The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109 30,962 190,994 SH   DFND 1,2,3 190,994 0 0
ADVANCED MICRO DEVICES INC COM 007903107 10,934 100,000 SH   DFND   100,000 0 0
AIRBNB INC COM CL A 009066101 5,153 30,000 SH   DFND   30,000 0 0
AIRBNB INC CALL 009066901 4,174 24,300 SH Call DFND   0 0 24,300
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 4,044 24,768 SH   DFND 1,2,3 24,768 0 0
ALTIMMUNE INC COM NEW 02155H200 7,959 1,306,953 SH   DFND 1,2,3 1,306,953 0 0
ARBE ROBOTICS LTD ORDINARY SHARES M1R95N100 300 43,165 SH   DFND   43,165 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 3,113 26,529 SH   DFND 1,2,3 26,529 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 55,514 836,817 SH   DFND 1,2,3 836,817 0 0
AYALA PHARMACEUTICALS INC COM 05465V108 995 250,000 SH   DFND 1,2,3 250,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 16,293 211,326 SH   DFND 1,2,3 211,326 0 0
C4 THERAPEUTICS INC COM STK 12529R107 8,795 362,528 SH   DFND 1,2,3 362,528 0 0
CAESARSTONE LTD ORD SHS M20598104 4,503 428,046 SH   DFND   428,046 0 0
CATERPILLAR INC COM 149123101 2,674 12,000 SH   DFND   12,000 0 0
CHINOOK THERAPEUTICS INC COM 16961L106 8,077 493,677 SH   DFND 1,2,3 493,677 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 11,457 521,947 SH   DFND 1,2,3 521,947 0 0
CYCLACEL PHARMACEUTICALS INC COM 23254L603 1,550 508,322 SH   DFND 1,2,3 508,322 0 0
FATE THERAPEUTICS INC COM 31189P102 3,467 89,425 SH   DFND 1,2,3 89,425 0 0
FIVE9 INC COM 338307101 3,279 29,699 SH   DFND   29,699 0 0
FIVE9 INC CALL 338307101 27,479 248,900 SH Call DFND   0 0 248,900
FIVERR INTL LTD NOTE 11/0 33835LAA3 4,227 4,951,000 SH   DFND   4,951,000 0 0
GENERAC HLDGS INC COM 368736104 12,548 42,211 SH   DFND   42,211 0 0
IMMATICS N.V *W EXP 07/01/202 N44445117 175 100,000 SH   DFND 1,2,3 100,000 0 0
IMMATICS N.V SHS N44445109 4,969 621,925 SH   DFND 1,2,3 621,925 0 0
IMMUNIC INC COM 4525EP101 6,590 583,206 SH   DFND 1,2,3 583,206 0 0
INVESCO QQQ TR PUT 46090E103 45,680 126,000 SH Put DFND   126,000 0 0
IRONSOURCE LTD CL A ORD SHS M5R75Y101 2,976 620,000 SH   DFND   620,000 0 0
IVERIC BIO INC COM 46583P102 13,029 774,130 SH   DFND 1,2,3 774,130 0 0
JOHNSON & JOHNSON COM 478160104 52,287 295,023 SH   DFND 1,2,3 295,023 0 0
KEROS THERAPEUTICS INC COM 492327101 7,590 139,581 SH   DFND 1,2,3 139,581 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 3,118 187,599 SH   DFND 1,2,3 187,599 0 0
KRYSTAL BIOTECH INC COM 501147102 1,684 25,310 SH   DFND 1,2,3 25,310 0 0
KURA ONCOLOGY INC COM 50127T109 9,941 618,244 SH   DFND 1,2,3 618,244 0 0
KYMERA THERAPEUTICS INC COM 501575104 15,576 368,061 SH   DFND 1,2,3 368,061 0 0
LIANBIO SPONSORED ADS 53000N108 1,020 275,007 SH   DFND 1,2,3 275,007 0 0
LILLY ELI & CO COM 532457108 20,130 70,295 SH   DFND 1,2,3 70,295 0 0
MAGIC SOFTWARE ENTERPRISES L ORD 559166103 1,401 81,293 SH   DFND   81,293 0 0
MASTERCARD INCORPORATED CL A 57636Q104 4,324 12,100 SH   DFND   12,100 0 0
MERCK & CO INC COM 58933Y105 22,826 278,200 SH   DFND 1,2,3 278,200 0 0
MERUS N V COM N5749R100 10,818 409,141 SH   DFND 1,2,3 409,141 0 0
NAUTILUS BIOTECHNOLOGY INC COM 63909J108 3,646 840,000 SH   DFND 1,2,3 840,000 0 0
NICE SYS INC NOTE 1.250% 1/1 65366HAB9 662 250,000 SH   DFND   250,000 0 0
NOVO-NORDISK A S ADR 670100205 26,363 237,400 SH   DFND 1,2,3 237,400 0 0
ONCORUS INC COM 68236R103 962 540,258 SH   DFND 1,2,3 540,258 0 0
OTONOMO TECHNOLOGIES LTD ORDINARY SHARES M7571L103 772 391,863 SH   DFND   391,863 0 0
OUTBRAIN INC COM 69002R103 564 52,531 SH   DFND   52,531 0 0
PERION NETWORK LTD SHS NEW M78673114 6,883 306,051 SH   DFND   306,051 0 0
PFIZER INC COM 717081103 26,665 515,070 SH   DFND 1,2,3 515,070 0 0
RELMADA THERAPEUTICS INC COM 75955J402 7,861 291,252 SH   DFND 1,2,3 291,252 0 0
REPLIMUNE GROUP INC COM 76029N106 3,611 212,640 SH   DFND 1,2,3 212,640 0 0
SANOFI SPONSORED ADR 80105N105 49,924 972,415 SH   DFND 1,2,3 972,415 0 0
SENTINELONE INC CL A 81730H109 2,518 65,000 SH   DFND   65,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 25,964 460,025 SH   DFND 1,2,3 460,025 0 0
SPRINGWORKS THERAPEUTICS INC CALL 85205L107 7,055 125,000 SH Call DFND 1,2,3 0 0 125,000
SUNRUN INC COM 86771W105 4,556 150,000 SH   DFND   150,000 0 0
SUNRUN INC CALL 86771W105 6,924 228,000 SH Call DFND   0 0 228,000
SYNDAX PHARMACEUTICALS INC COM 87164F105 22,201 1,277,413 SH   DFND 1,2,3 1,277,413 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 7,821 832,878 SH   DFND   832,878 0 0
TEVA PHARMACEUTICAL INDS LTD CALL 881624209 17,747 1,890,000 SH Call DFND   0 0 1,890,000
TEVA PHARMACEUTICAL INDS LTD PUT 881624209 1,972 210,000 SH Put DFND   210,000 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 3,325 666,339 SH   DFND 1,2,3 666,339 0 0
VINCERX PHARMA INC COM NEW 92731L106 2,881 720,161 SH   DFND 1,2,3 720,161 0 0
VISA INC COM CL A 92826C839 5,589 25,200 SH   DFND   25,200 0 0
VISTAGEN THERAPEUTICS INC COM NEW 92840H202 6,140 4,951,423 SH   DFND 1,2,3 4,951,423 0 0
WEREWOLF THERAPEUTICS INC COM 95075A107 2,570 584,203 SH   DFND 1,2,3 584,203 0 0
ZIM INTEGRATED SHIPPING SERV SHS M9T951109 10,761 148,000 SH   DFND   148,000 0 0