The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103 1,512 58,939 SH   DFND 1,2 58,939 0 0
ABBVIE INC COM 00287Y109 69,196 790,000 SH   DFND 1,2 790,000 0 0
ABBVIE INC CALL 00287Y109 10,949 125,000 SH Call DFND 1,2 0 0 125,000
ADMA BIOLOGICS INC COM 000899104 2,584 1,081,292 SH   DFND 1,2 1,081,292 0 0
ALBIREO PHARMA INC COM 01345P106 5,793 173,600 SH   DFND 1,2 173,600 0 0
ALLOT LTD SHS M0854Q105 9,513 1,045,337 SH   DFND   1,045,337 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100 1,743 198,260 SH   DFND 1,2 198,260 0 0
ALTIMMUNE INC COM NEW 02155H200 3,208 243,000 SH   DFND 1,2 243,000 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105 6,871 182,070 SH   DFND 1,2 182,070 0 0
AMAZON COM INC COM 023135106 12,028 3,820 SH   DFND   3,820 0 0
AMGEN INC COM 031162100 27,958 110,000 SH   DFND 1,2 110,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 17,559 1,243,550 SH   DFND 1,2 1,243,550 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 5,609 75,000 SH   DFND 1,2 75,000 0 0
ARGENX SE SPONSORED ADR 04016X101 2,695 10,265 SH   DFND 1,2 10,265 0 0
ARVINAS INC COM 04335A105 3,187 135,000 SH   DFND 1,2 135,000 0 0
ARYA SCIENCES ACQUISITION CO COM CL A G3166W106 4,288 400,000 SH   DFND 1,2 400,000 0 0
ARYA SCIENCES ACQUISTION CO UNIT 06/09/2027 G31655114 5,489 499,000 SH   DFND 1,2 499,000 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 5,031 32,599 SH   DFND 1,2 32,599 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 44,936 820,000 SH   DFND 1,2 820,000 0 0
ATHIRA PHARMA INC COM 04746L104 2,068 112,000 SH   DFND 1,2 112,000 0 0
AVROBIO INC COM 05455M100 4,238 325,500 SH   DFND 1,2 325,500 0 0
AXOVANT SCIENCES LTD COM G0750W203 5,327 1,152,998 SH   DFND 1,2 1,152,998 0 0
BIOXCEL THERAPEUTICS INC COM 09075P105 11,677 269,300 SH   DFND 1,2 269,300 0 0
BURLINGTON STORES INC COM 122017106 7,213 35,000 SH   DFND   35,000 0 0
CARDIFF ONCOLOGY INC COM 14147L108 568 40,000 SH   DFND 1,2 40,000 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 5,487 370,000 SH   DFND 1,2 370,000 0 0
CELLECTAR BIOSCIENCES INC COM PAR 15117F500 109 87,500 SH   DFND 1,2 87,500 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 3,044 310,000 SH   DFND 1,2 310,000 0 0
CORBUS PHARMACEUTICALS HLDGS CALL 21833P103 141 78,500 SH Call DFND 1,2 0 0 78,500
DECIPHERA PHARMACEUTICALS IN COM 24344T101 17,645 343,965 SH   DFND 1,2 343,965 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 3,598 199,980 SH   DFND 1,2 199,980 0 0
DOMINOS PIZZA INC COM 25754A201 6,898 16,221 SH   DFND   16,221 0 0
DYNE THERAPEUTICS INC COM 26818M108 1,413 70,000 SH   DFND 1,2 70,000 0 0
ESSA PHARMA INC COM NEW 29668H708 1,725 250,000 SH   DFND 1,2 250,000 0 0
EXICURE INC COM 30205M101 1,291 737,557 SH   DFND 1,2 737,557 0 0
FACEBOOK INC CL A 30303M102 9,167 35,000 SH   DFND   35,000 0 0
FATE THERAPEUTICS INC COM 31189P102 7,514 188,000 SH   DFND 1,2 188,000 0 0
FISERV INC COM 337738108 7,239 70,246 SH   DFND   70,246 0 0
FIVERR INTL LTD ORD SHS M4R82T106 7,964 57,301 SH   DFND   57,301 0 0
GALERA THERAPEUTICS INC COM 36338D108 4,242 469,245 SH   DFND 1,2 469,245 0 0
GENERAC HLDGS INC COM 368736104 12,974 67,000 SH   DFND   67,000 0 0
HEALTH SCIENCES ACQ CORP 2 ORD SHS G4411D109 1,100 100,000 SH   DFND 1,2 100,000 0 0
I MAB SPONSORED ADS 44975P103 8,551 181,820 SH   DFND 1,2 181,820 0 0
IMMATICS N.V *W EXP 07/01/202 N44445117 350 100,000 SH   DFND 1,2 100,000 0 0
IMMATICS N.V SHS N44445109 8,488 800,000 SH   DFND 1,2 800,000 0 0
IMMUNOVANT INC COM 45258J102 5,982 170,000 SH   DFND 1,2 170,000 0 0
INOZYME PHARMA INC COM 45790W108 5,164 196,411 SH   DFND 1,2 196,411 0 0
INVESCO QQQ TR PUT 46090E103 58,346 210,000 SH Put DFND   210,000 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 8,329 253,000 SH   DFND 1,2 253,000 0 0
ISHARES TR PUT 464287481 12,706 73,500 SH Put DFND   73,500 0 0
ITEOS THERAPEUTICS INC COM 46565G104 6,168 250,000 SH   DFND 1,2 250,000 0 0
JFROG LTD ORD SHS M6191J100 8,077 95,415 SH   DFND   95,415 0 0
JOHNSON & JOHNSON COM 478160104 56,574 380,000 SH   DFND 1,2 380,000 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 3,023 240,140 SH   DFND 1,2 240,140 0 0
KINIKSA PHARMACEUTICALS LTD COM CL A G5269C101 3,983 259,990 SH   DFND 1,2 259,990 0 0
KORNIT DIGITAL LTD SHS M6372Q113 9,301 143,381 SH   DFND   143,381 0 0
KRYSTAL BIOTECH INC COM 501147102 7,946 184,573 SH   DFND 1,2 184,573 0 0
KURA ONCOLOGY INC COM 50127T109 11,015 359,494 SH   DFND 1,2 359,494 0 0
KYMERA THERAPEUTICS INC COM 501575104 5,170 160,000 SH   DFND 1,2 160,000 0 0
LARIMAR THERAPEUTICS INC COM 517125100 5,189 342,064 SH   DFND 1,2 342,064 0 0
LEAP THERAPEUTICS INC COM 52187K101 1,584 800,000 SH   DFND 1,2 800,000 0 0
LILLY ELI & CO COM 532457108 23,091 156,000 SH   DFND 1,2 156,000 0 0
LILLY ELI & CO CALL 532457108 29,604 200,000 SH Call DFND 1,2 0 0 200,000
MERCK & CO. INC COM 58933Y105 73,312 883,808 SH   DFND 1,2 883,808 0 0
MICROSOFT CORP COM 594918104 10,785 51,278 SH   DFND   51,278 0 0
MIRATI THERAPEUTICS INC COM 60468T105 5,480 33,000 SH   DFND 1,2 33,000 0 0
MYOKARDIA INC COM 62857M105 11,043 81,000 SH   DFND 1,2 81,000 0 0
NEUBASE THERAPEUTICS INC COM 64132K102 1,139 150,000 SH   DFND 1,2 150,000 0 0
NICE LTD SPONSORED ADR 653656108 14,185 62,481 SH   DFND   62,481 0 0
NICE SYS INC NOTE 1.250% 1/1 65366HAB9 681 250,000 SH   DFND   250,000 0 0
NOVARTIS AG SPONSORED ADR 66987V109 24,784 285,000 SH   DFND 1,2 285,000 0 0
NURIX THERAPEUTICS INC COM 67080M103 785 22,480 SH   DFND 1,2 22,480 0 0
ORGENESIS INC COM NEW 68619K204 2,010 398,803 SH   DFND 1,2 398,803 0 0
OUTLOOK THERAPEUTICS INC *W EXP 02/18/202 69012T115 17 129,500 SH   DFND 1,2 129,500 0 0
PANDION THERAPEUTICS INC COM 698340106 1,089 95,000 SH   DFND 1,2 95,000 0 0
PASSAGE BIO INC COM 702712100 3,488 266,037 SH   DFND 1,2 266,037 0 0
PERRIGO CO PLC SHS G97822103 3,285 71,559 SH   DFND   71,559 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 5,761 59,139 SH   DFND 1,2 59,139 0 0
REPARE THERAPEUTICS INC COM 760273102 7,539 245,000 SH   DFND 1,2 245,000 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 5,212 228,016 SH   DFND 1,2 228,016 0 0
SANOFI SPONSORED ADR 80105N105 56,190 1,120,000 SH   DFND 1,2 1,120,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 24,084 171,500 SH   DFND 1,2 171,500 0 0
SAREPTA THERAPEUTICS INC PUT 803607100 21,064 150,000 SH Put DFND 1,2 150,000 0 0
SAREPTA THERAPEUTICS INC CALL 803607100 21,064 150,000 SH Call DFND 1,2 0 0 150,000
SOLAREDGE TECHNOLOGIES INC COM 83417M104 957 4,017 SH   DFND   4,017 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 7,528 510,000 SH   DFND 1,2 510,000 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 9,010 1,000,000 SH   DFND 1,2 1,000,000 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 5,252 582,878 SH   DFND   582,878 0 0
THERAPEUTICS ACQUISITION COR COM CL A 88339T103 288 20,000 SH   DFND 1,2 20,000 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 9,172 645,435 SH   DFND 1,2 645,435 0 0
UNIQURE NV SHS N90064101 4,641 126,000 SH   DFND 1,2 126,000 0 0
VARONIS SYS INC COM 922280102 6,951 60,225 SH   DFND   60,225 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 6,240 1,000,000 SH   DFND 1,2 1,000,000 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 7,906 931,200 SH   DFND 1,2 931,200 0 0
Y-MABS THERAPEUTICS INC COM 984241109 15,222 396,521 SH   DFND 1,2 396,521 0 0
ZENTALIS PHARMACEUTICALS INC COM 98943L107 6,374 194,996 SH   DFND 1,2 194,996 0 0
ZYMEWORKS INC COM 98985W102 3,726 80,000 SH   DFND 1,2 80,000 0 0