21,169,805 SH   SOLE   21,169,805 0 0
AnaptysBio, Inc. COM 032724106 14,844 427,179 SH   SOLE   427,179 0 0
argenx SE SPONSORED ADR 04016X101 392,058 1,119,557 SH   SOLE   1,119,557 0 0
Ascendis Pharma A/S SPONSORED ADR 04351P101 610,982 4,541,604 SH   SOLE   4,541,604 0 0
Athira Pharma, Inc. COM 04746L104 10,507 806,367 SH   SOLE   806,367 0 0
Atreca, Inc. CL A COM 04965G109 10,704 3,532,760 SH   SOLE   3,532,760 0 0
aTyr Pharma, Inc. COM 002120202 4,669 625,000 SH   SOLE   625,000 0 0
Axsome Therapeutics, Inc. COM 05464T104 23,082 610,970 SH   SOLE   610,970 0 0
BeiGene, Ltd. SPONSORED ADR 07725L102 3,161,454 11,668,897 SH   SOLE   11,668,897 0 0
Bellicum Pharmaceuticals, Inc. COM 079481404 371 249,123 SH   SOLE   249,123 0 0
BioAtla, Inc. COM 09077B104 16,195 825,000 SH   SOLE   825,000 0 0
BioCryst Pharmaceuticals, Inc. COM 09058V103 176,045 12,710,818 SH   SOLE   12,710,818 0 0
BioMarin Pharmaceutical Inc. COM 09061G101 673,271 7,620,494 SH   SOLE   7,620,494 0 0
Biomea Fusion, Inc. COM 09077A106 3,908 524,617 SH   SOLE   524,617 0 0
bluebird bio, Inc. COM 09609G100 24,972 2,499,715 SH   SOLE   2,499,715 0 0
Burning Rock Biotech Limited SPONSORED ADS 12233L107 1,993 209,131 SH   SOLE   209,131 0 0
Cabaletta Bio, Inc. COM 12674W109 2,509 662,063 SH   SOLE   662,063 0 0
Centessa Pharmaceuticals plc SPONSORED ADS 152309100 12,693 1,127,273 SH   SOLE   1,127,273 0 0
Cerus Corporation COM 157085101 93,387 13,713,195 SH   SOLE   13,713,195 0 0
ChemoCentryx, Inc. COM 16383L106 59,394 1,631,266 SH   SOLE   1,631,266 0 0
Chinook Therapeutics, Inc. COM 16961L106 38,069 2,334,102 SH   SOLE   2,334,102 0 0
Crinetics Pharmaceuticals, Inc. COM 22663K107 23,509 827,480 SH   SOLE   827,480 0 0
CymaBay Therapeutics, Inc. COM 23257D103 7,336 2,170,464 SH   SOLE   2,170,464 0 0
Cyteir Therapeutics, Inc. COM 23284P103 9,240 812,640 SH   SOLE   812,640 0 0
DBV Technologies S.A. SPONSORED ADR 23306J101 23,383 14,614,264 SH   SOLE   14,614,264 0 0
Denali Therapeutics Inc. COM 24823R105 3,958 88,738 SH   SOLE   88,738 0 0
Design Therapeutics, Inc. COM 25056L103 30,758 1,436,636 SH   SOLE   1,436,636 0 0
DICE Therapeutics, Inc. COM 23345J104 14,888 588,235 SH   SOLE   588,235 0 0
Edgewise Therapeutics, Inc. COM 28036F105 7,640 500,000 SH   SOLE   500,000 0 0
Entrada Therapeutics, Inc. COM 29384C108 80,540 4,704,419 SH   SOLE   4,704,419 0 0
Evofem Biosciences, Inc. COM 30048L104 1,013 2,697,110 SH   SOLE   2,697,110 0 0
FibroGen, Inc. COM 31572Q808 8,180 580,150 SH   SOLE   580,150 0 0
Foghorn Therapeutics Inc. COM 344174107 1,030 45,027 SH   SOLE   45,027 0 0
Forma Therapeutics Holdings, Inc. SHS 34633R104 28,794 2,024,876 SH   SOLE   2,024,876 0 0
Fulgent Genetics, Inc. COM 359664109 20,263 201,444 SH   SOLE   201,444 0 0
Gamida Cell Ltd. SHS M47364100 1,551 610,626 SH   SOLE   610,626 0 0
Genetron Holdings Limited ADS 37186H100 2,777 455,306 SH   SOLE   455,306 0 0
Global Blood Therapeutics, Inc. COM 37890U108 97,023 3,314,765 SH   SOLE   3,314,765 0 0
Harmony Biosciences Holdings, Inc. COM 413197104 5,270 123,600 SH   SOLE   123,600 0 0
Heron Therapeutics, Inc. COM 427746102 74,242 8,131,678 SH   SOLE   8,131,678 0 0
HOOKIPA Pharma Inc. COM 43906K100 1,632 700,481 SH   SOLE   700,481 0 0
Horizon Therapeutics Public Ltd Co SHS G46188101 64,560 599,110 SH   SOLE   599,110 0 0
IGM Biosciences, Inc. COM 449585108 92,568 3,156,102 SH   SOLE   3,156,102 0 0
Immatics N.V. SHS N44445109 59,455 4,423,731 SH   SOLE   4,423,731 0 0
Immunocore Holdings plc ADS 45258D105 86,310 2,520,730 SH   SOLE   2,520,730 0 0
Incyte Corporation COM 45337C102 2,467,566 33,618,063 SH   SOLE   33,618,063 0 0
Inozyme Pharma, Inc. COM 45790W108 730 106,999 SH   SOLE   106,999 0 0
Insmed Incorporated COM PAR $.01 457669307 58,729 2,156,001 SH   SOLE   2,156,001 0 0
Instil Bio, Inc. COM 45783C101 66,621 3,893,700 SH   SOLE   3,893,700 0 0
Invitae Corporation COM 46185L103 150,768 9,873,488 SH   SOLE   9,873,488 0 0
Iteos Therapeutics, Inc. COM 46565G104 7,000 150,346 SH   SOLE   150,346 0 0
Karuna Therapeutics, Inc. COM 48576A100 9,166 69,966 SH   SOLE   69,966 0 0
Kezar Life Sciences, Inc. COM 49372L100 2,335 139,676 SH   SOLE   139,676 0 0
Kiniksa Pharmaceuticals, Ltd. COM CL A G5269C101 32,951 2,799,577 SH   SOLE   2,799,577 0 0
Kodiak Sciences Inc. COM 50015M109 1,244,681 14,681,304 SH   SOLE   14,681,304 0 0
Krystal Biotech, Inc. COM 501147102 56,501 807,735 SH   SOLE   807,735 0 0
Kura Oncology, Inc. COM 50127T109 4,258 304,158 SH   SOLE   304,158 0 0
Kymera Therapeutics, Inc. COM 501575104 151,407 2,384,742 SH   SOLE   2,384,742 0 0
Leap Therapeutics, Inc. COM 52187K101 1,813 559,705 SH   SOLE   559,705 0 0
Legend Biotech Corporation SPONSORED ADS 52490G102 116,012 2,489,003 SH   SOLE   2,489,003 0 0
LogicBio Therapeutics, Inc. COM 54142F102 1,043 451,478 SH   SOLE   451,478 0 0
MacroGenics, Inc. COM 556099109 7,103 442,579 SH   SOLE   442,579 0 0
Madrigal Pharmaceuticals, Inc. COM 558868105 127,043 1,499,213 SH   SOLE   1,499,213 0 0
Merus N.V. COM N5749R100 64,792 2,037,469 SH   SOLE   2,037,469 0 0
Mirati Therapeutics, Inc. COM 60468T105 206,801 1,409,784 SH   SOLE   1,409,784 0 0
Neoleukin Therapeutics, Inc. COM 64049K104 18,421 3,821,740 SH   SOLE   3,821,740 0 0
Neurocrine Biosciences, Inc. COM 64125C109 57,658 676,975 SH   SOLE   676,975 0 0
NexImmune, Inc. COM 65344D109 1,356 294,117 SH   SOLE   294,117 0 0
NGM Biopharmaceuticals, Inc. COM 62921N105 5,168 291,801 SH   SOLE   291,801 0 0
Novavax, Inc. COM 670002401 6,891 48,168 SH   SOLE   48,168 0 0
Nurix Therapeutics, Inc. COM 67080M103 71,046 2,454,082 SH   SOLE   2,454,082 0 0
Opthea Limited SPONSORED ADS 68386J208 24,115 3,196,191 SH   SOLE   3,196,191 0 0
Otonomy, Inc. COM 68906L105 16,317 7,844,692 SH   SOLE   7,844,692 0 0
Oyster Point Pharma, Inc. COM 69242L106 1,122 61,424 SH   SOLE   61,424 0 0
Pacific Biosciences of California, Inc. COM 69404D108 111,404 5,444,963 SH   SOLE   5,444,963 0 0
Passage Bio, Inc. COM 702712100 744 117,161 SH   SOLE   117,161 0 0
Prelude Therapeutics Inc. COM 74065P101 126,042 10,123,824 SH   SOLE   10,123,824 0 0
Protara Therapeutics, Inc. COM STK 74365U107 1,348 199,671 SH   SOLE   199,671 0 0
Reata Pharmaceuticals, Inc. CL A 75615P103 5,906 223,976 SH   SOLE   223,976 0 0
Relmada Therapeutics, Inc. COM 75955J402 11,155 495,113 SH   SOLE   495,113 0 0
Replimune Group, Inc. COM 76029N106 16,081 593,395 SH   SOLE   593,395 0 0
Revolution Medicines, Inc. COM 76155X100 5,593 222,222 SH   SOLE   222,222 0 0
Rhythm Pharmaceuticals, Inc. COM 76243J105 38,555 3,863,239 SH   SOLE   3,863,239 0 0
Sarepta Therapeutics, Inc. COM 803607100 11,117 123,456 SH   SOLE   123,456 0 0
Seagen Inc. COM 81181C104 7,249,714 46,893,364 SH   SOLE   46,893,364 0 0
Sera Prognostics, Inc. CLASS A COM 81749D107 1,385 201,562 SH   SOLE   201,562 0 0
Surrozen, Inc. COM 86889P109 16,100 2,500,000 SH   SOLE   2,500,000 0 0
Surrozen, Inc. W EXP 8/11/2026 86889P117 958 833,333 SH   SOLE   833,333 0 0
Syndax Pharmaceuticals, Inc. COM 87164F105 2,424 110,729 SH   SOLE   110,729 0 0
Talis Biomedical Corporation COM 87424L108 30,576 7,624,835 SH   SOLE   7,624,835 0 0
Tango Therapeutics, Inc. COM 87583X109 8,205 750,000 SH   SOLE   750,000 0 0
TCR2 Therapeutics Inc. COM 87808K106 3,509 753,064 SH   SOLE   753,064 0 0
Travere Therapeutics, Inc. COM 89422G107 82,847 2,669,054 SH   SOLE   2,669,054 0 0
Tricida, Inc. COM 89610F101 12,285 1,285,014 SH   SOLE   1,285,014 0 0
TScan Therapeutics, Inc. COM 89854M101 6,413 1,425,000 SH   SOLE   1,425,000 0 0
Ultragenyx Pharmaceutical Inc. COM 90400D108 37,373 444,444 SH   SOLE   444,444 0 0
Verastem, Inc. COM 92337C104 44,058 21,491,630 SH   SOLE   21,491,630 0 0
Verve Therapeutics, Inc. COM 92539P101 52,227 1,416,530 SH   SOLE   1,416,530 0 0
Vincerx Pharma, Inc. COM 92731L106 2,460 241,379 SH   SOLE   241,379 0 0
Xenon Pharmaceuticals Inc. COM 98420N105 23,481 751,639 SH   SOLE   751,639 0 0
Zymeworks Inc. COM 98985W102 28,002 1,708,472 SH   SOLE   1,708,472 0 0
Apellis Pharmaceuticals, Inc. Note 3.5% 9/15/2026 03753UAB2 47,968 31,754,000 PRN   SOLE   31,754,000 0 0
Insmed Incorporated Note 0.75% 6/1/2028 457669AB5 43,336 40,000,000 PRN   SOLE   40,000,000 0 0
Invitae Corporation Note 2.0% 9/1/2024 46185LAB9 9,623 10,300,000 PRN   SOLE   10,300,000 0 0
Sarepta Therapeutics, Inc. DBCV 1.5% 11/15/2024 803607AB6 42,695 29,174,000 PRN   SOLE   29,174,000 0 0
Tricida, Inc. Note 3.5% 5/15/2027 89610FAB7 14,828 27,500,000 PRN   SOLE   27,500,000 0 0