The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABEONA THERAPEUTICS INC COM 00289Y107 4,313 336,939 SH   DFND 1,2 336,939 0 0
AC IMMUNE SA SHS H00263105 4,029 503,563 SH   DFND 1,2 503,563 0 0
ADVANCE AUTO PARTS INC COM 00751Y106 898 5,336 SH   DFND   5,336 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 454 75,000 SH   DFND 1,2 75,000 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 6,250 653,112 SH   DFND 1,2 653,112 0 0
AERPIO PHARMACEUTICALS INC COM 00810B105 3,497 1,131,819 SH   DFND 1,2 1,131,819 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 15,761 1,142,089 SH   DFND 1,2 1,142,089 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 19,698 141,700 SH   DFND 1,2 141,700 0 0
ALLENA PHARMACEUTICALS INC COM 018119107 3,170 295,199 SH   DFND 1,2 295,199 0 0
ALLOT COMMUNICATIONS LTD SHS M0854Q105 2,326 376,451 SH   DFND   376,451 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 3,501 40,000 SH   DFND 1,2 40,000 0 0
ALPHABET INC CAP STK CL A 02079K305 3,946 3,269 SH   DFND   3,269 0 0
AMICUS THERAPEUTICS INC COM 03152W109 21,617 1,787,994 SH   DFND 1,2 1,787,994 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 3,778 212,470 SH   DFND 1,2 212,470 0 0
AQUESTIVE THERAPEUTICS INC COM 03843E104 1,669 95,300 SH   DFND 1,2 95,300 0 0
ARBUTUS BIOPHARMA CORP COM 03879J100 378 40,000 SH   DFND 1,2 40,000 0 0
ARGENX SE SPONSORED ADR 04016X101 10,343 136,381 SH   DFND 1,2 136,381 0 0
ARQULE INC COM 04269E107 11,350 2,005,243 SH   DFND 1,2 2,005,243 0 0
ARRAY BIOPHARMA INC COM 04269X105 6,004 395,000 SH   DFND 1,2 395,000 0 0
ARVINAS INC COM 04335A105 4,049 240,000 SH   DFND 1,2 240,000 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 6,567 92,673 SH   DFND 1,2 92,673 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 3,730 100,431 SH   DFND 1,2 100,431 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 4,751 120,000 SH   DFND 1,2 120,000 0 0
AUDIOCODES LTD ORD M15342104 596 59,226 SH   DFND   59,226 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 8,935 296,251 SH   DFND 1,2 296,251 0 0
BENITEC BIOPHARMA LTD SPONS ADR NEW 082053307 294 120,000 SH   DFND 1,2 120,000 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 5,840 155,515 SH   DFND 1,2 155,515 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 8,533 88,000 SH   DFND 1,2 88,000 0 0
BLUEBIRD BIO INC COM 09609G100 11,446 78,396 SH   DFND 1,2 78,396 0 0
BRISTOL MYERS SQUIBB CO COM 110122108 33,523 540,000 SH   DFND 1,2 540,000 0 0
CAESARSTONE LTD ORD SHS M20598104 10,412 561,311 SH   DFND   561,311 0 0
CARA THERAPEUTICS INC COM 140755109 6,130 255,930 SH   DFND 1,2 255,930 0 0
CELLECTAR BIOSCIENCES INC COM PAR 15117F500 263 87,500 SH   DFND 1,2 87,500 0 0
CELLECTIS S A SPONSORED ADS 15117K103 12,642 447,970 SH   DFND 1,2 447,970 0 0
CHARTER COMMUNICATIONS INC N CL A 16119P108 462 1,419 SH   DFND   1,419 0 0
CISCO SYS INC COM 17275R102 4,865 100,000 SH   DFND   100,000 0 0
CISION LTD SHS G1992S109 252 15,000 SH   DFND   15,000 0 0
CLEARSIDE BIOMEDICAL INC COM 185063104 7,101 1,154,690 SH   DFND 1,2 1,154,690 0 0
COMCAST CORP NEW CL A 20030N101 212 5,993 SH   DFND   5,993 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 2,758 321,430 SH   DFND 1,2 321,430 0 0
CUE BIOPHARMA INC COM 22978P106 181 20,000 SH   DFND 1,2 20,000 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 4,313 233,151 SH   DFND 1,2 233,151 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 4,260 110,033 SH   DFND 1,2 110,033 0 0
DOVA PHARMACEUTICALS INC COM 25985T102 2,516 120,000 SH   DFND 1,2 120,000 0 0
EIDOS THERAPEUTICS INC COM 28249H104 315 31,522 SH   DFND 1,2 31,522 0 0
EPIZYME INC COM 29428V104 4,235 399,502 SH   DFND 1,2 399,502 0 0
ERYTECH PHARMA SPONSORED ADR 29604W108 1,046 120,000 SH   DFND 1,2 120,000 0 0
EVOKE PHARMA INC COM 30049G104 4,205 1,410,946 SH   DFND 1,2 1,410,946 0 0
FLEX LTD ORD Y2573F102 2,093 159,549 SH   DFND   159,549 0 0
FORESCOUT TECHNOLOGIES INC COM 34553D101 4,700 124,463 SH   DFND   124,463 0 0
GILAT SATELLITE NETWORKS LTD SHS NEW M51474118 1,398 163,367 SH   DFND   163,367 0 0
GILEAD SCIENCES INC COM 375558103 32,428 420,000 SH   DFND 1,2 420,000 0 0
GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105 34,747 865,000 SH   DFND 1,2 865,000 0 0
GLYCOMIMETICS INC COM 38000Q102 3,615 251,013 SH   DFND 1,2 251,013 0 0
HOMOLOGY MEDICINES INC COM 438083107 5,603 245,104 SH   DFND 1,2 245,104 0 0
IDERA PHARMACEUTICALS INC COM NEW 45168K306 3,970 445,558 SH   DFND 1,2 445,558 0 0
IMMUNOMEDICS INC COM 452907108 14,561 699,039 SH   DFND 1,2 699,039 0 0
INTERNATIONAL FLAVORS&FRAGRA COM 459506101 5,071 36,450 SH   DFND   36,450 0 0
JOHNSON & JOHNSON COM 478160104 44,905 325,000 SH   DFND 1,2 325,000 0 0
KADMON HLDGS INC COM 48283N106 4,977 1,490,000 SH   DFND 1,2 1,490,000 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 4,539 212,000 SH   DFND 1,2 212,000 0 0
LEAP THERAPEUTICS INC COM 52187K101 2,590 332,525 SH   DFND 1,2 332,525 0 0
LOWES COS INC COM 548661107 287 2,500 SH   DFND   2,500 0 0
MASTERCARD INCORPORATED CL A 57636Q104 5,067 22,760 SH   DFND   22,760 0 0
MELINTA THERAPEUTICS INC COM 58549G100 6,387 1,616,867 SH   DFND 1,2 1,616,867 0 0
MELLANOX TECHNOLOGIES LTD SHS M51363113 3,679 50,093 SH   DFND   50,093 0 0
MERCK & CO INC COM 58933Y105 55,333 780,000 SH   DFND 1,2 780,000 0 0
MICROSOFT CORP COM 594918104 7,967 69,656 SH   DFND   69,656 0 0
MINERVA NEUROSCIENCES INC COM 603380106 10,572 842,391 SH   DFND 1,2 842,391 0 0
MIRATI THERAPEUTICS INC COM 60468T105 5,318 112,908 SH   DFND 1,2 112,908 0 0
MOLECULAR TEMPLATES INC COM 608550109 2,156 400,000 SH   DFND 1,2 400,000 0 0
MYLAN N V SHS EURO N59465109 48,495 1,325,000 SH   DFND 1,2 1,325,000 0 0
NEOS THERAPEUTICS INC COM 64052L106 4,034 831,697 SH   DFND 1,2 831,697 0 0
NICE SYS INC NOTE 1.250% 1/1 65366HAB9 359 250,000 SH   DFND   250,000 0 0
O REILLY AUTOMOTIVE INC NEW COM 67103H107 3,766 10,844 SH   DFND   10,844 0 0
OBSEVA SA COM H5861P103 4,393 243,669 SH   DFND 1,2 243,669 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 5,066 904,686 SH   DFND 1,2 904,686 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 3,915 147,000 SH   DFND 1,2 147,000 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 7,716 398,749 SH   DFND 1,2 398,749 0 0
PTC THERAPEUTICS INC COM 69366J200 9,870 210,000 SH   DFND 1,2 210,000 0 0
RADWARE LTD ORD M81873107 464 17,527 SH   DFND   17,527 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 7,581 92,719 SH   DFND 1,2 92,719 0 0
RETROPHIN INC COM 761299106 9,357 325,678 SH   DFND 1,2 325,678 0 0
SAGE THERAPEUTICS INC COM 78667J108 8,475 60,000 SH   DFND 1,2 60,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 12,293 76,116 SH   DFND 1,2 76,116 0 0
SAVARA INC COM 805111101 2,339 209,596 SH   DFND 1,2 209,596 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 7,644 296,856 SH   DFND 1,2 296,856 0 0
SERVICEMASTER GLOBAL HLDGS I COM 81761R109 395 9,500 SH   DFND   9,500 0 0
SESEN BIO INC COM 817763105 1,355 630,000 SH   DFND 1,2 630,000 0 0
SIERRA ONCOLOGY INC COM 82640U107 1,739 1,022,759 SH   DFND 1,2 1,022,759 0 0
SITEONE LANDSCAPE SUPPLY INC COM 82982L103 226 3,000 SH   DFND   3,000 0 0
SNAP ON INC COM 833034101 3,978 21,666 SH   DFND   21,666 0 0
SOLAREDGE TECHNOLOGIES INC COM 83417M104 5,678 150,817 SH   DFND   150,817 0 0
SPDR SERIES TRUST PUT 78464A870 105,457 1,100,000 SH Put DFND 1,2 1,100,000 0 0
STRONGBRIDGE BIOPHARMA PLC SHS USD G85347105 5,718 1,179,010 SH   DFND 1,2 1,179,010 0 0
SUTRO BIOPHARMA INC COM 869367102 4,125 275,000 SH   DFND 1,2 275,000 0 0
TEVA PHARMACEUTICAL FIN LLC DBCV 0.250% 2/0 88163VAE9 862 2,135 SH   DFND   2,135 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADR 881624209 4,308 200,000 SH   DFND 1,2 200,000 0 0
TRANSLATE BIO INC COM 89374L104 2,766 276,639 SH   DFND 1,2 276,639 0 0
ULTIMATE SOFTWARE GROUP INC COM 90385D107 258 800 SH   DFND   800 0 0
UNIQURE NV SHS N90064101 6,472 177,849 SH   DFND 1,2 177,849 0 0
UNITEDHEALTH GROUP INC COM 91324P102 532 2,000 SH   DFND   2,000 0 0
UROVANT SCIENCES LTD SHS G9381B108 1,968 164,030 SH   DFND 1,2 164,030 0 0
VERINT SYS INC COM 92343X100 7,521 150,126 SH   DFND   150,126 0 0
VERRICA PHARMACEUTICALS INC COM 92511W108 1,901 117,000 SH   DFND 1,2 117,000 0 0
VIKING THERAPEUTICS INC CALL 92686J106 416 23,900 SH Call DFND 1,2 0 0 0
VIKING THERAPEUTICS INC COM 92686J106 14,976 859,727 SH   DFND 1,2 859,727 0 0
VISA INC COM CL A 92826C839 6,064 40,401 SH   DFND   40,401 0 0
VISTAGEN THERAPEUTICS INC COM NEW 92840H202 2,427 1,673,918 SH   DFND 1,2 1,673,918 0 0
WABTEC CORP COM 929740108 5,571 53,114 SH   DFND   53,114 0 0
XENON PHARMACEUTICALS INC COM 98420N105 5,009 379,484 SH   DFND 1,2 379,484 0 0
ZAFGEN INC COM 98885E103 5,027 430,000 SH   DFND 1,2 430,000 0 0
ZYMEWORKS INC COM 98985W102 1,159 73,800 SH   DFND 1,2 73,800 0 0