The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Abeona Therapeutics Inc. COM 00289Y107 27,960 2,184,364 SH   SOLE   2,184,364 0 0
ACADIA Pharmaceuticals Inc. COM 004225108 590,396 28,439,114 SH   SOLE   28,439,114 0 0
Acceleron Pharma Inc. COM 00434H108 4,802 83,900 SH   SOLE   83,900 0 0
Achillion Pharmaceuticals, Inc. COM 00448Q201 6,035 1,639,948 SH   SOLE   1,639,948 0 0
Adamas Pharmaceuticals, Inc. COM 00548A106 3,456 172,630 SH   SOLE   172,630 0 0
Aeglea BioTherapeutics, Inc. COM 00773J103 13,282 1,387,872 SH   SOLE   1,387,872 0 0
Aevi Genomic Medicine, Inc. COM 00835P105 4,859 3,950,419 SH   SOLE   3,950,419 0 0
Affimed N.V. COM N01045108 870 200,000 SH   SOLE   200,000 0 0
Aimmune Therapeutics, Inc. COM 00900T107 18,384 673,908 SH   SOLE   673,908 0 0
Albireo Pharma, Inc. COM 01345P106 8,240 250,000 SH   SOLE   250,000 0 0
Alexion Pharmaceuticals, Inc. COM 015351109 1,189,355 8,555,894 SH   SOLE   8,555,894 0 0
Alkermes plc SHS G01767105 4,255 100,251 SH   SOLE   100,251 0 0
Amarin Corporation plc SPONSORED ADR 023111206 554,311 34,069,509 SH   SOLE   34,069,509 0 0
AnaptysBio, Inc. COM 032724106 11,283 113,086 SH   SOLE   113,086 0 0
Apellis Pharmaceuticals, Inc. COM 03753U106 3,486 196,078 SH   SOLE   196,078 0 0
Aquestive Therapeutics, Inc. COM 03843E104 1,744 99,600 SH   SOLE   99,600 0 0
Aquinox Pharmaceuticals, Inc. COM 03842B101 32,037 10,934,154 SH   SOLE   10,934,154 0 0
Arcus Biosciences, Inc. COM 03969F109 1,694 121,534 SH   SOLE   121,534 0 0
argenx SE SPONSORED ADR 04016X101 77,323 1,019,557 SH   SOLE   1,019,557 0 0
Array BioPharma Inc. COM 04269X105 85,974 5,656,196 SH   SOLE   5,656,196 0 0
Arrowhead Pharmaceuticals, Inc. COM 04280A100 5,895 307,496 SH   SOLE   307,496 0 0
Ascendis Pharma A/S SPONSORED ADR 04351P101 201,055 2,837,352 SH   SOLE   2,837,352 0 0
Assembly Biosciences, Inc. COM 045396108 5,519 148,587 SH   SOLE   148,587 0 0
Audentes Therapeutics, Inc. COM 05070R104 15,568 393,222 SH   SOLE   393,222 0 0
Autolus Therapeutics plc SPON ADS 05280R100 7,216 235,294 SH   SOLE   235,294 0 0
BeiGene, Ltd. SPONSORED ADR 07725L102 2,059,721 11,959,824 SH   SOLE   11,959,824 0 0
Bellicum Pharmaceuticals, Inc. COM 079481107 16,495 2,677,818 SH   SOLE   2,677,818 0 0
BioCryst Pharmaceuticals, Inc. COM 09058V103 115,237 15,103,081 SH   SOLE   15,103,081 0 0
BioMarin Pharmaceutical Inc. COM 09061G101 735,332 7,583,084 SH   SOLE   7,583,084 0 0
bluebird bio, Inc. COM 09609G100 8,678 59,441 SH   SOLE   59,441 0 0
Catalyst Pharmaceuticals, Inc. COM 14888U101 10,962 2,900,000 SH   SOLE   2,900,000 0 0
Cerus Corporation COM 157085101 77,507 10,749,937 SH   SOLE   10,749,937 0 0
ChemoCentryx, Inc. COM 16383L106 5,233 414,029 SH   SOLE   414,029 0 0
Clementia Pharmaceuticals Inc. COM 185575107 21,560 1,933,624 SH   SOLE   1,933,624 0 0
ContraFect Corporation COM 212326102 14,807 7,153,076 SH   SOLE   7,153,076 0 0
Constellation Pharmaceuticals, Inc. COM 210373106 897 133,333 SH   SOLE   133,333 0 0
Crinetics Pharmaceuticals, Inc. COM 22663K107 3,760 131,250 SH   SOLE   131,250 0 0
CymaBay Therapeutics, Inc. COM 23257D103 54,488 4,917,700 SH   SOLE   4,917,700 0 0
DBV Technologies S.A. SPONSORED ADR 23306J101 123,745 5,509,560 SH   SOLE   5,509,560 0 0
Dynavax Technologies Corporation COM 268158201 930 75,000 SH   SOLE   75,000 0 0
Endocyte, Inc. COM 29269A102 45,254 2,548,069 SH   SOLE   2,548,069 0 0
ERYTECH Pharma S.A. SPONSORED ADR 29604W108 9,307 1,085,969 SH   SOLE   1,085,969 0 0
Foamix Pharmaceuticals Ltd. SHS M46135105 3,943 688,075 SH   SOLE   688,075 0 0
Forty Seven, Inc. COM 34983P104 3,730 250,000 SH   SOLE   250,000 0 0
Fulgent Genetics, Inc. COM 359664109 491 125,000 SH   SOLE   125,000 0 0
G1 Therapeutics, Inc. COM 3621LQ109 6,653 127,236 SH   SOLE   127,236 0 0
Galapagos NV SPONSORED ADR 36315X101 26,667 237,191 SH   SOLE   237,191 0 0
Galmed Pharmaceuticals Ltd. SHS M47238106 4,401 324,094 SH   SOLE   324,094 0 0
Genomic Health, Inc. COM 37244C101 968,402 13,790,970 SH   SOLE   13,790,970 0 0
GW Pharmaceuticals plc ADS 36197T103 68,526 396,700 SH   SOLE   396,700 0 0
Halozyme Therapeutics, Inc. COM 40637H109 8,176 449,969 SH   SOLE   449,969 0 0
Heron Therapeutics, Inc. COM 427746102 159,051 5,025,298 SH   SOLE   5,025,298 0 0
Idera Pharmaceuticals, Inc. COM 45168K405 43,070 4,833,897 SH   SOLE   4,833,897 0 0
Incyte Corporation COM 45337C102 2,366,080 34,251,309 SH   SOLE   34,251,309 0 0
Infinity Pharmaceuticals, Inc. COM 45665G303 1,573 580,400 SH   SOLE   580,400 0 0
InflaRx N.V. COM N44821101 6,143 178,987 SH   SOLE   178,987 0 0
Insmed Incorporated COM PAR $.01 457669307 37,447 1,851,982 SH   SOLE   1,851,982 0 0
Intellia Therapeutics, Inc. COM 45826J105 5,510 192,538 SH   SOLE   192,538 0 0
Invitae Corporation COM 46185L103 140,522 8,399,411 SH   SOLE   8,399,411 0 0
Kiniksa Pharmaceuticals, Ltd. COM CL A G5269C101 76,500 3,000,000 SH   SOLE   3,000,000 0 0
Krystal Biotech, Inc. COM 501147102 2,016 114,674 SH   SOLE   114,674 0 0
La Jolla Pharmaceutical Company COM PAR $.0001 2 503459604 3,114 154,675 SH   SOLE   154,675 0 0
Madrigal Pharmaceuticals, Inc. COM 558868105 250,377 1,169,278 SH   SOLE   1,169,278 0 0
Menlo Therapeutics Inc. COM 586858102 6,895 700,000 SH   SOLE   700,000 0 0
Merus N.V. COM N5749R100 22,899 1,160,014 SH   SOLE   1,160,014 0 0
Mirati Therapeutics, Inc. COM 60468T105 118,384 2,513,462 SH   SOLE   2,513,462 0 0
Molecular Templates, Inc. COM 608550109 1,370 254,230 SH   SOLE   254,230 0 0
Momenta Pharmaceuticals, Inc. COM 60877T100 8,114 308,500 SH   SOLE   308,500 0 0
MyoKardia, Inc. COM 62857M105 23,290 357,215 SH   SOLE   357,215 0 0
Neurocrine Biosciences, Inc. COM 64125C109 116,142 944,624 SH   SOLE   944,624 0 0
Novavax, Inc. COM 670002104 8,870 4,718,318 SH   SOLE   4,718,318 0 0
Ovid Therapeutics Inc. COM 690469101 1,260 222,139 SH   SOLE   222,139 0 0
Principia Biopharma Inc. COM 74257L108 52,240 1,787,807 SH   SOLE   1,787,807 0 0
Proteon Therapeutics, Inc. COM 74371L109 582 298,591 SH   SOLE   298,591 0 0
Ra Pharmaceuticals, Inc. COM 74933V108 3,219 177,952 SH   SOLE   177,952 0 0
Rhythm Pharmaceuticals, Inc. COM 76243J105 78,998 2,708,200 SH   SOLE   2,708,200 0 0
Ritter Pharmaceuticals, Inc. COM 767836307 521 279,999 SH   SOLE   279,999 0 0
Sage Therapeutics, Inc. COM 78667J108 80,159 567,497 SH   SOLE   567,497 0 0
Sangamo Therapeutics, Inc. COM 800677106 21,762 1,283,923 SH   SOLE   1,283,923 0 0
Seattle Genetics, Inc. COM 812578102 3,936,672 51,046,060 SH   SOLE   51,046,060 0 0
Solid Biosciences Inc. COM 83422E105 27,736 587,884 SH   SOLE   587,884 0 0
Spark Therapeutics, Inc. COM 84652J103 75,504 1,384,130 SH   SOLE   1,384,130 0 0
Spring Bank Pharmaceuticals, Inc. COM 849431101 7,388 613,144 SH   SOLE   613,144 0 0
Sunesis Pharmaceuticals, Inc. COM PAR 867328700 1,113 556,665 SH   SOLE   556,665 0 0
Syros Pharmaceuticals, Inc. COM 87184Q107 6,846 574,835 SH   SOLE   574,835 0 0
Tricida, Inc. COM 89610F101 48,880 1,600,000 SH   SOLE   1,600,000 0 0
Trillium Therapeutics Inc. COM 89620X506 2,931 505,262 SH   SOLE   505,262 0 0
uniQure N.V. SHS N90064101 22,016 605,000 SH   SOLE   605,000 0 0
Versartis, Inc. COM 92529L102 3,397 2,426,310 SH   SOLE   2,426,310 0 0
Viking Therapeutics, Inc. COM 92686J106 7,404 425,000 SH   SOLE   425,000 0 0
Xencor, Inc. COM 98401F105 23,479 602,495 SH   SOLE   602,495 0 0
Y-mAbs Therapeutics, Inc. COM 984241109 3,984 150,000 SH   SOLE   150,000 0 0
Zymeworks Inc. COM 98985W102 20,584 1,311,085 SH   SOLE   1,311,085 0 0
BioMarin Pharmaceutical Inc. NOTE 0.75% 10/15/2018 09061GAE1 12,599 12,228,000 SH   SOLE   12,228,000 0 0
BioMarin Pharmaceutical Inc. NOTE 0.599% 8/1/2024 09061GAH4 15,818 15,000,000 SH   SOLE   15,000,000 0 0
Corsicanto II Designated Activity Company NOTE 3.5% 1/5/2047 220485AB2 41,748 10,000,000 SH   SOLE   10,000,000 0 0
Neurocrine Biosciences, Inc. NOTE 2.25% 5/15/2024 64125CAD1 17,062 10,000,000 SH   SOLE   10,000,000 0 0