The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109 41,248 366,194 SH   DFND 1,2 366,194 0 0
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 2,861 292,194 SH   DFND 1,2 292,194 0 0
AFFIMED N V COM N01045108 10,852 1,276,702 SH   DFND 1,2 1,276,702 0 0
AGIOS PHARMACEUTICALS INC CALL 00847X104 6,393 116,000 SH Call DFND 1,2 0 0 116,000
ALDEYRA THERAPEUTICS INC COM 01438T106 1,700 150,000 SH   DFND 1,2 150,000 0 0
ALLOT LTD SHS M0854Q105 5,477 276,187 SH   DFND   276,187 0 0
ALTIMMUNE INC COM NEW 02155H200 6,731 683,395 SH   DFND 1,2 683,395 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105 10,538 192,728 SH   DFND 1,2 192,728 0 0
AMAZON COM INC COM 023135106 13,970 4,061 SH   DFND   4,061 0 0
ANNEXON INC COM 03589W102 3,339 148,318 SH   DFND 1,2 148,318 0 0
APOLLO STRATEGIC GROWTH CAPT SHS CL A G0411R106 714 73,055 SH   DFND   73,055 0 0
ARGENX SE SPONSORED ADR 04016X101 2,785 9,249 SH   DFND 1,2 9,249 0 0
ARKO CORP COM 041242108 3,399 369,875 SH   DFND   369,875 0 0
ARYA SCIENCES ACQU CORP IV CL A G31659108 5,360 500,000 SH   DFND 1,2 500,000 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 68,745 1,147,673 SH   DFND 1,2 1,147,673 0 0
ATERIAN INC COM 02156U101 5,852 399,999 SH   DFND   399,999 0 0
ATERIAN INC CALL 02156U101 5,202 355,600 SH Call DFND   0 0 355,600
AUDIOCODES LTD ORD M15342104 12,746 385,194 SH   DFND   385,194 0 0
BCLS ACQUISITION CORP COM CL A G0904B105 7,244 687,900 SH   DFND 1,2 687,900 0 0
BEAM THERAPEUTICS INC COM 07373V105 3,659 28,425 SH   DFND 1,2 28,425 0 0
BEIGENE LTD SPONSORED ADR 07725L102 7,173 20,900 SH   DFND 1,2 20,900 0 0
BIOGEN INC COM 09062X103 8,309 23,995 SH   DFND 1,2 23,995 0 0
BIOGEN INC CALL 09062X103 17,313 50,000 SH Call DFND 1,2 0 0 50,000
C4 THERAPEUTICS INC COM STK 12529R107 19,624 518,611 SH   DFND 1,2 518,611 0 0
CAESARSTONE LTD ORD SHS M20598104 9,508 644,146 SH   DFND   644,146 0 0
CELCUITY INC COM 15102K100 1,080 45,000 SH   DFND 1,2 45,000 0 0
CENTURY THERAPEUTICS INC COM 15673T100 2,347 80,000 SH   DFND 1,2 80,000 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128 236 9,212 SH   DFND 1,2 9,212 0 0
CEREVEL THERAPEUTICS HLDNG I *W EXP 06/09/202 15678U102 2,379 165,295 SH   DFND 1,2 165,295 0 0
CLARIM ACQUISITION CORP UNIT 99/99/9999 18049C207 1,478 148,886 SH   DFND   148,886 0 0
CM LIFE SCIENCES III INC UNIT 04/30/2028 125841205 821 75,000 SH   DFND 1,2 75,000 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 11,953 634,088 SH   DFND 1,2 634,088 0 0
CURIS INC COM NEW 231269200 4,747 588,264 SH   DFND 1,2 588,264 0 0
CVRX INC COM 126638105 4,200 150,000 SH   DFND 1,2 150,000 0 0
CYCLACEL PHARMACEUTICALS INC COM 23254L603 3,009 508,322 SH   DFND 1,2 508,322 0 0
CYTEIR THERAPEUTICS INC COM 23284P103 2,675 125,000 SH   DFND 1,2 125,000 0 0
DFP HEALTHCARE ACQUISITNS CO COM CL A 23343Q100 1,257 126,491 SH   DFND 1,2 126,491 0 0
DYNE THERAPEUTICS INC COM 26818M108 7,779 369,714 SH   DFND 1,2 369,714 0 0
E MERGE TECHNOLOGY ACQUISITI COM CL A 26873Y104 976 100,000 SH   DFND   100,000 0 0
ELEVATION ONCOLOGY INC COM 28623U101 407 30,000 SH   DFND 1,2 30,000 0 0
ENPHASE ENERGY INC CALL 29355A107 42,235 230,000 SH Call DFND   0 0 230,000
ESSA PHARMA INC COM NEW 29668H708 18,522 648,303 SH   DFND 1,2 648,303 0 0
EUCRATES BIOMEDICAL ACQU COR SHS G3141W106 3,239 329,025 SH   DFND 1,2 329,025 0 0
FACEBOOK INC CL A 30303M102 9,388 27,000 SH   DFND   27,000 0 0
FATE THERAPEUTICS INC COM 31189P102 14,346 165,299 SH   DFND 1,2 165,299 0 0
FIVERR INTL LTD ORD SHS M4R82T106 5,214 21,500 SH   DFND   21,500 0 0
FIVERR INTL LTD CALL M4R82T106 19,157 79,000 SH Call DFND   0 0 79,000
FRAZIER LIFESCIENCES ACQU CO CL A SHS G3710A105 1,237 126,687 SH   DFND 1,2 126,687 0 0
FREQUENCY THERAPEUTICS INC COM 35803L108 2,741 275,160 SH   DFND 1,2 275,160 0 0
GENERAC HLDGS INC COM 368736104 43,327 104,363 SH   DFND   104,363 0 0
GRACELL BIOTECHNOLOGIES INC SPONSORED ADS 38406L103 3,040 233,850 SH   DFND 1,2 233,850 0 0
GRAPHITE BIO INC COM 38870X104 767 24,957 SH   DFND 1,2 24,957 0 0
HEALTHCARE CAPITAL CORP UNIT 12/31/2025 42228C200 1,962 196,610 SH   DFND   196,610 0 0
HEALTHCOR CATALIO ACQU CORP CL A SHS G44125105 1,970 200,000 SH   DFND 1,2 200,000 0 0
I MAB SPONSORED ADS 44975P103 3,891 46,350 SH   DFND 1,2 46,350 0 0
IDEAYA BIOSCIENCES INC COM 45166A102 7,027 334,794 SH   DFND 1,2 334,794 0 0
IMMATICS N.V *W EXP 07/01/202 N44445117 344 100,000 SH   DFND 1,2 100,000 0 0
INHIBRX INC COM 45720L107 5,204 189,083 SH   DFND 1,2 189,083 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 8,508 52,550 SH   DFND 1,2 52,550 0 0
INVESCO EXCH TRADED FD TR II CALL 46138G706 18,759 210,000 SH Call DFND   0 0 210,000
IONIS PHARMACEUTICALS INC CALL 462222100 7,443 186,600 SH Call DFND 1,2 0 0 186,600
IOVANCE BIOTHERAPEUTICS INC COM 462260100 9,852 378,642 SH   DFND 1,2 378,642 0 0
ISHARES TR PUT 464287655 24,084 105,000 SH Put DFND   105,000 0 0
ISHARES TR PUT 464287515 40,954 105,000 SH Put DFND   105,000 0 0
IVERIC BIO INC COM 46583P102 3,155 500,000 SH   DFND 1,2 500,000 0 0
JIYA ACQUISITION CORP COM CL A 47760M102 1,978 199,028 SH   DFND 1,2 199,028 0 0
JOHNSON & JOHNSON COM 478160104 66,820 405,608 SH   DFND 1,2 405,608 0 0
KORNIT DIGITAL LTD SHS M6372Q113 18,375 147,793 SH   DFND   147,793 0 0
KURA ONCOLOGY INC COM 50127T109 18,116 868,886 SH   DFND 1,2 868,886 0 0
KYMERA THERAPEUTICS INC COM 501575104 12,605 259,895 SH   DFND 1,2 259,895 0 0
LAVA THERAPEUTICS NV SHS N51517105 2,343 215,359 SH   DFND 1,2 215,359 0 0
LEFTERIS ACQUISITION CORP COM CL A 52470X109 1,116 114,428 SH   DFND   114,428 0 0
LILLY ELI & CO COM 532457108 41,748 181,895 SH   DFND 1,2 181,895 0 0
LIONHEART ACQUISITION CORP I COM CL A 53625R104 986 99,859 SH   DFND   99,859 0 0
LIVEPERSON INC COM 538146101 14,229 225,000 SH   DFND   225,000 0 0
MAGIC SOFTWARE ENTERPRISES L ORD 559166103 259 15,976 SH   DFND   15,976 0 0
MERCK & CO INC COM 58933Y105 60,085 772,601 SH   DFND 1,2 772,601 0 0
MERCK & CO INC PUT 58933Y105 60,085 772,600 SH Put DFND 1,2 772,600 0 0
MERUS N V COM N5749R100 6,037 286,506 SH   DFND 1,2 286,506 0 0
MICROSOFT CORP COM 594918104 18,295 67,536 SH   DFND   67,536 0 0
MIRATI THERAPEUTICS INC COM 60468T105 7,642 47,309 SH   DFND 1,2 47,309 0 0
MONTE ROSA THERAPEUTICS INC COM 61225M102 2,270 100,000 SH   DFND 1,2 100,000 0 0
NAUTILUS BIOTECHNOLOGY INC COM 63909J108 8,080 800,000 SH   DFND 1,2 800,000 0 0
NICE LTD SPONSORED ADR 653656108 19,001 76,786 SH   DFND   76,786 0 0
NICE SYS INC NOTE 1.250% 1/1 65366HAB9 731 250,000 SH   DFND   250,000 0 0
NKARTA INC COM 65487U108 8,001 252,478 SH   DFND 1,2 252,478 0 0
NURIX THERAPEUTICS INC COM 67080M103 6,477 244,157 SH   DFND 1,2 244,157 0 0
OMEGA ALPHA SPAC CL A G6749V107 995 100,000 SH   DFND 1,2 100,000 0 0
ONCORUS INC COM 68236R103 12,331 893,548 SH   DFND 1,2 893,548 0 0
ONTO INNOVATION INC COM 683344105 7,855 107,548 SH   DFND   107,548 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 5,999 1,366,564 SH   DFND 1,2 1,366,564 0 0
OUTLOOK THERAPEUTICS INC *W EXP 02/18/202 69012T115 49 129,500 SH   DFND 1,2 129,500 0 0
PERRIGO CO PLC SHS G97822103 2,407 52,500 SH   DFND   52,500 0 0
PLAYTIKA HLDG CORP COM 72815L107 3,576 150,000 SH   DFND   150,000 0 0
PLIANT THERAPEUTICS INC COM 729139105 1,485 51,000 SH   DFND 1,2 51,000 0 0
PMV PHARMACEUTICALS INC COM 69353Y103 2,872 84,074 SH   DFND 1,2 84,074 0 0
PRAXIS PRECISION MEDICINES I COM 74006W108 1,382 75,600 SH   DFND 1,2 75,600 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 13,597 302,965 SH   DFND 1,2 302,965 0 0
REPARE THERAPEUTICS INC COM 760273102 3,130 100,391 SH   DFND 1,2 100,391 0 0
RESEARCH ALLIANCE CORP II COM CL A 760873109 6,000 600,000 SH   DFND 1,2 600,000 0 0
SANOFI SPONSORED ADR 80105N105 44,413 843,400 SH   DFND 1,2 843,400 0 0
SARISSA CAPITAL ACQUISITN CO CL A G7823W102 237 23,900 SH   DFND 1,2 23,900 0 0
SELECT SECTOR SPDR TR PUT 81369Y803 31,009 210,000 SH Put DFND   210,000 0 0
SENTINELONE INC CL A 81730H109 2,907 68,400 SH   DFND   68,400 0 0
SHATTUCK LABS INC COM 82024L103 7,949 274,214 SH   DFND 1,2 274,214 0 0
SIGILON THERAPEUTICS INC COM 82657L107 3,865 360,239 SH   DFND 1,2 360,239 0 0
SILVERBACK THERAPEUTICS INC COM 82835W108 5,371 173,891 SH   DFND 1,2 173,891 0 0
SINGULAR GENOMICS SYSTEMS IN COM 82933R100 1,480 53,867 SH   DFND 1,2 53,867 0 0
SOLAREDGE TECHNOLOGIES INC COM 83417M104 8,899 32,200 SH   DFND   32,200 0 0
SPDR SER TR PUT 78464A870 84,625 625,000 SH Put DFND 1,2 625,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 16,080 195,117 SH   DFND 1,2 195,117 0 0
STOKE THERAPEUTICS INC COM 86150R107 7,847 233,135 SH   DFND 1,2 233,135 0 0
SUNRUN INC COM 86771W105 4,016 72,000 SH   DFND   72,000 0 0
SUTRO BIOPHARMA INC COM 869367102 5,481 294,825 SH   DFND 1,2 294,825 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 9,395 547,187 SH   DFND 1,2 547,187 0 0
TAILWIND INTERNATNAL ACQ COR UNIT 99/99/9999 G8662F127 483 48,342 SH   DFND   48,342 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 8,245 832,878 SH   DFND   832,878 0 0
TEVA PHARMACEUTICAL INDS LTD CALL 881624209 18,909 1,910,000 SH Call DFND   0 0 1,910,000
THERAPEUTICS ACQUISITION COR COM CL A 88339T103 10,378 1,009,497 SH   DFND 1,2 1,009,497 0 0
TREMOR INTL LTD ADS 89484T104 2,985 150,000 SH   DFND   150,000 0 0
TURMERIC ACQUISITION CORP CL A G9127T108 2,170 219,440 SH   DFND 1,2 219,440 0 0
TWILIO INC CL A 90138F102 10,445 26,500 SH   DFND   26,500 0 0
TWIST BIOSCIENCE CORP COM 90184D100 2,399 18,000 SH   DFND 1,2 18,000 0 0
UNIQURE NV SHS N90064101 5,298 172,000 SH   DFND 1,2 172,000 0 0
VARONIS SYS INC COM 922280102 12,562 218,013 SH   DFND   218,013 0 0
VERINT SYS INC COM 92343X100 6,761 150,000 SH   DFND   150,000 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 5,240 801,256 SH   DFND 1,2 801,256 0 0
VINCERX PHARMA INC COM NEW 92731L106 2,955 227,450 SH   DFND 1,2 227,450 0 0
VISTAGEN THERAPEUTICS INC COM NEW 92840H202 12,854 4,080,673 SH   DFND 1,2 4,080,673 0 0
WEREWOLF THERAPEUTICS INC COM 95075A107 12,049 706,294 SH   DFND 1,2 706,294 0 0
WIX COM LTD SHS M98068105 1,655 5,700 SH   DFND   5,700 0 0
XENON PHARMACEUTICALS INC COM 98420N105 51,412 276,130 SH   DFND 1,2 276,130 0 0
YUMANITY THERAPEUTICS INC COM 98872L102 1,343 115,298 SH   DFND 1,2 115,298 0 0
ZAI LAB LTD ADR 98887Q104 17,335 97,946 SH   DFND 1,2 97,946 0 0