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ORBIMED ADVISORS LLC
> HRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 802,700 | 0 | 931,132,000 | -280,945,000 | $1,160.00 |
| 03/31/2023 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 802,700 | 802,700 | 1,212,077,000 | 1,212,077,000 | $1,510.00 |
| 12/31/2022 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 0 | -1,123,000 | 0 | -4,739,000 | |
| 09/30/2022 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 1,123,000 | 1,123,000 | 4,739,000 | 4,739,000 | $4.22 |
| 03/31/2021 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 0 | -1,191,846 | 0 | -25,225,000 | |
| 12/31/2020 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 1,191,846 | 0 | 25,225,000 | 7,562,000 | $21.16 |
| 09/30/2020 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 1,191,846 | 531,426 | 17,663,000 | 7,948,000 | $14.82 |
| 06/30/2020 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 660,420 | 123,000 | 9,715,000 | 3,406,000 | $14.71 |
| 03/31/2020 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 537,420 | 537,420 | 6,309,000 | 6,309,000 | $11.74 |
| 06/30/2019 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 0 | -1,069,000 | 0 | -26,126,000 | |
| 03/31/2019 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 1,069,000 | -331,300 | 26,126,000 | -10,198,000 | $24.44 |
| 12/31/2018 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 1,400,300 | -114,200 | 36,324,000 | -11,610,000 | $25.94 |
| 09/30/2018 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 1,514,500 | 199,400 | 47,934,000 | -3,158,000 | $31.65 |
| 06/30/2018 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 1,315,100 | 175,300 | 51,092,000 | 19,634,000 | $38.85 |
| 03/31/2018 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 1,139,800 | 489,800 | 31,458,000 | 19,693,000 | $27.60 |
| 12/31/2017 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 650,000 | 0 | 11,765,000 | 1,267,000 | $18.10 |
| 09/30/2017 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 650,000 | 0 | 10,498,000 | 1,495,000 | $16.15 |
| 06/30/2017 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 650,000 | 0 | 9,003,000 | -747,000 | $13.85 |
| 03/31/2017 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 650,000 | 650,000 | 9,750,000 | 9,750,000 | $15.00 |
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