The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABEONA THERAPEUTICS INC COM 00289Y107 3,571 223,172 SH   DFND 1,2 223,172 0 0
ADAMAS PHARMACEUTICALS INC COM 00548A106 5,518 213,625 SH   DFND 1,2 213,625 0 0
ADVANCE AUTO PARTS INC COM 00751Y106 724 5,336 SH   DFND   5,336 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 5,386 509,118 SH   DFND 1,2 509,118 0 0
AERPIO PHARMACEUTICALS INC COM 00810B105 4,580 1,103,554 SH   DFND 1,2 1,103,554 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 6,733 846,935 SH   DFND 1,2 846,935 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 19,932 160,544 SH   DFND 1,2 160,544 0 0
ALLENA PHARMACEUTICALS INC COM 018119107 3,484 267,349 SH   DFND 1,2 267,349 0 0
ALLERGAN PLC SHS G0177J108 10,003 60,000 SH   DFND 1,2 60,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 19,228 195,232 SH   DFND 1,2 195,232 0 0
ALPHABET INC CAP STK CL A 02079K305 3,691 3,269 SH   DFND   3,269 0 0
AMGEN INC COM 031162100 18,459 100,000 SH   DFND 1,2 100,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 18,573 1,189,056 SH   DFND 1,2 1,189,056 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 2,438 110,803 SH   DFND 1,2 110,803 0 0
APTINYX INC COM 03836N103 2,477 102,474 SH   DFND 1,2 102,474 0 0
AQUINOX PHARMACEUTICALS INC COM 03842B101 683 257,613 SH   DFND 1,2 257,613 0 0
ARQULE INC COM 04269E107 8,282 1,497,683 SH   DFND 1,2 1,497,683 0 0
ARRAY BIOPHARMA INC COM 04269X105 5,702 339,804 SH   DFND 1,2 339,804 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 5,192 78,048 SH   DFND 1,2 78,048 0 0
AUDIOCODES LTD ORD M15342104 461 59,226 SH   DFND   59,226 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 4,716 176,045 SH   DFND 1,2 176,045 0 0
BIOGEN INC COM 09062X103 14,512 50,000 SH   DFND 1,2 50,000 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 5,430 137,388 SH   DFND 1,2 137,388 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 589 6,250 SH   DFND 1,2 6,250 0 0
BLUEBIRD BIO INC COM 09609G100 11,376 72,483 SH   DFND 1,2 72,483 0 0
CAESARSTONE LTD ORD SHS M20598104 3,485 230,816 SH   DFND   230,816 0 0
CELLECTIS S A SPONSORED ADS 15117K103 9,955 351,874 SH   DFND 1,2 351,874 0 0
CHARTER COMMUNICATIONS INC N CL A 16119P108 416 1,419 SH   DFND   1,419 0 0
CISCO SYS INC COM 17275R102 4,303 100,000 SH   DFND   100,000 0 0
CISION LTD SHS G1992S109 224 15,000 SH   DFND   15,000 0 0
CLEARSIDE BIOMEDICAL INC COM 185063104 11,425 1,068,720 SH   DFND 1,2 1,068,720 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 3,689 335,987 SH   DFND 1,2 335,987 0 0
CTI BIOPHARMA CORP COM NEW 12648L601 4,355 874,407 SH   DFND 1,2 874,407 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 1,901 83,142 SH   DFND 1,2 83,142 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 3,661 93,031 SH   DFND 1,2 93,031 0 0
DELEK US HLDGS INC NEW COM 24665A103 1,231 24,533 SH   DFND   24,533 0 0
EIDOS THERAPEUTICS INC COM 28249H104 220 10,828 SH   DFND 1,2 10,828 0 0
ELOXX PHARMACEUTICALS INC COM 29014R103 2,859 167,474 SH   DFND 1,2 167,474 0 0
EPIZYME INC COM 29428V104 4,162 307,154 SH   DFND 1,2 307,154 0 0
EVOKE PHARMA INC COM 30049G104 3,527 1,410,946 SH   DFND 1,2 1,410,946 0 0
FACEBOOK INC CL A 30303M102 3,712 19,100 SH   DFND   19,100 0 0
FLEX LTD ORD Y2573F102 3,666 259,824 SH   DFND   259,824 0 0
FORESCOUT TECHNOLOGIES INC COM 34553D101 2,617 76,400 SH   DFND   76,400 0 0
GILAT SATELLITE NETWORKS LTD SHS NEW M51474118 1,501 163,367 SH   DFND   163,367 0 0
GILEAD SCIENCES INC COM 375558103 25,148 355,000 SH   DFND 1,2 355,000 0 0
GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105 30,837 765,000 SH   DFND 1,2 765,000 0 0
GLYCOMIMETICS INC COM 38000Q102 3,870 239,933 SH   DFND 1,2 239,933 0 0
HOMOLOGY MEDICINES INC COM 438083107 2,893 141,836 SH   DFND 1,2 141,836 0 0
IMMUNOMEDICS INC COM 452907108 7,259 306,655 SH   DFND 1,2 306,655 0 0
INNOVATE BIOPHARMACEUTICLS I COM PAR 45782F105 7,844 980,502 SH   DFND 1,2 980,502 0 0
ISHARES TR RUSSELL 2000 ETF 464287955 24,566 150,000 SH Put DFND   150,000 0 0
KADMON HLDGS INC COM 48283N106 6,196 1,552,846 SH   DFND 1,2 1,552,846 0 0
KEMPHARM INC COM 488445107 147 22,622 SH   DFND 1,2 22,622 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 3,943 227,900 SH   DFND 1,2 227,900 0 0
KORNIT DIGITAL LTD SHS M6372Q113 2,329 130,831 SH   DFND   130,831 0 0
KURA ONCOLOGY INC COM 50127T109 6,406 351,953 SH   DFND 1,2 351,953 0 0
LAM RESEARCH CORP COM 512807108 2,523 14,597 SH   DFND   14,597 0 0
LEAP THERAPEUTICS INC COM 52187K101 4,492 499,137 SH   DFND 1,2 499,137 0 0
MARVELL TECHNOLOGY GROUP LTD ORD G5876H105 2,355 109,842 SH   DFND   109,842 0 0
MASTERCARD INCORPORATED CL A 57636Q104 4,473 22,760 SH   DFND   22,760 0 0
MELINTA THERAPEUTICS INC COM 58549G100 6,252 984,492 SH   DFND 1,2 984,492 0 0
MELLANOX TECHNOLOGIES LTD SHS M51363113 7,246 85,954 SH   DFND   85,954 0 0
MERCK & CO INC COM 58933Y105 41,276 680,000 SH   DFND 1,2 680,000 0 0
MICROSOFT CORP COM 594918104 7,340 74,435 SH   DFND   74,435 0 0
MINERVA NEUROSCIENCES INC COM 603380106 6,766 820,120 SH   DFND 1,2 820,120 0 0
MIRATI THERAPEUTICS INC COM 60468T105 707 14,335 SH   DFND 1,2 14,335 0 0
MOHAWK INDS INC COM 608190104 236 1,100 SH   DFND   1,100 0 0
MYLAN N V SHS EURO N59465109 30,864 854,000 SH   DFND 1,2 854,000 0 0
NEOS THERAPEUTICS INC COM 64052L106 2,201 352,142 SH   DFND 1,2 352,142 0 0
NICE LTD SPONSORED ADR 653656108 6,231 60,043 SH   DFND   60,043 0 0
O REILLY AUTOMOTIVE INC NEW COM 67103H107 2,967 10,844 SH   DFND   10,844 0 0
OBSEVA SA COM H5861P103 3,689 243,669 SH   DFND 1,2 243,669 0 0
PFIZER INC COM 717081103 14,149 390,000 SH   DFND 1,2 390,000 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 216 42,632 SH   DFND 1,2 42,632 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 4,056 800,000 SH   DFND 1,2 800,000 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 1,385 120,000 SH   DFND 1,2 120,000 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 3,604 493,749 SH   DFND 1,2 493,749 0 0
RADCOM LTD SHS NEW M81865111 1,042 52,760 SH   DFND   52,760 0 0
RADWARE LTD ORD M81873107 443 17,527 SH   DFND   17,527 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 4,757 136,044 SH   DFND 1,2 136,044 0 0
RETROPHIN INC COM 761299106 9,625 353,072 SH   DFND 1,2 353,072 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 677 34,475 SH   DFND 1,2 34,475 0 0
SAREPTA THERAPEUTICS INC COM 803607100 19,179 145,096 SH   DFND 1,2 145,096 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 4,430 283,997 SH   DFND 1,2 283,997 0 0
SERVICEMASTER GLOBAL HLDGS I COM 81761R109 565 9,500 SH   DFND   9,500 0 0
SESEN BIO INC COM 817763105 4,635 2,377,068 SH   DFND 1,2 2,377,068 0 0
SHIRE PLC SPONSORED ADR 82481R106 21,353 126,500 SH   DFND 1,2 126,500 0 0
SIERRA ONCOLOGY INC COM 82640U107 3,184 1,075,806 SH   DFND 1,2 1,075,806 0 0
SITEONE LANDSCAPE SUPPLY INC COM 82982L103 252 3,000 SH   DFND   3,000 0 0
SNAP ON INC COM 833034101 220 1,366 SH   DFND   1,366 0 0
SODASTREAM INTERNATIONAL LTD USD SHS M9068E105 6,292 73,762 SH   DFND   73,762 0 0
SOLAREDGE TECHNOLOGIES INC COM 83417M104 2,342 48,948 SH   DFND   48,948 0 0
SPDR SERIES TRUST S&P BIOTECH 78464A950 71,393 750,000 SH Put DFND 1,2 750,000 0 0
STRONGBRIDGE BIOPHARMA PLC SHS USD G85347105 4,044 673,996 SH   DFND 1,2 673,996 0 0
TEVA PHARMACEUTICAL FIN LLC DBCV 0.250% 2/0 88163VAE9 970 2,135 SH   DFND   2,135 0 0
TRANSLATE BIO INC COM 89374L104 1,645 130,000 SH   DFND 1,2 130,000 0 0
TRICIDA INC COM 89610F101 610 20,410 SH   DFND 1,2 20,410 0 0
ULTIMATE SOFTWARE GROUP INC COM 90385D107 206 800 SH   DFND   800 0 0
UNIQURE NV SHS N90064101 5,764 152,490 SH   DFND 1,2 152,490 0 0
UNITEDHEALTH GROUP INC COM 91324P102 491 2,000 SH   DFND   2,000 0 0
VERRICA PHARMACEUTICALS INC COM 92511W108 2,482 125,800 SH   DFND 1,2 125,800 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 3,399 20,000 SH   DFND 1,2 20,000 0 0
VIKING THERAPEUTICS INC COM 92686J106 7,425 782,424 SH   DFND 1,2 782,424 0 0
VISA INC COM CL A 92826C839 5,351 40,401 SH   DFND   40,401 0 0
VISTAGEN THERAPEUTICS INC COM NEW 92840H202 1,879 1,371,892 SH   DFND 1,2 1,371,892 0 0
WABTEC CORP COM 929740108 4,590 46,564 SH   DFND   46,564 0 0
WIX COM LTD SHS M98068105 2,963 29,542 SH   DFND   29,542 0 0
XENON PHARMACEUTICALS INC COM 98420N105 4,039 439,034 SH   DFND 1,2 439,034 0 0
ZAFGEN INC COM 98885E103 4,910 480,000 SH   DFND 1,2 480,000 0 0
ZYMEWORKS INC COM 98985W102 1,091 73,800 SH   DFND 1,2 73,800 0 0