The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| Abeona Therapeutics Inc. | COM | 00289Y107 | 9,481 | 1,288,235 | SH | SOLE | 1,288,235 | 0 | 0 | ||
| ACADIA Pharmaceuticals Inc. | COM | 004225108 | 1,066,317 | 39,713,842 | SH | SOLE | 39,713,842 | 0 | 0 | ||
| Acceleron Pharma Inc. | COM | 00434H108 | 3,907 | 83,900 | SH | SOLE | 83,900 | 0 | 0 | ||
| Achillion Pharmaceuticals, Inc. | COM | 00448Q201 | 3,242 | 1,095,359 | SH | SOLE | 1,095,359 | 0 | 0 | ||
| Acorda Therapeutics, Inc. | COM | 00484M106 | 3,882 | 292,134 | SH | SOLE | 292,134 | 0 | 0 | ||
| Adamas Pharmaceuticals, Inc. | COM | 00548A106 | 1,227 | 172,630 | SH | SOLE | 172,630 | 0 | 0 | ||
| Aeglea BioTherapeutics, Inc. | COM | 00773J103 | 13,795 | 1,713,604 | SH | SOLE | 1,713,604 | 0 | 0 | ||
| Affimed N.V. | COM | N01045108 | 840 | 200,000 | SH | SOLE | 200,000 | 0 | 0 | ||
| Aimmune Therapeutics, Inc. | COM | 00900T107 | 15,062 | 673,908 | SH | SOLE | 673,908 | 0 | 0 | ||
| Albireo Pharma, Inc. | COM | 01345P106 | 8,053 | 250,000 | SH | SOLE | 250,000 | 0 | 0 | ||
| Alexion Pharmaceuticals, Inc. | COM | 015351109 | 1,156,880 | 8,558,068 | SH | SOLE | 8,558,068 | 0 | 0 | ||
| Alkermes plc | SHS | G01767105 | 2,445 | 67,000 | SH | SOLE | 67,000 | 0 | 0 | ||
| Amarin Corporation plc | SPONSORED ADR | 023111206 | 897,049 | 43,210,459 | SH | SOLE | 43,210,459 | 0 | 0 | ||
| AnaptysBio, Inc. | COM | 032724106 | 8,261 | 113,086 | SH | SOLE | 113,086 | 0 | 0 | ||
| Apellis Pharmaceuticals, Inc. | COM | 03753U106 | 6,118 | 313,725 | SH | SOLE | 313,725 | 0 | 0 | ||
| Aquestive Therapeutics, Inc. | COM | 03843E104 | 688 | 99,600 | SH | SOLE | 99,600 | 0 | 0 | ||
| Aquinox Pharmaceuticals, Inc. | COM | 03842B101 | 29,468 | 10,934,154 | SH | SOLE | 10,934,154 | 0 | 0 | ||
| Aravive, Inc. | COM | 03890D108 | 3,033 | 430,885 | SH | SOLE | 430,885 | 0 | 0 | ||
| Arcus Biosciences, Inc. | COM | 03969F109 | 1,518 | 121,534 | SH | SOLE | 121,534 | 0 | 0 | ||
| argenx SE | SPONSORED ADR | 04016X101 | 127,281 | 1,019,557 | SH | SOLE | 1,019,557 | 0 | 0 | ||
| Array BioPharma Inc. | COM | 04269X105 | 93,675 | 3,842,289 | SH | SOLE | 3,842,289 | 0 | 0 | ||
| Ascendis Pharma A/S | SPONSORED ADR | 04351P101 | 399,035 | 3,390,270 | SH | SOLE | 3,390,270 | 0 | 0 | ||
| Assembly Biosciences, Inc. | COM | 045396108 | 2,926 | 148,587 | SH | SOLE | 148,587 | 0 | 0 | ||
| Audentes Therapeutics, Inc. | COM | 05070R104 | 66,926 | 1,715,183 | SH | SOLE | 1,715,183 | 0 | 0 | ||
| Autolus Therapeutics plc | SPON ADS | 05280R100 | 4,934 | 156,773 | SH | SOLE | 156,773 | 0 | 0 | ||
| Axsome Therapeutics, Inc. | COM | 05464T104 | 17,076 | 1,200,000 | SH | SOLE | 1,200,000 | 0 | 0 | ||
| BeiGene, Ltd. | SPONSORED ADR | 07725L102 | 1,578,697 | 11,959,824 | SH | SOLE | 11,959,824 | 0 | 0 | ||
| Bellicum Pharmaceuticals, Inc. | COM | 079481107 | 9,024 | 2,677,818 | SH | SOLE | 2,677,818 | 0 | 0 | ||
| BioCryst Pharmaceuticals, Inc. | COM | 09058V103 | 123,061 | 15,118,081 | SH | SOLE | 15,118,081 | 0 | 0 | ||
| BioMarin Pharmaceutical Inc. | COM | 09061G101 | 674,157 | 7,589,294 | SH | SOLE | 7,589,294 | 0 | 0 | ||
| bluebird bio, Inc. | COM | 09609G100 | 6,293 | 40,000 | SH | SOLE | 40,000 | 0 | 0 | ||
| Catalyst Pharmaceuticals, Inc. | COM | 14888U101 | 14,790 | 2,900,000 | SH | SOLE | 2,900,000 | 0 | 0 | ||
| Cerus Corporation | COM | 157085101 | 66,972 | 10,749,937 | SH | SOLE | 10,749,937 | 0 | 0 | ||
| ChemoCentryx, Inc. | COM | 16383L106 | 2,876 | 207,029 | SH | SOLE | 207,029 | 0 | 0 | ||
| Clementia Pharmaceuticals Inc. | COM | 185575107 | 97,208 | 3,724,445 | SH | SOLE | 3,724,445 | 0 | 0 | ||
| ContraFect Corporation | COM | 212326102 | 1,159 | 2,914,536 | SH | SOLE | 2,914,536 | 0 | 0 | ||
| Constellation Pharmaceuticals, Inc. | COM | 210373106 | 1,807 | 133,333 | SH | SOLE | 133,333 | 0 | 0 | ||
| Crinetics Pharmaceuticals, Inc. | COM | 22663K107 | 2,987 | 131,250 | SH | SOLE | 131,250 | 0 | 0 | ||
| CymaBay Therapeutics, Inc. | COM | 23257D103 | 75,794 | 5,707,411 | SH | SOLE | 5,707,411 | 0 | 0 | ||
| CytomX Therapeutics, Inc. | COM | 23284F105 | 2,090 | 194,377 | SH | SOLE | 194,377 | 0 | 0 | ||
| DBV Technologies S.A. | SPONSORED ADR | 23306J101 | 42,479 | 5,509,560 | SH | SOLE | 5,509,560 | 0 | 0 | ||
| Dermira, Inc. | COM | 24983L104 | 12,289 | 906,943 | SH | SOLE | 906,943 | 0 | 0 | ||
| Dynavax Technologies Corporation | COM | 268158201 | 548 | 75,000 | SH | SOLE | 75,000 | 0 | 0 | ||
| Foamix Pharmaceuticals Ltd. | SHS | M46135105 | 1,868 | 498,189 | SH | SOLE | 498,189 | 0 | 0 | ||
| Forty Seven, Inc. | COM | 34983P104 | 4,040 | 250,000 | SH | SOLE | 250,000 | 0 | 0 | ||
| Fulgent Genetics, Inc. | COM | 359664109 | 744 | 125,000 | SH | SOLE | 125,000 | 0 | 0 | ||
| G1 Therapeutics, Inc. | COM | 3621LQ109 | 2,112 | 127,236 | SH | SOLE | 127,236 | 0 | 0 | ||
| Galapagos NV | SPONSORED ADR | 36315X101 | 2,953 | 25,072 | SH | SOLE | 25,072 | 0 | 0 | ||
| Galmed Pharmaceuticals Ltd. | SHS | M47238106 | 1,761 | 215,594 | SH | SOLE | 215,594 | 0 | 0 | ||
| Genomic Health, Inc. | COM | 37244C101 | 714,436 | 10,198,943 | SH | SOLE | 10,198,943 | 0 | 0 | ||
| GW Pharmaceuticals plc | ADS | 36197T103 | 72,206 | 428,345 | SH | SOLE | 428,345 | 0 | 0 | ||
| Halozyme Therapeutics, Inc. | COM | 40637H109 | 4,830 | 299,969 | SH | SOLE | 299,969 | 0 | 0 | ||
| Harpoon Therapeutics, Inc. | COM | 41358P106 | 2,029 | 214,285 | SH | SOLE | 214,285 | 0 | 0 | ||
| Heron Therapeutics, Inc. | COM | 427746102 | 122,642 | 5,018,104 | SH | SOLE | 5,018,104 | 0 | 0 | ||
| Idera Pharmaceuticals, Inc. | COM PAR | 45168K405 | 12,342 | 4,839,895 | SH | SOLE | 4,839,895 | 0 | 0 | ||
| Incyte Corporation | COM | 45337C102 | 2,947,720 | 34,271,827 | SH | SOLE | 34,271,827 | 0 | 0 | ||
| Infinity Pharmaceuticals, Inc. | COM | 45665G303 | 1,091 | 580,400 | SH | SOLE | 580,400 | 0 | 0 | ||
| InflaRx N.V. | COM | N44821101 | 6,764 | 178,987 | SH | SOLE | 178,987 | 0 | 0 | ||
| Insmed Incorporated | COM PAR $.01 | 457669307 | 60,396 | 2,077,601 | SH | SOLE | 2,077,601 | 0 | 0 | ||
| Intellia Therapeutics, Inc. | COM | 45826J105 | 2,195 | 128,538 | SH | SOLE | 128,538 | 0 | 0 | ||
| Invitae Corporation | COM | 46185L103 | 91,395 | 3,902,421 | SH | SOLE | 3,902,421 | 0 | 0 | ||
| Kiniksa Pharmaceuticals, Ltd. | COM CL A | G5269C101 | 54,180 | 3,000,000 | SH | SOLE | 3,000,000 | 0 | 0 | ||
| Kodiak Sciences Inc. | COM | 50015M109 | 59,718 | 9,145,115 | SH | SOLE | 9,145,115 | 0 | 0 | ||
| Krystal Biotech, Inc. | COM | 501147102 | 25,816 | 784,674 | SH | SOLE | 784,674 | 0 | 0 | ||
| La Jolla Pharmaceutical Company | COM PAR $.0001 2 | 503459604 | 3,249 | 505,240 | SH | SOLE | 505,240 | 0 | 0 | ||
| MacroGenics, Inc. | COM | 556099109 | 5,441 | 302,600 | SH | SOLE | 302,600 | 0 | 0 | ||
| Madrigal Pharmaceuticals, Inc. | COM | 558868105 | 146,464 | 1,169,278 | SH | SOLE | 1,169,278 | 0 | 0 | ||
| Marker Therapeutics, Inc. | COM | 57055L107 | 9,900 | 1,500,000 | SH | SOLE | 1,500,000 | 0 | 0 | ||
| Menlo Therapeutics Inc. | COM | 586858102 | 5,495 | 700,000 | SH | SOLE | 700,000 | 0 | 0 | ||
| Merus N.V. | COM | N5749R100 | 17,133 | 1,160,014 | SH | SOLE | 1,160,014 | 0 | 0 | ||
| Mirati Therapeutics, Inc. | COM | 60468T105 | 184,237 | 2,513,462 | SH | SOLE | 2,513,462 | 0 | 0 | ||
| Molecular Templates, Inc. | COM | 608550109 | 1,477 | 254,230 | SH | SOLE | 254,230 | 0 | 0 | ||
| MyoKardia, Inc. | COM | 62857M105 | 52,838 | 1,016,306 | SH | SOLE | 1,016,306 | 0 | 0 | ||
| Neurocrine Biosciences, Inc. | COM | 64125C109 | 96,793 | 1,098,670 | SH | SOLE | 1,098,670 | 0 | 0 | ||
| Orchard Therapeutics plc | ADS | 68570P101 | 2,235 | 125,000 | SH | SOLE | 125,000 | 0 | 0 | ||
| Principia Biopharma Inc. | COM | 74257L108 | 60,785 | 1,787,807 | SH | SOLE | 1,787,807 | 0 | 0 | ||
| Protagonist Therapeutics, Inc. | COM | 74366E102 | 5,077 | 403,893 | SH | SOLE | 403,893 | 0 | 0 | ||
| Ra Pharmaceuticals, Inc. | COM | 74933V108 | 18,438 | 823,113 | SH | SOLE | 823,113 | 0 | 0 | ||
| Rhythm Pharmaceuticals, Inc. | COM | 76243J105 | 74,232 | 2,708,200 | SH | SOLE | 2,708,200 | 0 | 0 | ||
| Ritter Pharmaceuticals, Inc. | COM | 767836307 | 244 | 279,999 | SH | SOLE | 279,999 | 0 | 0 | ||
| Sangamo Therapeutics, Inc. | COM | 800677106 | 9,538 | 999,823 | SH | SOLE | 999,823 | 0 | 0 | ||
| Seattle Genetics, Inc. | COM | 812578102 | 3,738,884 | 51,049,760 | SH | SOLE | 51,049,760 | 0 | 0 | ||
| Sierra Oncology, Inc. | COM | 82640U107 | 3,420 | 2,000,000 | SH | SOLE | 2,000,000 | 0 | 0 | ||
| Spark Therapeutics, Inc. | COM | 84652J103 | 85,629 | 751,927 | SH | SOLE | 751,927 | 0 | 0 | ||
| Spring Bank Pharmaceuticals, Inc. | COM | 849431101 | 6,432 | 613,144 | SH | SOLE | 613,144 | 0 | 0 | ||
| Sunesis Pharmaceuticals, Inc. | COM PAR | 867328700 | 676 | 556,665 | SH | SOLE | 556,665 | 0 | 0 | ||
| Syros Pharmaceuticals, Inc. | COM | 87184Q107 | 5,254 | 574,835 | SH | SOLE | 574,835 | 0 | 0 | ||
| Tricida, Inc. | COM | 89610F101 | 69,641 | 1,803,238 | SH | SOLE | 1,803,238 | 0 | 0 | ||
| Trillium Therapeutics Inc. | COM | 89620X506 | 333 | 505,262 | SH | SOLE | 505,262 | 0 | 0 | ||
| uniQure N.V. | SHS | N90064101 | 36,088 | 605,000 | SH | SOLE | 605,000 | 0 | 0 | ||
| Viking Therapeutics, Inc. | COM | 92686J106 | 4,225 | 425,000 | SH | SOLE | 425,000 | 0 | 0 | ||
| Xencor, Inc. | COM | 98401F105 | 13,297 | 428,120 | SH | SOLE | 428,120 | 0 | 0 | ||
| Y-mAbs Therapeutics, Inc. | COM | 984241109 | 2,694 | 102,800 | SH | SOLE | 102,800 | 0 | 0 | ||
| Zymeworks Inc. | COM | 98985W102 | 27,643 | 1,708,472 | SH | SOLE | 1,708,472 | 0 | 0 | ||
| BioMarin Pharmaceutical Inc. | NOTE 0.599% 8/1/2024 | 09061GAH4 | 15,385 | 15,000,000 | PRN | SOLE | 15,000,000 | 0 | 0 | ||
| Neurocrine Biosciences, Inc. | NOTE 2.25% 5/15/2024 | 64125CAD1 | 71,994 | 53,270,000 | PRN | SOLE | 53,270,000 | 0 | 0 | ||