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SPHERA FUNDS MANAGEMENT LTD.
> AGLE
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | Aeglea BioTherapeutics, Inc. | AGLE | 0 | -440,837 | 0 | -198,333,000 | |
| 12/31/2022 | Aeglea BioTherapeutics, Inc. | AGLE | 440,837 | 440,837 | 198,333,000 | 198,333,000 | $449.90 |
| 09/30/2019 | Aeglea BioTherapeutics, Inc. | AGLE | 0 | -187,206 | 0 | -1,282,000 | |
| 06/30/2019 | Aeglea BioTherapeutics, Inc. | AGLE | 187,206 | -787,794 | 1,282,000 | -6,567,000 | $6.85 |
| 03/31/2019 | Aeglea BioTherapeutics, Inc. | AGLE | 975,000 | 375,000 | 7,849,000 | 3,355,000 | $8.05 |
| 12/31/2018 | Aeglea BioTherapeutics, Inc. | AGLE | 600,000 | -53,112 | 4,494,000 | -1,756,000 | $7.49 |
| 09/30/2018 | Aeglea BioTherapeutics, Inc. | AGLE | 653,112 | 143,994 | 6,250,000 | 864,000 | $9.57 |
| 06/30/2018 | Aeglea BioTherapeutics, Inc. | AGLE | 509,118 | 509,118 | 5,386,000 | 5,386,000 | $10.58 |
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