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BAKER BROS. ADVISORS LP
> AGLE
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | Aeglea BioTherapeutics, Inc. | AGLE | 3,410,106 | 0 | 1,536,253,000 | 2,046,000 | $450.50 |
| 12/31/2022 | Aeglea BioTherapeutics, Inc. | AGLE | 3,410,106 | 0 | 1,534,207,000 | 1,532,413,000 | $449.90 |
| 09/30/2022 | Aeglea BioTherapeutics, Inc. | AGLE | 3,410,106 | 0 | 1,794,000 | 72,000 | $0.53 |
| 06/30/2022 | Aeglea BioTherapeutics, Inc. | AGLE | 3,410,106 | 0 | 1,722,000 | -6,121,000 | $0.50 |
| 03/31/2022 | Aeglea BioTherapeutics, Inc. | AGLE | 3,410,106 | 0 | 7,843,000 | -8,355,000 | $2.30 |
| 12/31/2021 | Aeglea BioTherapeutics, Inc. | AGLE | 3,410,106 | 0 | 16,198,000 | -10,912,000 | $4.75 |
| 09/30/2021 | Aeglea BioTherapeutics, Inc. | AGLE | 3,410,106 | 0 | 27,110,000 | 3,376,000 | $7.95 |
| 06/30/2021 | Aeglea BioTherapeutics, Inc. | AGLE | 3,410,106 | 0 | 23,734,000 | -3,274,000 | $6.96 |
| 03/31/2021 | Aeglea BioTherapeutics, Inc. | AGLE | 3,410,106 | 0 | 27,008,000 | 170,000 | $7.92 |
| 03/16/2021 | Aeglea BioTherapeutics, Inc. | AGLE | 4,901,190 | 1,491,084 | 37,543,115 | 10,705,115 | $7.66 |
| 02/23/2021 | Aeglea BioTherapeutics, Inc. | AGLE | 4,892,533 | 1,482,427 | 34,785,910 | 7,947,910 | $7.11 |
| 12/31/2020 | Aeglea BioTherapeutics, Inc. | AGLE | 4,892,533 | 512,941 | 38,504,235 | 7,453,235 | $7.87 |
| 09/30/2020 | Aeglea BioTherapeutics, Inc. | AGLE | 4,379,592 | 0 | 31,051,000 | -9,460,000 | $7.09 |
| 06/30/2020 | Aeglea BioTherapeutics, Inc. | AGLE | 4,379,592 | 2,665,988 | 40,511,000 | 32,526,000 | $9.25 |
| 03/31/2020 | Aeglea BioTherapeutics, Inc. | AGLE | 1,713,604 | 0 | 7,985,000 | -5,107,000 | $4.66 |
| 12/31/2019 | Aeglea BioTherapeutics, Inc. | AGLE | 1,713,604 | 0 | 13,091,935 | -86,065 | $7.64 |
| 09/30/2019 | Aeglea BioTherapeutics, Inc. | AGLE | 1,713,604 | 0 | 13,178,000 | 1,440,000 | $7.69 |
| 06/30/2019 | Aeglea BioTherapeutics, Inc. | AGLE | 1,713,604 | 0 | 11,738,000 | -2,057,000 | $6.85 |
| 03/31/2019 | Aeglea BioTherapeutics, Inc. | AGLE | 1,713,604 | 0 | 13,795,000 | 960,000 | $8.05 |
| 12/31/2018 | Aeglea BioTherapeutics, Inc. | AGLE | 1,713,604 | 325,732 | 12,834,894 | -447,106 | $7.49 |
| 09/30/2018 | Aeglea BioTherapeutics, Inc. | AGLE | 1,387,872 | 0 | 13,282,000 | -1,402,000 | $9.57 |
| 06/30/2018 | Aeglea BioTherapeutics, Inc. | AGLE | 1,387,872 | 250,000 | 14,684,000 | 8,528,000 | $10.58 |
| 12/31/2017 | Aeglea BioTherapeutics, Inc. | AGLE | 1,137,872 | 0 | 6,156,000 | 547,000 | $5.41 |
| 09/30/2017 | Aeglea BioTherapeutics, Inc. | AGLE | 1,137,872 | 0 | 5,609,000 | 1,228,000 | $4.93 |
| 06/30/2017 | Aeglea BioTherapeutics, Inc. | AGLE | 1,137,872 | 947,885 | 4,381,000 | 2,966,000 | $3.85 |
| 03/31/2017 | Aeglea BioTherapeutics, Inc. | AGLE | 189,987 | -214,243 | 1,415,000 | -343,000 | $7.45 |
| 12/31/2016 | Aeglea BioTherapeutics, Inc. | AGLE | 404,230 | 0 | 1,758,000 | -833,000 | $4.35 |
| 09/30/2016 | Aeglea BioTherapeutics, Inc. | AGLE | 404,230 | 0 | 2,591,000 | 626,000 | $6.41 |
| 06/30/2016 | Aeglea BioTherapeutics, Inc. | AGLE | 404,230 | 404,230 | 1,965,000 | 1,965,000 | $4.86 |
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