The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2seventy bio, Inc. COMMON STOCK 901384107 35,190 2,062,744 SH   SOLE   2,062,744 0 0
AbCellera Biologics Inc. COM 00288U106 101,889 10,450,180 SH   SOLE   10,450,180 0 0
ACADIA Pharmaceuticals Inc. COM 004225108 1,015,077 41,910,704 SH   SOLE   41,910,704 0 0
Achilles Therapeutics plc SPONSORED ADS 00449L102 7,619 2,591,366 SH   SOLE   2,591,366 0 0
Adaptimmune Therapeutics plc SPONSORED ADR 00653A107 20,252 9,830,877 SH   SOLE   9,830,877 0 0
Aeglea BioTherapeutics, Inc. COM 00773J103 7,843 3,410,106 SH   SOLE   3,410,106 0 0
Aerovate Therapeutics, Inc. COM 008064107 37,943 2,070,010 SH   SOLE   2,070,010 0 0
Affimed N.V. COM N01045108 22,519 5,153,169 SH   SOLE   5,153,169 0 0
Akero Therapeutics, Inc. COM 00973Y108 1,680 118,378 SH   SOLE   118,378 0 0
Alector, Inc. COM 014442107 3,409 239,228 SH   SOLE   239,228 0 0
Aligos Therapeutics, Inc. COM 01626L105 4,464 2,076,400 SH   SOLE   2,076,400 0 0
Alkermes plc SHS G01767105 39,465 1,500,000 SH   SOLE   1,500,000 0 0
Allakos Inc. COM 01671P100 4,007 703,050 SH   SOLE   703,050 0 0
Altimmune, Inc. COM 02155H200 6,529 1,072,038 SH   SOLE   1,072,038 0 0
Amarin Corporation plc SPONSORED ADR 023111206 69,649 21,169,805 SH   SOLE   21,169,805 0 0
AnaptysBio, Inc. COM 032724106 10,568 427,179 SH   SOLE   427,179 0 0
argenx SE SPONSORED ADR 04016X101 353,008 1,119,557 SH   SOLE   1,119,557 0 0
Ascendis Pharma A/S SPONSORED ADR 04351P101 533,003 4,541,604 SH   SOLE   4,541,604 0 0
Athira Pharma, Inc. COM 04746L104 10,886 806,367 SH   SOLE   806,367 0 0
Atreca, Inc. CL A COM 04965G109 11,199 3,532,760 SH   SOLE   3,532,760 0 0
aTyr Pharma, Inc. COM 002120202 3,344 625,000 SH   SOLE   625,000 0 0
Axsome Therapeutics, Inc. COM 05464T104 25,288 610,970 SH   SOLE   610,970 0 0
BeiGene, Ltd. SPONSORED ADR 07725L102 2,200,754 11,668,897 SH   SOLE   11,668,897 0 0
Bellicum Pharmaceuticals, Inc. COM 079481404 538 249,123 SH   SOLE   249,123 0 0
BioAtla, Inc. COM 09077B104 4,125 825,000 SH   SOLE   825,000 0 0
BioCryst Pharmaceuticals, Inc. COM 09058V103 206,678 12,710,818 SH   SOLE   12,710,818 0 0
BioMarin Pharmaceutical Inc. COM 09061G101 587,540 7,620,494 SH   SOLE   7,620,494 0 0
Biomea Fusion, Inc. COM 09077A106 6,919 1,551,445 SH   SOLE   1,551,445 0 0
bluebird bio, Inc. COM 09609G100 12,124 2,499,715 SH   SOLE   2,499,715 0 0
Burning Rock Biotech Limited SPONSORED ADS 12233L107 1,943 209,131 SH   SOLE   209,131 0 0
Cabaletta Bio, Inc. COM 12674W109 1,344 662,063 SH   SOLE   662,063 0 0
Centessa Pharmaceuticals plc SPONSORED ADS 152309100 10,112 1,127,273 SH   SOLE   1,127,273 0 0
Cerus Corporation COM 157085101 75,285 13,713,195 SH   SOLE   13,713,195 0 0
ChemoCentryx, Inc. COM 16383L106 22,986 916,862 SH   SOLE   916,862 0 0
Chinook Therapeutics, Inc. COM 16961L106 38,186 2,334,102 SH   SOLE   2,334,102 0 0
Crinetics Pharmaceuticals, Inc. COM 22663K107 18,163 827,480 SH   SOLE   827,480 0 0
CymaBay Therapeutics, Inc. COM 23257D103 6,750 2,170,464 SH   SOLE   2,170,464 0 0
Cyteir Therapeutics, Inc. COM 23284P103 3,064 812,640 SH   SOLE   812,640 0 0
DBV Technologies S.A. SPONSORED ADR 23306J101 23,237 14,614,264 SH   SOLE   14,614,264 0 0
Denali Therapeutics Inc. COM 24823R105 2,855 88,738 SH   SOLE   88,738 0 0
Design Therapeutics, Inc. COM 25056L103 23,202 1,436,636 SH   SOLE   1,436,636 0 0
DICE Therapeutics, Inc. COM 23345J104 11,253 588,235 SH   SOLE   588,235 0 0
Edgewise Therapeutics, Inc. COM 28036F105 4,850 500,000 SH   SOLE   500,000 0 0
Entrada Therapeutics, Inc. COM 29384C108 44,174 4,704,419 SH   SOLE   4,704,419 0 0
Epizyme, Inc. COM 29428V104 1,150 1,000,000 SH   SOLE   1,000,000 0 0
FibroGen, Inc. COM 31572Q808 6,993 581,750 SH   SOLE   581,750 0 0
Foghorn Therapeutics Inc. COM 344174107 686 45,027 SH   SOLE   45,027 0 0
Forma Therapeutics Holdings, Inc. SHS 34633R104 18,831 2,024,876 SH   SOLE   2,024,876 0 0
Fulgent Genetics, Inc. COM 359664109 12,572 201,444 SH   SOLE   201,444 0 0
Genetron Holdings Limited ADS 37186H100 997 455,306 SH   SOLE   455,306 0 0
Global Blood Therapeutics, Inc. COM 37890U108 114,823 3,314,765 SH   SOLE   3,314,765 0 0
Harmony Biosciences Holdings, Inc. COM 413197104 6,013 123,600 SH   SOLE   123,600 0 0
Heron Therapeutics, Inc. COM 427746102 46,513 8,131,678 SH   SOLE   8,131,678 0 0
HOOKIPA Pharma Inc. COM 43906K100 5,473 2,400,481 SH   SOLE   2,400,481 0 0
Horizon Therapeutics Public Ltd Co SHS G46188101 94,567 898,842 SH   SOLE   898,842 0 0
IGM Biosciences, Inc. COM 449585108 84,363 3,156,102 SH   SOLE   3,156,102 0 0
Immatics N.V. SHS N44445109 35,346 4,423,731 SH   SOLE   4,423,731 0 0
Immunocore Holdings plc ADS 45258D105 75,370 2,520,730 SH   SOLE   2,520,730 0 0
Incyte Corporation COM 45337C102 2,871,326 36,153,684 SH   SOLE   36,153,684 0 0
Inozyme Pharma, Inc. COM 45790W108 438 106,999 SH   SOLE   106,999 0 0
Insmed Incorporated COM PAR $.01 457669307 50,666 2,156,001 SH   SOLE   2,156,001 0 0
Instil Bio, Inc. COM 45783C101 41,857 3,893,700 SH   SOLE   3,893,700 0 0
Invitae Corporation COM 46185L103 78,692 9,873,488 SH   SOLE   9,873,488 0 0
Iteos Therapeutics, Inc. COM 46565G104 4,838 150,346 SH   SOLE   150,346 0 0
Karuna Therapeutics, Inc. COM 48576A100 8,871 69,966 SH   SOLE   69,966 0 0
Kezar Life Sciences, Inc. COM 49372L100 2,321 139,676 SH   SOLE   139,676 0 0
Kiniksa Pharmaceuticals, Ltd. COM CL A G5269C101 27,828 2,799,577 SH   SOLE   2,799,577 0 0
Kodiak Sciences Inc. COM 50015M109 122,988 15,931,045 SH   SOLE   15,931,045 0 0
Krystal Biotech, Inc. COM 501147102 53,747 807,735 SH   SOLE   807,735 0 0
Kura Oncology, Inc. COM 50127T109 4,413 274,458 SH   SOLE   274,458 0 0
Kymera Therapeutics, Inc. COM 501575104 100,922 2,384,742 SH   SOLE   2,384,742 0 0
Leap Therapeutics, Inc. COM 52187K101 979 559,705 SH   SOLE   559,705 0 0
Legend Biotech Corporation SPONSORED ADS 52490G102 73,007 2,008,999 SH   SOLE   2,008,999 0 0
LogicBio Therapeutics, Inc. COM 54142F102 307 451,478 SH   SOLE   451,478 0 0
MacroGenics, Inc. COM 556099109 3,899 442,579 SH   SOLE   442,579 0 0
Madrigal Pharmaceuticals, Inc. COM 558868105 147,103 1,499,213 SH   SOLE   1,499,213 0 0
Merus N.V. COM N5749R100 53,871 2,037,469 SH   SOLE   2,037,469 0 0
Mirati Therapeutics, Inc. COM 60468T105 115,912 1,409,784 SH   SOLE   1,409,784 0 0
Neoleukin Therapeutics, Inc. COM 64049K104 7,185 3,821,740 SH   SOLE   3,821,740 0 0
Neurocrine Biosciences, Inc. COM 64125C109 63,466 676,975 SH   SOLE   676,975 0 0
NexImmune, Inc. COM 65344D109 1,238 294,117 SH   SOLE   294,117 0 0
NGM Biopharmaceuticals, Inc. COM 62921N105 4,450 291,801 SH   SOLE   291,801 0 0
Novavax, Inc. COM 670002401 3,548 48,168 SH   SOLE   48,168 0 0
Nurix Therapeutics, Inc. COM 67080M103 34,382 2,454,082 SH   SOLE   2,454,082 0 0
Opthea Limited SPONSORED ADS 68386J208 18,485 2,696,191 SH   SOLE   2,696,191 0 0
Otonomy, Inc. COM 68906L105 18,827 7,844,692 SH   SOLE   7,844,692 0 0
Oyster Point Pharma, Inc. COM 69242L106 715 61,424 SH   SOLE   61,424 0 0
Pacific Biosciences of California, Inc. COM 69404D108 49,549 5,444,963 SH   SOLE   5,444,963 0 0
Passage Bio, Inc. COM 702712100 363 117,161 SH   SOLE   117,161 0 0
Prelude Therapeutics Inc. COM 74065P101 69,854 10,123,824 SH   SOLE   10,123,824 0 0
Protara Therapeutics, Inc. COM STK 74365U107 1,020 199,671 SH   SOLE   199,671 0 0
Reata Pharmaceuticals, Inc. CL A 75615P103 7,337 223,976 SH   SOLE   223,976 0 0
Relmada Therapeutics, Inc. COM 75955J402 13,363 495,113 SH   SOLE   495,113 0 0
Replimune Group, Inc. COM 76029N106 27,367 1,611,703 SH   SOLE   1,611,703 0 0
Revolution Medicines, Inc. COM 76155X100 5,669 222,222 SH   SOLE   222,222 0 0
Rhythm Pharmaceuticals, Inc. COM 76243J105 47,521 4,125,062 SH   SOLE   4,125,062 0 0
Sarepta Therapeutics, Inc. COM 803607100 9,644 123,456 SH   SOLE   123,456 0 0
Seagen Inc. COM 81181C104 6,757,712 46,912,266 SH   SOLE   46,912,266 0 0
Sera Prognostics, Inc. CLASS A COM 81749D107 764 201,562 SH   SOLE   201,562 0 0
Surrozen, Inc. COM 86889P109 7,525 2,500,000 SH   SOLE   2,500,000 0 0
Surrozen, Inc. W EXP 8/11/2026 86889P117 208 833,333 SH   SOLE   833,333 0 0
Syndax Pharmaceuticals, Inc. COM 87164F105 1,924 110,729 SH   SOLE   110,729 0 0
Talis Biomedical Corporation COM 87424L108 10,751 7,624,835 SH   SOLE   7,624,835 0 0
Tango Therapeutics, Inc. COM 87583X109 5,685 750,000 SH   SOLE   750,000 0 0
TCR2 Therapeutics Inc. COM 87808K106 2,078 753,064 SH   SOLE   753,064 0 0
Travere Therapeutics, Inc. COM 89422G107 85,041 3,300,009 SH   SOLE   3,300,009 0 0
Tricida, Inc. COM 89610F101 14,235 1,731,714 SH   SOLE   1,731,714 0 0
TScan Therapeutics, Inc. COM 89854M101 3,990 1,425,000 SH   SOLE   1,425,000 0 0
Ultragenyx Pharmaceutical Inc. COM 90400D108 32,276 444,444 SH   SOLE   444,444 0 0
Vera Therapeutics, Inc. CL A 92337R101 7,830 333,333 SH   SOLE   333,333 0 0
Verastem, Inc. COM 92337C104 38,054 26,988,898 SH   SOLE   26,988,898 0 0
Verve Therapeutics, Inc. COM 92539P101 32,325 1,416,530 SH   SOLE   1,416,530 0 0
Vincerx Pharma, Inc. COM 92731L106 966 241,379 SH   SOLE   241,379 0 0
Xenon Pharmaceuticals Inc. COM 98420N105 22,978 751,639 SH   SOLE   751,639 0 0
Zymeworks Inc. COM 98985W102 11,190 1,708,472 SH   SOLE   1,708,472 0 0
Insmed Incorporated Note 0.75% 6/1/2028 457669AB5 38,614 40,000,000 PRN   SOLE   40,000,000 0 0
Invitae Corporation Note 2.0% 9/1/2024 46185LAB9 8,379 10,300,000 PRN   SOLE   10,300,000 0 0
Sarepta Therapeutics, Inc. DBCV 1.5% 11/15/2024 803607AB6 38,359 29,174,000 PRN   SOLE   29,174,000 0 0