The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABEONA THERAPEUTICS INC COM 00289Y107 1,928 270,036 SH   DFND 1,2 270,036 0 0
AC IMMUNE SA SHS H00263105 2,935 310,613 SH   DFND 1,2 310,613 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 200 63,355 SH   DFND 1,2 63,355 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 4,494 600,000 SH   DFND 1,2 600,000 0 0
AERPIO PHARMACEUTICALS INC COM 00810B105 1,924 1,131,819 SH   DFND 1,2 1,131,819 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 3,112 67,500 SH   DFND 1,2 67,500 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 10,226 1,232,089 SH   DFND 1,2 1,232,089 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 16,366 168,100 SH   DFND 1,2 168,100 0 0
ALLENA PHARMACEUTICALS INC COM 018119107 1,881 345,199 SH   DFND 1,2 345,199 0 0
ALLOGENE THERAPEUTICS INC COM 019770106 3,055 113,437 SH   DFND 1,2 113,437 0 0
ALLOT COMMUNICATIONS LTD SHS M0854Q105 13,513 595,764 SH   DFND   595,764 0 0
AMICUS THERAPEUTICS INC COM 03152W109 23,452 2,447,994 SH   DFND 1,2 2,447,994 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 1,543 117,000 SH   DFND 1,2 117,000 0 0
ARGENX SE SPONSORED ADR 04016X101 8,366 87,081 SH   DFND 1,2 87,081 0 0
ARQULE INC COM 04269E107 5,630 2,032,643 SH   DFND 1,2 2,032,643 0 0
ARRAY BIOPHARMA INC COM 04269X105 1,781 125,000 SH   DFND 1,2 125,000 0 0
ARVINAS INC COM 04335A105 3,483 271,053 SH   DFND 1,2 271,053 0 0
ARYA SCIENCES ACQUISITION CO SHS CL A G3165V109 2,048 200,000 SH   DFND 1,2 200,000 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 3,651 58,273 SH   DFND 1,2 58,273 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 19,560 515,000 SH   DFND 1,2 515,000 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 6,666 202,994 SH   DFND 1,2 202,994 0 0
AXOVANT SCIENCES LTD COM G0750W104 8,167 8,200,000 SH   DFND 1,2 8,200,000 0 0
BENITEC BIOPHARMA LTD SPONS ADR NEW 082053307 180 120,000 SH   DFND 1,2 120,000 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 4,919 133,015 SH   DFND 1,2 133,015 0 0
BLUEBIRD BIO INC COM 09609G100 13,769 138,796 SH   DFND 1,2 138,796 0 0
BRISTOL MYERS SQUIBB CO COM 110122108 32,747 630,000 SH   DFND 1,2 630,000 0 0
CAESARSTONE LTD ORD SHS M20598104 23,808 469,160 SH   DFND   469,160 0 0
CARA THERAPEUTICS INC COM 140755109 3,951 303,930 SH   DFND 1,2 303,930 0 0
CELGENE CORP COM 151020104 29,802 465,000 SH   DFND 1,2 465,000 0 0
CELLECTAR BIOSCIENCES INC COM PAR 15117F500 136 87,500 SH   DFND 1,2 87,500 0 0
CELLECTIS S A SPONSORED ADS 15117K103 7,459 447,970 SH   DFND 1,2 447,970 0 0
CLEARSIDE BIOMEDICAL INC COM 185063104 1,268 1,185,124 SH   DFND 1,2 1,185,124 0 0
CONSTELLATION PHARMCETICLS I COM 210373106 281 70,162 SH   DFND 1,2 70,162 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 1,180 321,430 SH   DFND 1,2 321,430 0 0
CUE BIOPHARMA INC COM 22978P106 235 50,000 SH   DFND 1,2 50,000 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 4,125 273,151 SH   DFND 1,2 273,151 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 2,415 115,033 SH   DFND 1,2 115,033 0 0
DOVA PHARMACEUTICALS INC COM 25985T102 1,402 185,000 SH   DFND 1,2 185,000 0 0
EPIZYME INC COM 29428V104 4,617 749,502 SH   DFND 1,2 749,502 0 0
ERYTECH PHARMA SPONSORED ADR 29604W108 796 120,000 SH   DFND 1,2 120,000 0 0
EVOKE PHARMA INC COM 30049G104 3,499 1,410,946 SH   DFND 1,2 1,410,946 0 0
FORESCOUT TECHNOLOGIES INC COM 34553D101 5,746 59,169 SH   DFND   59,169 0 0
GILAT SATELLITE NETWORKS LTD SHS NEW M51474118 5,705 166,663 SH   DFND   166,663 0 0
GILEAD SCIENCES INC COM 375558103 21,893 350,000 SH   DFND 1,2 350,000 0 0
GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105 11,845 310,000 SH   DFND 1,2 310,000 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 6,034 147,000 SH   DFND 1,2 147,000 0 0
GLYCOMIMETICS INC COM 38000Q102 2,377 251,013 SH   DFND 1,2 251,013 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 7,499 77,000 SH   DFND 1,2 77,000 0 0
HOMOLOGY MEDICINES INC COM 438083107 3,600 161,000 SH   DFND 1,2 161,000 0 0
IDERA PHARMACEUTICALS INC COM PAR 45168K405 1,234 445,558 SH   DFND 1,2 445,558 0 0
IMMUNOMEDICS INC COM 452907108 10,082 706,539 SH   DFND 1,2 706,539 0 0
ITURAN LOCATION AND CONTROL SHS M6158M104 14,637 122,177 SH   DFND   122,177 0 0
KADMON HLDGS INC COM 48283N106 3,099 1,490,000 SH   DFND 1,2 1,490,000 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 472 20,000 SH   DFND 1,2 20,000 0 0
KORNIT DIGITAL LTD SHS M6372Q113 2,122 30,342 SH   DFND   30,342 0 0
KRYSTAL BIOTECH INC COM 501147102 3,629 174,625 SH   DFND 1,2 174,625 0 0
LOGICBIO THERAPEUTICS INC COM 54142F102 4,343 417,625 SH   DFND 1,2 417,625 0 0
MEIRAGTX HOLDINGS PLC COM G59665102 686 71,159 SH   DFND 1,2 71,159 0 0
MELINTA THERAPEUTICS INC COM 58549G100 1,282 1,616,867 SH   DFND 1,2 1,616,867 0 0
MELLANOX TECHNOLOGIES LTD SHS M51363113 9,787 28,351 SH   DFND   28,351 0 0
MERCK & CO INC COM 58933Y105 36,066 472,000 SH   DFND 1,2 472,000 0 0
MICROSOFT CORP COM 594918104 17,838 46,998 SH   DFND   46,998 0 0
MINERVA NEUROSCIENCES INC COM 603380106 5,271 782,018 SH   DFND 1,2 782,018 0 0
MOHAWK INDS INC COM 608190104 4,659 10,661 SH   DFND   10,661 0 0
MOLECULAR TEMPLATES INC COM 608550109 1,616 400,000 SH   DFND 1,2 400,000 0 0
MYLAN N V SHS EURO N59465109 45,956 1,677,241 SH   DFND 1,2 1,677,241 0 0
NEOS THERAPEUTICS INC COM 64052L106 3,633 2,201,697 SH   DFND 1,2 2,201,697 0 0
NICE SYS INC NOTE 1.250% 1/1 65366HAB9 1,286 250,000 SH   DFND   250,000 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 5,820 370,000 SH   DFND 1,2 370,000 0 0
OSMOTICA PHARMACEUTICALS PLC SHS G6S41R101 7,147 922,200 SH   DFND 1,2 922,200 0 0
PALO ALTO NETWORKS INC COM 697435105 17,514 24,885 SH   DFND   24,885 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 1,862 700,000 SH   DFND 1,2 700,000 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 2,869 147,000 SH   DFND 1,2 147,000 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 5,365 340,000 SH   DFND 1,2 340,000 0 0
PTC THERAPEUTICS INC COM 69366J200 11,858 345,500 SH   DFND 1,2 345,500 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 12,413 221,269 SH   DFND 1,2 221,269 0 0
RETROPHIN INC COM 761299106 7,370 325,678 SH   DFND 1,2 325,678 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 4,298 290,001 SH   DFND 1,2 290,001 0 0
SAGE THERAPEUTICS INC PUT 78667J108 2,347 24,500 SH Put DFND 1,2 24,500 0 0
SAGE THERAPEUTICS INC COM 78667J108 9,914 103,500 SH   DFND 1,2 103,500 0 0
SANGAMO THERAPEUTICS INC COM 800677106 3,903 340,000 SH   DFND 1,2 340,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 12,716 116,517 SH   DFND 1,2 116,517 0 0
SAVARA INC COM 805111101 833 110,000 SH   DFND 1,2 110,000 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 4,031 175,511 SH   DFND 1,2 175,511 0 0
SIERRA ONCOLOGY INC COM 82640U107 341 258,510 SH   DFND 1,2 258,510 0 0
SPDR SERIES TRUST PUT 78464A870 193,725 2,700,000 SH Put DFND 1,2 2,700,000 0 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 3,228 45,000 SH   DFND 1,2 45,000 0 0
SPRING BK PHARMACEUTICALS IN COM 849431101 530 51,015 SH   DFND 1,2 51,015 0 0
STRONGBRIDGE BIOPHARMA PLC SHS USD G85347105 4,174 931,600 SH   DFND 1,2 931,600 0 0
SUTRO BIOPHARMA INC COM 869367102 3,679 407,889 SH   DFND 1,2 407,889 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADR 881624209 10,863 704,500 SH   DFND 1,2 704,500 0 0
TRANSLATE BIO INC COM 89374L104 2,321 309,400 SH   DFND 1,2 309,400 0 0
UNIQURE NV SHS N90064101 6,711 232,849 SH   DFND 1,2 232,849 0 0
UROVANT SCIENCES LTD SHS G9381B108 1,410 214,030 SH   DFND 1,2 214,030 0 0
VERINT SYS INC COM 92343X100 23,573 149,100 SH   DFND   149,100 0 0
VERRICA PHARMACEUTICALS INC COM 92511W108 791 97,000 SH   DFND 1,2 97,000 0 0
VIKING THERAPEUTICS INC COM 92686J106 5,705 745,727 SH   DFND 1,2 745,727 0 0
VISTAGEN THERAPEUTICS INC COM NEW 92840H202 2,211 1,473,918 SH   DFND 1,2 1,473,918 0 0
XENON PHARMACEUTICALS INC COM 98420N105 2,836 449,484 SH   DFND 1,2 449,484 0 0
ZAFGEN INC COM 98885E103 1,881 380,000 SH   DFND 1,2 380,000 0 0