The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103   2,558,250 135,000 SH   DFND 1,2 135,000 0 0
ABBVIE INC COM 00287Y109   7,544,880 56,000 SH   DFND 1,2 56,000 0 0
ADVANCED MICRO DEVICES INC COM 007903107   13,669,200 120,000 SH Call DFND   0 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107   7,597,600 40,000 SH   DFND 1,2 40,000 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100   2,056,000 200,000 SH   DFND 1,2 200,000 0 0
ALTIMMUNE INC COM NEW 02155H200   1,765,000 500,000 SH   DFND 1,2 500,000 0 0
AMAZON COM INC COM 023135106   16,203,748 124,300 SH   DFND   124,300 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101   2,157,000 100,000 SH   DFND 1,2 100,000 0 0
ARBE ROBOTICS LTD ORDINARY SHARES M1R95N100   124,747 43,165 SH   DFND   43,165 0 0
ARCELLX INC COMMON STOCK 03940C100   2,450,171 77,488 SH   DFND 1,2 77,488 0 0
ARGENX SE SPONSORED ADR 04016X101   3,897,300 10,000 SH Put DFND 1,2 10,000 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108   20,401,744 285,060 SH   DFND 1,2 285,060 0 0
ASTRIA THERAPEUTICS INC COM 04635X102   3,923,580 471,018 SH   DFND 1,2 471,018 0 0
BIOGEN INC COM 09062X103   6,792,533 23,846 SH   DFND 1,2 23,846 0 0
BRIDGEBIO PHARMA INC COM 10806X102   5,532,122 321,635 SH   DFND 1,2 321,635 0 0
BRIDGEBIO PHARMA INC COM 10806X102   2,236,000 130,000 SH Call DFND 1,2 0 0 0
CAMTEK LTD ORD M20791105   6,751,671 189,494 SH   DFND   189,494 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202   5,428,800 160,000 SH   DFND 1,2 160,000 0 0
COGENT BIOSCIENCES INC COM 19240Q201   4,972,800 420,000 SH   DFND 1,2 420,000 0 0
COMPUGEN LTD ORD M25722105   1,401,981 1,229,808 SH   DFND 1,2 1,229,808 0 0
CYCLACEL PHARMACEUTICALS INC COM 23254L603   147,275 250,000 SH   DFND 1,2 250,000 0 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109   6,328,200 530,000 SH   DFND 1,2 530,000 0 0
DISC MEDICINE INC COM 254604101   7,573,663 170,578 SH   DFND 1,2 170,578 0 0
DYNE THERAPEUTICS INC COM 26818M108   1,349,078 119,918 SH   DFND 1,2 119,918 0 0
ELEVATION ONCOLOGY INC COM 28623U101   1,368,000 900,000 SH   DFND 1,2 900,000 0 0
ENLIGHT RENEWABLE ENERGY LTD SHS M4056D110   3,755,652 211,586 SH   DFND   211,586 0 0
ENPHASE ENERGY INC NOTE 3/0 29355AAK3   13,434,944 14,310,000 SH   DFND   14,310,000 0 0
ENPHASE ENERGY INC COM 29355A107   6,699,200 40,000 SH Call DFND   0 0 0
FUSION PHARMACEUTICALS INC COM 36118A100   6,207,635 1,329,258 SH   DFND 1,2 1,329,258 0 0
GENERAC HLDGS INC COM 368736104   7,829,325 52,500 SH Call DFND   0 0 0
GILEAD SCIENCES INC COM 375558103   3,082,800 40,000 SH   DFND 1,2 40,000 0 0
GRACELL BIOTECHNOLOGIES INC SPONSORED ADS 38406L103   4,681,214 1,228,665 SH   DFND 1,2 1,228,665 0 0
GSK PLC SPONSORED ADR 37733W204   3,564,000 100,000 SH   DFND 1,2 100,000 0 0
IMMATICS N.V *W EXP 07/01/202 N44445117   342,000 100,000 SH   DFND 1,2 100,000 0 0
IMMATICS N.V SHS N44445109   7,122,176 617,173 SH   DFND 1,2 617,173 0 0
INFINITY PHARMACEUTICALS INC COM 45665G303   310,698 1,476,000 SH   DFND 1,2 1,476,000 0 0
INHIBRX INC COM 45720L107   1,298,000 50,000 SH   DFND 1,2 50,000 0 0
INOZYME PHARMA INC COM 45790W108   6,305,056 1,131,967 SH   DFND 1,2 1,131,967 0 0
INVESCO QQQ TR UNIT SER 1 46090E103   46,546,922 126,000 SH Put DFND   126,000 0 0
IVERIC BIO INC COM 46583P102   5,287,847 134,414 SH   DFND 1,2 134,414 0 0
JASPER THERAPEUTICS INC COM 471871103   5,855,391 4,274,008 SH   DFND 1,2 4,274,008 0 0
JOHNSON & JOHNSON COM 478160104   19,834,427 119,831 SH   DFND 1,2 119,831 0 0
KEZAR LIFE SCIENCES INC COM 49372L100   4,871,159 1,988,228 SH   DFND 1,2 1,988,228 0 0
KURA ONCOLOGY INC COM 50127T109   6,382,776 603,287 SH   DFND 1,2 603,287 0 0
LILLY ELI & CO COM 532457108   7,358,296 15,690 SH   DFND 1,2 15,690 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105   5,775,000 25,000 SH   DFND 1,2 25,000 0 0
MEDIWOUND LTD SHS NEW M68830112   662,490 62,147 SH   DFND   62,147 0 0
MEDIWOUND LTD SHS NEW M68830112   522,124 48,980 SH   DFND 1,2 48,980 0 0
MERCK & CO INC COM 58933Y105   13,916,034 120,600 SH   DFND 1,2 120,600 0 0
MERSANA THERAPEUTICS INC COM 59045L106   1,377,069 418,562 SH   DFND 1,2 418,562 0 0
MERUS N V COM N5749R100   7,328,508 278,333 SH   DFND 1,2 278,333 0 0
MICROSOFT CORP COM 594918104   11,684,608 34,312 SH   DFND   34,312 0 0
MICROSOFT CORP COM 594918104   7,151,340 21,000 SH Call DFND   0 0 0
MINERALYS THERAPEUTICS INC COM 603170101   6,912,070 405,400 SH   DFND 1,2 405,400 0 0
MORPHIC HLDG INC COM 61775R105   5,159,700 90,000 SH   DFND 1,2 90,000 0 0
NICE LTD SPONSORED ADR 653656108   18,065,033 87,482 SH   DFND   87,482 0 0
NICE LTD SPONSORED ADR 653656108   3,097,500 15,000 SH Call DFND   0 0 0
NOVA LTD COM M7516K103   8,211,000 70,000 SH   DFND   70,000 0 0
NOVARTIS AG SPONSORED ADR 66987V109   6,054,600 60,000 SH   DFND 1,2 60,000 0 0
NOVO-NORDISK A S ADR 670100205   9,149,868 56,540 SH   DFND 1,2 56,540 0 0
PALO ALTO NETWORKS INC COM 697435105   6,898,770 27,000 SH   DFND   27,000 0 0
PFIZER INC COM 717081103   5,135,200 140,000 SH   DFND 1,2 140,000 0 0
PMV PHARMACEUTICALS INC COM 69353Y103   1,175,628 187,800 SH   DFND 1,2 187,800 0 0
POINT BIOPHARMA GLOBAL INC COM 730541109   8,630,937 952,642 SH   DFND 1,2 952,642 0 0
PRAXIS PRECISION MEDICINES I COM 74006W108   10,078,984 8,764,334 SH   DFND 1,2 8,764,334 0 0
PTC THERAPEUTICS INC COM 69366J200   4,071,067 100,100 SH   DFND 1,2 100,100 0 0
QUALCOMM INC COM 747525103   3,809,280 32,000 SH   DFND   32,000 0 0
REZOLUTE INC COM NEW 76200L309   2,288,676 1,155,897 SH   DFND 1,2 1,155,897 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603   1,584,283 1,228,126 SH   DFND 1,2 1,228,126 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106   4,689,320 236,000 SH   DFND 1,2 236,000 0 0
SAGE THERAPEUTICS INC COM 78667J108   6,018,560 128,000 SH   DFND 1,2 128,000 0 0
SANOFI SPONSORED ADR 80105N105   28,540,859 529,515 SH   DFND 1,2 529,515 0 0
SAREPTA THERAPEUTICS INC COM 803607100   5,726,000 50,000 SH   DFND 1,2 50,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100   8,966,916 78,300 SH Call DFND 1,2 0 0 0
SELECTA BIOSCIENCES INC COM 816212104   2,283,120 2,038,500 SH   DFND 1,2 2,038,500 0 0
SHL TELEMEDICINE LTD SPONSORED ADS 78423T200   7,960,343 714,573 SH   DFND   714,573 0 0
SPDR SER TR S&P BIOTECH 78464A870   4,160,000 50,000 SH   DFND 1,2 50,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107   8,197,028 312,625 SH   DFND 1,2 312,625 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105   15,133,667 723,061 SH   DFND 1,2 723,061 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209   61,329,593 8,144,700 SH Call DFND   0 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209   7,906,500 1,050,000 SH   DFND 1,2 1,050,000 0 0
TOWER SEMICONDUCTOR LTD SHS NEW M87915274   6,282,574 167,446 SH   DFND   167,446 0 0
TOWER SEMICONDUCTOR LTD SHS NEW M87915274   12,460,392 332,100 SH Put DFND   332,100 0 0
TRAVERE THERAPEUTICS INC COM 89422G107   3,278,776 213,462 SH   DFND 1,2 213,462 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108   8,473,896 183,696 SH   DFND 1,2 183,696 0 0
UNIQURE NV SHS N90064101   1,704,492 148,734 SH   DFND 1,2 148,734 0 0
VERA THERAPEUTICS INC CL A 92337R101   1,685,250 105,000 SH   DFND 1,2 105,000 0 0
WEREWOLF THERAPEUTICS INC COM 95075A107   1,911,771 626,810 SH   DFND 1,2 626,810 0 0