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SPHERA FUNDS MANAGEMENT LTD.
> ISEE
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | IVERIC bio, Inc. | ISEE | 134,414 | -61,177 | 5,287,847,000 | 1,100,244,000 | $39,340.00 |
| 12/31/2022 | IVERIC bio, Inc. | ISEE | 195,591 | -386,238 | 4,187,603,000 | 4,177,165,000 | $21,410.00 |
| 09/30/2022 | IVERIC bio, Inc. | ISEE | 581,829 | -380,641 | 10,438,000 | 1,179,000 | $17.94 |
| 06/30/2022 | IVERIC bio, Inc. | ISEE | 962,470 | 188,340 | 9,259,000 | -3,770,000 | $9.62 |
| 03/31/2022 | IVERIC bio, Inc. | ISEE | 774,130 | 289,129 | 13,029,000 | 4,920,000 | $16.83 |
| 12/31/2021 | IVERIC bio, Inc. | ISEE | 485,001 | 0 | 8,109,000 | 233,000 | $16.72 |
| 09/30/2021 | IVERIC bio, Inc. | ISEE | 485,001 | -14,999 | 7,876,000 | 4,721,000 | $16.24 |
| 06/30/2021 | IVERIC bio, Inc. | ISEE | 500,000 | 500,000 | 3,155,000 | 3,155,000 | $6.31 |
| 09/30/2020 | IVERIC bio, Inc. | ISEE | 0 | -200,000 | 0 | -1,020,000 | |
| 06/30/2020 | IVERIC bio, Inc. | ISEE | 200,000 | 76,576 | 1,020,000 | 595,000 | $5.10 |
| 03/31/2020 | IVERIC bio, Inc. | ISEE | 123,424 | -744,776 | 425,000 | -7,024,000 | $3.44 |
| 12/31/2019 | IVERIC bio, Inc. | ISEE | 868,200 | 868,200 | 7,449,000 | 7,449,000 | $8.58 |
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