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The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACADIA Pharmaceuticals Inc. COM 004225108 1,050,277 39,292,086 SH   SOLE   39,292,086 0 0
Abeona Therapeutics Inc. COM 00289Y107 6,158 1,288,235 SH   SOLE   1,288,235 0 0
Acceleron Pharma Inc. COM 00434H108 3,447 83,900 SH   SOLE   83,900 0 0
Achillion Pharmaceuticals, Inc. COM 00448Q201 2,936 1,095,359 SH   SOLE   1,095,359 0 0
Acorda Therapeutics, Inc. COM 00484M106 15,426 2,011,189 SH   SOLE   2,011,189 0 0
Adamas Pharmaceuticals, Inc. COM 00548A106 1,070 172,630 SH   SOLE   172,630 0 0
Adaptive Biotechnologies Corporation COM 00650F109 56,289 1,165,411 SH   SOLE   1,165,411 0 0
Aeglea BioTherapeutics, Inc. COM 00773J103 11,738 1,713,604 SH   SOLE   1,713,604 0 0
Affimed N.V. COM N01045108 574 200,000 SH   SOLE   200,000 0 0
Aileron Therapeutics, Inc. COM 00887A105 1,469 2,040,000 SH   SOLE   2,040,000 0 0
Aimmune Therapeutics, Inc. COM 00900T107 14,031 673,908 SH   SOLE   673,908 0 0
Albireo Pharma, Inc. COM 01345P106 8,060 250,000 SH   SOLE   250,000 0 0
Alexion Pharmaceuticals, Inc. COM 015351109 1,081,642 8,258,068 SH   SOLE   8,258,068 0 0
Alkermes plc SHS G01767105 9,016 400,000 SH   SOLE   400,000 0 0
Amarin Corporation plc SPONSORED ADR 023111206 805,544 41,544,288 SH   SOLE   41,544,288 0 0
AnaptysBio, Inc. COM 032724106 6,380 113,086 SH   SOLE   113,086 0 0
Apellis Pharmaceuticals, Inc. COM 03753U106 7,950 313,725 SH   SOLE   313,725 0 0
Aquestive Therapeutics, Inc. COM 03843E104 418 99,600 SH   SOLE   99,600 0 0
Aquinox Pharmaceuticals, Inc. COM 03842B101 25,805 10,934,154 SH   SOLE   10,934,154 0 0
Aravive, Inc. COM 03890D108 2,910 484,947 SH   SOLE   484,947 0 0
Arcus Biosciences, Inc. COM 03969F109 966 121,534 SH   SOLE   121,534 0 0
argenx SE SPONSORED ADR 04016X101 144,349 1,019,557 SH   SOLE   1,019,557 0 0
Array BioPharma Inc. COM 04269X105 131,974 2,848,567 SH   SOLE   2,848,567 0 0
Ascendis Pharma A/S SPONSORED ADR 04351P101 390,390 3,390,270 SH   SOLE   3,390,270 0 0
Assembly Biosciences, Inc. COM 045396108 10,836 803,246 SH   SOLE   803,246 0 0
Atreca, Inc. CL A Common 04965G109 66,557 3,532,760 SH   SOLE   3,532,760 0 0
Audentes Therapeutics, Inc. COM 05070R104 57,034 1,506,438 SH   SOLE   1,506,438 0 0
Autolus Therapeutics plc SPONSORED ADS 05280R100 2,524 156,773 SH   SOLE   156,773 0 0
Axsome Therapeutics, Inc. COM 05464T104 19,886 772,286 SH   SOLE   772,286 0 0
BeiGene, Ltd. SPONSORED ADR 07725L102 1,459,794 11,777,285 SH   SOLE   11,777,285 0 0
Bellicum Pharmaceuticals, Inc. COM 079481107 4,552 2,677,818 SH   SOLE   2,677,818 0 0
BioCryst Pharmaceuticals, Inc. COM 09058V103 54,510 14,382,673 SH   SOLE   14,382,673 0 0
BioMarin Pharmaceutical Inc. COM 09061G101 650,023 7,589,294 SH   SOLE   7,589,294 0 0
bluebird bio, Inc. COM 09609G100 5,088 40,000 SH   SOLE   40,000 0 0
Catalyst Pharmaceuticals, Inc. COM 14888U101 9,828 2,559,461 SH   SOLE   2,559,461 0 0
Cerus Corporation COM 157085101 60,415 10,749,937 SH   SOLE   10,749,937 0 0
ChemoCentryx, Inc. COM 16383L106 1,925 207,029 SH   SOLE   207,029 0 0
Constellation Pharmaceuticals, Inc. COM 210373106 1,637 133,333 SH   SOLE   133,333 0 0
Crinetics Pharmaceuticals, Inc. COM 22663K107 3,325 132,985 SH   SOLE   132,985 0 0
Cyclerion Therapeutics, Inc. COM 23255M105 2,320 202,581 SH   SOLE   202,581 0 0
CymaBay Therapeutics, Inc. COM 23257D103 40,865 5,707,411 SH   SOLE   5,707,411 0 0
CytomX Therapeutics, Inc. COM 23284F105 2,181 194,377 SH   SOLE   194,377 0 0
DBV Technologies S.A. SPONSORED ADR 23306J101 45,289 5,509,560 SH   SOLE   5,509,560 0 0
Dermira, Inc. COM 24983L104 8,670 906,943 SH   SOLE   906,943 0 0
Dova Pharmaceuticals, Inc. COM 25985T102 1,402 99,405 SH   SOLE   99,405 0 0
Dynavax Technologies Corporation COM 268158201 299 75,000 SH   SOLE   75,000 0 0
Foamix Pharmaceuticals Ltd. SHS M46135105 1,186 498,189 SH   SOLE   498,189 0 0
Forty Seven, Inc. COM 34983P104 2,650 250,000 SH   SOLE   250,000 0 0
Fulgent Genetics, Inc. COM 359664109 835 125,000 SH   SOLE   125,000 0 0
G1 Therapeutics, Inc. COM 3621LQ109 3,901 127,236 SH   SOLE   127,236 0 0
GW Pharmaceuticals plc ADS 36197T103 63,930 370,845 SH   SOLE   370,845 0 0
Galapagos NV SPONSORED ADR 36315X101 3,233 25,072 SH   SOLE   25,072 0 0
Galmed Pharmaceuticals Ltd. SHS M47238106 1,585 215,594 SH   SOLE   215,594 0 0
Genomic Health, Inc. COM 37244C101 538,708 9,260,922 SH   SOLE   9,260,922 0 0
HOOKIPA Pharma Inc. COM 43906K100 6,009 892,857 SH   SOLE   892,857 0 0
Halozyme Therapeutics, Inc. COM 40637H109 5,153 299,969 SH   SOLE   299,969 0 0
Harpoon Therapeutics, Inc. COM 41358P106 2,786 214,285 SH   SOLE   214,285 0 0
Heron Therapeutics, Inc. COM 427746102 111,877 6,018,104 SH   SOLE   6,018,104 0 0
IDEAYA Biosciences, Inc. COM 45166A102 1,992 200,000 SH   SOLE   200,000 0 0
Idera Pharmaceuticals, Inc. COM PAR 45168K405 12,298 4,605,822 SH   SOLE   4,605,822 0 0
Incyte Corporation COM 45337C102 2,716,697 31,976,193 SH   SOLE   31,976,193 0 0
Infinity Pharmaceuticals, Inc. COM 45665G303 1,045 580,400 SH   SOLE   580,400 0 0
Insmed Incorporated COM PAR $.01 457669307 63,033 2,462,216 SH   SOLE   2,462,216 0 0
Intellia Therapeutics, Inc. COM 45826J105 2,104 128,538 SH   SOLE   128,538 0 0
Invitae Corporation COM 46185L103 91,707 3,902,421 SH   SOLE   3,902,421 0 0
Kiniksa Pharmaceuticals, Ltd. COM CL A G5269C101 37,906 2,799,577 SH   SOLE   2,799,577 0 0
Kodiak Sciences, Inc. COM 50015M109 106,998 9,145,115 SH   SOLE   9,145,115 0 0
Krystal Biotech, Inc. COM 501147102 41,666 1,034,674 SH   SOLE   1,034,674 0 0
La Jolla Pharmaceutical Company COM PAR $.0001 2 503459604 14,423 1,559,231 SH   SOLE   1,559,231 0 0
Madrigal Pharmaceuticals, Inc. COM 558868105 122,552 1,169,278 SH   SOLE   1,169,278 0 0
Marker Therapeutics, Inc. COM 57055L107 11,880 1,500,000 SH   SOLE   1,500,000 0 0
Menlo Therapeutics Inc. COM 586858102 4,193 700,000 SH   SOLE   700,000 0 0
Merus N.V. COM N5749R100 16,994 1,160,014 SH   SOLE   1,160,014 0 0
Milestone Pharmaceuticals Inc. COM 59935V107 7,240 266,667 SH   SOLE   266,667 0 0
Mirati Therapeutics, Inc. COM 60468T105 258,887 2,513,462 SH   SOLE   2,513,462 0 0
Molecular Templates, Inc. COM 608550109 2,123 254,230 SH   SOLE   254,230 0 0
MyoKardia, Inc. COM 62857M105 50,958 1,016,306 SH   SOLE   1,016,306 0 0
NGM Biopharmaceuticals, Inc. COM 62921N105 3,660 250,000 SH   SOLE   250,000 0 0
Neurocrine Biosciences, Inc. COM 64125C109 119,492 1,415,283 SH   SOLE   1,415,283 0 0
NextCure, Inc. COM 65343E108 2,247 150,000 SH   SOLE   150,000 0 0
Orchard Therapeutics plc ADS 68570P101 5,676 405,702 SH   SOLE   405,702 0 0
Principia Biopharma Inc. COM 74257L108 59,337 1,787,807 SH   SOLE   1,787,807 0 0
Protagonist Therapeutics, Inc. COM 74366E102 12,050 995,082 SH   SOLE   995,082 0 0
Ra Pharmaceuticals, Inc. COM 74933V108 54,177 1,801,695 SH   SOLE   1,801,695 0 0
Rhythm Pharmaceuticals, Inc. COM 76243J105 59,580 2,708,200 SH   SOLE   2,708,200 0 0
Ritter Pharmaceuticals, Inc. COM 767836307 300 279,999 SH   SOLE   279,999 0 0
Sangamo Therapeutics, Inc. COM 800677106 10,768 999,823 SH   SOLE   999,823 0 0
Seattle Genetics, Inc. COM 812578102 3,464,464 50,057,277 SH   SOLE   50,057,277 0 0
Sierra Oncology, Inc. COM 82640U107 1,120 2,000,000 SH   SOLE   2,000,000 0 0
Spark Therapeutics, Inc. COM 84652J103 76,982 751,927 SH   SOLE   751,927 0 0
Spring Bank Pharmaceuticals, Inc. COM 849431101 2,263 613,144 SH   SOLE   613,144 0 0
Sunesis Pharmaceuticals, Inc. COM PAR 867328700 405 556,665 SH   SOLE   556,665 0 0
Syros Pharmaceuticals, Inc. COM 87184Q107 9,027 974,835 SH   SOLE   974,835 0 0
Tricida, Inc. COM 89610F101 77,732 1,969,905 SH   SOLE   1,969,905 0 0
Trillium Therapeutics Inc. COM 89620X506 166 505,262 SH   SOLE   505,262 0 0
uniQure N.V. SHS N90064101 40,458 517,700 SH   SOLE   517,700 0 0
Viking Therapeutics, Inc. COM 92686J106 3,528 425,000 SH   SOLE   425,000 0 0
XBiotech Inc. COM 98400H102 2,884 380,442 SH   SOLE   380,442 0 0
Xencor, Inc. COM 98401F105 17,523 428,120 SH   SOLE   428,120 0 0
Y-mAbs Therapeutics, Inc. COM 984241109 2,351 102,800 SH   SOLE   102,800 0 0
Zymeworks Inc. COM 98985W102 37,586 1,708,472 SH   SOLE   1,708,472 0 0
BioMarin Pharmaceutical Inc. NOTE 0.599% 8/1/2024 09061GAH4 15,566 15,000,000 PRN   SOLE   15,000,000 0 0
Neurocrine Biosciences, Inc. NOTE 2.25% 5/15/2024 64125CAD1 40,541 30,770,000 PRN   SOLE   30,770,000 0 0