The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103   2,299,038 180,600 SH   DFND 1,2 180,600 0 0
89BIO INC CALL 282559903   45,828 3,600 SH Call DFND 1,2 0 0 3,600
ABBVIE INC COM 00287Y109   9,696,600 60,000 SH   DFND 1,2 60,000 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103   198,333 440,837 SH   DFND 1,2 440,837 0 0
ALBIREO PHARMA INC COM 01345P106   10,023,323 463,828 SH   DFND 1,2 463,828 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100   1,470,000 200,000 SH   DFND 1,2 200,000 0 0
ALTIMMUNE INC COM NEW 02155H200   6,255,902 380,298 SH   DFND 1,2 380,298 0 0
APELLIS PHARMACEUTICALS INC PUT 03753U956   3,102,600 60,000 SH Put DFND 1,2 60,000 0 0
APPLIED MATLS INC COM 038222105   827,558 8,499 SH   DFND   8,499 0 0
ARBE ROBOTICS LTD ORDINARY SHARES M1R95N100   147,193 43,165 SH   DFND   43,165 0 0
ARCELLX INC COMMON STOCK 03940C100   7,357,378 237,488 SH   DFND 1,2 237,488 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108   27,124,068 400,060 SH   DFND 1,2 400,060 0 0
ASTRIA THERAPEUTICS INC COM 04635X102   6,988,473 469,340 SH   DFND 1,2 469,340 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100   950,000 500,000 SH   DFND 1,2 500,000 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204   4,026,649 489,860 SH   DFND 1,2 489,860 0 0
BIOATLA INC COM 09077B104   1,539,450 186,600 SH   DFND 1,2 186,600 0 0
BIOGEN INC COM 09062X103   2,081,331 7,516 SH   DFND 1,2 7,516 0 0
CAMTEK LTD ORD M20791105   2,415,600 110,000 SH   DFND   110,000 0 0
CHINOOK THERAPEUTICS INC COM 16961L106   3,332,640 127,200 SH   DFND 1,2 127,200 0 0
CINCOR PHARMA INC COM 17240Y109   6,509,276 529,640 SH   DFND 1,2 529,640 0 0
CONCERT PHARMACEUTICALS INC COM 206022105   5,856,253 1,002,783 SH   DFND 1,2 1,002,783 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107   12,291,085 671,644 SH   DFND 1,2 671,644 0 0
CYCLACEL PHARMACEUTICALS INC COM 23254L603   166,750 250,000 SH   DFND 1,2 250,000 0 0
DYNE THERAPEUTICS INC COM 26818M108   82,857 7,149 SH   DFND 1,2 7,149 0 0
FIVE9 INC COM 338307101   6,446,600 95,000 SH   DFND   95,000 0 0
FIVERR INTL LTD NOTE 11/0 33835LAA3   4,013,955 4,951,000 SH   DFND   4,951,000 0 0
GENERAC HLDGS INC COM 368736104   5,032,995 50,000 SH   DFND   50,000 0 0
IMMATICS N.V *W EXP 07/01/202 N44445117   251,000 100,000 SH   DFND 1,2 100,000 0 0
IMMATICS N.V SHS N44445109   6,801,221 780,852 SH   DFND 1,2 780,852 0 0
INFINITY PHARMACEUTICALS INC COM 45665G303   819,180 1,476,000 SH   DFND 1,2 1,476,000 0 0
INOZYME PHARMA INC COM 45790W108   1,706,311 1,625,058 SH   DFND 1,2 1,625,058 0 0
INVESCO QQQ TR PUT 46090E953   55,918,800 210,000 SH Put DFND   210,000 0 0
INVESCO QQQ TR CALL 46090E903   61,510,680 231,000 SH Call DFND   0 0 231,000
IVERIC BIO INC COM 46583P102   4,187,603 195,591 SH   DFND 1,2 195,591 0 0
JOHNSON & JOHNSON COM 478160104   19,401,646 109,831 SH   DFND 1,2 109,831 0 0
KEROS THERAPEUTICS INC COM 492327101   7,623,511 158,757 SH   DFND 1,2 158,757 0 0
KEZAR LIFE SCIENCES INC COM 49372L100   9,188,446 1,305,183 SH   DFND 1,2 1,305,183 0 0
KINIKSA PHARMACEUTICALS LTD COM CL A G5269C101   4,603,099 307,283 SH   DFND 1,2 307,283 0 0
KURA ONCOLOGY INC COM 50127T109   6,928,342 558,287 SH   DFND 1,2 558,287 0 0
LEONARDO DRS INC COM 52661A108   4,288,418 335,557 SH   DFND   335,557 0 0
LILLY ELI & CO COM 532457108   9,398,430 25,690 SH   DFND 1,2 25,690 0 0
MAGIC SOFTWARE ENTERPRISES L ORD 559166103   352,199 21,981 SH   DFND   21,981 0 0
MEDIWOUND LTD SHS NEW M68830112   1,017,321 75,413 SH   DFND   75,413 0 0
MERCK & CO INC COM 58933Y105   13,380,570 120,600 SH   DFND 1,2 120,600 0 0
MERUS N V COM N5749R100   4,903,882 316,993 SH   DFND 1,2 316,993 0 0
NICE SYS INC NOTE 1.250% 1/1 65366HAB9   576,550 250,000 SH   DFND   250,000 0 0
NOVO-NORDISK A S ADR 670100205   9,682,224 71,540 SH   DFND 1,2 71,540 0 0
ONCORUS INC COM 68236R103   136,847 540,258 SH   DFND 1,2 540,258 0 0
OTONOMO TECHNOLOGIES LTD ORDINARY SHARES M7571L103   159,488 391,863 SH   DFND   391,863 0 0
OUTBRAIN INC COM 69002R103   43,976 12,148 SH   DFND   12,148 0 0
PMV PHARMACEUTICALS INC COM 69353Y103   1,633,860 187,800 SH   DFND 1,2 187,800 0 0
POINT BIOPHARMA GLOBAL INC COM 730541109   6,944,760 952,642 SH   DFND 1,2 952,642 0 0
REZOLUTE INC COM NEW 76200L309   2,392,707 1,155,897 SH   DFND 1,2 1,155,897 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603   3,418,268 2,278,845 SH   DFND 1,2 2,278,845 0 0
SANOFI SPONSORED ADR 80105N105   27,097,311 559,515 SH   DFND 1,2 559,515 0 0
SPDR SER TR S&P BIOTECH 78464A870   5,810,000 70,000 SH   DFND 1,2 70,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107   8,235,416 316,625 SH   DFND 1,2 316,625 0 0
STOKE THERAPEUTICS INC COM 86150R107   1,741,147 188,640 SH   DFND 1,2 188,640 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105   18,083,777 710,561 SH   DFND 1,2 710,561 0 0
TABOOLA.COM LTD ORD SHS M8744T106   369,600 120,000 SH   DFND   120,000 0 0
TEVA PHARMACEUTICAL INDS LTD CALL 881624909   20,267,376 2,222,300 SH Call DFND   0 0 2,222,300
TOWER SEMICONDUCTOR LTD PUT M87915954   6,981,120 161,600 SH Put DFND   161,600 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108   8,510,636 183,696 SH   DFND 1,2 183,696 0 0
WEREWOLF THERAPEUTICS INC COM 95075A107   1,284,961 626,810 SH   DFND 1,2 626,810 0 0