The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2seventy bio, Inc. COM 901384107 30,013 2,062,744 SH   SOLE   2,062,744 0 0
Aadi Bioscience, Inc. COM 00032Q104 13,988 989,928 SH   SOLE   989,928 0 0
AbCellera Biologics Inc. COM 00288U106 103,352 10,450,180 SH   SOLE   10,450,180 0 0
ACADIA Pharmaceuticals Inc. COM 004225108 685,868 41,923,486 SH   SOLE   41,923,486 0 0
Achilles Therapeutics plc SPONSORED ADS 00449L102 5,856 2,591,366 SH   SOLE   2,591,366 0 0
Adaptimmune Therapeutics plc SPONSORED ADR 00653A107 10,568 9,830,877 SH   SOLE   9,830,877 0 0
Aeglea BioTherapeutics, Inc. COM 00773J103 1,794 3,410,106 SH   SOLE   3,410,106 0 0
Aerovate Therapeutics, Inc. COM 008064107 32,821 1,979,568 SH   SOLE   1,979,568 0 0
Affimed N.V. COM N01045108 13,589 6,596,830 SH   SOLE   6,596,830 0 0
Akero Therapeutics, Inc. COM 00973Y108 80,643 2,368,378 SH   SOLE   2,368,378 0 0
Alector, Inc. COM 014442107 2,263 239,228 SH   SOLE   239,228 0 0
Aligos Therapeutics, Inc. COM 01626L105 2,284 2,076,400 SH   SOLE   2,076,400 0 0
Alkermes plc SHS G01767105 18,199 815,016 SH   SOLE   815,016 0 0
Allakos Inc. COM 01671P100 4,303 703,050 SH   SOLE   703,050 0 0
Altimmune, Inc. COM 02155H200 22,599 1,769,681 SH   SOLE   1,769,681 0 0
Amarin Corporation plc SPONSORED ADR 023111206 5,861 5,377,113 SH   SOLE   5,377,113 0 0
AnaptysBio, Inc. COM 032724106 10,897 427,179 SH   SOLE   427,179 0 0
argenx SE SPONSORED ADR 04016X101 98,910 280,159 SH   SOLE   280,159 0 0
Ascendis Pharma A/S SPONSORED ADR 04351P101 501,085 4,852,655 SH   SOLE   4,852,655 0 0
Atara Biotherapeutics, Inc. COM 046513107 2,813 744,186 SH   SOLE   744,186 0 0
Athira Pharma, Inc. COM 04746L104 3,091 1,040,834 SH   SOLE   1,040,834 0 0
Atreca, Inc. CL A COM 04965G109 5,546 3,532,760 SH   SOLE   3,532,760 0 0
aTyr Pharma, Inc. COM 002120202 604 201,361 SH   SOLE   201,361 0 0
BeiGene, Ltd. SPONSORED ADR 07725L102 1,573,201 11,668,897 SH   SOLE   11,668,897 0 0
Bellicum Pharmaceuticals, Inc. COM 079481404 299 249,123 SH   SOLE   249,123 0 0
Bicycle Therapeutics plc SPONSORED ADS 088786108 19,627 843,814 SH   SOLE   843,814 0 0
BioCryst Pharmaceuticals, Inc. COM 09058V103 160,156 12,710,818 SH   SOLE   12,710,818 0 0
BioMarin Pharmaceutical Inc. COM 09061G101 645,989 7,620,494 SH   SOLE   7,620,494 0 0
Biomea Fusion, Inc. COM 09077A106 20,583 2,104,559 SH   SOLE   2,104,559 0 0
bluebird bio, Inc. COM 09609G100 15,823 2,499,715 SH   SOLE   2,499,715 0 0
Cabaletta Bio, Inc. COM 12674W109 430 662,063 SH   SOLE   662,063 0 0
Century Therapeutics, Inc. COM 15673T100 3,665 370,587 SH   SOLE   370,587 0 0
Cerus Corporation COM 157085101 57,843 16,067,558 SH   SOLE   16,067,558 0 0
ChemoCentryx, Inc. COM 16383L106 92,609 1,792,657 SH   SOLE   1,792,657 0 0
Chinook Therapeutics, Inc. COM 16961L106 49,820 2,534,102 SH   SOLE   2,534,102 0 0
CinCor Pharma, Inc. COM 17240Y109 26,493 807,212 SH   SOLE   807,212 0 0
Crinetics Pharmaceuticals, Inc. COM 22663K107 14,449 735,716 SH   SOLE   735,716 0 0
CymaBay Therapeutics, Inc. COM 23257D103 7,597 2,170,464 SH   SOLE   2,170,464 0 0
Cyteir Therapeutics, Inc. COM 23284P103 5,076 2,643,640 SH   SOLE   2,643,640 0 0
DBV Technologies S.A. SPONSORED ADR 23306J101 25,867 14,614,264 SH   SOLE   14,614,264 0 0
Denali Therapeutics Inc. COM 24823R105 18,068 588,738 SH   SOLE   588,738 0 0
Design Therapeutics, Inc. COM 25056L103 24,021 1,436,636 SH   SOLE   1,436,636 0 0
DICE Therapeutics, Inc. COM 23345J104 11,929 588,235 SH   SOLE   588,235 0 0
Edgewise Therapeutics, Inc. COM 28036F105 4,920 500,000 SH   SOLE   500,000 0 0
Eiger BioPharmaceuticals, Inc. COM 28249U105 4,065 539,851 SH   SOLE   539,851 0 0
Entrada Therapeutics, Inc. COM 29384C108 76,685 4,865,819 SH   SOLE   4,865,819 0 0
Fate Therapeutics, Inc. COM 31189P102 4,834 215,695 SH   SOLE   215,695 0 0
FibroGen, Inc. COM 31572Q808 10,612 815,718 SH   SOLE   815,718 0 0
Foghorn Therapeutics Inc. COM 344174107 386 45,027 SH   SOLE   45,027 0 0
Forma Therapeutics Holdings, Inc. SHS 34633R104 37,641 1,886,760 SH   SOLE   1,886,760 0 0
Fulgent Genetics, Inc. COM 359664109 6,352 166,619 SH   SOLE   166,619 0 0
Genetron Holdings Limited ADS 37186H100 356 455,306 SH   SOLE   455,306 0 0
Global Blood Therapeutics, Inc. COM 37890U108 254,183 3,732,502 SH   SOLE   3,732,502 0 0
Heron Therapeutics, Inc. COM 427746102 34,316 8,131,678 SH   SOLE   8,131,678 0 0
HOOKIPA Pharma Inc. COM 43906K100 3,217 2,400,481 SH   SOLE   2,400,481 0 0
Horizon Therapeutics Public Ltd Co SHS G46188101 60,016 969,727 SH   SOLE   969,727 0 0
IDEAYA Biosciences, Inc. COM 45166A102 24,892 1,668,355 SH   SOLE   1,668,355 0 0
IGM Biosciences, Inc. COM 449585108 71,770 3,156,102 SH   SOLE   3,156,102 0 0
Immatics N.V. SHS N44445109 44,237 4,423,731 SH   SOLE   4,423,731 0 0
Immunocore Holdings plc ADS 45258D105 118,323 2,520,731 SH   SOLE   2,520,731 0 0
Incyte Corporation COM 45337C102 2,409,341 36,154,574 SH   SOLE   36,154,574 0 0
Insmed Incorporated COM PAR $.01 457669307 430 19,950 SH   SOLE   19,950 0 0
Instil Bio, Inc. COM 45783C101 18,846 3,893,700 SH   SOLE   3,893,700 0 0
Invitae Corporation COM 46185L103 20,669 8,402,035 SH   SOLE   8,402,035 0 0
iTeos Therapeutics, Inc. COM 46565G104 2,864 150,346 SH   SOLE   150,346 0 0
Kezar Life Sciences, Inc. COM 49372L100 533 61,946 SH   SOLE   61,946 0 0
Kiniksa Pharmaceuticals, Ltd. COM CL A G5269C101 35,947 2,799,577 SH   SOLE   2,799,577 0 0
Kodiak Sciences Inc. COM 50015M109 133,983 17,310,490 SH   SOLE   17,310,490 0 0
Kronos Bio, Inc. COM 50107A104 5,158 1,539,616 SH   SOLE   1,539,616 0 0
Krystal Biotech, Inc. COM 501147102 29,426 422,185 SH   SOLE   422,185 0 0
Kymera Therapeutics, Inc. COM 501575104 62,694 2,879,825 SH   SOLE   2,879,825 0 0
Leap Therapeutics, Inc. COM 52187K101 493 559,705 SH   SOLE   559,705 0 0
LogicBio Therapeutics, Inc. COM 54142F102 38 139,105 SH   SOLE   139,105 0 0
MacroGenics, Inc. COM 556099109 3,088 892,579 SH   SOLE   892,579 0 0
Madrigal Pharmaceuticals, Inc. COM 558868105 97,434 1,499,213 SH   SOLE   1,499,213 0 0
Mirati Therapeutics, Inc. COM 60468T105 98,459 1,409,784 SH   SOLE   1,409,784 0 0
Natera, Inc. COM 632307104 4,382 100,000 SH   SOLE   100,000 0 0
Neoleukin Therapeutics, Inc. COM 64049K104 2,446 3,821,740 SH   SOLE   3,821,740 0 0
Nkarta, Inc. COM 65487U108 5,264 400,000 SH   SOLE   400,000 0 0
Nurix Therapeutics, Inc. COM 67080M103 50,584 3,882,125 SH   SOLE   3,882,125 0 0
Opthea Limited SPONSORED ADS 68386J208 16,687 2,691,391 SH   SOLE   2,691,391 0 0
Otonomy, Inc. COM 68906L105 2,491 8,443,134 SH   SOLE   8,443,134 0 0
Pacific Biosciences of California, Inc. COM 69404D108 6,547 1,127,782 SH   SOLE   1,127,782 0 0
PMV Pharmaceuticals, Inc. COM 69353Y103 3,832 322,024 SH   SOLE   322,024 0 0
POINT Biopharma Global Inc. COM 730541109 9,037 1,169,103 SH   SOLE   1,169,103 0 0
Prelude Therapeutics Inc. COM 74065P101 66,918 10,123,824 SH   SOLE   10,123,824 0 0
Protara Therapeutics, Inc. COM STK 74365U107 591 199,671 SH   SOLE   199,671 0 0
Reata Pharmaceuticals, Inc. CL A 75615P103 5,629 223,976 SH   SOLE   223,976 0 0
Relmada Therapeutics, Inc. COM 75955J402 18,329 495,113 SH   SOLE   495,113 0 0
Replimune Group, Inc. COM 76029N106 67,247 3,893,843 SH   SOLE   3,893,843 0 0
Revolution Medicines, Inc. COM 76155X100 4,382 222,222 SH   SOLE   222,222 0 0
Rhythm Pharmaceuticals, Inc. COM 76243J105 148,536 6,062,702 SH   SOLE   6,062,702 0 0
Seagen Inc. COM 81181C104 6,419,005 46,912,266 SH   SOLE   46,912,266 0 0
Sera Prognostics, Inc. CLASS A COM 81749D107 322 201,562 SH   SOLE   201,562 0 0
Stoke Therapeutics, Inc. COM 86150R107 4,742 369,327 SH   SOLE   369,327 0 0
Surrozen, Inc. COM 86889P109 5,050 2,500,000 SH   SOLE   2,500,000 0 0
Surrozen, Inc. W EXP 8/11/2026 86889P117 154 833,333 SH   SOLE   833,333 0 0
Syndax Pharmaceuticals, Inc. COM 87164F105 2,661 110,729 SH   SOLE   110,729 0 0
Talis Biomedical Corporation COM 87424L108 5,197 7,624,835 SH   SOLE   7,624,835 0 0
Tango Therapeutics, Inc. COM 87583X109 2,715 750,000 SH   SOLE   750,000 0 0
TCR2 Therapeutics Inc. COM 87808K106 1,356 753,064 SH   SOLE   753,064 0 0
Travere Therapeutics, Inc. COM 89422G107 81,312 3,300,009 SH   SOLE   3,300,009 0 0
Tricida, Inc. COM 89610F101 13,837 1,320,290 SH   SOLE   1,320,290 0 0
TScan Therapeutics, Inc. COM 89854M101 8,494 2,784,792 SH   SOLE   2,784,792 0 0
Ultragenyx Pharmaceutical Inc. COM 90400D108 19,503 470,974 SH   SOLE   470,974 0 0
Vera Therapeutics, Inc. CL A 92337R101 7,103 333,333 SH   SOLE   333,333 0 0
Verastem, Inc. COM 92337C104 22,941 26,988,898 SH   SOLE   26,988,898 0 0
Verve Therapeutics, Inc. COM 92539P101 48,658 1,416,530 SH   SOLE   1,416,530 0 0
Veru Inc. COM 92536C103 18,542 1,609,579 SH   SOLE   1,609,579 0 0
Vincerx Pharma, Inc. COM 92731L106 333 241,379 SH   SOLE   241,379 0 0
Vor Biopharma Inc. COM 929033108 5,834 1,465,925 SH   SOLE   1,465,925 0 0
Xenon Pharmaceuticals Inc. COM 98420N105 27,134 751,639 SH   SOLE   751,639 0 0
Zymeworks Inc. COM 98985W102 10,507 1,708,472 SH   SOLE   1,708,472 0 0
Insmed Incorporated Note 0.75% 6/1/2028 457669AB5 36,296 40,000,000 PRN   SOLE   40,000,000 0 0
Invitae Corporation Note 2.0% 9/1/2024 46185LAB9 8,148 10,300,000 PRN   SOLE   10,300,000 0 0