The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2seventy bio, Inc. COMMON STOCK 901384107 27,228 2,062,744 SH   SOLE   2,062,744 0 0
AbCellera Biologics Inc. COM 00288U106 111,294 10,450,180 SH   SOLE   10,450,180 0 0
ACADIA Pharmaceuticals Inc. COM 004225108 590,702 41,923,486 SH   SOLE   41,923,486 0 0
Achilles Therapeutics plc SPONSORED ADS 00449L102 6,530 2,591,366 SH   SOLE   2,591,366 0 0
Adaptimmune Therapeutics plc SPONSORED ADR 00653A107 16,712 9,830,877 SH   SOLE   9,830,877 0 0
Aeglea BioTherapeutics, Inc. COM 00773J103 1,722 3,410,106 SH   SOLE   3,410,106 0 0
Aerovate Therapeutics, Inc. COM 008064107 32,354 2,070,010 SH   SOLE   2,070,010 0 0
Affimed N.V. COM N01045108 18,273 6,596,830 SH   SOLE   6,596,830 0 0
Akero Therapeutics, Inc. COM 00973Y108 1,119 118,378 SH   SOLE   118,378 0 0
Alector, Inc. COM 014442107 2,431 239,228 SH   SOLE   239,228 0 0
Aligos Therapeutics, Inc. COM 01626L105 2,512 2,076,400 SH   SOLE   2,076,400 0 0
Alkermes plc SHS G01767105 44,685 1,500,000 SH   SOLE   1,500,000 0 0
Allakos Inc. COM 01671P100 2,201 703,050 SH   SOLE   703,050 0 0
Altimmune, Inc. COM 02155H200 24,282 2,075,403 SH   SOLE   2,075,403 0 0
Amarin Corporation plc SPONSORED ADR 023111206 31,543 21,169,805 SH   SOLE   21,169,805 0 0
AnaptysBio, Inc. COM 032724106 8,672 427,179 SH   SOLE   427,179 0 0
argenx SE SPONSORED ADR 04016X101 424,178 1,119,557 SH   SOLE   1,119,557 0 0
Ascendis Pharma A/S SPONSORED ADR 04351P101 451,103 4,852,655 SH   SOLE   4,852,655 0 0
Atara Biotherapeutics, Inc. COM 046513107 5,797 744,186 SH   SOLE   744,186 0 0
Athira Pharma, Inc. COM 04746L104 3,175 1,040,834 SH   SOLE   1,040,834 0 0
Atreca, Inc. CL A COM 04965G109 6,324 3,532,760 SH   SOLE   3,532,760 0 0
aTyr Pharma, Inc. COM 002120202 1,060 374,395 SH   SOLE   374,395 0 0
BeiGene, Ltd. SPONSORED ADR 07725L102 1,888,611 11,668,897 SH   SOLE   11,668,897 0 0
Bellicum Pharmaceuticals, Inc. COM 079481404 296 249,123 SH   SOLE   249,123 0 0
BioAtla, Inc. COM 09077B104 2,351 825,000 SH   SOLE   825,000 0 0
BioCryst Pharmaceuticals, Inc. COM 09058V103 134,480 12,710,818 SH   SOLE   12,710,818 0 0
BioMarin Pharmaceutical Inc. COM 09061G101 631,510 7,620,494 SH   SOLE   7,620,494 0 0
Biomea Fusion, Inc. COM 09077A106 25,213 2,104,559 SH   SOLE   2,104,559 0 0
bluebird bio, Inc. COM 09609G100 10,349 2,499,715 SH   SOLE   2,499,715 0 0
Burning Rock Biotech Limited SPONSORED ADS 12233L107 609 209,131 SH   SOLE   209,131 0 0
Cabaletta Bio, Inc. COM 12674W109 702 662,063 SH   SOLE   662,063 0 0
Centessa Pharmaceuticals plc SPONSORED ADS 152309100 5,490 1,127,273 SH   SOLE   1,127,273 0 0
Cerus Corporation COM 157085101 84,997 16,067,558 SH   SOLE   16,067,558 0 0
ChemoCentryx, Inc. COM 16383L106 44,422 1,792,657 SH   SOLE   1,792,657 0 0
Chinook Therapeutics, Inc. COM 16961L106 44,321 2,534,102 SH   SOLE   2,534,102 0 0
Crinetics Pharmaceuticals, Inc. COM 22663K107 15,433 827,480 SH   SOLE   827,480 0 0
CymaBay Therapeutics, Inc. COM 23257D103 6,403 2,170,464 SH   SOLE   2,170,464 0 0
Cyteir Therapeutics, Inc. COM 23284P103 7,904 2,643,640 SH   SOLE   2,643,640 0 0
DBV Technologies S.A. SPONSORED ADR 23306J101 37,266 14,614,264 SH   SOLE   14,614,264 0 0
Denali Therapeutics Inc. COM 24823R105 17,327 588,738 SH   SOLE   588,738 0 0
Design Therapeutics, Inc. COM 25056L103 20,113 1,436,636 SH   SOLE   1,436,636 0 0
DICE Therapeutics, Inc. COM 23345J104 9,129 588,235 SH   SOLE   588,235 0 0
Edgewise Therapeutics, Inc. COM 28036F105 3,980 500,000 SH   SOLE   500,000 0 0
Entrada Therapeutics, Inc. COM 29384C108 59,266 4,865,819 SH   SOLE   4,865,819 0 0
Epizyme, Inc. COM 29428V104 1,470 1,000,000 SH   SOLE   1,000,000 0 0
Evofem Biosciences, Inc. COM 30048L203 2,919 2,583,616 SH   SOLE   2,583,616 0 0
FibroGen, Inc. COM 31572Q808 8,614 815,718 SH   SOLE   815,718 0 0
Foghorn Therapeutics Inc. COM 344174107 612 45,027 SH   SOLE   45,027 0 0
Forma Therapeutics Holdings, Inc. SHS 34633R104 13,951 2,024,876 SH   SOLE   2,024,876 0 0
Fulgent Genetics, Inc. COM 359664109 10,985 201,444 SH   SOLE   201,444 0 0
Genetron Holdings Limited ADS 37186H100 774 455,306 SH   SOLE   455,306 0 0
Global Blood Therapeutics, Inc. COM 37890U108 119,253 3,732,502 SH   SOLE   3,732,502 0 0
Harmony Biosciences Holdings, Inc. COM 413197104 6,028 123,600 SH   SOLE   123,600 0 0
Heron Therapeutics, Inc. COM 427746102 22,687 8,131,678 SH   SOLE   8,131,678 0 0
HOOKIPA Pharma Inc. COM 43906K100 3,913 2,400,481 SH   SOLE   2,400,481 0 0
Horizon Therapeutics Public Ltd Co SHS G46188101 91,605 1,148,504 SH   SOLE   1,148,504 0 0
IGM Biosciences, Inc. COM 449585108 56,905 3,156,102 SH   SOLE   3,156,102 0 0
Immatics N.V. SHS N44445109 38,531 4,423,731 SH   SOLE   4,423,731 0 0
Immunocore Holdings plc ADS 45258D105 94,048 2,520,730 SH   SOLE   2,520,730 0 0
Incyte Corporation COM 45337C102 2,746,628 36,154,117 SH   SOLE   36,154,117 0 0
Inozyme Pharma, Inc. COM 45790W108 510 106,999 SH   SOLE   106,999 0 0
Insmed Incorporated COM PAR $.01 457669307 42,516 2,156,001 SH   SOLE   2,156,001 0 0
Instil Bio, Inc. COM 45783C101 17,989 3,893,700 SH   SOLE   3,893,700 0 0
Invitae Corporation COM 46185L103 24,091 9,873,488 SH   SOLE   9,873,488 0 0
iTeos Therapeutics, Inc. COM 46565G104 3,097 150,346 SH   SOLE   150,346 0 0
Karuna Therapeutics, Inc. COM 48576A100 8,851 69,966 SH   SOLE   69,966 0 0
Kezar Life Sciences, Inc. COM 49372L100 512 61,946 SH   SOLE   61,946 0 0
Kiniksa Pharmaceuticals, Ltd. COM CL A G5269C101 27,128 2,799,577 SH   SOLE   2,799,577 0 0
Kodiak Sciences Inc. COM 50015M109 132,252 17,310,490 SH   SOLE   17,310,490 0 0
Krystal Biotech, Inc. COM 501147102 53,036 807,735 SH   SOLE   807,735 0 0
Kymera Therapeutics, Inc. COM 501575104 56,704 2,879,825 SH   SOLE   2,879,825 0 0
Leap Therapeutics, Inc. COM 52187K101 644 559,705 SH   SOLE   559,705 0 0
Legend Biotech Corporation SPONSORED ADS 52490G102 47,116 856,658 SH   SOLE   856,658 0 0
LogicBio Therapeutics, Inc. COM 54142F102 158 451,478 SH   SOLE   451,478 0 0
MacroGenics, Inc. COM 556099109 2,633 892,579 SH   SOLE   892,579 0 0
Madrigal Pharmaceuticals, Inc. COM 558868105 107,314 1,499,213 SH   SOLE   1,499,213 0 0
Merus N.V. COM N5749R100 22,536 995,397 SH   SOLE   995,397 0 0
Mirati Therapeutics, Inc. COM 60468T105 94,639 1,409,784 SH   SOLE   1,409,784 0 0
Natera, Inc. COM 632307104 3,544 100,000 SH   SOLE   100,000 0 0
Neoleukin Therapeutics, Inc. COM 64049K104 3,936 3,821,740 SH   SOLE   3,821,740 0 0
NexImmune, Inc. COM 65344D109 32 20,000 SH   SOLE   20,000 0 0
NGM Biopharmaceuticals, Inc. COM 62921N105 709 55,294 SH   SOLE   55,294 0 0
Nkarta, Inc. COM 65487U108 4,928 400,000 SH   SOLE   400,000 0 0
Nurix Therapeutics, Inc. COM 67080M103 49,187 3,882,125 SH   SOLE   3,882,125 0 0
Opthea Limited SPONSORED ADS 68386J208 16,986 2,696,191 SH   SOLE   2,696,191 0 0
Otonomy, Inc. COM 68906L105 17,498 8,412,634 SH   SOLE   8,412,634 0 0
Pacific Biosciences of California, Inc. COM 69404D108 24,067 5,444,963 SH   SOLE   5,444,963 0 0
Passage Bio, Inc. COM 702712100 276 117,161 SH   SOLE   117,161 0 0
Prelude Therapeutics Inc. COM 74065P101 52,846 10,123,824 SH   SOLE   10,123,824 0 0
Protara Therapeutics, Inc. COM STK 74365U107 585 199,671 SH   SOLE   199,671 0 0
Reata Pharmaceuticals, Inc. CL A 75615P103 6,807 223,976 SH   SOLE   223,976 0 0
Relmada Therapeutics, Inc. COM 75955J402 9,402 495,113 SH   SOLE   495,113 0 0
Replimune Group, Inc. COM 76029N106 62,772 3,591,081 SH   SOLE   3,591,081 0 0
Revolution Medicines, Inc. COM 76155X100 4,331 222,222 SH   SOLE   222,222 0 0
Rhythm Pharmaceuticals, Inc. COM 76243J105 17,119 4,125,062 SH   SOLE   4,125,062 0 0
Seagen Inc. COM 81181C104 8,300,656 46,912,266 SH   SOLE   46,912,266 0 0
Sera Prognostics, Inc. CLASS A COM 81749D107 331 201,562 SH   SOLE   201,562 0 0
Surrozen, Inc. COM 86889P109 7,500 2,500,000 SH   SOLE   2,500,000 0 0
Surrozen, Inc. W EXP 8/11/2026 86889P117 159 833,333 SH   SOLE   833,333 0 0
Syndax Pharmaceuticals, Inc. COM 87164F105 2,130 110,729 SH   SOLE   110,729 0 0
Talis Biomedical Corporation COM 87424L108 6,191 7,624,835 SH   SOLE   7,624,835 0 0
Tango Therapeutics, Inc. COM 87583X109 3,398 750,000 SH   SOLE   750,000 0 0
TCR2 Therapeutics Inc. COM 87808K106 2,184 753,064 SH   SOLE   753,064 0 0
Travere Therapeutics, Inc. COM 89422G107 79,959 3,300,009 SH   SOLE   3,300,009 0 0
Tricida, Inc. COM 89610F101 14,550 1,503,090 SH   SOLE   1,503,090 0 0
TScan Therapeutics, Inc. COM 89854M101 8,758 2,784,792 SH   SOLE   2,784,792 0 0
Ultragenyx Pharmaceutical Inc. COM 90400D108 28,098 470,974 SH   SOLE   470,974 0 0
Vera Therapeutics, Inc. CL A 92337R101 4,537 333,333 SH   SOLE   333,333 0 0
Verastem, Inc. COM 92337C104 31,307 26,988,898 SH   SOLE   26,988,898 0 0
Verve Therapeutics, Inc. COM 92539P101 21,645 1,416,530 SH   SOLE   1,416,530 0 0
Vincerx Pharma, Inc. COM 92731L106 319 241,379 SH   SOLE   241,379 0 0
Vor Biopharma Inc. COM 929033108 5,660 1,138,768 SH   SOLE   1,138,768 0 0
Xenon Pharmaceuticals Inc. COM 98420N105 22,865 751,639 SH   SOLE   751,639 0 0
Zymeworks Inc. COM 98985W102 9,055 1,708,472 SH   SOLE   1,708,472 0 0
Insmed Incorporated Note 0.75% 6/1/2028 457669AB5 33,278 40,000,000 PRN   SOLE   40,000,000 0 0
Invitae Corporation Note 2.0% 9/1/2024 46185LAB9 8,087 10,300,000 PRN   SOLE   10,300,000 0 0
Sarepta Therapeutics, Inc. DBCV 1.5% 11/15/2024 803607AB6 36,577 29,174,000 PRN   SOLE   29,174,000 0 0