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BAKER BROS. ADVISORS LP
> XENE
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | Xenon Pharmaceuticals Inc. | XENE | 751,639 | 0 | 28,938,102,000 | -699,024,000 | $38,500.00 |
| 12/31/2022 | Xenon Pharmaceuticals Inc. | XENE | 751,639 | 0 | 29,637,126,000 | 29,609,992,000 | $39,430.00 |
| 09/30/2022 | Xenon Pharmaceuticals Inc. | XENE | 751,639 | 0 | 27,134,000 | 4,269,000 | $36.10 |
| 06/30/2022 | Xenon Pharmaceuticals Inc. | XENE | 751,639 | 0 | 22,865,000 | -113,000 | $30.42 |
| 03/31/2022 | Xenon Pharmaceuticals Inc. | XENE | 751,639 | 0 | 22,978,000 | -503,000 | $30.57 |
| 12/31/2021 | Xenon Pharmaceuticals Inc. | XENE | 751,639 | 0 | 23,481,000 | 11,996,000 | $31.24 |
| 09/30/2021 | Xenon Pharmaceuticals Inc. | XENE | 751,639 | 0 | 11,485,000 | -2,511,000 | $15.28 |
| 06/30/2021 | Xenon Pharmaceuticals Inc. | XENE | 751,639 | 0 | 13,996,000 | 542,000 | $18.62 |
| 03/31/2021 | Xenon Pharmaceuticals Inc. | XENE | 751,639 | 64,253 | 13,454,000 | 2,882,000 | $17.90 |
| 12/31/2020 | Xenon Pharmaceuticals Inc. | XENE | 687,386 | -72,922 | 10,572,000 | 2,155,000 | $15.38 |
| 09/30/2020 | Xenon Pharmaceuticals Inc. | XENE | 760,308 | -38,794 | 8,417,000 | -1,604,000 | $11.07 |
| 06/30/2020 | Xenon Pharmaceuticals Inc. | XENE | 799,102 | 799,102 | 10,021,000 | 10,021,000 | $12.54 |
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