The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109 12,571 165,000 SH   DFND 1,2 165,000 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 6,633 157,000 SH   DFND 1,2 157,000 0 0
ADMA BIOLOGICS INC COM 000899104 5,294 1,838,100 SH   DFND 1,2 1,838,100 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 2,641 1,069,089 SH   DFND 1,2 1,069,089 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 22,393 249,396 SH   DFND 1,2 249,396 0 0
ALLENA PHARMACEUTICALS INC COM 018119107 643 667,800 SH   DFND 1,2 667,800 0 0
ALLOT LTD SHS M0854Q105 8,650 915,302 SH   DFND   915,302 0 0
AMAZON COM INC COM 023135106 10,275 5,270 SH   DFND   5,270 0 0
AMICUS THERAPEUTICS INC COM 03152W109 18,643 2,017,624 SH   DFND 1,2 2,017,624 0 0
APPLIED THERAPEUTICS INC COM 03828A101 2,222 67,967 SH   DFND 1,2 67,967 0 0
APTINYX INC COM 03836N103 889 411,666 SH   DFND 1,2 411,666 0 0
ARGENX SE SPONSORED ADR 04016X101 1,352 10,265 SH   DFND 1,2 10,265 0 0
ARVINAS INC COM 04335A105 5,875 145,781 SH   DFND 1,2 145,781 0 0
ARYA SCIENCES ACQUISITION CO UNIT 10/04/2023 G3165V117 2,258 200,000 SH   DFND 1,2 200,000 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 3,668 32,573 SH   DFND 1,2 32,573 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 25,456 570,000 SH   DFND 1,2 570,000 0 0
AUDIOCODES LTD ORD M15342104 4,936 206,619 SH   DFND   206,619 0 0
AXOVANT GENE THERAPIES LTD COM G0750W203 7,152 2,931,018 SH   DFND 1,2 2,931,018 0 0
BEAM THERAPEUTICS INC COM 07373V105 4,764 264,681 SH   DFND 1,2 264,681 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 6,404 109,500 SH   DFND 1,2 109,500 0 0
BRISTOL-MYERS SQUIBB CO RIGHT 99/99/9999 110122157 190 50,000 SH   DFND 1,2 50,000 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 43,477 780,000 SH   DFND 1,2 780,000 0 0
CASSAVA SCIENCES INC COM 14817C107 2,528 615,000 SH   DFND 1,2 615,000 0 0
CELLECTAR BIOSCIENCES INC COM PAR 15117F500 111 87,500 SH   DFND 1,2 87,500 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 8,955 1,013,039 SH   DFND 1,2 1,013,039 0 0
CYCLERION THERAPEUTICS INC COM 23255M105 331 124,976 SH   DFND 1,2 124,976 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 4,920 119,500 SH   DFND 1,2 119,500 0 0
EVOLUS INC COM 30052C107 2,283 550,000 SH   DFND 1,2 550,000 0 0
EXICURE INC COM 30205M101 4,861 3,284,795 SH   DFND 1,2 3,284,795 0 0
FIVERR INTL LTD ORD SHS M4R82T106 2,639 104,839 SH   DFND   104,839 0 0
GALERA THERAPEUTICS INC COM 36338D108 4,519 475,677 SH   DFND 1,2 475,677 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 1,265 24,752 SH   DFND 1,2 24,752 0 0
IMMUNOVANT INC COM 45258J102 296 19,032 SH   DFND 1,2 19,032 0 0
IMMUNOVANT INC UNIT 12/18/2024 45258J201 1,564 94,500 SH   DFND 1,2 94,500 0 0
ISHARES TR PUT 464287655 103,014 900,000 SH Put DFND 1,2 0 0 900,000
IVERIC BIO INC COM 46583P102 425 123,424 SH   DFND 1,2 123,424 0 0
JOHNSON & JOHNSON COM 478160104 45,719 348,653 SH   DFND 1,2 348,653 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 1,837 240,140 SH   DFND 1,2 240,140 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 10,566 550,000 SH   DFND 1,2 550,000 0 0
LEAP THERAPEUTICS INC COM 52187K101 948 600,000 SH   DFND 1,2 600,000 0 0
MERCK & CO. INC COM 58933Y105 66,824 868,518 SH   DFND 1,2 868,518 0 0
MICROSOFT CORP COM 594918104 14,819 93,964 SH   DFND   93,964 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 125 67,992 SH   DFND 1,2 67,992 0 0
MINERVA NEUROSCIENCES INC COM 603380106 1,014 168,357 SH   DFND 1,2 168,357 0 0
NEOLEUKIN THERAPEUTICS INC COM 64049K104 4,518 397,000 SH   DFND 1,2 397,000 0 0
NEOS THERAPEUTICS INC COM 64052L106 1,882 2,509,468 SH   DFND 1,2 2,509,468 0 0
NICE SYS INC NOTE 1.250% 1/1 65366HAB9 445 250,000 SH   DFND   250,000 0 0
NOVARTIS A G SPONSORED ADR 66987V109 11,543 140,000 SH   DFND 1,2 140,000 0 0
NOVO-NORDISK A S ADR 670100205 34,675 576,000 SH   DFND 1,2 576,000 0 0
ORGENESIS INC COM NEW 68619K204 4,216 1,109,564 SH   DFND 1,2 1,109,564 0 0
OUTLOOK THERAPEUTICS INC *W EXP 02/18/202 69012T115 130 129,500 SH   DFND 1,2 0 0 129,500
PALO ALTO NETWORKS INC COM 697435105 2,697 16,452 SH   DFND   16,452 0 0
PASSAGE BIO INC COM 702712100 7,135 478,171 SH   DFND 1,2 478,171 0 0
PFIZER INC COM 717081103 17,952 550,000 SH   DFND 1,2 550,000 0 0
PRECISION BIOSCIENCES INC COM 74019P108 889 147,352 SH   DFND 1,2 147,352 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 1,900 346,148 SH   DFND 1,2 346,148 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 3,714 526,075 SH   DFND 1,2 526,075 0 0
PROTEOSTASIS THERAPEUTICS IN COM 74373B109 2,892 2,536,600 SH   DFND 1,2 2,536,600 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 4,673 335,016 SH   DFND 1,2 335,016 0 0
SALESFORCE COM INC COM 79466L302 5,115 35,529 SH   DFND   35,529 0 0
SANOFI SPONSORED ADR 80105N105 42,408 970,000 SH   DFND 1,2 970,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 25,238 258,000 SH   DFND 1,2 258,000 0 0
SELECT SECTOR SPDR TR SBI CONS STPLS 81369Y308 7,909 145,207 SH   DFND   145,207 0 0
SPDR S&P 500 ETF TR PUT 78462F103 54,102 209,900 SH Put DFND   0 0 209,900
SPDR SER TR PUT 78464A870 38,720 500,000 SH Put DFND 1,2 0 0 500,000
STOKE THERAPEUTICS INC COM 86150R107 624 27,254 SH   DFND 1,2 27,254 0 0
SUNESIS PHARMACEUTICALS INC COM 867328700 299 721,800 SH   DFND 1,2 721,800 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 747 68,134 SH   DFND 1,2 68,134 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 3,203 356,713 SH   DFND   356,713 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 5,093 1,260,694 SH   DFND 1,2 1,260,694 0 0
UNIQURE NV SHS N90064101 9,543 201,107 SH   DFND 1,2 201,107 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 1,666 7,000 SH   DFND 1,2 7,000 0 0
VIKING THERAPEUTICS INC COM 92686J106 2,761 590,000 SH   DFND 1,2 590,000 0 0
X4 PHARMACEUTICALS INC COM 98420X103 8,732 873,215 SH   DFND 1,2 873,215 0 0
Y-MABS THERAPEUTICS INC COM 984241109 8,023 307,379 SH   DFND 1,2 307,379 0 0
ZAFGEN INC COM 98885E103 2,434 3,161,562 SH   DFND 1,2 3,161,562 0 0
ZYMEWORKS INC COM 98985W102 7,336 206,830 SH   DFND 1,2 206,830 0 0
ZYNERBA PHARMACEUTICALS INC COM 98986X109 383 100,000 SH   DFND 1,2 100,000 0 0